GREMLIN Database
OMPF - Outer membrane protein F
UniProt: P02931 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10671
Length: 362 (328)
Sequences: 5655 (4105)
Seq/√Len: 226.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_Y66_G3.8551.00
291_L321_A3.5751.00
69_G81_G3.4021.00
78_T111_K3.3481.00
297_Y315_N3.2721.00
82_Q107_F3.1771.00
70_E78_T3.1691.00
80_Y109_G3.1081.00
247_I285_Y2.8571.00
163_N175_F2.8431.00
335_Y352_D2.7581.00
291_L323_Y2.5471.00
211_G236_W2.4821.00
129_D160_T2.4251.00
253_Y277_Q2.3791.00
161_Y164_S2.3781.00
39_A89_G2.3481.00
255_E277_Q2.3361.00
292_R324_Y2.3221.00
80_Y117_S2.3101.00
68_K82_Q2.3001.00
299_K315_N2.2911.00
41_G89_G2.2661.00
215_A234_E2.2591.00
126_V178_Q2.2421.00
209_I240_L2.1951.00
322_T330_S2.1911.00
80_Y119_D2.1861.00
325_F331_T2.1851.00
177_V198_G2.1781.00
175_F200_I2.1761.00
330_S359_V2.1181.00
17_A21_N2.1031.00
35_L67_F2.1001.00
287_F293_P2.0511.00
158_V178_Q2.0091.00
111_K117_S1.9991.00
105_L124_Y1.9791.00
174_N201_S1.9521.00
126_V176_A1.8971.00
36_Y84_E1.8961.00
122_R156_G1.8891.00
77_L110_L1.8711.00
211_G238_T1.8351.00
169_L174_N1.8241.00
163_N170_V1.8131.00
77_L114_D1.8101.00
244_A249_L1.8081.00
36_Y82_Q1.7531.00
329_M360_Y1.7331.00
90_N183_N1.7331.00
38_K64_R1.7271.00
118_F159_A1.6921.00
339_Q350_S1.6811.00
331_T358_I1.6611.00
120_Y159_A1.6571.00
100_G156_G1.6531.00
85_Y101_N1.6481.00
213_Y236_W1.6371.00
164_S170_V1.6081.00
215_A232_K1.6071.00
40_V332_Y1.6011.00
240_L251_A1.6001.00
86_N104_R1.5991.00
246_N285_Y1.5661.00
293_P321_A1.5651.00
80_Y111_K1.5581.00
36_Y68_K1.5561.00
162_R176_A1.5561.00
73_I79_G1.5421.00
330_S361_Q1.5181.00
284_Q292_R1.5081.00
249_L283_A1.5041.00
64_R104_R1.5021.00
207_F242_Y1.5021.00
241_K250_A1.4751.00
64_R84_E1.4591.00
250_A282_V1.4331.00
72_Q76_D1.4211.00
119_D162_R1.4131.00
119_D160_T1.4061.00
337_I350_S1.4051.00
328_N360_Y1.4051.00
287_F291_L1.3861.00
65_L85_Y1.3831.00
116_G161_Y1.3481.00
115_V161_Y1.3461.00
123_N158_V1.3461.00
84_E104_R1.3411.00
134_T208_G1.3381.00
80_Y107_F1.3371.00
35_L65_L1.3191.00
119_D123_N1.3051.00
155_V195_G1.3021.00
98_Q103_T1.2981.00
332_Y357_G1.2951.00
337_I352_D1.2891.00
163_N172_G1.2851.00
255_E275_K1.2841.00
82_Q105_L1.2791.00
100_G103_T1.2771.00
78_T113_A1.2751.00
247_I283_A1.2711.00
61_T359_V1.2611.00
252_N280_L1.2541.00
180_L195_G1.2531.00
130_A210_V1.2521.00
159_A181_G1.2511.00
283_A295_I1.2491.00
296_A318_E1.2451.00
288_D291_L1.2451.00
105_L123_N1.2391.00
71_T326_N1.2371.00
206_G242_Y1.2371.00
203_E208_G1.2361.00
209_I238_T1.2341.00
286_Q292_R1.2291.00
241_K248_Y1.2221.00
297_Y317_F1.2211.00
42_L59_D1.2131.00
