GREMLIN Database
PBPA - Penicillin-binding protein 1A
UniProt: P02918 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10748
Length: 850 (794)
Sequences: 327 (201)
Seq/√Len: 7.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
431_S737_T7.7671.00
392_G395_P5.8551.00
69_V188_V5.3410.99
405_G408_I5.0350.99
597_N601_G4.8900.99
402_L405_G4.5860.98
392_G405_G4.3060.98
392_G398_V3.9830.96
392_G397_K3.9660.96
392_G400_D3.8820.95
392_G402_L3.7310.94
77_E239_Q3.6510.94
520_G528_V3.5040.92
395_P400_D3.4360.91
396_R400_D3.4170.91
392_G408_I3.4100.91
101_I123_Q3.3960.91
402_L408_I3.3750.90
82_F204_K3.3400.90
308_L446_F3.3250.90
431_S739_V3.2240.88
307_V425_V3.2010.88
395_P398_V3.1960.88
391_Q395_P3.1860.88
392_G396_R3.1690.87
395_P401_V3.1160.86
71_L157_D3.1060.86
729_S738_S3.0530.85
395_P405_G2.9990.84
403_Q406_Q2.9620.83
398_V401_V2.8820.81
578_A615_C2.8400.80
505_K562_A2.8350.80
123_Q195_E2.8300.80
50_I61_Y2.7470.78
395_P399_T2.7280.78
431_S780_Y2.6700.76
349_L353_A2.6350.75
400_D405_G2.6340.75
56_E293_R2.6230.75
392_G399_T2.5870.73
114_A135_R2.5820.73
82_F164_L2.5730.73
236_T239_Q2.5720.73
392_G401_V2.5480.72
433_N440_M2.4700.70
306_N776_A2.4680.70
473_T679_L2.4640.70
15_I155_T2.4450.69
515_I528_V2.4170.68
405_G411_R2.4090.68
392_G403_Q2.3910.67
538_V541_A2.3610.66
403_Q408_I2.3440.66
91_Y157_D2.3430.66
440_M735_V2.3360.65
395_P408_I2.3290.65
71_L91_Y2.2990.64
28_Y31_P2.2970.64
596_E602_V2.2630.63
362_A374_L2.2430.62
478_K540_Y2.2420.62
268_V289_T2.2400.62
399_T402_L2.2330.62
76_P80_K2.1840.60
395_P402_L2.1350.58
194_N246_E2.1310.58
466_N729_S2.1300.58
168_Y174_Y2.1250.58
392_G406_Q2.1050.57
82_F176_V2.1040.57
397_K402_L2.0970.56
14_C587_V2.0920.56
402_L406_Q2.0740.56
687_L735_V2.0600.55
246_E249_N2.0510.55
239_Q242_Q2.0430.54
737_T780_Y2.0300.54
388_D748_R2.0170.53
24_G28_Y2.0130.53
164_L176_V2.0130.53
406_Q409_W1.9950.53
397_K400_D1.9950.53
184_F195_E1.9610.51
230_L237_Q1.9490.51
401_V405_G1.9420.51
711_R790_E1.9320.50
512_A515_I1.9300.50
128_N167_I1.9250.50
558_T565_S1.9190.50
168_Y202_L1.9170.50
396_R399_T1.9060.49
405_G410_V1.8940.49
579_V674_V1.8770.48
822_F825_G1.8730.48
398_V405_G1.8640.48
398_V403_Q1.8520.47
354_V364_A1.8430.47
80_K230_L1.8250.46
399_T403_Q1.8210.46
114_A137_L1.8200.46
798_G824_E1.8160.46
264_L591_F1.8160.46
392_G409_W1.8120.46
460_L554_N1.8040.45
822_F828_P1.7980.45
74_I246_E1.7920.45
714_G732_G1.7870.45
405_G409_W1.7850.44
522_G689_T1.7800.44
167_I204_K1.7650.44
204_K208_T1.7600.44
436_N590_W1.7590.43
562_A691_I1.7560.43
59_A257_I1.7540.43
440_M484_S1.7490.43
804_I809_G1.7370.43
393_P397_K1.7310.42
