LACY - ECOLI - GREMLIN Contacts

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LACY - Lactose permease

UniProt:	P02920	Sequences: MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLRRQVNEVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10526
Length:	417 (366)
Sequences:	35216 (26523)
Seq/√Len:	1386.4

ECOLI - LACY YAAU NUPG MDTM EXUT YDJE XAPB MDTH MDTL YGCS PROP YJJL NANT YEGT RHMT ENTS MELB XYLE YDFJ ARAE YIHN YDIM GALP UIDB YDJK GLPT UHPT AMPG MHPT HSRA YJHB UHPC MDFA YDEE GUDP YQCE YAGG YIHP TSGA YAJR YICJ MDTG GARP MDTD YDHC YEBQ YIHO YBJJ KGTP ARAJ YHJX BCR YDHP CYNX YDIN YHHS SHIA DGOT SOTB HCAT YHJE YCAD NEPI LPLT FUCP NARU SETA SETC YGAY YNFM NARK EMRD FSR YEAN SETB YJIJ YFCJ EMRY EMRB DTPA
BACSU - EXUT YFIS YXAM YKUC GLCP YTTB YJBB YFKF YXIO CSBC YWBF YQJV YFMI YVQJ YBFB IOLT YFIG YNCC YWTG GUDP YVMA YCEJ YFKL NAIP YOAB YYCB ARAE CSBX NARK BBEX IOLF YITG YHJO YFHI YCNB YYBO YCXA NASA MMR YYAJ YQGE YVKA YUXJ YWOG YJMB YBCL YNAJ YWOD YDDS YWFA YTBD TCRB BMR2 YYBF GLPT YFNC YUBD YFMO PBUE GUTA YDGK YXLH YDEG BMR1 YHCA LMRB YDER BMR3 YUSP YFIU YCLF
HALSA - Q9HPD6 Q9HMR5 O54630 Q9HRX5 Q9HN67 Q9HSM8 Q9HS33 Q9HSK3 Q9HMQ8 Q9HSE5
SULSO - Q7LX65 Q97U80 Q97YL8 Q97U43 Q97VV2 Q7LX71 Q97U99 Q97UR4 Q97VT2 Q97WR1 Q97UY7 Q97Y11 Q97WS7 Q97ZC9 Q97U98 Q980K3 Q97VU3 Q97V89 Q97VB7 Q97X92 Q97YY8 Q97WT1 Q97Y43 Q97UD8 Q97XW7 Q97U76 Q97YH0 Q97VQ5 Q97VB9 Q97X47 Q97X63 Q97X02 Q97YG2 Q97Z36 Q97VD1 Q97VC8 Q97WR9 Q97WP8 Q97Z07 Q97U91 Q97U71 Q97Y15 Q97Z05 Q97UK1 Q97UJ4 Q97YI4 Q97WJ7 Q97YW8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
288_G	339_S	3.928	1.00
63_F	120_A	3.353	1.00
214_L	218_R	3.294	1.00
83_M	117_C	3.259	1.00
90_F	110_G	3.231	1.00
68_D	347_A	3.200	1.00
298_I	325_E	3.119	1.00
287_G	290_N	3.019	1.00
72_L	131_K	2.995	1.00
305_G	318_L	2.920	1.00
133_S	139_E	2.806	1.00
257_G	260_V	2.800	1.00
64_G	68_D	2.655	1.00
104_L	108_I	2.647	1.00
342_E	345_F	2.573	1.00
313_L	317_I	2.480	1.00
271_L	320_T	2.479	1.00
341_F	349_I	2.469	1.00
211_K	214_L	2.463	1.00
41_S	44_D	2.424	1.00
87_F	110_G	2.378	1.00
230_I	361_A	2.331	1.00
302_R	325_E	2.311	1.00
103_I	106_G	2.259	1.00
55_F	112_I	2.236	1.00
105_V	109_V	2.236	1.00
307_S	383_L	2.219	1.00
302_R	318_L	2.186	1.00
171_W	175_G	2.148	1.00
64_G	347_A	2.135	1.00
311_S	314_E	2.130	1.00
55_F	59_F	2.117	1.00
59_F	116_F	2.088	1.00
234_C	365_M	1.977	1.00
137_N	284_N	1.969	1.00
300_S	393_T	1.953	1.00
281_L	284_N	1.935	1.00
