OMPF - ECOLI - GREMLIN Contacts

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OMPF - Outer membrane protein F

UniProt:	P02931	Sequences: MMKRNILAVIVPALLVAGTANAAEIYNKDGNKVDLYGKAVGLHYFSKGNGENSYGGNGDMTYARLGFKGETQINSDLTGYGQWEYNFQGNNSEGADAQTGNKTRLAFAGLKYADVGSFDYGRNYGVVYDALGYTDMLPEFGGDTAYSDDFFVGRVGGVATYRNSNFFGLVDGLNFAVQYLGKNERDTARRSNGDGVGGSISYEYEGFGIVGAYGAADRTNLQEAQPLGNGKKAEQWATGLKYDANNIYLAANYGETRNATPITNKFTNTSGFANKTQDVLLVAQYQFDFGLRPSIAYTKSKAKDVEGIGDVDLVNYFEVGATYYFNKNMSTYVDYIINQIDSDNKLGVGSDDTVAVGIVYQF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10671
Length:	362 (328)
Sequences:	5655 (4105)
Seq/√Len:	226.7

ECOLI - OMPF PHOE OMPN OMPC YEDS NMPC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
36_Y	66_G	3.855	1.00
291_L	321_A	3.575	1.00
69_G	81_G	3.402	1.00
78_T	111_K	3.348	1.00
297_Y	315_N	3.272	1.00
82_Q	107_F	3.177	1.00
70_E	78_T	3.169	1.00
80_Y	109_G	3.108	1.00
247_I	285_Y	2.857	1.00
163_N	175_F	2.843	1.00
335_Y	352_D	2.758	1.00
291_L	323_Y	2.547	1.00
211_G	236_W	2.482	1.00
129_D	160_T	2.425	1.00
253_Y	277_Q	2.379	1.00
161_Y	164_S	2.378	1.00
39_A	89_G	2.348	1.00
255_E	277_Q	2.336	1.00
292_R	324_Y	2.322	1.00
80_Y	117_S	2.310	1.00
68_K	82_Q	2.300	1.00
299_K	315_N	2.291	1.00
41_G	89_G	2.266	1.00
215_A	234_E	2.259	1.00
126_V	178_Q	2.242	1.00
209_I	240_L	2.195	1.00
322_T	330_S	2.191	1.00
80_Y	119_D	2.186	1.00
325_F	331_T	2.185	1.00
177_V	198_G	2.178	1.00
175_F	200_I	2.176	1.00
330_S	359_V	2.118	1.00
17_A	21_N	2.103	1.00
35_L	67_F	2.100	1.00
287_F	293_P	2.051	1.00
158_V	178_Q	2.009	1.00
111_K	117_S	1.999	1.00
105_L	124_Y	1.979	1.00
174_N	201_S	1.952	1.00
126_V	176_A	1.897	1.00
36_Y	84_E	1.896	1.00
122_R	156_G	1.889	1.00
77_L	110_L	1.871	1.00
211_G	238_T	1.835	1.00
169_L	174_N	1.824	1.00
163_N	170_V	1.813	1.00
77_L	114_D	1.810	1.00
244_A	249_L	1.808	1.00
36_Y	82_Q	1.753	1.00
329_M	360_Y	1.733	1.00
90_N	183_N	1.733	1.00
38_K	64_R	1.727	1.00
118_F	159_A	1.692	1.00
339_Q	350_S	1.681	1.00
331_T	358_I	1.661	1.00
120_Y	159_A	1.657	1.00
100_G	156_G	1.653	1.00
85_Y	101_N	1.648	1.00
213_Y	236_W	1.637	1.00
164_S	170_V	1.608	1.00
215_A	232_K	1.607	1.00
40_V	332_Y	1.601	1.00
240_L	251_A	1.600	1.00
86_N	104_R	1.599	1.00
246_N	285_Y	1.566	1.00
293_P	321_A	1.565	1.00
80_Y	111_K	1.558	1.00
36_Y	68_K	1.556	1.00
162_R	176_A	1.556	1.00
73_I	79_G	1.542	1.00
330_S	361_Q	1.518	1.00
284_Q	292_R	1.508	1.00
249_L	283_A	1.504	1.00
64_R	104_R	1.502	1.00
207_F	242_Y	1.502	1.00
241_K	250_A	1.475	1.00
64_R	84_E	1.459	1.00
