GREMLIN Database
LACY - Lactose permease
UniProt: P02920 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10526
Length: 417 (366)
Sequences: 35216 (26523)
Seq/√Len: 1386.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_G339_S3.9281.00
63_F120_A3.3531.00
214_L218_R3.2941.00
83_M117_C3.2591.00
90_F110_G3.2311.00
68_D347_A3.2001.00
298_I325_E3.1191.00
287_G290_N3.0191.00
72_L131_K2.9951.00
305_G318_L2.9201.00
133_S139_E2.8061.00
257_G260_V2.8001.00
64_G68_D2.6551.00
104_L108_I2.6471.00
342_E345_F2.5731.00
313_L317_I2.4801.00
271_L320_T2.4791.00
341_F349_I2.4691.00
211_K214_L2.4631.00
41_S44_D2.4241.00
87_F110_G2.3781.00
230_I361_A2.3311.00
302_R325_E2.3111.00
103_I106_G2.2591.00
55_F112_I2.2361.00
105_V109_V2.2361.00
307_S383_L2.2191.00
302_R318_L2.1861.00
171_W175_G2.1481.00
64_G347_A2.1351.00
311_S314_E2.1301.00
55_F59_F2.1171.00
59_F116_F2.0881.00
234_C365_M1.9771.00
137_N284_N1.9691.00
300_S393_T1.9531.00
281_L284_N1.9351.00
42_K374_E1.9201.00
256_Q260_V1.8791.00
92_I171_W1.8781.00
281_L285_R1.8571.00
43_S374_E1.8431.00
188_K191_A1.8401.00
75_Y80_I1.8271.00
300_S390_L1.8261.00
212_L215_E1.8151.00
371_N375_S1.8121.00
210_L214_L1.7921.00
44_D104_L1.7681.00
287_G291_A1.7551.00
280_P284_N1.7501.00
13_G146_F1.7411.00
75_Y79_I1.7241.00
380_G383_L1.7201.00
370_G374_E1.7141.00
309_A314_E1.6661.00
173_G176_C1.6411.00
71_G75_Y1.6351.00
275_I324_F1.6161.00
50_A367_V1.6111.00
345_F348_T1.6051.00
102_N106_G1.5961.00
59_F62_L1.5751.00
312_A316_V1.5721.00
87_F114_L1.5511.00
77_L80_I1.5501.00
164_I168_F1.5501.00
186_F189_T1.5461.00
85_V181_A1.5431.00
293_L393_T1.5371.00
313_L316_V1.5341.00
289_K293_L1.5221.00
92_I174_S1.5211.00
208_F212_L1.5121.00
307_S386_G1.5111.00
290_N294_L1.5101.00
215_E219_Q1.5081.00
59_F119_N1.5071.00
182_V186_F1.5071.00
85_V178_L1.5041.00
279_A328_F1.4831.00
376_I380_G1.4401.00
87_F117_C1.4401.00
89_P174_S1.4271.00
290_N293_L1.4261.00
75_Y78_W1.4201.00
40_I44_D1.4121.00
214_L217_F1.4101.00
42_K249_S1.4001.00
215_E218_R1.4001.00
304_I386_G1.3871.00
268_G323_M1.3851.00
244_A248_T1.3851.00
282_I286_I1.3791.00
105_V108_I1.3771.00
156_S266_T1.3661.00
297_T393_T1.3661.00
67_S124_A1.3641.00
71_G74_K1.3581.00
275_I278_F1.3511.00
380_G384_V1.3291.00
76_L80_I1.3221.00
168_F171_W1.3211.00
210_L213_A1.3161.00
383_L386_G1.3091.00
87_F113_Y1.3031.00
220_P223_W1.3001.00
302_R321_L1.3001.00
111_G115_G1.2981.00
48_I108_I1.2941.00
248_T258_T1.2871.00
54_L363_I1.2861.00
295_A329_L1.2781.00
238_V369_A1.2701.00
175_G179_I1.2621.00
213_A216_L1.2571.00
211_K215_E1.2461.00
165_N168_F1.2441.00
217_F223_W1.2441.00
383_L387_L1.2371.00
394_L398_F1.2351.00
263_Y267_M1.2341.00
295_A325_E1.2291.00
372_M376_I1.2281.00
379_Q383_L1.2151.00
302_R322_H1.2111.00
381_A385_L1.2081.00
260_V312_A1.2041.00
343_V346_S1.2041.00
223_W227_L1.1991.00
309_A318_L1.1921.00
212_L216_L1.1901.00
373_Y378_F1.1881.00
131_K346_S1.1831.00
