GREMLIN Database
MALF - Maltose transport system permease protein MalF
UniProt: P02916 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10555
Length: 514 (445)
Sequences: 580 (431)
Seq/√Len: 20.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_A264_F10.2671.00
244_G248_D6.4831.00
412_Q416_K5.1891.00
278_L282_V4.5991.00
221_N224_S3.6411.00
204_F214_D3.4391.00
370_T374_I3.2541.00
179_N182_A3.0880.99
294_L377_T2.9530.99
113_S116_A2.9200.99
264_F492_T2.8720.99
204_F211_Y2.8490.99
372_L443_L2.7480.99
205_S214_D2.7300.99
152_G155_Q2.6720.98
411_F415_F2.6190.98
122_F133_L2.6090.98
366_T370_T2.4710.97
204_F213_L2.4290.97
380_G437_N2.4050.97
143_N146_S2.3950.97
296_V430_M2.3920.97
143_N148_A2.3210.96
295_T380_G2.3060.96
205_S213_L2.2340.95
478_G483_D2.2170.95
205_S212_T2.2080.95
207_T213_L2.1850.94
457_T460_P2.1720.94
240_I244_G2.1590.94
175_V178_Q2.1530.94
471_T494_I2.1340.94
131_W179_N2.1150.93
409_G412_Q2.1030.93
266_R483_D2.0590.92
409_G416_K2.0430.92
496_L500_A2.0350.92
360_A363_S2.0190.92
204_F207_T1.9880.91
207_T210_L1.9870.91
146_S151_F1.9600.90
286_V290_I1.9540.90
211_Y214_D1.9530.90
204_F212_T1.9450.90
206_G214_D1.9340.90
340_F371_M1.9230.90
381_Y488_A1.9200.89
120_Y127_A1.9190.89
215_G218_T1.8950.89
149_F156_K1.8950.89
231_N238_Q1.8920.89
395_I412_Q1.8570.88
176_I183_L1.8460.88
208_Q212_T1.8410.87
204_F210_L1.8390.87
210_L214_D1.8390.87
395_I426_L1.8390.87
295_T433_S1.8370.87
395_I422_L1.8280.87
466_L469_N1.8050.86
250_K262_K1.7830.86
149_F155_Q1.7830.86
302_L305_L1.7740.85
261_W265_T1.7650.85
280_I461_A1.7480.84
285_V289_L1.7430.84
279_A456_G1.7380.84
111_D114_W1.7320.84
205_S208_Q1.7310.84
209_P213_L1.7300.84
290_I294_L1.7280.84
210_L221_N1.6960.83
443_L447_L1.6630.81
139_E192_D1.6610.81
173_L176_I1.6540.81
329_S443_L1.6340.80
206_G213_L1.6300.80
178_Q182_A1.6280.80
185_D190_L1.6270.80
90_A492_T1.6100.79
335_I476_F1.6010.79
208_Q214_D1.6000.79
444_I469_N1.5980.79
154_E157_L1.5810.78
329_S369_R1.5540.77
186_I190_L1.5510.76
241_T249_E1.5480.76
366_T369_R1.5120.74
126_P129_D1.5060.74
240_I248_D1.4960.74
146_S152_G1.4930.74
313_G406_D1.4820.73
294_L298_V1.4670.72
280_I442_V1.4600.72
143_N149_F1.4570.72
206_G212_T1.4460.71
210_L213_L1.4430.71
450_G465_D1.4390.71
431_I486_L1.4370.71
258_T261_W1.4330.70
316_V320_L1.4270.70
228_Y251_L1.4140.69
143_N147_D1.4140.69
181_Q251_L1.4020.69
457_T493_L1.3920.68
429_L433_S1.3830.68
204_F208_Q1.3830.68
295_T377_T1.3810.67
162_T165_Q1.3800.67
461_A471_T1.3720.67
417_I426_L1.3610.66
422_L478_G1.3610.66
335_I373_I1.3580.66
124_L403_S1.3550.66
183_L186_I1.3510.66
279_A294_L1.3450.65
430_M476_F1.3330.65
112_R115_Q1.3300.64
470_Y474_I1.3240.64
322_I456_G1.3240.64
130_E133_L1.3240.64
121_N135_L1.3230.64
156_K176_I1.3210.64
209_P212_T1.3210.64
138_G141_G1.3170.64
207_T211_Y1.3150.64
176_I301_V1.3150.64