250_A	282_V	1.433	1.00
72_Q	76_D	1.421	1.00
119_D	162_R	1.413	1.00
119_D	160_T	1.406	1.00
337_I	350_S	1.405	1.00
328_N	360_Y	1.405	1.00
287_F	291_L	1.386	1.00
65_L	85_Y	1.383	1.00
116_G	161_Y	1.348	1.00
115_V	161_Y	1.346	1.00
123_N	158_V	1.346	1.00
84_E	104_R	1.341	1.00
134_T	208_G	1.338	1.00
80_Y	107_F	1.337	1.00
35_L	65_L	1.319	1.00
119_D	123_N	1.305	1.00
155_V	195_G	1.302	1.00
98_Q	103_T	1.298	1.00
332_Y	357_G	1.295	1.00
337_I	352_D	1.289	1.00
163_N	172_G	1.285	1.00
255_E	275_K	1.284	1.00
82_Q	105_L	1.279	1.00
100_G	103_T	1.277	1.00
78_T	113_A	1.275	1.00
247_I	283_A	1.271	1.00
61_T	359_V	1.261	1.00
252_N	280_L	1.254	1.00
180_L	195_G	1.253	1.00
130_A	210_V	1.252	1.00
159_A	181_G	1.251	1.00
283_A	295_I	1.249	1.00
296_A	318_E	1.245	1.00
288_D	291_L	1.245	1.00
105_L	123_N	1.239	1.00
71_T	326_N	1.237	1.00
206_G	242_Y	1.237	1.00
203_E	208_G	1.236	1.00
209_I	238_T	1.234	1.00
286_Q	292_R	1.229	1.00
241_K	248_Y	1.222	1.00
297_Y	317_F	1.221	1.00
42_L	59_D	1.213	1.00
115_V	118_F	1.212	1.00
77_L	115_V	1.211	1.00
88_Q	93_E	1.209	1.00
299_K	313_L	1.205	1.00
301_K	313_L	1.203	1.00
18_G	21_N	1.189	1.00
236_W	255_E	1.166	1.00
243_D	246_N	1.161	1.00
5_N	9_V	1.158	1.00
295_I	317_F	1.152	1.00
207_F	240_L	1.152	1.00
104_R	154_R	1.150	1.00
340_I	348_V	1.149	1.00
179_Y	196_V	1.147	1.00
294_S	320_G	1.146	1.00
247_I	251_A	1.146	1.00
158_V	180_L	1.145	1.00
44_Y	355_A	1.141	1.00
243_D	248_Y	1.139	1.00
208_G	241_K	1.138	1.00
72_Q	78_T	1.137	1.00
38_K	361_Q	1.122	1.00
178_Q	197_G	1.119	1.00
39_A	87_F	1.117	1.00
55_G	90_N	1.115	1.00
107_F	119_D	1.115	1.00
213_Y	234_E	1.105	1.00
251_A	281_L	1.092	1.00
320_G	334_D	1.088	1.00
41_G	55_G	1.083	1.00
79_G	108_A	1.082	1.00
85_Y	94_G	1.081	1.00
251_A	279_V	1.069	1.00
160_T	178_Q	1.066	1.00
127_V	212_A	1.065	1.00
70_E	80_Y	1.058	1.00
294_S	322_T	1.058	1.00
282_V	296_A	1.048	1.00
76_D	113_A	1.044	1.00
314_V	340_I	1.041	1.00
278_D	300_S	1.040	1.00
177_V	196_V	1.039	1.00
173_L	200_I	1.037	1.00
237_A	254_G	1.037	1.00
290_G	324_Y	1.034	1.00
70_E	111_K	1.033	1.00
174_N	203_E	1.030	1.00
77_L	113_A	1.030	1.00
314_V	338_N	1.028	1.00
333_V	356_V	1.027	1.00
313_L	341_D	1.024	1.00
33_V	81_G	1.024	1.00
47_K	352_D	1.023	1.00
42_L	355_A	1.018	1.00
83_W	102_K	1.014	1.00
333_V	354_V	1.010	1.00
164_S	169_L	1.008	1.00
173_L	204_Y	1.006	1.00
83_W	106_A	1.001	1.00
79_G	110_L	0.999	1.00
155_V	158_V	0.997	1.00
5_N	8_A	0.992	1.00
127_V	235_Q	0.989	1.00
335_Y	354_V	0.987	1.00
71_T	328_N	0.984	1.00
117_S	160_T	0.983	1.00