42_K	374_E	1.920	1.00
256_Q	260_V	1.879	1.00
92_I	171_W	1.878	1.00
281_L	285_R	1.857	1.00
43_S	374_E	1.843	1.00
188_K	191_A	1.840	1.00
75_Y	80_I	1.827	1.00
300_S	390_L	1.826	1.00
212_L	215_E	1.815	1.00
371_N	375_S	1.812	1.00
210_L	214_L	1.792	1.00
44_D	104_L	1.768	1.00
287_G	291_A	1.755	1.00
280_P	284_N	1.750	1.00
13_G	146_F	1.741	1.00
75_Y	79_I	1.724	1.00
380_G	383_L	1.720	1.00
370_G	374_E	1.714	1.00
309_A	314_E	1.666	1.00
173_G	176_C	1.641	1.00
71_G	75_Y	1.635	1.00
275_I	324_F	1.616	1.00
50_A	367_V	1.611	1.00
345_F	348_T	1.605	1.00
102_N	106_G	1.596	1.00
59_F	62_L	1.575	1.00
312_A	316_V	1.572	1.00
87_F	114_L	1.551	1.00
77_L	80_I	1.550	1.00
164_I	168_F	1.550	1.00
186_F	189_T	1.546	1.00
85_V	181_A	1.543	1.00
293_L	393_T	1.537	1.00
313_L	316_V	1.534	1.00
289_K	293_L	1.522	1.00
92_I	174_S	1.521	1.00
208_F	212_L	1.512	1.00
307_S	386_G	1.511	1.00
290_N	294_L	1.510	1.00
215_E	219_Q	1.508	1.00
59_F	119_N	1.507	1.00
182_V	186_F	1.507	1.00
85_V	178_L	1.504	1.00
279_A	328_F	1.483	1.00
376_I	380_G	1.440	1.00
87_F	117_C	1.440	1.00
89_P	174_S	1.427	1.00
290_N	293_L	1.426	1.00
75_Y	78_W	1.420	1.00
40_I	44_D	1.412	1.00
214_L	217_F	1.410	1.00
42_K	249_S	1.400	1.00
215_E	218_R	1.400	1.00
304_I	386_G	1.387	1.00
268_G	323_M	1.385	1.00
244_A	248_T	1.385	1.00
282_I	286_I	1.379	1.00
105_V	108_I	1.377	1.00
156_S	266_T	1.366	1.00
297_T	393_T	1.366	1.00
67_S	124_A	1.364	1.00
71_G	74_K	1.358	1.00
275_I	278_F	1.351	1.00
380_G	384_V	1.329	1.00
76_L	80_I	1.322	1.00
168_F	171_W	1.321	1.00
210_L	213_A	1.316	1.00
383_L	386_G	1.309	1.00
87_F	113_Y	1.303	1.00
220_P	223_W	1.300	1.00
302_R	321_L	1.300	1.00
111_G	115_G	1.298	1.00
48_I	108_I	1.294	1.00
248_T	258_T	1.287	1.00
54_L	363_I	1.286	1.00
295_A	329_L	1.278	1.00
238_V	369_A	1.270	1.00
175_G	179_I	1.262	1.00
213_A	216_L	1.257	1.00
211_K	215_E	1.246	1.00
165_N	168_F	1.244	1.00
217_F	223_W	1.244	1.00
383_L	387_L	1.237	1.00
394_L	398_F	1.235	1.00
263_Y	267_M	1.234	1.00
295_A	325_E	1.229	1.00
372_M	376_I	1.228	1.00
379_Q	383_L	1.215	1.00
302_R	322_H	1.211	1.00
381_A	385_L	1.208	1.00
260_V	312_A	1.204	1.00
343_V	346_S	1.204	1.00
223_W	227_L	1.199	1.00
309_A	318_L	1.192	1.00
212_L	216_L	1.190	1.00
373_Y	378_F	1.188	1.00
131_K	346_S	1.183	1.00
16_F	20_F	1.178	1.00
226_S	357_F	1.178	1.00
184_L	188_K	1.177	1.00
187_A	190_D	1.171	1.00
245_N	249_S	1.164	1.00
70_L	75_Y	1.160	1.00
80_I	120_A	1.154	1.00
28_P	31_P	1.149	1.00
183_L	186_F	1.134	1.00
387_L	391_G	1.131	1.00
