GREMLIN Database
TONB - Protein TonB
UniProt: P02929 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11012
Length: 239 (221)
Sequences: 3132 (2993)
Seq/√Len: 201.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_A203_E4.0251.00
183_T187_R4.0071.00
167_A201_M3.7671.00
179_K192_Q3.7641.00
172_I199_A3.4981.00
172_I201_M3.2791.00
191_V207_K3.2591.00
183_T189_D3.2181.00
198_P203_E3.1651.00
167_A172_I2.9551.00
176_V193_I2.9421.00
181_D190_N2.7901.00
177_K195_S2.7251.00
16_S20_H2.6641.00
161_P209_A2.4731.00
197_K202_F2.4371.00
197_K203_E2.4181.00
179_K225_V2.3651.00
161_P213_W2.2101.00
215_Y220_P2.1711.00
205_E208_N2.1421.00
205_E209_A2.0501.00
206_V230_F2.0351.00
175_Q227_N1.9391.00
175_Q229_L1.9221.00
158_R161_P1.9201.00
216_E219_K1.8761.00
168_Q232_I1.8631.00
207_K211_R1.7641.00
200_N204_R1.6951.00
191_V210_M1.6511.00
194_L225_V1.6381.00
163_Y167_A1.6261.00
157_S213_W1.6101.00
196_A202_F1.5921.00
166_R201_M1.5911.00
219_K222_S1.5851.00
180_F210_M1.5511.00
166_R170_L1.5451.00
163_Y174_G1.5421.00
66_E69_V1.5421.00
156_L215_Y1.5301.00
167_A199_A1.5051.00
193_I207_K1.4701.00
215_Y218_G1.4631.00
157_S161_P1.4551.00
173_E232_I1.4541.00
178_V191_V1.4391.00
24_V28_L1.4001.00
179_K194_L1.3851.00
191_V211_R1.3831.00
177_K225_V1.3731.00
216_E220_P1.3711.00
70_E74_E1.3641.00
178_V207_K1.3611.00
165_A169_A1.3451.00
25_A28_L1.3381.00
153_P157_S1.3191.00
177_K227_N1.3151.00
160_Q213_W1.3151.00
25_A29_Y1.3041.00
178_V193_I1.2771.00
167_A202_F1.2761.00
149_V153_P1.2661.00
165_A168_Q1.2591.00
204_R208_N1.2501.00
69_V72_E1.2411.00
149_V219_K1.2351.00
198_P202_F1.2311.00
88_V91_K1.2311.00
206_V209_A1.2281.00
188_V191_V1.2261.00
137_T140_A1.2141.00
182_V224_I1.2121.00
218_G222_S1.2101.00
156_L160_Q1.2091.00
173_E231_K1.2071.00
85_A89_I1.1991.00
101_K105_K1.1951.00
79_P82_P1.1771.00
109_Q117_V1.1741.00
72_E80_E1.1701.00
163_Y173_E1.1581.00
193_I206_V1.1501.00
153_P156_L1.1471.00
154_R158_R1.1461.00
78_I82_P1.1411.00
90_E93_K1.1391.00
136_S140_A1.1321.00
177_K194_L1.1261.00
102_P106_V1.1091.00
153_P213_W1.1021.00
199_A202_F1.0901.00
163_Y202_F1.0891.00
153_P215_Y1.0871.00
22_A25_A1.0871.00
174_G202_F1.0531.00
87_V91_K1.0521.00
220_P223_G1.0501.00
115_K119_S1.0451.00
66_E70_E1.0441.00
27_L30_T1.0421.00
180_F226_V1.0371.00
209_A230_F1.0341.00
9_F12_P1.0311.00
151_S154_R1.0151.00
149_V161_P1.0091.00
12_P16_S1.0051.00
156_L213_W1.0031.00
182_V215_Y1.0031.00
93_K97_K1.0001.00
