GREMLIN Database
ARAF - L-arabinose-binding periplasmic protein
UniProt: P02924 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10057
Length: 329 (288)
Sequences: 38618 (29324)
Seq/√Len: 1727.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_T180_D3.5631.00
149_Q220_K3.2381.00
83_G290_L2.8391.00
140_Q252_I2.7161.00
175_T179_M2.6531.00
127_P293_W2.6401.00
256_G276_L2.6251.00
149_Q250_I2.5081.00
138_E184_A2.4001.00
50_A53_D2.3241.00
206_F241_G2.3181.00
210_N242_Q2.2571.00
138_E180_D2.2241.00
50_A288_E2.2181.00
142_Q181_A2.1751.00
138_E181_A2.1651.00
285_K288_E2.1301.00
145_Y185_A2.1191.00
135_K139_R2.1071.00
210_N238_A2.1021.00
136_I254_I2.0671.00
51_G287_S2.0591.00
137_G141_G2.0341.00
134_T176_T2.0321.00
144_L223_L2.0021.00
46_F283_G1.9951.00
50_A284_Y1.9731.00
142_Q146_K1.9501.00
205_A234_G1.9501.00
147_E317_F1.8721.00
214_V242_Q1.8391.00
239_T249_I1.8281.00
137_G225_V1.8271.00
49_K280_D1.8151.00
29_G81_A1.7971.00
276_L310_V1.7891.00
141_G178_S1.7731.00
138_E142_Q1.7671.00
160_V219_V1.7601.00
161_M227_M1.7461.00
206_F238_A1.7411.00
142_Q185_A1.7311.00
226_G235_G1.7311.00
278_S281_V1.7051.00
209_A235_G1.7041.00
111_V286_S1.6841.00
244_F248_D1.6761.00
46_F280_D1.6571.00
176_T180_D1.6451.00
292_N298_V1.6431.00
50_A54_L1.6421.00
135_K138_E1.6341.00
143_E147_E1.6281.00
139_R309_V1.6151.00
245_K248_D1.5911.00
238_A242_Q1.5751.00
266_A315_D1.5581.00
145_Y181_A1.5561.00
54_L291_Y1.5441.00
143_E146_K1.5291.00
252_I273_G1.5241.00
240_E264_S1.5171.00
199_S204_G1.4951.00
173_R176_T1.4931.00
281_V285_K1.4891.00
179_M183_K1.4841.00
238_A241_G1.4801.00
26_L82_K1.4781.00
206_F237_R1.4551.00
132_A135_K1.4501.00
189_E192_I1.4451.00
50_A287_S1.4341.00
137_G177_G1.4191.00
281_V284_Y1.4161.00
136_I309_V1.4031.00
29_G76_L1.3981.00
256_G314_R1.3871.00
143_E313_T1.3861.00
141_G145_Y1.3861.00
210_N241_G1.3751.00
99_A103_G1.3721.00
160_V212_M1.3691.00
239_T244_F1.3681.00
181_A184_A1.3661.00
141_G177_G1.3651.00
74_D100_K1.3581.00
141_G181_A1.3391.00
177_G181_A1.3371.00
209_A224_I1.3281.00
134_T138_E1.3251.00
206_F210_N1.3241.00
288_E292_N1.3191.00
149_Q223_L1.3181.00
61_I76_L1.3121.00
85_V286_S1.3071.00
209_A239_T1.3051.00
51_G58_V1.3021.00
196_P211_S1.2911.00
26_L56_F1.2871.00
28_L51_G1.2811.00
190_K193_Y1.2771.00
139_R142_Q1.2651.00
27_K57_E1.2641.00
61_I72_A1.2591.00
210_N214_V1.2501.00
47_A287_S1.2411.00
48_D52_K1.2131.00
30_F47_A1.2061.00
236_V251_G1.2061.00
280_D284_Y1.2041.00
216_H219_V1.2031.00
178_S182_L1.1741.00
234_G238_A1.1741.00
161_M175_T1.1741.00
54_L288_E1.1711.00
203_P207_D1.1681.00
15_A18_S1.1671.00
211_S215_Q1.1551.00
134_T177_G1.1491.00
47_A85_V1.1431.00
178_S225_V1.1401.00
30_F58_V1.1361.00
27_K59_I1.1331.00
229_D274_S1.1311.00
142_Q184_A1.1311.00
134_T173_R1.1301.00
162_A235_G1.1271.00
143_E317_F1.1231.00
224_I235_G1.1151.00
250_I317_F1.1141.00
180_D184_A1.1111.00
201_D204_G1.1101.00
6_K9_A1.0981.00
208_A211_S1.0801.00
229_D253_G1.0781.00
285_K289_M1.0761.00
181_A185_A1.0671.00
172_R176_T1.0671.00
159_A182_L1.0661.00
140_Q225_V1.0551.00
182_L187_F1.0551.00
283_G287_S1.0551.00
68_K71_N1.0541.00