293_L	397_V	1.123	1.00
220_P	224_F	1.121	1.00
66_L	70_L	1.114	1.00
46_G	50_A	1.111	1.00
101_Y	106_G	1.106	1.00
259_R	263_Y	1.103	1.00
208_F	211_K	1.096	1.00
120_A	124_A	1.087	1.00
51_A	108_I	1.084	1.00
278_F	281_L	1.080	1.00
271_L	275_I	1.077	1.00
24_G	151_W	1.075	1.00
209_S	212_L	1.058	1.00
382_Y	386_G	1.057	1.00
167_Q	171_W	1.051	1.00
129_I	143_A	1.051	1.00
44_D	108_I	1.048	1.00
140_F	338_T	1.045	1.00
377_G	380_G	1.043	1.00
63_F	66_L	1.042	1.00
207_A	210_L	1.034	1.00
72_L	75_Y	1.029	1.00
84_L	88_A	1.025	1.00
235_T	389_A	1.023	1.00
390_L	394_L	1.019	1.00
65_L	69_K	1.013	1.00
235_T	238_V	1.013	1.00
213_A	217_F	1.012	1.00
275_I	327_P	1.011	1.00
294_L	298_I	1.010	1.00
384_V	387_L	1.005	1.00
231_G	235_T	1.001	1.00
282_I	291_A	1.001	1.00
90_F	93_F	0.998	1.00
41_S	374_E	0.995	1.00
212_L	217_F	0.994	1.00
138_F	284_N	0.994	1.00
237_D	362_M	0.992	1.00
304_I	308_F	0.992	1.00
130_E	338_T	0.992	1.00
268_G	272_N	0.982	1.00
286_I	290_N	0.982	1.00
267_M	316_V	0.981	1.00
31_P	35_H	0.980	1.00
42_K	373_Y	0.978	1.00
360_L	364_F	0.976	1.00
386_G	390_L	0.976	1.00
168_F	172_L	0.976	1.00
85_V	89_P	0.974	1.00
52_I	115_G	0.974	1.00
144_R	148_C	0.973	1.00
300_S	386_G	0.973	1.00
293_L	297_T	0.972	1.00
381_A	384_V	0.971	1.00
367_V	371_N	0.967	1.00
34_L	40_I	0.963	1.00
154_C	158_V	0.963	1.00
106_G	109_V	0.956	1.00
270_L	274_S	0.955	1.00
31_P	34_L	0.954	1.00
130_E	140_F	0.954	1.00
148_C	272_N	0.954	1.00
111_G	114_L	0.950	1.00
47_I	51_A	0.949	1.00
209_S	217_F	0.947	1.00
63_F	119_N	0.947	1.00
206_S	209_S	0.945	1.00
63_F	117_C	0.942	1.00
286_I	291_A	0.940	1.00
209_S	215_E	0.940	1.00
272_N	327_P	0.938	1.00
317_I	321_L	0.931	1.00
76_L	79_I	0.930	1.00
44_D	47_I	0.926	1.00
295_A	328_F	0.924	1.00
389_A	393_T	0.924	1.00
178_L	182_V	0.923	1.00
337_I	354_F	0.921	1.00
141_G	145_M	0.918	1.00
86_M	90_F	0.917	1.00
295_A	332_G	0.909	1.00
138_F	142_R	0.908	1.00
174_S	178_L	0.896	1.00
67_S	72_L	0.893	1.00
87_F	92_I	0.892	1.00
323_M	327_P	0.891	1.00
53_S	366_S	0.890	1.00
247_F	256_Q	0.889	1.00
46_G	370_G	0.885	1.00
85_V	174_S	0.881	1.00
21_F	154_C	0.878	1.00
73_R	131_K	0.877	1.00
382_Y	385_L	0.877	1.00
299_M	325_E	0.874	1.00
384_V	388_V	0.873	1.00
59_F	63_F	0.870	1.00
275_I	279_A	0.869	1.00
385_L	389_A	0.868	1.00
185_F	188_K	0.861	1.00
331_V	335_K	0.861	1.00
222_L	349_I	0.856	1.00
277_F	280_P	0.855	1.00
393_T	397_V	0.854	1.00
314_E	317_I	0.852	1.00
338_T	350_Y	0.847	1.00
296_G	393_T	0.846	1.00
62_L	65_L	0.843	1.00