333_I443_L1.3090.63
376_N380_G1.3070.63
209_P214_D1.3060.63
146_S149_F1.3050.63
152_G190_L1.2970.62
339_L393_K1.2940.62
306_V398_D1.2930.62
322_I417_I1.2890.62
262_K496_L1.2810.61
346_E453_D1.2770.61
241_T248_D1.2770.61
132_Q135_L1.2760.61
139_E142_K1.2750.61
194_N203_Q1.2740.61
261_W499_G1.2690.61
363_S377_T1.2660.60
198_M201_L1.2610.60
386_I393_K1.2570.60
307_Q318_R1.2570.60
146_S155_Q1.2330.58
324_P450_G1.2260.58
72_M79_V1.2240.58
400_Y418_T1.2170.57
129_D132_Q1.2120.57
324_P336_F1.2060.57
331_I483_D1.2060.57
153_G156_K1.2030.56
65_W68_V1.1970.56
267_V363_S1.1930.56
390_G439_N1.1910.56
430_M438_F1.1910.56
120_Y136_S1.1860.55
56_I69_Y1.1830.55
414_F490_I1.1760.55
181_Q222_N1.1690.54
273_I456_G1.1510.53
140_T145_L1.1480.53
500_A503_I1.1480.53
291_T384_M1.1460.53
243_D248_D1.1430.53
117_G122_F1.1350.52
111_D116_A1.1320.52
148_A152_G1.1320.52
283_W435_A1.1300.52
397_D483_D1.1280.52
356_G361_W1.1240.51
324_P485_G1.1210.51
372_L444_I1.1170.51
220_T224_S1.1160.51
388_C417_I1.1140.51
414_F476_F1.1080.50
200_S207_T1.1060.50
297_A419_L1.1030.50
292_V401_E1.0980.50
448_T465_D1.0950.49
207_T212_T1.0890.49
112_R121_N1.0860.49
161_E164_A1.0850.49
154_E169_E1.0850.49
453_D456_G1.0850.49
125_Y132_Q1.0840.49
438_F495_F1.0840.49
145_L151_F1.0830.49
321_L395_I1.0800.48
330_F440_N1.0790.48
66_R254_G1.0790.48
226_V251_L1.0780.48
365_P463_Y1.0750.48
59_N123_G1.0750.48
190_L289_L1.0720.48
170_R271_E1.0720.48
300_M392_L1.0680.48
438_F464_T1.0670.48
177_T183_L1.0640.47
317_Y380_G1.0620.47
327_V471_T1.0620.47
146_S150_K1.0610.47
341_N428_P1.0610.47
243_D269_T1.0600.47
196_V417_I1.0580.47
317_Y437_N1.0530.47
222_N226_V1.0500.46
288_S495_F1.0380.46
241_T244_G1.0380.46
80_L214_D1.0370.46
68_V80_L1.0350.46
156_K162_T1.0240.45
121_N128_G1.0160.44
414_F418_T1.0160.44
266_R270_D1.0140.44
156_K160_K1.0080.44
82_P471_T1.0080.44
144_Y149_F1.0070.44
201_L205_S1.0070.44
363_S366_T1.0010.43
301_V304_C0.9980.43
383_Y438_F0.9970.43
369_R466_L0.9950.43
169_E172_N0.9930.43
313_G392_L0.9920.43
369_R372_L0.9910.43
241_T289_L0.9800.42
131_W135_L0.9790.42
434_F439_N0.9790.42
348_N434_F0.9780.42
179_N183_L0.9780.42
169_E175_V0.9770.42
153_G160_K0.9760.42
76_G403_S0.9740.42
236_F250_K0.9730.42
145_L150_K0.9720.41
135_L354_L0.9710.41
265_T268_F0.9680.41
82_P446_L0.9530.40
143_N150_K0.9530.40
470_Y482_Q0.9500.40
117_G121_N0.9480.40
414_F457_T0.9410.40
147_D150_K0.9410.40
444_I448_T0.9400.39
137_D141_G0.9360.39
340_F403_S0.9330.39
428_P440_N0.9330.39
197_M279_A0.9320.39
77_L180_R0.9250.39
193_G200_S0.9250.39
149_F152_G0.9240.38
121_N218_T0.9230.38
409_G496_L0.9180.38
388_C463_Y0.9160.38
280_I443_L0.9150.38
326_A382_P0.9140.38
403_S413_N0.9070.37
428_P438_F0.9050.37
429_L439_N0.9030.37
394_A431_I0.8860.36
243_D268_F0.8840.36
99_Q340_F0.8790.36
306_V399_L0.8770.36
448_T452_P0.8740.35
101_T177_T0.8730.35
