GREMLIN Database
TOLC - Outer membrane protein TolC
UniProt: P02930 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11009
Length: 493 (405)
Sequences: 18330 (14359)
Seq/√Len: 713.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_A131_T3.0701.00
259_I331_F2.7511.00
31_Q210_N2.7181.00
163_T167_N2.6411.00
156_Y187_L2.5901.00
163_T180_R2.5641.00
149_Q194_R2.4341.00
149_Q190_E2.4051.00
374_Q405_K2.2971.00
48_A330_N2.2751.00
41_K337_Q2.2421.00
44_A329_Y2.2391.00
45_D333_G2.1711.00
390_T393_D2.1601.00
381_E385_S2.1571.00
52_K326_Q2.1341.00
38_E340_S2.1321.00
53_I113_A2.1301.00
119_T247_Q2.1151.00
142_I197_L2.1051.00
375_S378_D2.0731.00
170_L388_T2.0691.00
145_L194_R2.0401.00
173_I375_S2.0301.00
51_E322_S2.0221.00
108_L258_Q1.9941.00
152_K190_E1.9631.00
164_Q382_A1.9571.00
166_F176_V1.9471.00
184_D187_L1.9461.00
144_V406_Q1.9441.00
143_D146_S1.9361.00
266_H324_V1.9301.00
30_Q34_L1.9001.00
157_R160_D1.8871.00
156_Y183_Y1.8801.00
367_K408_L1.8751.00
118_V246_L1.8451.00
111_K250_L1.8401.00
152_K183_Y1.8401.00
138_V197_L1.8301.00
24_N27_Q1.7781.00
360_I415_Y1.7741.00
256_R331_F1.7561.00
152_K187_L1.7531.00
408_L412_R1.7501.00
145_L197_L1.7501.00
330_N333_G1.7391.00
374_Q378_D1.7151.00
145_L190_E1.7071.00
141_A200_A1.7031.00
140_N413_Y1.6701.00
184_D368_Q1.6611.00
249_R338_L1.6601.00
72_Y85_N1.6591.00
40_R336_E1.6541.00
156_Y160_D1.6471.00
115_I251_S1.6401.00
273_T307_G1.6391.00
46_R120_Y1.6211.00
112_A254_L1.6081.00
141_A193_A1.5851.00
112_A258_Q1.5781.00
270_L310_F1.5711.00
359_S411_A1.5701.00
159_L180_R1.5621.00
133_T417_I1.5541.00
197_L201_V1.5511.00
316_Q320_V1.5431.00
29_Y128_I1.5431.00
140_N409_A1.5391.00
252_Q338_L1.5271.00
177_Q375_S1.5161.00
159_L163_T1.5071.00
340_S344_S1.5051.00
250_L253_D1.5031.00
159_L183_Y1.4971.00
166_F173_I1.4891.00
347_Q351_S1.4891.00
150_A405_K1.4851.00
401_L405_K1.4801.00
27_Q30_Q1.4761.00
28_V131_T1.4711.00
118_V121_Q1.4691.00
114_G117_D1.4681.00
338_L342_H1.4641.00
55_E326_Q1.4561.00
191_V361_S1.4551.00
259_I324_V1.4531.00
153_E157_R1.4521.00
253_D256_R1.4511.00
105_A261_Q1.4481.00
252_Q335_S1.4451.00
133_T421_N1.4411.00
331_F335_S1.4291.00
44_A336_E1.4291.00
145_L149_Q1.4251.00
102_K269_T1.4251.00
44_A332_V1.4221.00
48_A333_G1.4201.00
132_A420_L1.4131.00
60_L106_L1.4081.00
53_I110_E1.4051.00
144_V410_N1.3981.00
150_A153_E1.3871.00
332_V335_S1.3821.00
31_Q208_T1.3801.00
47_D50_F1.3761.00
115_I254_L1.3661.00
190_E194_R1.3641.00
183_Y187_L1.3611.00
45_D48_A1.3601.00
382_A385_S1.3491.00
363_I408_L1.3431.00
168_V386_V1.3311.00
359_S418_N1.3271.00
333_G337_Q1.3231.00