331_W477_D1.7280.42
73_Q787_G1.7260.42
429_L737_T1.7190.42
675_I680_A1.7080.42
555_I580_M1.6960.41
427_S523_Q1.6930.41
45_Q516_R1.6840.41
812_A815_G1.6780.40
459_A573_V1.6740.40
267_M442_L1.6590.40
295_V784_V1.6390.39
585_F611_A1.6370.39
108_A137_L1.6330.39
121_I167_I1.6300.39
809_G822_F1.6170.38
580_M680_A1.6120.38
184_F215_M1.6080.38
59_A254_A1.5970.37
466_N573_V1.5950.37
391_Q405_G1.5910.37
80_K813_N1.5880.37
483_A804_I1.5800.37
116_Q135_R1.5750.37
127_R135_R1.5740.37
204_K209_F1.5730.37
392_G411_R1.5730.37
319_P585_F1.5530.36
108_A111_S1.5480.36
215_M728_F1.5450.36
250_A282_E1.5430.36
184_F565_S1.5310.35
820_E825_G1.5250.35
198_V704_A1.5230.35
701_G704_A1.5220.35
167_I202_L1.5210.35
365_M808_T1.5140.34
408_I411_R1.5110.34
398_V411_R1.5090.34
114_A204_K1.5020.34
379_V382_A1.5010.34
49_Q286_R1.5010.34
529_M558_T1.4960.34
612_C615_C1.4950.34
456_A574_A1.4950.34
593_S605_E1.4950.34
820_E828_P1.4950.34
168_Y188_V1.4690.33
308_L349_L1.4680.33
398_V408_I1.4680.33
688_N691_I1.4630.33
399_T405_G1.4620.33
453_F577_Y1.4620.33
427_S739_V1.4600.33
268_V485_M1.4590.33
147_A456_A1.4580.33
209_F224_V1.4510.32
271_E275_R1.4500.32
76_P779_A1.4490.32
272_M780_Y1.4480.32
562_A585_F1.4420.32
687_L731_Y1.4350.32
482_L682_L1.4350.32
398_V402_L1.4350.32
84_A234_Y1.4300.32
486_L532_A1.4270.32
573_V729_S1.4230.31
137_L168_Y1.4100.31
457_T713_I1.4100.31
380_R385_Y1.4050.31
267_M439_V1.4030.31
805_D809_G1.4020.31
402_L411_R1.3980.31
133_P565_S1.3950.30
382_A385_Y1.3950.30
575_R586_L1.3940.30
174_Y269_R1.3850.30
264_L439_V1.3850.30
72_D603_I1.3780.30
374_L379_V1.3740.30
520_G532_A1.3730.30
741_I772_S1.3730.30
725_D740_W1.3710.30
184_F704_A1.3700.30
176_V199_I1.3690.30
52_S240_F1.3660.30
272_M287_I1.3640.29
242_Q246_E1.3630.29
527_V530_V1.3450.29
294_K587_V1.3440.29
391_Q396_R1.3380.29
461_R725_D1.3380.29
463_V525_K1.3160.28
429_L685_S1.3150.28
726_A772_S1.3100.28
202_L458_Q1.3090.28
91_Y176_V1.3080.28
264_L442_L1.3080.28
806_R812_A1.3020.27
731_Y787_G1.2960.27
396_R402_L1.2960.27
338_D735_V1.2950.27
168_Y733_P1.2950.27
493_R511_Y1.2930.27
684_K714_G1.2920.27
91_Y198_V1.2890.27
376_M379_V1.2870.27
804_I811_L1.2870.27
400_D406_Q1.2850.27
37_A410_V1.2770.27
402_L410_V1.2770.27
150_I691_I1.2720.27
85_T224_V1.2700.27
295_V440_M1.2640.26
289_T726_A1.2630.26
195_E271_E1.2610.26
546_Q734_G1.2600.26
477_D540_Y1.2590.26
395_P410_V1.2580.26
29_I37_A1.2560.26
68_P712_D1.2560.26
115_S135_R1.2500.26
561_L734_G1.2490.26
301_Q305_N1.2460.26
185_G253_H1.2430.26
49_Q204_K1.2410.26
135_R209_F1.2390.26
60_Q255_P1.2380.26
83_I456_A1.2350.25
804_I808_T1.2330.25
80_K272_M1.2330.25