64_R	154_R	0.961	1.00
7_L	11_V	0.959	1.00
324_Y	330_S	0.957	1.00
317_F	337_I	0.952	1.00
277_Q	303_K	0.949	1.00
137_L	320_G	0.948	1.00
176_A	199_S	0.946	1.00
329_M	358_I	0.942	1.00
246_N	286_Q	0.939	1.00
243_D	286_Q	0.936	1.00
243_D	285_Y	0.929	1.00
136_M	284_Q	0.927	1.00
248_Y	286_Q	0.916	1.00
127_V	237_A	0.915	1.00
123_N	160_T	0.915	1.00
38_K	359_V	0.911	0.99
125_G	155_V	0.909	0.99
41_G	90_N	0.905	0.99
137_L	294_S	0.902	0.99
4_R	7_L	0.896	0.99
111_K	114_D	0.893	0.99
126_V	199_S	0.890	0.99
63_A	87_F	0.890	0.99
32_K	70_E	0.889	0.99
287_F	321_A	0.889	0.99
177_V	200_I	0.889	0.99
31_N	71_T	0.887	0.99
61_T	330_S	0.884	0.99
61_T	361_Q	0.878	0.99
66_G	84_E	0.878	0.99
199_S	212_A	0.874	0.99
60_M	330_S	0.873	0.99
248_Y	284_Q	0.869	0.99
280_L	298_T	0.869	0.99
325_F	329_M	0.868	0.99
130_A	199_S	0.866	0.99
11_V	15_L	0.864	0.99
12_P	15_L	0.860	0.99
295_I	319_V	0.858	0.99
210_V	239_G	0.851	0.99
71_T	329_M	0.842	0.99
136_M	282_V	0.835	0.99
276_T	300_S	0.832	0.99
136_M	296_A	0.832	0.99
160_T	176_A	0.832	0.99
162_R	174_N	0.827	0.99
6_I	9_V	0.826	0.99
34_D	68_K	0.821	0.99
137_L	296_A	0.819	0.99
94_G	101_N	0.817	0.99
180_L	183_N	0.816	0.99
164_S	172_G	0.814	0.99
318_E	336_I	0.814	0.99
40_V	58_G	0.814	0.99
130_A	201_S	0.813	0.99
126_V	212_A	0.808	0.99
233_A	256_T	0.807	0.99
8_A	11_V	0.801	0.99
279_V	301_K	0.800	0.99
11_V	14_L	0.797	0.99
134_T	239_G	0.795	0.99
250_A	284_Q	0.795	0.99
340_I	344_N	0.793	0.99
136_M	280_L	0.792	0.99
71_T	74_N	0.791	0.99
126_V	197_G	0.789	0.99
42_L	61_T	0.787	0.98
92_S	102_K	0.786	0.98
278_D	298_T	0.785	0.98
9_V	13_A	0.783	0.98
17_A	20_A	0.782	0.98
86_N	103_T	0.781	0.98
129_D	162_R	0.780	0.98
322_T	359_V	0.780	0.98
12_P	17_A	0.771	0.98
66_G	104_R	0.768	0.98
122_R	154_R	0.766	0.98
131_L	237_A	0.764	0.98
277_Q	301_K	0.764	0.98
88_Q	91_N	0.763	0.98
74_N	326_N	0.762	0.98
124_Y	128_Y	0.762	0.98
10_I	13_A	0.761	0.98
107_F	123_N	0.761	0.98
130_A	162_R	0.760	0.98
140_F	143_D	0.758	0.98
163_N	177_V	0.754	0.98
76_D	114_D	0.751	0.98
221_L	226_P	0.751	0.98
256_T	276_T	0.749	0.98
183_N	186_D	0.747	0.98
133_Y	201_S	0.745	0.98
65_L	101_N	0.744	0.98
72_Q	75_S	0.743	0.98
313_L	339_Q	0.738	0.98
50_G	53_S	0.738	0.98
163_N	171_D	0.736	0.98
117_S	162_R	0.736	0.98
155_V	178_Q	0.732	0.98
292_R	322_T	0.732	0.98
48_G	351_D	0.725	0.97
344_N	348_V	0.725	0.97
206_G	244_A	0.724	0.97
125_G	197_G	0.722	0.97
257_R	275_K	0.721	0.97
71_T	360_Y	0.719	0.97
284_Q	294_S	0.718	0.97
226_P	229_N	0.715	0.97
127_V	197_G	0.715	0.97