247_Q251_S1.3211.00
138_V201_V1.3191.00
26_M30_Q1.3091.00
107_T257_E1.3051.00
51_E325_K1.3011.00
248_A334_A1.3001.00
380_M389_R1.2981.00
114_G250_L1.2961.00
23_E28_V1.2931.00
160_D164_Q1.2921.00
33_R128_I1.2911.00
108_L261_Q1.2751.00
339_E342_H1.2721.00
326_Q330_N1.2711.00
46_R117_D1.2671.00
180_R368_Q1.2631.00
257_E260_R1.2611.00
155_I186_V1.2581.00
111_K253_D1.2581.00
146_S150_A1.2581.00
121_Q124_Q1.2561.00
259_I328_Q1.2561.00
164_Q167_N1.2541.00
370_V408_L1.2541.00
146_S149_Q1.2521.00
44_A47_D1.2481.00
116_Q119_T1.2471.00
368_Q371_V1.2451.00
142_I201_V1.2441.00
323_Q326_Q1.2401.00
41_K336_E1.2381.00
206_Q347_Q1.2351.00
381_E398_T1.2321.00
377_L381_E1.2301.00
367_K371_V1.2271.00
403_N407_E1.2271.00
152_K156_Y1.2231.00
356_I415_Y1.2171.00
118_V250_L1.2101.00
370_V405_K1.2081.00
122_T126_T1.2071.00
202_E351_S1.2071.00
137_N417_I1.2061.00
43_A120_Y1.2011.00
199_N355_N1.2011.00
364_N368_Q1.1951.00
153_E156_Y1.1891.00
377_L401_L1.1861.00
378_D382_A1.1841.00
191_V194_R1.1831.00
52_K55_E1.1801.00
55_E323_Q1.1791.00
149_Q153_E1.1781.00
263_Q324_V1.1771.00
29_Y33_R1.1711.00
367_K412_R1.1701.00
410_N414_N1.1691.00
31_Q35_S1.1631.00
383_G389_R1.1581.00
54_N322_S1.1571.00
177_Q180_R1.1571.00
396_D399_T1.1531.00
140_N410_N1.1491.00
374_Q401_L1.1471.00
370_V401_L1.1461.00
131_T204_L1.1421.00
242_N425_A1.1421.00
181_A373_A1.1401.00
173_I177_Q1.1391.00
148_T186_V1.1391.00
129_L424_S1.1361.00
51_E329_Y1.1311.00
50_F113_A1.1251.00
53_I57_R1.1141.00
70_Y87_T1.1131.00
29_Y132_A1.1121.00
163_T176_V1.1121.00
40_R43_A1.1091.00
182_Q185_T1.1031.00
319_M323_Q1.1031.00
160_D163_T1.1021.00
273_T309_S1.1011.00
384_Y391_I1.1001.00
33_R124_Q1.0971.00
275_S305_K1.0961.00
159_L176_V1.0951.00
103_W106_L1.0941.00
111_K257_E1.0931.00
130_N133_T1.0871.00
325_K328_Q1.0861.00
120_Y124_Q1.0821.00
320_V324_V1.0781.00
327_A330_N1.0771.00
199_N354_N1.0731.00
111_K114_G1.0731.00
46_R113_A1.0691.00
122_T244_S1.0691.00
25_L132_A1.0691.00
47_D332_V1.0651.00
43_A47_D1.0541.00
42_S123_D1.0531.00
126_T130_N1.0521.00
12_S15_G1.0451.00
134_A200_A1.0451.00
315_Y318_G1.0411.00
119_T251_S1.0401.00
415_Y419_Q1.0381.00
32_A127_L1.0371.00
252_Q331_F1.0361.00
249_R253_D1.0331.00
96_S99_D1.0331.00
147_Y409_A1.0291.00
184_D372_S1.0231.00
162_T171_V1.0211.00
145_L193_A1.0171.00
37_P336_E1.0161.00
27_Q31_Q1.0141.00
129_L420_L1.0091.00
251_S337_Q1.0061.00
28_V208_T1.0011.00
58_S319_M1.0011.00
324_V328_Q0.9961.00
98_F101_S0.9951.00
336_E339_E0.9911.00
361_S364_N0.9831.00
266_H320_V0.9831.00
362_S414_N0.9811.00
180_R184_D0.9781.00
189_N192_T0.9761.00