202_I237_R1.0491.00
176_T179_M1.0461.00
44_W48_D1.0461.00
204_G207_D1.0431.00
14_A17_M1.0371.00
147_E313_T1.0371.00
145_Y187_F1.0351.00
207_D211_S1.0331.00
226_G231_T1.0301.00
147_E250_I1.0281.00
52_K68_K1.0231.00
290_L294_V1.0121.00
284_Y288_E1.0081.00
291_Y296_K1.0071.00
16_V19_Q1.0031.00
205_A209_A1.0011.00
53_D284_Y0.9981.00
70_L74_D0.9981.00
56_F291_Y0.9961.00
135_K308_D0.9931.00
45_K49_K0.9881.00
74_D78_A0.9831.00
146_K185_A0.9801.00
95_S99_A0.9761.00
140_Q275_L0.9751.00
285_K307_T0.9711.00
14_A20_S0.9691.00
65_D68_K0.9691.00
143_E273_G0.9661.00
226_G232_V0.9601.00
164_T200_N0.9571.00
141_G182_L0.9521.00
39_W279_P0.9471.00
169_D173_R0.9421.00
28_L85_V0.9351.00
209_A213_L0.9351.00
17_M20_S0.9311.00
127_P289_M0.9281.00
85_V290_L0.9271.00
151_R220_K0.9241.00
261_S265_K0.9231.00
159_A223_L0.9151.00
310_V313_T0.9131.00
166_N197_T0.9111.00
13_L18_S0.9101.00
229_D256_G0.9011.00
49_K284_Y0.8981.00
213_L238_A0.8961.00
131_M278_S0.8941.00
47_A283_G0.8931.00
278_S310_V0.8911.00
145_Y150_K0.8881.00
207_D210_N0.8841.00
49_K53_D0.8801.00
204_G208_A0.8781.00
131_M277_P0.8761.00
239_T251_G0.8741.00
133_A174_R0.8701.00
244_F249_I0.8691.00
27_K79_S0.8691.00
83_G294_V0.8681.00
167_E172_R0.8681.00
160_V224_I0.8681.00
236_V263_L0.8641.00
30_F44_W0.8641.00
224_I249_I0.8621.00
151_R190_K0.8601.00
256_G260_V0.8591.00
180_D183_K0.8531.00
276_L312_I0.8531.00
278_S307_T0.8511.00
150_K187_F0.8451.00
150_K220_K0.8361.00
232_V253_G0.8361.00
44_W60_K0.8341.00
43_E111_V0.8301.00
198_K231_T0.8271.00
31_L72_A0.8261.00
289_M292_N0.8261.00
71_N74_D0.8251.00
253_G274_S0.8231.00
163_I175_T0.8201.00
196_P208_A0.8201.00
47_A58_V0.8181.00
100_K103_G0.8171.00
59_I81_A0.8161.00
25_N82_K0.8141.00
129_V289_M0.8141.00
131_M309_V0.8091.00
68_K72_A0.8051.00
287_S291_Y0.8031.00
255_N277_P0.8021.00
12_G78_A0.7981.00
161_M225_V0.7931.00
179_M189_E0.7891.00
42_T280_D0.7891.00
13_L16_V0.7861.00
209_A238_A0.7841.00
135_K309_V0.7841.00
83_G109_I0.7771.00
46_F284_Y0.7761.00
101_A108_V0.7751.00
45_K48_D0.7731.00
213_L242_Q0.7711.00
33_K40_F0.7701.00
229_D232_V0.7701.00
144_L252_I0.7701.00
143_E311_L0.7691.00
256_G312_I0.7691.00
173_R177_G0.7681.00
209_A212_M0.7651.00
237_R240_E0.7641.00
138_E177_G0.7601.00
59_I79_S0.7601.00
162_A226_G0.7551.00
46_F50_A0.7421.00
29_G84_F0.7391.00
24_E82_K0.7381.00
273_G311_L0.7361.00
73_I84_F0.7331.00
48_D58_V0.7291.00
7_A10_A0.7281.00
211_S214_V0.7261.00
132_A308_D0.7211.00
228_N255_N0.7151.00
99_A102_R0.7111.00
110_A115_F0.7101.00
193_Y196_P0.7101.00
215_Q218_E0.7091.00
85_V111_V0.7061.00
97_I100_K0.7061.00
48_D62_A0.7061.00
130_M306_V0.7051.00
182_L189_E0.7011.00
218_E244_F0.6981.00
37_E230_S0.6971.00
12_G16_V0.6961.00
225_V252_I0.6921.00
28_L287_S0.6871.00
313_T317_F0.6861.00
12_G74_D0.6851.00
303_F306_V0.6851.00
77_A104_Y0.6831.00
139_R275_L0.6811.00
112_D170_T0.6801.00
67_E71_N0.6801.00
171_A200_N0.6781.00
109_I293_W0.6771.00
70_L97_I0.6731.00
233_L263_L0.6721.00
102_R126_V0.6721.00
198_K204_G0.6711.00
260_V265_K0.6701.00
200_N227_M0.6681.00
151_R218_E0.6661.00
25_N57_E0.6651.00
11_I14_A0.6651.00
209_A234_G0.6631.00