113_A	161_Y	0.715	0.97
244_A	247_I	0.713	0.97
319_V	335_Y	0.708	0.97
334_D	355_A	0.705	0.97
30_G	34_D	0.705	0.97
238_T	253_Y	0.701	0.97
236_W	277_Q	0.699	0.97
46_S	353_T	0.698	0.97
287_F	290_G	0.698	0.97
86_N	154_R	0.696	0.97
289_F	323_Y	0.694	0.97
10_I	14_L	0.690	0.97
31_N	72_Q	0.686	0.96
321_A	333_V	0.684	0.96
16_V	21_N	0.683	0.96
175_F	198_G	0.681	0.96
253_Y	279_V	0.679	0.96
90_N	157_G	0.678	0.96
339_Q	349_G	0.677	0.96
44_Y	54_Y	0.675	0.96
169_L	203_E	0.675	0.96
6_I	10_I	0.674	0.96
356_V	360_Y	0.673	0.96
44_Y	353_T	0.673	0.96
196_V	200_I	0.672	0.96
236_W	253_Y	0.669	0.96
197_G	214_G	0.669	0.96
157_G	183_N	0.668	0.96
137_L	143_D	0.663	0.96
15_L	19_T	0.658	0.95
86_N	102_K	0.654	0.95
279_V	283_A	0.654	0.95
98_Q	101_N	0.652	0.95
275_K	301_K	0.650	0.95
280_L	296_A	0.650	0.95
326_N	329_M	0.650	0.95
172_G	202_Y	0.650	0.95
64_R	86_N	0.648	0.95
30_G	72_Q	0.648	0.95
36_Y	104_R	0.647	0.95
179_Y	194_D	0.645	0.95
33_V	69_G	0.639	0.95
13_A	21_N	0.639	0.95
10_I	16_V	0.638	0.95
95_A	103_T	0.637	0.95
186_D	189_R	0.634	0.95
182_K	186_D	0.634	0.95
115_V	164_S	0.634	0.95
65_L	87_F	0.633	0.94
302_A	312_D	0.633	0.94
191_S	217_D	0.632	0.94
5_N	12_P	0.630	0.94
164_S	174_N	0.630	0.94
45_F	354_V	0.628	0.94
71_T	79_G	0.626	0.94
99_T	103_T	0.625	0.94
316_Y	338_N	0.624	0.94
195_G	216_A	0.619	0.94
62_Y	138_P	0.618	0.94
155_V	180_L	0.617	0.94
163_N	169_L	0.617	0.94
59_D	62_Y	0.617	0.94
141_G	144_T	0.615	0.94
108_A	326_N	0.613	0.93
88_Q	95_A	0.613	0.93
275_K	303_K	0.612	0.93
279_V	299_K	0.612	0.93
124_Y	154_R	0.611	0.93
120_Y	123_N	0.611	0.93
298_T	316_Y	0.610	0.93
45_F	337_I	0.609	0.93
135_D	141_G	0.606	0.93
206_G	243_D	0.606	0.93
113_A	118_F	0.606	0.93
14_L	19_T	0.605	0.93
201_S	210_V	0.599	0.93
135_D	140_F	0.598	0.93
318_E	334_D	0.597	0.93
258_N	276_T	0.591	0.92
140_F	144_T	0.588	0.92
130_A	176_A	0.587	0.92
310_D	342_S	0.586	0.92
8_A	12_P	0.584	0.92
285_Y	291_L	0.581	0.92
3_K	6_I	0.580	0.91
141_G	355_A	0.579	0.91
85_Y	102_K	0.579	0.91
45_F	352_D	0.576	0.91
200_I	205_E	0.576	0.91
44_Y	336_I	0.575	0.91
194_D	217_D	0.574	0.91
6_I	14_L	0.574	0.91
300_S	314_V	0.574	0.91
73_I	326_N	0.572	0.91
233_A	258_N	0.570	0.91
126_V	129_D	0.569	0.91
171_D	204_Y	0.565	0.90
91_N	102_K	0.564	0.90
42_L	357_G	0.562	0.90
198_G	213_Y	0.559	0.90
85_Y	106_A	0.559	0.90
62_Y	86_N	0.559	0.90
62_Y	124_Y	0.558	0.90
55_G	58_G	0.556	0.90
170_V	174_N	0.555	0.90
12_P	16_V	0.554	0.90
33_V	71_T	0.554	0.90
135_D	138_P	0.551	0.89
116_G	164_S	0.551	0.89
204_Y	207_F	0.550	0.89