70_Y85_N0.9721.00
39_L127_L0.9711.00
192_T196_N0.9701.00
67_G90_S0.9671.00
276_T302_G0.9661.00
370_V374_Q0.9651.00
389_R393_D0.9641.00
419_Q423_K0.9631.00
363_I415_Y0.9621.00
51_E54_N0.9601.00
360_I364_N0.9591.00
143_D412_R0.9591.00
148_T193_A0.9561.00
262_A265_G0.9551.00
136_F420_L0.9541.00
266_H321_N0.9501.00
413_Y417_I0.9481.00
246_L249_R0.9451.00
248_A341_A0.9451.00
165_R171_V0.9411.00
255_A327_A0.9411.00
245_L345_V0.9401.00
334_A337_Q0.9401.00
357_N361_S0.9371.00
195_N358_A0.9351.00
198_D354_N0.9351.00
382_A386_V0.9301.00
371_V374_Q0.9281.00
249_R342_H0.9271.00
121_Q246_L0.9241.00
104_R107_T0.9191.00
412_R416_L0.9181.00
258_Q262_A0.9131.00
195_N355_N0.9101.00
44_A333_G0.9091.00
113_A117_D0.9071.00
191_V365_A0.9051.00
242_N348_T0.9041.00
57_R106_L0.9031.00
141_A144_V0.9001.00
373_A404_A0.8971.00
344_S348_T0.8961.00
248_A251_S0.8951.00
174_T380_M0.8951.00
194_R361_S0.8951.00
328_Q332_V0.8931.00
366_Y411_A0.8921.00
137_N203_Q0.8911.00
242_N345_V0.8881.00
176_V180_R0.8851.00
109_Q112_A0.8831.00
195_N199_N0.8821.00
17_S20_S0.8791.00
55_E322_S0.8781.00
180_R372_S0.8781.00
206_Q340_S0.8781.00
230_P233_A0.8771.00
166_F171_V0.8751.00
363_I367_K0.8751.00
192_T362_S0.8731.00
138_V142_I0.8701.00
106_L110_E0.8691.00
108_L112_A0.8681.00
164_Q168_V0.8651.00
47_D329_Y0.8581.00
60_L103_W0.8571.00
178_N396_D0.8571.00
234_L426_L0.8561.00
143_D409_A0.8551.00
53_I106_L0.8551.00
258_Q261_Q0.8541.00
56_A109_Q0.8531.00
353_F357_N0.8481.00
125_Q243_L0.8471.00
187_L365_A0.8411.00
201_V205_R0.8401.00
162_T179_A0.8381.00
363_I411_A0.8371.00
421_N424_S0.8361.00
363_I412_R0.8341.00
126_T424_S0.8341.00
171_V175_D0.8331.00
265_G323_Q0.8331.00
182_Q399_T0.8321.00
11_L14_S0.8301.00
255_A258_Q0.8281.00
65_G316_Q0.8281.00
364_N367_K0.8271.00
352_S418_N0.8261.00
371_V375_S0.8231.00
148_T190_E0.8231.00
43_A124_Q0.8231.00
58_S317_G0.8221.00
152_K186_V0.8211.00
238_A349_V0.8201.00
37_P343_R0.8191.00
185_T369_A0.8131.00
127_L131_T0.8101.00
144_V148_T0.8101.00
244_S345_V0.8071.00
313_P316_Q0.8021.00
138_V200_A0.8021.00
259_I263_Q0.8011.00
172_A175_D0.7991.00
61_L317_G0.7981.00
64_L93_L0.7981.00
337_Q341_A0.7951.00
262_A327_A0.7941.00
28_V204_L0.7941.00
349_V422_I0.7911.00
134_A207_I0.7911.00
252_Q256_R0.7901.00
177_Q372_S0.7891.00
196_N200_A0.7881.00
188_A362_S0.7871.00
198_D201_V0.7861.00
41_K333_G0.7851.00
41_K340_S0.7821.00
355_N421_N0.7811.00
49_A116_Q0.7791.00
136_F413_Y0.7761.00
40_R339_E0.7741.00
132_A423_K0.7721.00
155_I179_A0.7721.00
94_T271_D0.7721.00
239_E346_V0.7711.00
396_D400_T0.7711.00
133_T137_N0.7701.00
96_S271_D0.7641.00