68_D	348_T	0.842	1.00
161_M	164_I	0.840	1.00
127_A	350_Y	0.839	1.00
216_L	219_Q	0.838	1.00
20_F	147_G	0.835	1.00
298_I	302_R	0.835	1.00
300_S	389_A	0.834	1.00
277_F	281_L	0.832	1.00
274_S	278_F	0.832	1.00
241_Q	244_A	0.832	1.00
207_A	212_L	0.831	1.00
140_F	335_K	0.830	1.00
93_F	171_W	0.830	1.00
137_N	335_K	0.828	1.00
72_L	127_A	0.824	1.00
17_F	146_F	0.824	1.00
300_S	304_I	0.823	1.00
139_E	143_A	0.822	1.00
221_K	224_F	0.822	1.00
123_P	127_A	0.815	1.00
23_M	28_P	0.815	1.00
228_Y	396_S	0.814	1.00
22_I	25_A	0.813	1.00
391_G	395_I	0.812	1.00
264_V	268_G	0.812	1.00
109_V	113_Y	0.811	1.00
163_T	259_R	0.810	1.00
55_F	115_G	0.808	1.00
306_S	319_K	0.808	1.00
57_L	359_Q	0.807	1.00
49_F	241_Q	0.805	1.00
262_G	266_T	0.803	1.00
35_H	42_K	0.803	1.00
166_N	170_F	0.802	1.00
186_F	190_D	0.801	1.00
297_T	301_V	0.799	1.00
209_S	214_L	0.798	1.00
127_A	130_E	0.795	1.00
368_L	371_N	0.794	1.00
265_T	269_E	0.794	1.00
106_G	110_G	0.793	1.00
43_S	47_I	0.792	1.00
89_P	93_F	0.791	1.00
144_R	147_G	0.790	1.00
17_F	21_F	0.789	1.00
305_G	308_F	0.789	1.00
269_E	273_A	0.788	1.00
305_G	309_A	0.783	1.00
101_Y	105_V	0.782	1.00
82_G	86_M	0.781	1.00
20_F	23_M	0.777	1.00
263_Y	266_T	0.774	1.00
74_K	78_W	0.772	1.00
299_M	389_A	0.771	1.00
236_Y	239_F	0.768	1.00
172_L	176_C	0.766	1.00
84_L	87_F	0.765	1.00
157_I	160_I	0.765	1.00
51_A	112_I	0.765	1.00
83_M	87_F	0.765	1.00
395_I	398_F	0.765	1.00
306_S	315_V	0.764	1.00
292_L	332_G	0.763	1.00
48_I	107_S	0.762	1.00
141_G	276_M	0.761	1.00
238_V	242_Q	0.761	1.00
333_C	354_F	0.761	1.00
50_A	363_I	0.760	1.00
317_I	320_T	0.759	1.00
274_S	277_F	0.758	1.00
16_F	19_Y	0.757	1.00
78_W	81_T	0.755	1.00
25_A	158_V	0.755	1.00
47_I	108_I	0.754	1.00
20_F	24_G	0.752	1.00
191_A	194_S	0.749	1.00
361_A	365_M	0.748	1.00
246_F	249_S	0.746	1.00
50_A	54_L	0.745	1.00
260_V	263_Y	0.744	1.00
185_F	189_T	0.742	1.00
301_V	305_G	0.740	1.00
271_L	274_S	0.740	1.00
60_Q	351_L	0.739	1.00
155_A	159_G	0.738	1.00
65_L	348_T	0.736	1.00
126_E	350_Y	0.736	1.00
351_L	356_F	0.735	1.00
245_N	248_T	0.734	1.00
61_P	65_L	0.732	1.00
232_V	238_V	0.727	1.00
262_G	265_T	0.724	1.00
57_L	363_I	0.724	1.00
225_L	336_Y	0.723	1.00
32_I	36_D	0.721	1.00
124_A	127_A	0.721	1.00
79_I	120_A	0.721	1.00
162_F	169_V	0.718	1.00
264_V	319_K	0.718	1.00
156_S	160_I	0.716	1.00
335_K	338_T	0.716	1.00
26_Y	29_F	0.715	1.00
226_S	352_V	0.712	1.00
152_A	156_S	0.712	1.00
60_Q	359_Q	0.709	1.00
109_V	112_I	0.708	1.00
27_F	34_L	0.706	1.00