16_F20_F1.1781.00
226_S357_F1.1781.00
184_L188_K1.1771.00
187_A190_D1.1711.00
245_N249_S1.1641.00
70_L75_Y1.1601.00
80_I120_A1.1541.00
28_P31_P1.1491.00
183_L186_F1.1341.00
387_L391_G1.1311.00
293_L397_V1.1231.00
220_P224_F1.1211.00
66_L70_L1.1141.00
46_G50_A1.1111.00
101_Y106_G1.1061.00
259_R263_Y1.1031.00
208_F211_K1.0961.00
120_A124_A1.0871.00
51_A108_I1.0841.00
278_F281_L1.0801.00
271_L275_I1.0771.00
24_G151_W1.0751.00
209_S212_L1.0581.00
382_Y386_G1.0571.00
167_Q171_W1.0511.00
129_I143_A1.0511.00
44_D108_I1.0481.00
140_F338_T1.0451.00
377_G380_G1.0431.00
63_F66_L1.0421.00
207_A210_L1.0341.00
72_L75_Y1.0291.00
84_L88_A1.0251.00
235_T389_A1.0231.00
390_L394_L1.0191.00
65_L69_K1.0131.00
235_T238_V1.0131.00
213_A217_F1.0121.00
275_I327_P1.0111.00
294_L298_I1.0101.00
384_V387_L1.0051.00
231_G235_T1.0011.00
282_I291_A1.0011.00
90_F93_F0.9981.00
41_S374_E0.9951.00
212_L217_F0.9941.00
138_F284_N0.9941.00
237_D362_M0.9921.00
304_I308_F0.9921.00
130_E338_T0.9921.00
268_G272_N0.9821.00
286_I290_N0.9821.00
267_M316_V0.9811.00
31_P35_H0.9801.00
42_K373_Y0.9781.00
360_L364_F0.9761.00
386_G390_L0.9761.00
168_F172_L0.9761.00
85_V89_P0.9741.00
52_I115_G0.9741.00
144_R148_C0.9731.00
300_S386_G0.9731.00
293_L297_T0.9721.00
381_A384_V0.9711.00
367_V371_N0.9671.00
34_L40_I0.9631.00
154_C158_V0.9631.00
106_G109_V0.9561.00
270_L274_S0.9551.00
31_P34_L0.9541.00
130_E140_F0.9541.00
148_C272_N0.9541.00
111_G114_L0.9501.00
47_I51_A0.9491.00
209_S217_F0.9471.00
63_F119_N0.9471.00
206_S209_S0.9451.00
63_F117_C0.9421.00
286_I291_A0.9401.00
209_S215_E0.9401.00
272_N327_P0.9381.00
317_I321_L0.9311.00
76_L79_I0.9301.00
44_D47_I0.9261.00
295_A328_F0.9241.00
389_A393_T0.9241.00
178_L182_V0.9231.00
337_I354_F0.9211.00
141_G145_M0.9181.00
86_M90_F0.9171.00
295_A332_G0.9091.00
138_F142_R0.9081.00
174_S178_L0.8961.00
67_S72_L0.8931.00
87_F92_I0.8921.00
323_M327_P0.8911.00
53_S366_S0.8901.00
247_F256_Q0.8891.00
46_G370_G0.8851.00
85_V174_S0.8811.00
21_F154_C0.8781.00
73_R131_K0.8771.00
382_Y385_L0.8771.00
299_M325_E0.8741.00
384_V388_V0.8731.00
59_F63_F0.8701.00
275_I279_A0.8691.00
385_L389_A0.8681.00
185_F188_K0.8611.00
331_V335_K0.8611.00
222_L349_I0.8561.00
277_F280_P0.8551.00
393_T397_V0.8541.00
314_E317_I0.8521.00
338_T350_Y0.8471.00
296_G393_T0.8461.00
62_L65_L0.8431.00
68_D348_T0.8421.00
161_M164_I0.8401.00
127_A350_Y0.8391.00
216_L219_Q0.8381.00
20_F147_G0.8351.00
298_I302_R0.8351.00
300_S389_A0.8341.00
277_F281_L0.8321.00
274_S278_F0.8321.00
241_Q244_A0.8321.00
207_A212_L0.8311.00
140_F335_K0.8301.00
93_F171_W0.8301.00
137_N335_K0.8281.00
72_L127_A0.8241.00
17_F146_F0.8241.00
300_S304_I0.8231.00
139_E143_A0.8221.00
221_K224_F0.8221.00
123_P127_A0.8151.00
23_M28_P0.8151.00
228_Y396_S0.8141.00
22_I25_A0.8131.00
391_G395_I0.8121.00
264_V268_G0.8121.00
109_V113_Y0.8111.00
163_T259_R0.8101.00
55_F115_G0.8081.00
306_S319_K0.8081.00
57_L359_Q0.8071.00