137_L141_I1.2320.25
629_V687_L1.2290.25
184_F194_N1.2290.25
687_L737_T1.2280.25
47_P62_G1.2270.25
265_S686_A1.2240.25
809_G820_E1.2220.25
266_E281_Y1.2220.25
527_V559_E1.2210.25
356_S363_T1.2210.25
56_E258_A1.2200.25
400_D411_R1.2180.25
427_S566_A1.2160.25
395_P403_Q1.2160.25
42_V45_Q1.2160.25
246_E736_V1.2100.25
135_R204_K1.2100.25
401_V425_V1.2100.25
456_A709_Q1.2090.25
68_P710_R1.2080.25
89_R97_D1.1980.24
80_K234_Y1.1960.24
400_D408_I1.1930.24
403_Q409_W1.1890.24
237_Q241_D1.1830.24
463_V482_L1.1810.24
288_Y323_L1.1770.24
456_A557_H1.1570.23
267_M303_V1.1520.23
78_M176_V1.1500.23
107_V115_S1.1430.23
64_K182_V1.1430.23
51_Y136_T1.1410.23
355_T588_D1.1330.23
79_V83_I1.1290.22
123_Q225_V1.1260.22
397_K405_G1.1260.22
268_V591_F1.1220.22
404_T407_Q1.1200.22
823_I826_T1.1170.22
31_P704_A1.1120.22
467_I676_N1.1120.22
48_M213_Y1.1090.22
398_V471_L1.1050.22
806_R816_N1.1050.22
85_T225_V1.1050.22
400_D403_Q1.1010.22
74_I83_I1.1000.22
391_Q398_V1.0990.22
463_V690_N1.0950.22
511_Y527_V1.0920.22
168_Y199_I1.0900.21
516_R567_S1.0810.21
632_N635_V1.0800.21
804_I820_E1.0780.21
681_F821_Y1.0760.21
230_L240_F1.0740.21
291_I687_L1.0730.21
594_K605_E1.0690.21
132_S576_G1.0680.21
62_G68_P1.0670.21
92_E786_E1.0650.21
31_P591_F1.0620.21
123_Q194_N1.0620.21
508_P723_S1.0620.21
512_A525_K1.0590.21
240_F244_R1.0580.21
207_S712_D1.0530.21
125_L690_N1.0510.20
471_L541_A1.0500.20
301_Q551_P1.0490.20
269_R278_E1.0480.20
167_I203_P1.0460.20
52_S560_S1.0450.20
63_E266_E1.0440.20
44_L47_P1.0420.20
272_M562_A1.0420.20
466_N507_S1.0420.20
52_S485_M1.0420.20
199_I674_V1.0390.20
395_P404_T1.0380.20
461_R740_W1.0380.20
348_P432_I1.0330.20
35_D38_T1.0320.20
219_V223_N1.0300.20
804_I822_F1.0250.20
28_Y46_I1.0230.20
466_N574_A1.0230.20
450_Q491_I1.0210.20
374_L485_M1.0210.20
322_V482_L1.0200.20
391_Q402_L1.0190.20
403_Q410_V1.0190.20
209_F728_F1.0180.20
84_A89_R1.0180.20
566_A686_A1.0180.20
467_I511_Y1.0160.20
253_H671_A1.0160.20
118_A142_K1.0160.20
121_I269_R1.0150.20
231_D562_A1.0120.19
305_N779_A1.0120.19
225_V525_K1.0090.19
223_N266_E1.0090.19
130_F435_Q1.0060.19
270_Q577_Y1.0050.19
273_Y456_A1.0040.19
45_Q172_R1.0010.19
392_G410_V0.9990.19
704_A740_W0.9980.19
442_L798_G0.9970.19
50_I234_Y0.9960.19
174_Y690_N0.9950.19
511_Y798_G0.9870.19
63_E172_R0.9870.19
29_I40_K0.9860.19
519_Q528_V0.9850.19
689_T825_G0.9810.19
135_R225_V0.9810.19
565_S728_F0.9810.19
109_L523_Q0.9800.19
480_L600_G0.9800.19
390_Q395_P0.9790.19
391_Q408_I0.9780.19
378_G381_W0.9780.19
118_A482_L0.9780.19
68_P570_P0.9780.19
298_A783_A0.9770.19
587_V786_E0.9750.19
555_I561_L0.9750.19
14_C714_G0.9740.19