238_V	241_Q	0.704	1.00
288_G	335_K	0.702	1.00
212_L	219_Q	0.701	1.00
267_M	320_T	0.700	1.00
55_F	116_F	0.699	1.00
346_S	350_Y	0.696	1.00
334_F	338_T	0.696	1.00
88_A	91_F	0.696	1.00
53_S	56_S	0.695	1.00
152_A	270_L	0.695	1.00
229_V	233_S	0.693	1.00
280_P	283_I	0.693	1.00
170_F	173_G	0.693	1.00
160_I	263_Y	0.693	1.00
119_N	123_P	0.692	1.00
77_L	81_T	0.686	1.00
149_V	153_L	0.686	1.00
46_G	242_Q	0.680	1.00
187_A	191_A	0.679	1.00
63_F	124_A	0.679	1.00
379_Q	382_Y	0.679	1.00
51_A	55_F	0.678	1.00
138_F	141_G	0.676	1.00
22_I	88_A	0.673	1.00
337_I	349_I	0.672	1.00
32_I	35_H	0.672	1.00
267_M	271_L	0.671	1.00
271_L	323_M	0.670	1.00
310_T	314_E	0.669	1.00
165_N	169_V	0.668	1.00
348_T	351_L	0.667	1.00
140_F	144_R	0.666	1.00
53_S	362_M	0.663	1.00
84_L	177_A	0.661	1.00
247_F	315_V	0.660	1.00
276_M	280_P	0.660	1.00
293_L	296_G	0.659	1.00
21_F	24_G	0.659	1.00
102_N	105_V	0.658	1.00
268_G	326_V	0.658	1.00
91_F	110_G	0.657	1.00
160_I	163_T	0.656	1.00
33_W	166_N	0.655	1.00
56_S	60_Q	0.655	1.00
30_F	33_W	0.655	1.00
57_L	356_F	0.654	1.00
230_I	357_F	0.653	1.00
386_G	389_A	0.652	1.00
223_W	226_S	0.652	1.00
261_F	265_T	0.651	1.00
378_F	382_Y	0.650	1.00
86_M	89_P	0.648	1.00
237_D	240_D	0.648	1.00
40_I	104_L	0.647	1.00
48_I	52_I	0.647	1.00
347_A	351_L	0.645	1.00
159_G	266_T	0.637	1.00
81_T	181_A	0.637	1.00
190_D	193_S	0.636	1.00
184_L	187_A	0.636	1.00
184_L	190_D	0.633	1.00
173_G	177_A	0.632	1.00
29_F	32_I	0.632	1.00
369_A	381_A	0.631	1.00
335_K	339_S	0.629	1.00
388_V	392_F	0.628	1.00
159_G	262_G	0.626	1.00
170_F	174_S	0.626	1.00
158_V	162_F	0.623	1.00
316_V	319_K	0.622	1.00
130_E	346_S	0.622	1.00
243_F	247_F	0.620	1.00
161_M	172_L	0.619	1.00
283_I	288_G	0.619	1.00
110_G	114_L	0.618	1.00
161_M	169_V	0.617	1.00
231_G	392_F	0.616	1.00
297_T	300_S	0.616	1.00
233_S	358_K	0.616	1.00
67_S	347_A	0.614	1.00
81_T	84_L	0.614	1.00
67_S	127_A	0.614	1.00
215_E	345_F	0.609	1.00
264_V	316_V	0.608	1.00
286_I	294_L	0.607	1.00
29_F	33_W	0.606	1.00
172_L	175_G	0.603	1.00
47_I	367_V	0.602	1.00
140_F	143_A	0.601	1.00
235_T	388_V	0.599	1.00
58_L	61_P	0.599	1.00
205_H	208_F	0.597	1.00
144_R	272_N	0.597	1.00
239_F	243_F	0.597	1.00
177_A	181_A	0.596	1.00
24_G	27_F	0.595	1.00
242_Q	245_N	0.595	1.00
316_V	320_T	0.594	1.00
219_Q	223_W	0.592	1.00
179_I	183_L	0.592	1.00
392_F	396_S	0.588	1.00
171_W	174_S	0.587	1.00
61_P	356_F	0.583	1.00
284_N	288_G	0.581	1.00
35_H	45_T	0.581	1.00
242_Q	246_F	0.580	1.00