49_F241_Q0.8051.00
262_G266_T0.8031.00
35_H42_K0.8031.00
166_N170_F0.8021.00
186_F190_D0.8011.00
297_T301_V0.7991.00
209_S214_L0.7981.00
127_A130_E0.7951.00
368_L371_N0.7941.00
265_T269_E0.7941.00
106_G110_G0.7931.00
43_S47_I0.7921.00
89_P93_F0.7911.00
144_R147_G0.7901.00
17_F21_F0.7891.00
305_G308_F0.7891.00
269_E273_A0.7881.00
305_G309_A0.7831.00
101_Y105_V0.7821.00
82_G86_M0.7811.00
20_F23_M0.7771.00
263_Y266_T0.7741.00
74_K78_W0.7721.00
299_M389_A0.7711.00
236_Y239_F0.7681.00
172_L176_C0.7661.00
84_L87_F0.7651.00
157_I160_I0.7651.00
51_A112_I0.7651.00
83_M87_F0.7651.00
395_I398_F0.7651.00
306_S315_V0.7641.00
292_L332_G0.7631.00
48_I107_S0.7621.00
141_G276_M0.7611.00
238_V242_Q0.7611.00
333_C354_F0.7611.00
50_A363_I0.7601.00
317_I320_T0.7591.00
274_S277_F0.7581.00
16_F19_Y0.7571.00
78_W81_T0.7551.00
25_A158_V0.7551.00
47_I108_I0.7541.00
20_F24_G0.7521.00
191_A194_S0.7491.00
361_A365_M0.7481.00
246_F249_S0.7461.00
50_A54_L0.7451.00
260_V263_Y0.7441.00
185_F189_T0.7421.00
301_V305_G0.7401.00
271_L274_S0.7401.00
60_Q351_L0.7391.00
155_A159_G0.7381.00
65_L348_T0.7361.00
126_E350_Y0.7361.00
351_L356_F0.7351.00
245_N248_T0.7341.00
61_P65_L0.7321.00
232_V238_V0.7271.00
262_G265_T0.7241.00
57_L363_I0.7241.00
225_L336_Y0.7231.00
32_I36_D0.7211.00
124_A127_A0.7211.00
79_I120_A0.7211.00
162_F169_V0.7181.00
264_V319_K0.7181.00
156_S160_I0.7161.00
335_K338_T0.7161.00
26_Y29_F0.7151.00
226_S352_V0.7121.00
152_A156_S0.7121.00
60_Q359_Q0.7091.00
109_V112_I0.7081.00
27_F34_L0.7061.00
238_V241_Q0.7041.00
288_G335_K0.7021.00
212_L219_Q0.7011.00
267_M320_T0.7001.00
55_F116_F0.6991.00
346_S350_Y0.6961.00
334_F338_T0.6961.00
88_A91_F0.6961.00
53_S56_S0.6951.00
152_A270_L0.6951.00
229_V233_S0.6931.00
280_P283_I0.6931.00
170_F173_G0.6931.00
160_I263_Y0.6931.00
119_N123_P0.6921.00
77_L81_T0.6861.00
149_V153_L0.6861.00
46_G242_Q0.6801.00
187_A191_A0.6791.00
63_F124_A0.6791.00
379_Q382_Y0.6791.00
51_A55_F0.6781.00
138_F141_G0.6761.00
22_I88_A0.6731.00
337_I349_I0.6721.00
32_I35_H0.6721.00
267_M271_L0.6711.00
271_L323_M0.6701.00
310_T314_E0.6691.00
165_N169_V0.6681.00
348_T351_L0.6671.00
140_F144_R0.6661.00
53_S362_M0.6631.00
84_L177_A0.6611.00
247_F315_V0.6601.00
276_M280_P0.6601.00
293_L296_G0.6591.00
21_F24_G0.6591.00
102_N105_V0.6581.00
268_G326_V0.6581.00
91_F110_G0.6571.00
160_I163_T0.6561.00
33_W166_N0.6551.00
56_S60_Q0.6551.00
30_F33_W0.6551.00
57_L356_F0.6541.00
230_I357_F0.6531.00
386_G389_A0.6521.00
223_W226_S0.6521.00
261_F265_T0.6511.00
378_F382_Y0.6501.00
86_M89_P0.6481.00
237_D240_D0.6481.00
40_I104_L0.6471.00
48_I52_I0.6471.00
347_A351_L0.6451.00
159_G266_T0.6371.00
81_T181_A0.6371.00
190_D193_S0.6361.00
184_L187_A0.6361.00
184_L190_D0.6331.00
173_G177_A0.6321.00
29_F32_I0.6321.00
369_A381_A0.6311.00
335_K339_S0.6291.00
388_V392_F0.6281.00
159_G262_G0.6261.00
170_F174_S0.6261.00
158_V162_F0.6231.00
316_V319_K0.6221.00