338_G447_L0.8720.35
89_I488_A0.8720.35
426_L461_A0.8700.35
153_G226_V0.8690.35
336_F485_G0.8680.35
438_F485_G0.8670.35
322_I379_L0.8630.35
208_Q213_L0.8600.35
144_Y147_D0.8600.35
88_A92_T0.8590.35
137_D140_T0.8570.34
434_F462_G0.8550.34
327_V331_I0.8540.34
395_I425_P0.8520.34
312_R411_F0.8520.34
407_G420_P0.8510.34
424_K468_V0.8490.34
428_P467_L0.8490.34
69_Y339_L0.8440.34
260_G287_F0.8420.34
288_S469_N0.8390.33
72_M427_T0.8370.33
77_L149_F0.8360.33
212_T222_N0.8340.33
324_P451_G0.8330.33
70_P324_P0.8330.33
100_L104_R0.8320.33
65_W73_A0.8320.33
174_R192_D0.8280.33
299_G382_P0.8270.33
183_L354_L0.8260.33
459_T474_I0.8250.33
153_G176_I0.8220.32
444_I495_F0.8220.32
165_Q169_E0.8220.32
182_A185_D0.8220.32
142_K145_L0.8210.32
204_F209_P0.8210.32
119_T374_I0.8210.32
232_N275_K0.8200.32
295_T321_L0.8160.32
333_I395_I0.8130.32
382_P392_L0.8080.32
114_W136_S0.8070.31
71_G325_Y0.8070.31
207_T214_D0.8070.31
283_W440_N0.8060.31
60_R199_S0.8050.31
137_D156_K0.8040.31
164_A347_I0.8030.31
106_Q213_L0.8010.31
399_L417_I0.7990.31
63_Y66_R0.7990.31
274_Q460_P0.7970.31
156_K194_N0.7950.31
341_N440_N0.7930.31
93_N99_Q0.7850.30
175_V181_Q0.7830.30
196_V253_P0.7830.30
323_L431_I0.7830.30
71_G105_A0.7830.30
76_G259_T0.7820.30
269_T275_K0.7810.30
171_A178_Q0.7800.30
202_R209_P0.7800.30
187_T201_L0.7780.30
268_F274_Q0.7750.30
241_T261_W0.7750.30
76_G101_T0.7750.30
119_T196_V0.7730.30
442_V505_N0.7730.30
482_Q490_I0.7720.30
71_G296_V0.7690.29
105_A254_G0.7660.29
278_L481_G0.7650.29
329_S333_I0.7640.29
321_L470_Y0.7640.29
206_G210_L0.7620.29
386_I483_D0.7600.29
299_G450_G0.7600.29
259_T264_F0.7570.29
78_F421_L0.7570.29
456_G460_P0.7560.29
298_V377_T0.7550.29
190_L221_N0.7530.29
223_Q230_P0.7520.28
397_D417_I0.7500.28
205_S209_P0.7480.28
176_I208_Q0.7480.28
167_E171_A0.7470.28
73_A478_G0.7460.28
153_G192_D0.7460.28
331_I346_E0.7440.28
116_A131_W0.7430.28
316_V496_L0.7410.28
143_N152_G0.7400.28
463_Y477_E0.7400.28
468_V506_L0.7390.28
331_I484_F0.7390.28
150_K154_E0.7360.28
229_R269_T0.7360.28
414_F493_L0.7360.28
127_A289_L0.7340.28
117_G196_V0.7330.27
315_A502_A0.7330.27
159_L195_K0.7300.27
89_I92_T0.7300.27
200_S212_T0.7270.27
291_T372_L0.7260.27
287_F326_A0.7250.27
162_T167_E0.7250.27
395_I399_L0.7240.27
450_G485_G0.7220.27
129_D175_V0.7220.27
172_N175_V0.7210.27
436_F440_N0.7210.27
178_Q181_Q0.7200.27
118_K137_D0.7180.27
326_A438_F0.7160.27
130_E140_T0.7160.27
59_N87_I0.7160.27
160_K164_A0.7150.27
147_D229_R0.7130.26
403_S426_L0.7120.26
201_L240_I0.7110.26
166_P169_E0.7100.26
87_I101_T0.7080.26
177_T375_V0.7070.26
337_K456_G0.7070.26
273_I297_A0.7060.26
104_R196_V0.7050.26
286_V465_D0.7050.26
200_S204_F0.7050.26
93_N428_P0.7030.26
433_S441_F0.7010.26
201_L230_P0.7000.26
401_E472_Y0.6970.26
142_K240_I0.6960.26
81_F85_C0.6960.26
155_Q159_L0.6950.26
175_V196_V0.6940.25