5_N	10_I	0.550	0.89
87_F	94_G	0.550	0.89
125_G	214_G	0.549	0.89
144_T	153_G	0.547	0.89
110_L	113_A	0.547	0.89
41_G	45_F	0.547	0.89
317_F	339_Q	0.546	0.89
62_Y	95_A	0.544	0.89
239_G	252_N	0.544	0.89
64_R	105_L	0.544	0.89
134_T	250_A	0.542	0.89
217_D	232_K	0.542	0.89
286_Q	324_Y	0.542	0.89
216_A	233_A	0.542	0.89
195_G	214_G	0.542	0.89
114_D	118_F	0.541	0.88
59_D	355_A	0.541	0.88
192_N	218_R	0.541	0.88
190_R	194_D	0.540	0.88
340_I	343_D	0.540	0.88
322_T	361_Q	0.540	0.88
44_Y	56_G	0.540	0.88
161_Y	175_F	0.538	0.88
103_T	154_R	0.538	0.88
316_Y	336_I	0.537	0.88
152_V	214_G	0.537	0.88
13_A	17_A	0.537	0.88
315_N	341_D	0.536	0.88
258_N	261_P	0.532	0.88
178_Q	195_G	0.531	0.87
71_T	81_G	0.531	0.87
185_R	189_R	0.530	0.87
291_L	295_I	0.530	0.87
338_N	351_D	0.530	0.87
317_F	350_S	0.529	0.87
69_G	109_G	0.528	0.87
204_Y	211_G	0.527	0.87
257_R	277_Q	0.527	0.87
249_L	281_L	0.526	0.87
131_L	252_N	0.526	0.87
246_N	287_F	0.525	0.87
304_D	312_D	0.525	0.87
109_G	119_D	0.523	0.87
173_L	202_Y	0.523	0.87
63_A	89_G	0.523	0.87
204_Y	240_L	0.522	0.87
290_G	323_Y	0.521	0.87
319_V	333_V	0.520	0.86
46_S	54_Y	0.520	0.86
109_G	117_S	0.519	0.86
200_I	211_G	0.518	0.86
57_N	89_G	0.518	0.86
41_G	63_A	0.518	0.86
47_K	348_V	0.517	0.86
58_G	63_A	0.516	0.86
161_Y	170_V	0.516	0.86
285_Y	288_D	0.516	0.86
183_N	189_R	0.515	0.86
62_Y	103_T	0.515	0.86
103_T	156_G	0.515	0.86
128_Y	151_F	0.515	0.86
16_V	19_T	0.514	0.86
7_L	14_L	0.513	0.86
73_I	76_D	0.513	0.86
103_T	106_A	0.513	0.86
8_A	15_L	0.513	0.86
135_D	143_D	0.511	0.85
30_G	33_V	0.510	0.85
314_V	344_N	0.510	0.85
42_L	332_Y	0.509	0.85
110_L	115_V	0.509	0.85
336_I	353_T	0.507	0.85
72_Q	327_K	0.506	0.85
185_R	191_S	0.505	0.85
254_G	278_D	0.505	0.85
137_L	141_G	0.505	0.85
73_I	329_M	0.504	0.85
245_N	251_A	0.504	0.85
7_L	12_P	0.503	0.85
43_H	58_G	0.503	0.85
7_L	13_A	0.503	0.85
91_N	100_G	0.502	0.84
127_V	214_G	0.502	0.84
40_V	357_G	0.502	0.84
204_Y	209_I	0.501	0.84
235_Q	256_T	0.500	0.84
60_M	359_V	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zfgA	3	0.9254	100	0.278	Contact Map
1phoA	3	0.8923	100	0.282	Contact Map
3nsgA	3	0.9116	100	0.287	Contact Map
2j1nA	3	0.8923	100	0.294	Contact Map
2fgqX	3	0.8398	100	0.321	Contact Map
3vy8X	3	0.8646	100	0.344	Contact Map
3wi5A	3	0.8343	100	0.37	Contact Map
2porA	3	0.7901	100	0.417	Contact Map
3prnA	3	0.7569	100	0.418	Contact Map
2o4vA	3	0.9254	99.5	0.763	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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