130_E346_S0.6221.00
243_F247_F0.6201.00
161_M172_L0.6191.00
283_I288_G0.6191.00
110_G114_L0.6181.00
161_M169_V0.6171.00
231_G392_F0.6161.00
297_T300_S0.6161.00
233_S358_K0.6161.00
67_S347_A0.6141.00
81_T84_L0.6141.00
67_S127_A0.6141.00
215_E345_F0.6091.00
264_V316_V0.6081.00
286_I294_L0.6071.00
29_F33_W0.6061.00
172_L175_G0.6031.00
47_I367_V0.6021.00
140_F143_A0.6011.00
235_T388_V0.5991.00
58_L61_P0.5991.00
205_H208_F0.5971.00
144_R272_N0.5971.00
239_F243_F0.5971.00
177_A181_A0.5961.00
24_G27_F0.5951.00
242_Q245_N0.5951.00
316_V320_T0.5941.00
219_Q223_W0.5921.00
179_I183_L0.5921.00
392_F396_S0.5881.00
171_W174_S0.5871.00
61_P356_F0.5831.00
284_N288_G0.5811.00
35_H45_T0.5811.00
242_Q246_F0.5801.00
22_I29_F0.5791.00
256_Q259_R0.5781.00
236_Y240_D0.5771.00
233_S236_Y0.5771.00
15_F121_G0.5761.00
73_R77_L0.5751.00
207_A214_L0.5751.00
22_I173_G0.5701.00
87_F91_F0.5691.00
48_I111_G0.5691.00
146_F150_G0.5691.00
224_F395_I0.5691.00
293_L300_S0.5681.00
151_W154_C0.5681.00
137_N144_R0.5671.00
143_A147_G0.5671.00
394_L397_V0.5661.00
43_S371_N0.5651.00
225_L229_V0.5651.00
155_A158_V0.5641.00
82_G181_A0.5641.00
244_A247_F0.5631.00
278_F282_I0.5621.00
314_E318_L0.5611.00
227_L231_G0.5611.00
235_T392_F0.5601.00
266_T269_E0.5601.00
34_L38_N0.5601.00
337_I350_Y0.5591.00
108_I111_G0.5591.00
229_V357_F0.5571.00
189_T192_P0.5561.00
155_A266_T0.5561.00
182_V185_F0.5541.00
27_F31_P0.5521.00
338_T346_S0.5491.00
70_L74_K0.5481.00
125_V128_F0.5461.00
141_G280_P0.5441.00
89_P171_W0.5441.00
62_L66_L0.5431.00
80_I117_C0.5431.00
232_V236_Y0.5431.00
372_M381_A0.5431.00
85_V92_I0.5421.00
267_M270_L0.5411.00
308_F383_L0.5411.00
211_K217_F0.5391.00
14_L18_F0.5381.00
184_L189_T0.5381.00
279_A283_I0.5381.00
379_Q386_G0.5381.00
16_F143_A0.5381.00
17_F149_V0.5361.00
228_Y232_V0.5321.00
294_L297_T0.5321.00
337_I341_F0.5301.00
283_I286_I0.5301.00
88_A92_I0.5291.00
246_F254_G0.5271.00
307_S379_Q0.5271.00
17_F20_F0.5261.00
231_G388_V0.5241.00
206_S212_L0.5241.00
364_F367_V0.5231.00
234_C364_F0.5221.00
153_L156_S0.5211.00
273_A277_F0.5191.00
19_Y25_A0.5191.00
53_S363_I0.5171.00
150_G154_C0.5171.00
47_I371_N0.5161.00
363_I367_V0.5151.00
103_I107_S0.5141.00
162_F166_N0.5141.00
82_G85_V0.5131.00
33_W38_N0.5111.00
234_C368_L0.5101.00
260_V316_V0.5101.00
128_F131_K0.5081.00
242_Q373_Y0.5071.00
181_A185_F0.5051.00
209_S213_A0.5001.00
243_F319_K0.5001.00
15_F19_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.9952 100 0.201 Contact Map
4j05A 3 0.9137 100 0.294 Contact Map
3wdoA 1 0.9472 100 0.297 Contact Map
1pw4A 1 0.9496 100 0.298 Contact Map
3o7qA 1 0.9113 100 0.319 Contact Map
4w6vA 1 0.9209 100 0.328 Contact Map
4m64A 1 0.9712 100 0.335 Contact Map
4pypA 1 0.9305 100 0.336 Contact Map
4xnjA 1 0.9233 100 0.336 Contact Map
2gfpA 2 0.8849 100 0.341 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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