114_V118_E0.9981.00
146_V150_A0.9981.00
85_A88_V0.9951.00
112_R115_K0.9941.00
107_Q111_K0.9871.00
95_K99_K0.9751.00
116_P119_S0.9650.99
180_F188_V0.9630.99
113_D118_E0.9630.99
72_E75_P0.9560.99
26_G30_T0.9400.99
208_N212_R0.9270.99
120_R123_S0.9200.99
167_A174_G0.9180.99
99_K103_V0.9150.99
149_V157_S0.9110.99
162_Q205_E0.9050.99
117_V120_R0.9000.99
155_A161_P0.9000.99
55_L58_P0.8900.99
62_Q65_P0.8890.99
157_S160_Q0.8870.99
164_P174_G0.8790.99
180_F191_V0.8790.99
178_V206_V0.8770.99
153_P216_E0.8740.99
173_E202_F0.8720.99
26_G29_Y0.8700.99
153_P158_R0.8700.99
83_K87_V0.8700.99
16_S21_G0.8680.99
60_A63_P0.8670.99
149_V215_Y0.8610.99
107_Q112_R0.8500.99
196_A200_N0.8470.99
75_P78_I0.8440.99
83_K90_E0.8430.99
92_P95_K0.8330.98
22_A26_G0.8300.98
161_P215_Y0.8280.98
158_R228_I0.8270.98
149_V156_L0.8240.98
162_Q209_A0.8200.98
126_E130_P0.8170.98
91_K95_K0.8020.98
84_E87_V0.8020.98
149_V213_W0.8000.98
205_E230_F0.8000.98
224_I227_N0.7960.98
182_V216_E0.7920.98
103_V107_Q0.7900.98
156_L161_P0.7890.98
226_V230_F0.7850.98
124_P130_P0.7830.98
157_S180_F0.7790.98
111_K117_V0.7760.98
67_P70_E0.7740.98
174_G206_V0.7740.98
89_I94_P0.7730.97
103_V111_K0.7620.97
123_S126_E0.7580.97
29_Y33_H0.7580.97
128_T131_A0.7570.97
137_T141_A0.7520.97
54_D57_P0.7520.97
214_R220_P0.7510.97
68_V72_E0.7490.97
20_H197_K0.7350.97
19_I23_V0.7340.97
9_F13_T0.7330.97
16_S25_A0.7320.97
70_E73_P0.7290.96
213_W230_F0.7270.96
115_K118_E0.7240.96
164_P167_A0.7200.96
73_P76_E0.7170.96
150_A155_A0.7120.96
188_V213_W0.7040.96
105_K113_D0.7020.96
180_F215_Y0.7020.96
210_M228_I0.7000.96
83_K89_I0.6980.95
150_A154_R0.6980.95
156_L209_A0.6980.95
159_N180_F0.6970.95
218_G224_I0.6950.95
153_P161_P0.6930.95
105_K111_K0.6930.95
15_L20_H0.6930.95
134_T138_A0.6910.95
69_V73_P0.6900.95
20_H24_V0.6900.95
85_A91_K0.6830.95
149_V158_R0.6820.95
188_V215_Y0.6820.95
109_Q113_D0.6810.95
133_L139_T0.6760.95
76_E82_P0.6730.94
28_L32_V0.6680.94
119_S122_A0.6660.94
153_P159_N0.6650.94
175_Q198_P0.6650.94
113_D117_V0.6630.94
89_I95_K0.6630.94
178_V210_M0.6630.94
153_P224_I0.6570.94
149_V155_A0.6560.94
104_K110_P0.6550.94
133_L136_S0.6540.94
158_R213_W0.6520.93
149_V220_P0.6520.93
176_V182_V0.6480.93
158_R180_F0.6450.93
82_P87_V0.6390.93
161_P230_F0.6370.93
20_H180_F0.6350.93
11_W29_Y0.6340.93
114_V119_S0.6340.93
10_P14_L0.6320.92
142_T148_S0.6320.92
94_P97_K0.6310.92
216_E222_S0.6300.92
163_Y232_I0.6300.92