202_E350_R0.7631.00
18_S26_M0.7611.00
41_K45_D0.7611.00
329_Y332_V0.7611.00
260_R263_Q0.7601.00
237_E240_K0.7571.00
330_N334_A0.7561.00
256_R260_R0.7551.00
346_V350_R0.7531.00
165_R170_L0.7511.00
205_R210_N0.7511.00
245_L338_L0.7481.00
185_T407_E0.7461.00
362_S366_Y0.7451.00
157_R381_E0.7431.00
129_L421_N0.7431.00
276_T304_N0.7411.00
359_S362_S0.7391.00
245_L342_H0.7391.00
254_L258_Q0.7381.00
48_A52_K0.7381.00
148_T189_N0.7381.00
377_L398_T0.7381.00
61_L315_Y0.7361.00
122_T247_Q0.7351.00
194_R198_D0.7351.00
416_L419_Q0.7341.00
246_L250_L0.7311.00
357_N360_I0.7271.00
178_N393_D0.7201.00
356_I419_Q0.7171.00
184_D365_A0.7161.00
141_A197_L0.7161.00
265_G320_V0.7161.00
107_T110_E0.7151.00
337_Q340_S0.7131.00
356_I422_I0.7121.00
199_N351_S0.7081.00
16_F19_L0.7081.00
16_F20_S0.7071.00
110_E114_G0.7061.00
69_D88_S0.7051.00
321_N325_K0.7041.00
54_N325_K0.7031.00
233_A237_E0.7031.00
112_A115_I0.7021.00
339_E343_R0.7001.00
48_A329_Y0.7001.00
68_A89_A0.6981.00
137_N200_A0.6981.00
203_Q347_Q0.6971.00
356_I360_I0.6971.00
32_A208_T0.6951.00
151_Q155_I0.6941.00
185_T189_N0.6941.00
141_A196_N0.6941.00
341_A344_S0.6941.00
407_E410_N0.6931.00
271_D309_S0.6931.00
9_I12_S0.6931.00
148_T406_Q0.6911.00
235_L346_V0.6901.00
66_L312_L0.6901.00
157_R161_Q0.6891.00
108_L254_L0.6851.00
369_A373_A0.6841.00
118_V243_L0.6831.00
236_K240_K0.6821.00
115_I119_T0.6821.00
255_A334_A0.6811.00
352_S425_A0.6811.00
140_N144_V0.6801.00
256_R335_S0.6791.00
90_S275_S0.6731.00
60_L104_R0.6721.00
130_N134_A0.6721.00
98_F267_L0.6701.00
378_D381_E0.6701.00
10_G13_L0.6661.00
117_D121_Q0.6661.00
355_N418_N0.6651.00
177_Q379_A0.6651.00
38_E41_K0.6651.00
39_L124_Q0.6651.00
29_Y131_T0.6631.00
37_P339_E0.6621.00
99_D103_W0.6601.00
188_A366_Y0.6601.00
233_A236_K0.6601.00
147_Y406_Q0.6581.00
144_V196_N0.6581.00
166_F172_A0.6571.00
137_N141_A0.6561.00
50_F117_D0.6561.00
200_A203_Q0.6541.00
328_Q331_F0.6521.00
149_Q152_K0.6521.00
66_L91_L0.6511.00
202_E354_N0.6511.00
31_Q34_L0.6501.00
269_T311_S0.6501.00
359_S414_N0.6481.00
335_S339_E0.6471.00
178_N182_Q0.6461.00
375_S379_A0.6461.00
320_V323_Q0.6411.00
210_N214_E0.6391.00
358_A361_S0.6381.00
237_E241_R0.6331.00
187_L368_Q0.6321.00
17_S26_M0.6321.00
274_A304_N0.6311.00
258_Q330_N0.6301.00
174_T379_A0.6291.00
414_N418_N0.6271.00
155_I182_Q0.6271.00
96_S102_K0.6251.00
383_G388_T0.6191.00
196_N199_N0.6181.00
39_L120_Y0.6171.00
124_Q128_I0.6171.00
36_N207_I0.6171.00
57_R61_L0.6161.00
46_R50_F0.6151.00
158_Q391_I0.6111.00
105_A108_L0.6101.00
72_Y83_N0.6091.00
373_A400_T0.6091.00
248_A338_L0.6081.00