11_I17_M0.6611.00
161_M178_S0.6611.00
215_Q219_V0.6601.00
112_D133_A0.6581.00
77_A106_M0.6571.00
192_I195_V0.6561.00
237_R266_A0.6551.00
145_Y182_L0.6521.00
273_G317_F0.6441.00
228_N231_T0.6431.00
237_R264_S0.6421.00
220_K223_L0.6411.00
266_A314_R0.6381.00
190_K194_Q0.6371.00
189_E194_Q0.6351.00
236_V240_E0.6341.00
66_G70_L0.6331.00
237_R241_G0.6321.00
28_L83_G0.6291.00
220_K250_I0.6281.00
205_A208_A0.6271.00
83_G286_S0.6251.00
46_F279_P0.6241.00
10_A13_L0.6201.00
174_R277_P0.6201.00
262_E265_K0.6181.00
102_R108_V0.6171.00
110_A128_L0.6161.00
239_T242_Q0.6131.00
202_I234_G0.6121.00
28_L56_F0.6111.00
109_I129_V0.6091.00
159_A220_K0.6081.00
102_R119_K0.6081.00
225_V254_I0.6081.00
144_L225_V0.6061.00
51_G56_F0.6061.00
96_A99_A0.6051.00
40_F87_C0.6041.00
229_D257_V0.6031.00
280_D283_G0.6021.00
133_A173_R0.6001.00
18_S22_M0.5991.00
43_E279_P0.5991.00
84_F106_M0.5991.00
39_W43_E0.5981.00
42_T279_P0.5971.00
28_L294_V0.5951.00
164_T171_A0.5911.00
56_F82_K0.5901.00
219_V244_F0.5881.00
148_M220_K0.5871.00
254_I277_P0.5861.00
45_K280_D0.5851.00
133_A170_T0.5841.00
109_I290_L0.5841.00
127_P302_K0.5831.00
297_D301_P0.5831.00
71_N75_S0.5811.00
171_A227_M0.5791.00
196_P212_M0.5791.00
285_K304_T0.5791.00
240_E245_K0.5791.00
114_Q128_L0.5731.00
189_E193_Y0.5731.00
61_I75_S0.5731.00
151_R217_P0.5721.00
138_E141_G0.5711.00
159_A178_S0.5711.00
140_Q223_L0.5701.00
110_A126_V0.5691.00
118_A126_V0.5681.00
203_P206_F0.5681.00
226_G253_G0.5671.00
282_H307_T0.5651.00
100_K104_Y0.5621.00
233_L257_V0.5611.00
261_S266_A0.5571.00
112_D282_H0.5571.00
143_E252_I0.5571.00
27_K82_K0.5571.00
16_V20_S0.5551.00
289_M293_W0.5541.00
260_V263_L0.5541.00
139_R143_E0.5531.00
56_F294_V0.5531.00
200_N231_T0.5511.00
76_L81_A0.5501.00
109_I289_M0.5501.00
208_A212_M0.5491.00
292_N296_K0.5491.00
130_M133_A0.5471.00
206_F234_G0.5471.00
132_A306_V0.5431.00
297_D300_P0.5431.00
263_L266_A0.5421.00
72_A75_S0.5411.00
187_F190_K0.5391.00
212_M216_H0.5391.00
19_Q22_M0.5391.00
131_M136_I0.5361.00
108_V126_V0.5361.00
51_G291_Y0.5351.00
77_A100_K0.5321.00
206_F209_A0.5311.00
26_L294_V0.5291.00
75_S78_A0.5291.00
174_R255_N0.5281.00
289_M304_T0.5271.00
63_V69_T0.5261.00
223_L250_I0.5251.00
202_I258_D0.5241.00
219_V224_I0.5241.00
77_A80_G0.5211.00
38_P230_S0.5211.00
109_I286_S0.5171.00
75_S79_S0.5161.00
81_A84_F0.5141.00
63_V72_A0.5131.00
11_I16_V0.5131.00
232_V251_G0.5131.00
235_G239_T0.5111.00
131_M254_I0.5091.00
194_Q215_Q0.5071.00
196_P215_Q0.5061.00
236_V272_Y0.5051.00
275_L309_V0.5041.00
37_E40_F0.5021.00
229_D259_A0.5021.00
135_K142_Q0.5001.00
107_K294_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3huuA 2 0.7994 100 0.19 Contact Map
2iksA 2 0.8298 100 0.194 Contact Map
2hsgA 1 0.8845 100 0.202 Contact Map
3e3mA 2 0.8116 100 0.203 Contact Map
3brqA 2 0.8298 100 0.204 Contact Map
3dbiA 2 0.8359 100 0.206 Contact Map
1qpzA 2 0.9179 100 0.207 Contact Map
3h5oA 2 0.8146 100 0.212 Contact Map
4o5aA 2 0.8116 100 0.212 Contact Map
2o20A 2 0.8298 100 0.216 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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