71_L168_Y0.9730.19
351_P481_T0.9730.19
210_N310_Y0.9700.18
429_L739_V0.9690.18
313_R767_E0.9680.18
689_T819_E0.9680.18
422_V432_I0.9680.18
252_Y703_R0.9670.18
381_W384_P0.9660.18
71_L82_F0.9650.18
101_I225_V0.9630.18
111_S459_A0.9630.18
146_L683_I0.9630.18
61_Y459_A0.9620.18
59_A398_V0.9620.18
266_E269_R0.9620.18
123_Q184_F0.9610.18
291_I779_A0.9600.18
118_A774_Q0.9600.18
127_R812_A0.9590.18
168_Y561_L0.9580.18
252_Y281_Y0.9570.18
265_S307_V0.9560.18
713_I732_G0.9560.18
160_L246_E0.9540.18
47_P68_P0.9540.18
381_W385_Y0.9520.18
268_V271_E0.9520.18
248_I439_V0.9500.18
172_R253_H0.9500.18
319_P601_G0.9490.18
588_D683_I0.9480.18
96_V101_I0.9470.18
238_Q241_D0.9470.18
395_P406_Q0.9470.18
233_G609_K0.9470.18
609_K669_E0.9450.18
199_I530_V0.9430.18
144_V150_I0.9430.18
400_D410_V0.9420.18
116_Q141_I0.9420.18
107_V116_Q0.9410.18
484_S545_L0.9400.18
144_V492_S0.9400.18
523_Q771_K0.9360.18
4_V7_F0.9350.18
298_A691_I0.9350.18
116_Q142_K0.9350.18
109_L675_I0.9330.18
85_T89_R0.9330.18
68_P314_H0.9310.18
72_D279_S0.9300.18
527_V689_T0.9290.18
198_V214_S0.9290.18
224_V463_V0.9270.18
132_S190_Q0.9250.17
702_W706_R0.9240.17
726_A770_A0.9240.17
653_Q656_Q0.9230.17
107_V135_R0.9230.17
113_H209_F0.9230.17
519_Q523_Q0.9200.17
312_M418_W0.9190.17
303_V615_C0.9190.17
406_Q410_V0.9170.17
146_L458_Q0.9140.17
45_Q63_E0.9130.17
649_V787_G0.9130.17
168_Y209_F0.9120.17
453_F726_A0.9110.17
166_K314_H0.9110.17
279_S283_D0.9090.17
459_A728_F0.9090.17
127_R724_K0.9090.17
168_Y530_V0.9070.17
528_V577_Y0.9040.17
22_I578_A0.9040.17
82_F196_M0.9040.17
77_E80_K0.9010.17
196_M248_I0.9010.17
345_T351_P0.9000.17
19_A234_Y0.8990.17
304_R478_K0.8980.17
173_A810_Q0.8980.17
133_P604_F0.8980.17
41_D674_V0.8970.17
68_P671_A0.8970.17
225_V686_A0.8940.17
60_Q499_G0.8930.17
115_S204_K0.8920.17
394_T399_T0.8910.17
155_T240_F0.8910.17
351_P538_V0.8900.17
118_A772_S0.8880.17
72_D157_D0.8870.17
56_E562_A0.8840.17
618_P621_Y0.8830.17
207_S710_R0.8820.17
16_L573_V0.8810.16
816_N819_E0.8810.16
285_Y484_S0.8800.16
285_Y351_P0.8790.16
590_W593_S0.8790.16
184_F558_T0.8780.16
132_S168_Y0.8770.16
734_G791_Q0.8750.16
199_I202_L0.8730.16
263_Y582_N0.8720.16
195_E249_N0.8710.16
608_P671_A0.8690.16
378_G383_R0.8690.16
61_Y542_A0.8670.16
41_D808_T0.8640.16
463_V559_E0.8640.16
385_Y389_T0.8630.16
118_A306_N0.8600.16
725_D728_F0.8600.16
580_M604_F0.8600.16
384_P387_S0.8590.16
312_M316_Y0.8590.16
538_V561_L0.8580.16
508_P525_K0.8570.16
78_M196_M0.8560.16
511_Y825_G0.8550.16
59_A64_K0.8540.16
509_P525_K0.8520.16
390_Q398_V0.8520.16
274_N687_L0.8520.16
48_M85_T0.8510.16
560_S722_S0.8470.16
306_N482_L0.8470.16