428_P495_F0.6930.25
444_I464_T0.6930.25
60_R240_I0.6930.25
215_G220_T0.6920.25
322_I455_L0.6910.25
324_P378_W0.6870.25
332_S368_A0.6860.25
348_N440_N0.6850.25
466_L470_Y0.6840.25
256_T261_W0.6840.25
300_M412_Q0.6830.25
325_Y382_P0.6830.25
336_F448_T0.6810.25
210_L223_Q0.6810.25
279_A405_M0.6810.25
66_R71_G0.6790.25
284_T318_R0.6780.25
106_Q217_G0.6760.25
418_T473_R0.6750.25
164_A172_N0.6750.25
131_W137_D0.6740.24
263_N266_R0.6740.24
196_V405_M0.6710.24
477_E481_G0.6710.24
428_P465_D0.6710.24
422_L445_Q0.6710.24
282_V414_F0.6690.24
132_Q136_S0.6680.24
437_N448_T0.6670.24
307_Q314_K0.6660.24
333_I442_V0.6650.24
105_A108_V0.6650.24
145_L173_L0.6650.24
151_F155_Q0.6640.24
325_Y439_N0.6640.24
336_F450_G0.6630.24
336_F468_V0.6630.24
144_Y148_A0.6630.24
337_K482_Q0.6620.24
222_N237_Y0.6600.24
439_N494_I0.6590.24
111_D153_G0.6590.24
272_G320_L0.6580.24
96_S162_T0.6570.24
72_M130_E0.6560.24
163_T236_F0.6550.24
137_D222_N0.6550.24
129_D167_E0.6530.23
450_G464_T0.6520.23
210_L224_S0.6510.23
116_A179_N0.6500.23
80_L84_V0.6500.23
351_L354_L0.6480.23
276_P375_V0.6470.23
80_L88_A0.6470.23
365_P372_L0.6460.23
248_D251_L0.6440.23
75_M361_W0.6440.23
376_N440_N0.6420.23
307_Q491_A0.6420.23
130_E138_G0.6420.23
190_L360_A0.6390.23
463_Y488_A0.6380.23
275_K285_V0.6370.23
220_T228_Y0.6370.23
136_S139_E0.6370.23
164_A243_D0.6360.23
299_G393_K0.6350.23
431_I498_V0.6330.23
372_L387_L0.6320.23
350_M354_L0.6320.23
412_Q422_L0.6320.23
446_L470_Y0.6310.22
130_E135_L0.6290.22
248_D257_V0.6280.22
89_I99_Q0.6280.22
72_M333_I0.6270.22
395_I461_A0.6270.22
139_E293_F0.6270.22
294_L358_K0.6260.22
177_T180_R0.6260.22
341_N390_G0.6240.22
84_V108_V0.6210.22
340_F442_V0.6200.22
180_R192_D0.6190.22
330_F384_M0.6190.22
121_N289_L0.6190.22
194_N198_M0.6180.22
222_N230_P0.6180.22
318_R465_D0.6170.22
216_D227_K0.6150.22
288_S434_F0.6150.22
65_W72_M0.6140.22
121_N175_V0.6090.21
307_Q322_I0.6090.21
256_T500_A0.6090.21
64_A67_Y0.6080.21
82_P331_I0.6080.21
331_I336_F0.6080.21
226_V231_N0.6080.21
410_P415_F0.6070.21
117_G123_G0.6070.21
446_L474_I0.6060.21
92_T263_N0.6050.21
390_G428_P0.6040.21
406_D412_Q0.6030.21
181_Q202_R0.6030.21
240_I264_F0.6010.21
280_I372_L0.6000.21
443_L494_I0.5980.21
76_G262_K0.5980.21
140_T162_T0.5970.21
158_Q161_E0.5970.21
500_A504_V0.5960.21
325_Y432_A0.5940.21
149_F153_G0.5890.21
120_Y496_L0.5890.21
216_D226_V0.5870.21
171_A175_V0.5870.21
126_P134_A0.5870.21
120_Y124_L0.5850.20
141_G144_Y0.5840.20
267_V350_M0.5840.20
319_V460_P0.5840.20
59_N62_A0.5840.20
465_D487_A0.5840.20
157_L160_K0.5830.20
223_Q271_E0.5830.20
123_G128_G0.5820.20
215_G500_A0.5800.20
176_I184_S0.5800.20
444_I452_P0.5790.20
443_L459_T0.5790.20
154_E159_L0.5790.20
171_A223_Q0.5790.20
350_M372_L0.5780.20
190_L200_S0.5780.20
393_K450_G0.5770.20
219_L414_F0.5770.20
274_Q459_T0.5770.20
208_Q279_A0.5760.20