22_I	29_F	0.579	1.00
256_Q	259_R	0.578	1.00
236_Y	240_D	0.577	1.00
233_S	236_Y	0.577	1.00
15_F	121_G	0.576	1.00
73_R	77_L	0.575	1.00
207_A	214_L	0.575	1.00
22_I	173_G	0.570	1.00
87_F	91_F	0.569	1.00
48_I	111_G	0.569	1.00
146_F	150_G	0.569	1.00
224_F	395_I	0.569	1.00
293_L	300_S	0.568	1.00
151_W	154_C	0.568	1.00
137_N	144_R	0.567	1.00
143_A	147_G	0.567	1.00
394_L	397_V	0.566	1.00
43_S	371_N	0.565	1.00
225_L	229_V	0.565	1.00
155_A	158_V	0.564	1.00
82_G	181_A	0.564	1.00
244_A	247_F	0.563	1.00
278_F	282_I	0.562	1.00
314_E	318_L	0.561	1.00
227_L	231_G	0.561	1.00
235_T	392_F	0.560	1.00
266_T	269_E	0.560	1.00
34_L	38_N	0.560	1.00
337_I	350_Y	0.559	1.00
108_I	111_G	0.559	1.00
229_V	357_F	0.557	1.00
189_T	192_P	0.556	1.00
155_A	266_T	0.556	1.00
182_V	185_F	0.554	1.00
27_F	31_P	0.552	1.00
338_T	346_S	0.549	1.00
70_L	74_K	0.548	1.00
125_V	128_F	0.546	1.00
141_G	280_P	0.544	1.00
89_P	171_W	0.544	1.00
62_L	66_L	0.543	1.00
80_I	117_C	0.543	1.00
232_V	236_Y	0.543	1.00
372_M	381_A	0.543	1.00
85_V	92_I	0.542	1.00
267_M	270_L	0.541	1.00
308_F	383_L	0.541	1.00
211_K	217_F	0.539	1.00
14_L	18_F	0.538	1.00
184_L	189_T	0.538	1.00
279_A	283_I	0.538	1.00
379_Q	386_G	0.538	1.00
16_F	143_A	0.538	1.00
17_F	149_V	0.536	1.00
228_Y	232_V	0.532	1.00
294_L	297_T	0.532	1.00
337_I	341_F	0.530	1.00
283_I	286_I	0.530	1.00
88_A	92_I	0.529	1.00
246_F	254_G	0.527	1.00
307_S	379_Q	0.527	1.00
17_F	20_F	0.526	1.00
231_G	388_V	0.524	1.00
206_S	212_L	0.524	1.00
364_F	367_V	0.523	1.00
234_C	364_F	0.522	1.00
153_L	156_S	0.521	1.00
273_A	277_F	0.519	1.00
19_Y	25_A	0.519	1.00
53_S	363_I	0.517	1.00
150_G	154_C	0.517	1.00
47_I	371_N	0.516	1.00
363_I	367_V	0.515	1.00
103_I	107_S	0.514	1.00
162_F	166_N	0.514	1.00
82_G	85_V	0.513	1.00
33_W	38_N	0.511	1.00
234_C	368_L	0.510	1.00
260_V	316_V	0.510	1.00
128_F	131_K	0.508	1.00
242_Q	373_Y	0.507	1.00
181_A	185_F	0.505	1.00
209_S	213_A	0.500	1.00
243_F	319_K	0.500	1.00
15_F	19_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cfqA	1	0.9952	100	0.201	Contact Map
4j05A	3	0.9137	100	0.294	Contact Map
3wdoA	1	0.9472	100	0.297	Contact Map
1pw4A	1	0.9496	100	0.298	Contact Map
3o7qA	1	0.9113	100	0.319	Contact Map
4w6vA	1	0.9209	100	0.328	Contact Map
4m64A	1	0.9712	100	0.335	Contact Map
4pypA	1	0.9305	100	0.336	Contact Map
4xnjA	1	0.9233	100	0.336	Contact Map
2gfpA	2	0.8849	100	0.341	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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