332_V336_E0.6081.00
393_D396_D0.6071.00
42_S45_D0.6031.00
418_N421_N0.5981.00
194_R358_A0.5971.00
48_A326_Q0.5971.00
161_Q165_R0.5941.00
107_T111_K0.5941.00
316_Q319_M0.5931.00
123_D126_T0.5931.00
191_V195_N0.5931.00
102_K264_D0.5921.00
274_A306_V0.5901.00
137_N140_N0.5901.00
119_T122_T0.5871.00
37_P340_S0.5851.00
392_V396_D0.5851.00
376_S397_A0.5841.00
193_A196_N0.5821.00
365_A368_Q0.5811.00
203_Q351_S0.5811.00
129_L133_T0.5781.00
239_E342_H0.5751.00
7_I10_G0.5731.00
115_I247_Q0.5731.00
377_L394_V0.5701.00
380_M397_A0.5681.00
255_A331_F0.5671.00
140_N414_N0.5671.00
256_R259_I0.5641.00
37_P209_G0.5621.00
92_Q275_S0.5621.00
258_Q327_A0.5621.00
318_G322_S0.5581.00
381_E394_V0.5581.00
142_I217_A0.5571.00
144_V193_A0.5571.00
237_E428_T0.5571.00
222_N225_T0.5561.00
351_S355_N0.5551.00
35_S209_G0.5551.00
167_N385_S0.5541.00
73_S84_S0.5541.00
400_T403_N0.5531.00
147_Y402_Y0.5531.00
100_M267_L0.5481.00
325_K329_Y0.5471.00
359_S415_Y0.5461.00
215_L218_L0.5461.00
160_D378_D0.5451.00
262_A323_Q0.5451.00
379_A383_G0.5441.00
67_G92_Q0.5421.00
322_S325_K0.5421.00
344_S347_Q0.5421.00
251_S255_A0.5411.00
148_T152_K0.5391.00
350_R354_N0.5391.00
102_K105_A0.5361.00
49_A52_K0.5361.00
99_D271_D0.5351.00
44_A48_A0.5351.00
348_T351_S0.5351.00
23_E31_Q0.5351.00
45_D119_T0.5341.00
234_L422_I0.5341.00
187_L361_S0.5331.00
139_L142_I0.5321.00
54_N57_R0.5311.00
47_D51_E0.5281.00
66_L314_I0.5271.00
123_D127_L0.5271.00
270_L308_L0.5261.00
399_T403_N0.5241.00
156_Y159_L0.5231.00
366_Y407_E0.5231.00
238_A345_V0.5221.00
40_R44_A0.5221.00
52_K112_A0.5211.00
90_S277_G0.5211.00
206_Q344_S0.5201.00
205_R211_Y0.5201.00
341_A345_V0.5191.00
65_G313_P0.5191.00
414_N417_I0.5191.00
99_D270_L0.5171.00
174_T376_S0.5161.00
159_L179_A0.5141.00
181_A376_S0.5131.00
370_V404_A0.5121.00
151_Q402_Y0.5101.00
51_E326_Q0.5080.99
165_R175_D0.5080.99
342_H346_V0.5070.99
174_T177_Q0.5060.99
127_L207_I0.5050.99
139_L143_D0.5050.99
188_A365_A0.5040.99
376_S400_T0.5040.99
308_L312_L0.5030.99
29_Y32_A0.5010.99
366_Y404_A0.5010.99
356_I418_N0.5000.99
411_A414_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ek9A 3 0.8682 100 0.268 Contact Map
1yc9A 3 0.8195 100 0.293 Contact Map
4mt4A 3 0.8986 100 0.294 Contact Map
3d5kA 3 0.8621 100 0.297 Contact Map
4mt0A 3 0.86 100 0.31 Contact Map
4k7rA 3 0.8377 100 0.312 Contact Map
2f1mA 2 0.4503 65.2 0.948 Contact Map
4tkoB 1 0.4564 43.5 0.954 Contact Map
4dk0A 5 0.4199 36 0.956 Contact Map
3zbiC 1 0.0507 29.8 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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