12_V731_Y0.8460.16
73_Q805_D0.8450.16
408_I412_Q0.8450.16
285_Y448_F0.8450.16
821_Y825_G0.8440.16
82_F188_V0.8430.16
210_N531_R0.8430.16
576_G726_A0.8420.16
484_S535_A0.8410.16
505_K723_S0.8400.16
291_I308_L0.8390.16
68_P207_S0.8390.16
351_P354_V0.8390.16
317_R562_A0.8390.16
85_T306_N0.8390.16
457_T571_M0.8380.16
577_Y726_A0.8350.16
470_F729_S0.8350.16
480_L532_A0.8320.15
314_H531_R0.8320.15
482_L689_T0.8310.15
402_L407_Q0.8310.15
98_P225_V0.8290.15
825_G828_P0.8270.15
222_R310_Y0.8270.15
359_P456_A0.8260.15
97_D164_L0.8250.15
137_L184_F0.8250.15
396_R405_G0.8250.15
177_G188_V0.8250.15
116_Q522_G0.8240.15
222_R314_H0.8220.15
55_G340_L0.8210.15
123_Q453_F0.8200.15
68_P222_R0.8190.15
439_V450_Q0.8190.15
648_S652_P0.8190.15
587_V771_K0.8180.15
128_N281_Y0.8170.15
123_Q164_L0.8160.15
809_G812_A0.8160.15
268_V682_L0.8160.15
100_G438_A0.8150.15
295_V735_V0.8140.15
520_G768_G0.8130.15
89_R507_S0.8110.15
417_W547_R0.8110.15
115_S167_I0.8100.15
29_I160_L0.8090.15
167_I209_F0.8090.15
353_A439_V0.8090.15
384_P595_I0.8080.15
71_L199_I0.8060.15
264_L291_I0.8060.15
701_G740_W0.8060.15
91_Y214_S0.8050.15
814_G818_R0.8050.15
49_Q714_G0.8050.15
190_Q219_V0.8040.15
10_L14_C0.8030.15
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216_D276_Y0.5140.10
529_M670_Y0.5140.10
246_E303_V0.5130.10
31_P225_V0.5130.10
279_S735_V0.5130.10
303_V772_S0.5120.10
150_I456_A0.5110.10
10_L274_N0.5110.10
63_E516_R0.5110.10
125_L728_F0.5100.10
176_V320_A0.5100.10
320_A520_G0.5100.10
581_A725_D0.5100.10
29_I155_T0.5090.10
463_V488_D0.5090.10
142_K768_G0.5080.10
128_N712_D0.5080.10
426_N690_N0.5080.10
238_Q384_P0.5080.10
51_Y484_S0.5070.10
44_L130_F0.5070.10
78_M706_R0.5070.10
83_I736_V0.5070.10
384_P580_M0.5070.10
68_P310_Y0.5060.10
130_F210_N0.5060.10
304_R471_L0.5060.10
300_Q542_A0.5050.10
404_T416_A0.5050.10
125_L215_M0.5040.10
213_Y522_G0.5040.10
796_P805_D0.5040.10
800_V824_E0.5040.10
269_R577_Y0.5030.10
198_V709_Q0.5030.10
401_V408_I0.5030.10
26_Y45_Q0.5030.10
47_P166_K0.5030.10
474_A477_D0.5030.10
15_I344_P0.5020.10
543_E606_A0.5020.10
359_P805_D0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oonA 1 0.5859 100 0.381 Contact Map
3udfA 2 0.7035 100 0.442 Contact Map
3vmaA 1 0.7235 100 0.521 Contact Map
2jchA 1 0.4788 100 0.532 Contact Map
2olvA 1 0.6776 100 0.584 Contact Map
3zg9B 1 0.5188 100 0.664 Contact Map
2y2mA 2 0.5106 100 0.757 Contact Map
2oqoA 2 0.2129 100 0.797 Contact Map
3vmtA 1 0.2529 100 0.8 Contact Map
2v2fF 1 0.4141 100 0.804 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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