281_F416_K0.5760.20
390_G429_L0.5750.20
112_R234_I0.5740.20
231_N240_I0.5740.20
153_G241_T0.5730.20
327_V340_F0.5720.20
293_F373_I0.5720.20
201_L355_F0.5720.20
369_R373_I0.5710.20
94_Y444_I0.5710.20
129_D143_N0.5700.20
134_A217_G0.5700.20
74_G267_V0.5700.20
339_L366_T0.5690.20
448_T476_F0.5680.20
445_Q508_A0.5680.20
406_D441_F0.5660.20
319_V490_I0.5660.20
376_N439_N0.5660.20
381_Y387_L0.5650.20
68_V71_G0.5610.19
62_A232_N0.5600.19
168_G202_R0.5600.19
77_L214_D0.5600.19
176_I222_N0.5600.19
311_L321_L0.5590.19
65_W400_Y0.5590.19
226_V249_E0.5590.19
119_T203_Q0.5580.19
391_L506_L0.5580.19
140_T316_V0.5580.19
260_G299_G0.5570.19
147_D157_L0.5570.19
70_P450_G0.5570.19
274_Q335_I0.5570.19
318_R422_L0.5560.19
335_I372_L0.5550.19
156_K347_I0.5540.19
299_G324_P0.5540.19
69_Y305_L0.5530.19
364_D463_Y0.5520.19
196_V203_Q0.5520.19
399_L419_L0.5520.19
280_I502_A0.5510.19
267_V446_L0.5500.19
258_T501_L0.5500.19
167_E202_R0.5470.19
410_P503_I0.5470.19
428_P433_S0.5470.19
278_L497_L0.5470.19
82_P470_Y0.5460.19
268_F271_E0.5460.19
390_G465_D0.5460.19
126_P175_V0.5460.19
98_N260_G0.5460.19
286_V373_I0.5460.19
391_L424_K0.5450.19
473_R478_G0.5450.19
462_G499_G0.5450.19
284_T367_T0.5430.19
295_T443_L0.5430.19
307_Q389_M0.5420.19
283_W428_P0.5420.19
186_I189_I0.5410.19
77_L367_T0.5410.19
75_M339_L0.5400.19
395_I503_I0.5400.19
121_N125_Y0.5400.19
67_Y466_L0.5390.19
265_T274_Q0.5360.18
201_L204_F0.5360.18
129_D164_A0.5340.18
116_A199_S0.5340.18
170_R192_D0.5330.18
399_L447_L0.5320.18
390_G494_I0.5310.18
324_P438_F0.5310.18
464_T495_F0.5300.18
137_D265_T0.5300.18
306_V377_T0.5290.18
61_K197_M0.5280.18
86_T92_T0.5270.18
391_L468_V0.5270.18
341_N467_L0.5270.18
201_L207_T0.5260.18
281_F501_L0.5260.18
447_L476_F0.5240.18
342_Q442_V0.5230.18
99_Q343_S0.5230.18
294_L373_I0.5230.18
74_G296_V0.5220.18
240_I298_V0.5220.18
321_L482_Q0.5210.18
378_W438_F0.5200.18
441_F445_Q0.5190.18
309_E419_L0.5180.18
436_F439_N0.5170.18
361_W388_C0.5160.18
135_L153_G0.5160.18
379_L494_I0.5150.18
432_A437_N0.5140.18
332_S378_W0.5140.18
483_D493_L0.5130.18
208_Q211_Y0.5120.17
398_D509_T0.5100.17
346_E471_T0.5100.17
355_F471_T0.5090.17
99_Q453_D0.5090.17
308_W400_Y0.5080.17
202_R211_Y0.5070.17
403_S425_P0.5070.17
96_S109_L0.5070.17
259_T263_N0.5060.17
69_Y371_M0.5060.17
232_N417_I0.5030.17
164_A223_Q0.5010.17
158_Q226_V0.5000.17
262_K268_F0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfF 1 0.9533 100 0.377 Contact Map
4tquM 1 0.5447 100 0.72 Contact Map
2onkC 2 0.4903 100 0.732 Contact Map
3d31C 2 0.4825 100 0.743 Contact Map
3rlfG 1 0.5214 100 0.749 Contact Map
4tquN 1 0.5233 100 0.758 Contact Map
4ymuD 2 0.4163 100 0.796 Contact Map
3tuiA 2 0.4047 100 0.804 Contact Map
4i0uA 4 0.1187 58.3 0.972 Contact Map
4ev6A 3 0.1226 58.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0131 seconds.