115_V118_F1.2121.00
77_L115_V1.2111.00
88_Q93_E1.2091.00
299_K313_L1.2051.00
301_K313_L1.2031.00
18_G21_N1.1891.00
236_W255_E1.1661.00
243_D246_N1.1611.00
5_N9_V1.1581.00
295_I317_F1.1521.00
207_F240_L1.1521.00
104_R154_R1.1501.00
340_I348_V1.1491.00
179_Y196_V1.1471.00
294_S320_G1.1461.00
247_I251_A1.1461.00
158_V180_L1.1451.00
44_Y355_A1.1411.00
243_D248_Y1.1391.00
208_G241_K1.1381.00
72_Q78_T1.1371.00
38_K361_Q1.1221.00
178_Q197_G1.1191.00
39_A87_F1.1171.00
55_G90_N1.1151.00
107_F119_D1.1151.00
213_Y234_E1.1051.00
251_A281_L1.0921.00
320_G334_D1.0881.00
41_G55_G1.0831.00
79_G108_A1.0821.00
85_Y94_G1.0811.00
251_A279_V1.0691.00
160_T178_Q1.0661.00
127_V212_A1.0651.00
70_E80_Y1.0581.00
294_S322_T1.0581.00
282_V296_A1.0481.00
76_D113_A1.0441.00
314_V340_I1.0411.00
278_D300_S1.0401.00
177_V196_V1.0391.00
173_L200_I1.0371.00
237_A254_G1.0371.00
290_G324_Y1.0341.00
70_E111_K1.0331.00
174_N203_E1.0301.00
77_L113_A1.0301.00
314_V338_N1.0281.00
333_V356_V1.0271.00
313_L341_D1.0241.00
33_V81_G1.0241.00
47_K352_D1.0231.00
42_L355_A1.0181.00
83_W102_K1.0141.00
333_V354_V1.0101.00
164_S169_L1.0081.00
173_L204_Y1.0061.00
83_W106_A1.0011.00
79_G110_L0.9991.00
155_V158_V0.9971.00
5_N8_A0.9921.00
127_V235_Q0.9891.00
335_Y354_V0.9871.00
71_T328_N0.9841.00
117_S160_T0.9831.00
64_R154_R0.9611.00
7_L11_V0.9591.00
324_Y330_S0.9571.00
317_F337_I0.9521.00
277_Q303_K0.9491.00
137_L320_G0.9481.00
176_A199_S0.9461.00
329_M358_I0.9421.00
246_N286_Q0.9391.00
243_D286_Q0.9361.00
243_D285_Y0.9291.00
136_M284_Q0.9271.00
248_Y286_Q0.9161.00
127_V237_A0.9151.00
123_N160_T0.9151.00
38_K359_V0.9110.99
125_G155_V0.9090.99
41_G90_N0.9050.99
137_L294_S0.9020.99
4_R7_L0.8960.99
111_K114_D0.8930.99
126_V199_S0.8900.99
63_A87_F0.8900.99
32_K70_E0.8890.99
287_F321_A0.8890.99
177_V200_I0.8890.99
31_N71_T0.8870.99
61_T330_S0.8840.99
61_T361_Q0.8780.99
66_G84_E0.8780.99
199_S212_A0.8740.99
60_M330_S0.8730.99
248_Y284_Q0.8690.99
280_L298_T0.8690.99
325_F329_M0.8680.99
130_A199_S0.8660.99
11_V15_L0.8640.99
12_P15_L0.8600.99
295_I319_V0.8580.99
210_V239_G0.8510.99
71_T329_M0.8420.99
136_M282_V0.8350.99
276_T300_S0.8320.99
136_M296_A0.8320.99
160_T176_A0.8320.99
162_R174_N0.8270.99
6_I9_V0.8260.99
34_D68_K0.8210.99
137_L296_A0.8190.99
94_G101_N0.8170.99
180_L183_N0.8160.99
164_S172_G0.8140.99
318_E336_I0.8140.99
40_V58_G0.8140.99
130_A201_S0.8130.99
126_V212_A0.8080.99
233_A256_T0.8070.99
8_A11_V0.8010.99
279_V301_K0.8000.99
11_V14_L0.7970.99
134_T239_G0.7950.99
250_A284_Q0.7950.99
340_I344_N0.7930.99
136_M280_L0.7920.99
71_T74_N0.7910.99
126_V197_G0.7890.99