113_D116_P0.6290.92
45_I52_P0.6260.92
78_I81_P0.6230.92
161_P205_E0.6230.92
83_K86_P0.6230.92
155_A159_N0.6210.92
209_A228_I0.6200.92
185_D189_D0.6190.92
159_N209_A0.6110.91
109_Q115_K0.6110.91
155_A215_Y0.6080.91
97_K101_K0.6070.91
91_K97_K0.6060.91
110_P113_D0.6020.90
187_R214_R0.6020.90
104_K107_Q0.6010.90
177_K226_V0.6000.90
170_L201_M0.5990.90
72_E87_V0.5990.90
26_G32_V0.5990.90
209_A213_W0.5990.90
160_Q209_A0.5970.90
62_Q66_E0.5940.90
166_R232_I0.5940.90
149_V218_G0.5930.90
160_Q212_R0.5930.90
134_T137_T0.5920.90
153_P226_V0.5910.90
89_I97_K0.5910.90
154_R216_E0.5900.90
158_R226_V0.5900.90
149_V152_G0.5870.89
153_P180_F0.5860.89
72_E76_E0.5850.89
157_S219_K0.5840.89
158_R209_A0.5820.89
156_L205_E0.5810.89
94_P99_K0.5800.89
96_P102_P0.5790.89
84_E90_E0.5780.89
152_G156_L0.5770.89
57_P60_A0.5770.89
181_D188_V0.5770.89
99_K109_Q0.5760.88
105_K109_Q0.5750.88
81_P84_E0.5690.88
116_P120_R0.5690.88
19_I30_T0.5680.88
172_I202_F0.5670.88
94_P98_P0.5660.88
77_P87_V0.5650.88
168_Q231_K0.5640.87
147_T188_V0.5610.87
150_A153_P0.5570.87
75_P81_P0.5540.87
60_A64_P0.5540.87
14_L31_S0.5540.87
155_A180_F0.5530.86
16_S19_I0.5510.86
100_P106_V0.5510.86
193_I203_E0.5500.86
100_P105_K0.5490.86
11_W15_L0.5480.86
93_K96_P0.5450.86
182_V210_M0.5440.86
157_S209_A0.5430.85
126_E129_A0.5400.85
155_A188_V0.5390.85
168_Q171_R0.5380.85
131_A137_T0.5360.85
171_R174_G0.5330.84
56_E59_Q0.5320.84
90_E94_P0.5310.84
151_S155_A0.5290.84
114_V117_V0.5280.84
194_L227_N0.5280.84
17_V20_H0.5270.84
124_P128_T0.5240.83
176_V230_F0.5240.83
123_S127_N0.5230.83
18_C21_G0.5230.83
136_S139_T0.5210.83
54_D63_P0.5210.83
79_P83_K0.5200.83
65_P68_V0.5200.83
220_P224_I0.5180.83
16_S30_T0.5170.83
202_F227_N0.5140.82
125_F129_A0.5140.82
180_F190_N0.5100.82
90_E99_K0.5090.82
102_P111_K0.5080.81
125_F128_T0.5040.81
182_V189_D0.5040.81
156_L214_R0.5030.81
91_K102_P0.5030.81
61_V64_P0.5020.81
72_E78_I0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2grxC 1 0.3264 100 0.338 Contact Map
2m2kA 1 0.5188 99.8 0.54 Contact Map
1u07A 2 0.3766 99.8 0.555 Contact Map
2k9kA 1 0.4184 99.8 0.566 Contact Map
1lr0A 3 0.4812 99.7 0.619 Contact Map
4g7xB 1 0.3891 99.4 0.68 Contact Map
1tolA 1 0.477 99 0.737 Contact Map
2yizA 5 0.2092 40.4 0.924 Contact Map
3onrA 5 0.2218 33.8 0.927 Contact Map
2cc6A 5 0.1925 33 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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