42_L61_T0.7870.98
92_S102_K0.7860.98
278_D298_T0.7850.98
9_V13_A0.7830.98
17_A20_A0.7820.98
86_N103_T0.7810.98
129_D162_R0.7800.98
322_T359_V0.7800.98
12_P17_A0.7710.98
66_G104_R0.7680.98
122_R154_R0.7660.98
131_L237_A0.7640.98
277_Q301_K0.7640.98
88_Q91_N0.7630.98
74_N326_N0.7620.98
124_Y128_Y0.7620.98
10_I13_A0.7610.98
107_F123_N0.7610.98
130_A162_R0.7600.98
140_F143_D0.7580.98
163_N177_V0.7540.98
76_D114_D0.7510.98
221_L226_P0.7510.98
256_T276_T0.7490.98
183_N186_D0.7470.98
133_Y201_S0.7450.98
65_L101_N0.7440.98
72_Q75_S0.7430.98
313_L339_Q0.7380.98
50_G53_S0.7380.98
163_N171_D0.7360.98
117_S162_R0.7360.98
155_V178_Q0.7320.98
292_R322_T0.7320.98
48_G351_D0.7250.97
344_N348_V0.7250.97
206_G244_A0.7240.97
125_G197_G0.7220.97
257_R275_K0.7210.97
71_T360_Y0.7190.97
284_Q294_S0.7180.97
226_P229_N0.7150.97
127_V197_G0.7150.97
113_A161_Y0.7150.97
244_A247_I0.7130.97
319_V335_Y0.7080.97
334_D355_A0.7050.97
30_G34_D0.7050.97
238_T253_Y0.7010.97
236_W277_Q0.6990.97
46_S353_T0.6980.97
287_F290_G0.6980.97
86_N154_R0.6960.97
289_F323_Y0.6940.97
10_I14_L0.6900.97
31_N72_Q0.6860.96
321_A333_V0.6840.96
16_V21_N0.6830.96
175_F198_G0.6810.96
253_Y279_V0.6790.96
90_N157_G0.6780.96
339_Q349_G0.6770.96
44_Y54_Y0.6750.96
169_L203_E0.6750.96
6_I10_I0.6740.96
356_V360_Y0.6730.96
44_Y353_T0.6730.96
196_V200_I0.6720.96
236_W253_Y0.6690.96
197_G214_G0.6690.96
157_G183_N0.6680.96
137_L143_D0.6630.96
15_L19_T0.6580.95
86_N102_K0.6540.95
279_V283_A0.6540.95
98_Q101_N0.6520.95
275_K301_K0.6500.95
280_L296_A0.6500.95
326_N329_M0.6500.95
172_G202_Y0.6500.95
64_R86_N0.6480.95
30_G72_Q0.6480.95
36_Y104_R0.6470.95
179_Y194_D0.6450.95
33_V69_G0.6390.95
13_A21_N0.6390.95
10_I16_V0.6380.95
95_A103_T0.6370.95
186_D189_R0.6340.95
182_K186_D0.6340.95
115_V164_S0.6340.95
65_L87_F0.6330.94
302_A312_D0.6330.94
191_S217_D0.6320.94
5_N12_P0.6300.94
164_S174_N0.6300.94
45_F354_V0.6280.94
71_T79_G0.6260.94
99_T103_T0.6250.94
316_Y338_N0.6240.94
195_G216_A0.6190.94
62_Y138_P0.6180.94
155_V180_L0.6170.94
163_N169_L0.6170.94
59_D62_Y0.6170.94
141_G144_T0.6150.94
108_A326_N0.6130.93
88_Q95_A0.6130.93
275_K303_K0.6120.93
279_V299_K0.6120.93
124_Y154_R0.6110.93
120_Y123_N0.6110.93
298_T316_Y0.6100.93
45_F337_I0.6090.93
135_D141_G0.6060.93
206_G243_D0.6060.93
113_A118_F0.6060.93
14_L19_T0.6050.93
201_S210_V0.5990.93
135_D140_F0.5980.93
318_E334_D0.5970.93
258_N276_T0.5910.92
140_F144_T0.5880.92
130_A176_A0.5870.92
310_D342_S0.5860.92
8_A12_P0.5840.92
285_Y291_L0.5810.92
3_K6_I0.5800.91
141_G355_A0.5790.91
85_Y102_K0.5790.91
45_F352_D0.5760.91
200_I205_E0.5760.91
44_Y336_I0.5750.91
194_D217_D0.5740.91
6_I14_L0.5740.91
300_S314_V0.5740.91
73_I326_N0.5720.91
233_A258_N0.5700.91
126_V129_D0.5690.91
171_D204_Y0.5650.90
91_N102_K0.5640.90
42_L357_G0.5620.90
198_G213_Y0.5590.90
85_Y106_A0.5590.90
62_Y86_N0.5590.90
62_Y124_Y0.5580.90
55_G58_G0.5560.90
170_V174_N0.5550.90
12_P16_V0.5540.90
33_V71_T0.5540.90
135_D138_P0.5510.89
116_G164_S0.5510.89
204_Y207_F0.5500.89
5_N10_I0.5500.89
87_F94_G0.5500.89
125_G214_G0.5490.89
144_T153_G0.5470.89
110_L113_A0.5470.89
41_G45_F0.5470.89
317_F339_Q0.5460.89
62_Y95_A0.5440.89
239_G252_N0.5440.89
64_R105_L0.5440.89
134_T250_A0.5420.89
217_D232_K0.5420.89
286_Q324_Y0.5420.89
216_A233_A0.5420.89
195_G214_G0.5420.89
114_D118_F0.5410.88
59_D355_A0.5410.88
192_N218_R0.5410.88
190_R194_D0.5400.88
340_I343_D0.5400.88
322_T361_Q0.5400.88
44_Y56_G0.5400.88
161_Y175_F0.5380.88
103_T154_R0.5380.88
316_Y336_I0.5370.88
152_V214_G0.5370.88
13_A17_A0.5370.88
315_N341_D0.5360.88
258_N261_P0.5320.88
178_Q195_G0.5310.87
71_T81_G0.5310.87
185_R189_R0.5300.87
291_L295_I0.5300.87
338_N351_D0.5300.87
317_F350_S0.5290.87
69_G109_G0.5280.87
204_Y211_G0.5270.87
257_R277_Q0.5270.87
249_L281_L0.5260.87
131_L252_N0.5260.87
246_N287_F0.5250.87
304_D312_D0.5250.87
109_G119_D0.5230.87
173_L202_Y0.5230.87
63_A89_G0.5230.87
204_Y240_L0.5220.87
290_G323_Y0.5210.87
319_V333_V0.5200.86
46_S54_Y0.5200.86
109_G117_S0.5190.86
200_I211_G0.5180.86
57_N89_G0.5180.86
41_G63_A0.5180.86
47_K348_V0.5170.86
58_G63_A0.5160.86
161_Y170_V0.5160.86
285_Y288_D0.5160.86
183_N189_R0.5150.86
62_Y103_T0.5150.86
103_T156_G0.5150.86
128_Y151_F0.5150.86
16_V19_T0.5140.86
7_L14_L0.5130.86
73_I76_D0.5130.86
103_T106_A0.5130.86
8_A15_L0.5130.86
135_D143_D0.5110.85
30_G33_V0.5100.85
314_V344_N0.5100.85
42_L332_Y0.5090.85
110_L115_V0.5090.85
336_I353_T0.5070.85
72_Q327_K0.5060.85
185_R191_S0.5050.85
254_G278_D0.5050.85
137_L141_G0.5050.85
73_I329_M0.5040.85
245_N251_A0.5040.85
7_L12_P0.5030.85
43_H58_G0.5030.85
7_L13_A0.5030.85
91_N100_G0.5020.84
127_V214_G0.5020.84
40_V357_G0.5020.84
204_Y209_I0.5010.84
235_Q256_T0.5000.84
60_M359_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zfgA 3 0.9254 100 0.278 Contact Map
1phoA 3 0.8923 100 0.282 Contact Map
3nsgA 3 0.9116 100 0.287 Contact Map
2j1nA 3 0.8923 100 0.294 Contact Map
2fgqX 3 0.8398 100 0.321 Contact Map
3vy8X 3 0.8646 100 0.344 Contact Map
3wi5A 3 0.8343 100 0.37 Contact Map
2porA 3 0.7901 100 0.417 Contact Map
3prnA 3 0.7569 100 0.418 Contact Map
2o4vA 3 0.9254 99.5 0.763 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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