GREMLIN Database
RL15 - 50S ribosomal protein L15
UniProt: P02413 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10876
Length: 144 (143)
Sequences: 2997 (1511)
Seq/√Len: 126.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_R136_E3.8121.00
123_R143_E3.4391.00
17_K27_L2.9261.00
91_D94_T2.7261.00
124_G127_V2.7161.00
27_L32_G2.6551.00
127_V142_I2.6071.00
121_T141_K2.5621.00
112_L130_G2.5061.00
83_A117_T2.3431.00
129_K132_R2.2701.00
80_S113_A2.1421.00
93_N97_A2.1331.00
133_A137_A2.0431.00
89_V123_R1.9441.00
92_L125_L1.9131.00
88_G94_T1.8531.00
86_E119_P1.8081.00
110_V124_G1.7951.00
129_K133_A1.7851.00
76_E128_T1.7271.00
19_L31_G1.6981.00
36_K40_S1.6671.00
23_I29_K1.6641.00
81_D84_K1.6421.00
83_A118_T1.6361.00
29_K35_H1.6211.00
127_V132_R1.6171.00
116_V120_V1.6141.00
109_K126_R1.6101.00
133_A136_E1.5711.00
91_D123_R1.5691.00
2_R5_T1.5411.00
39_K45_G1.5241.00
136_E141_K1.4681.00
82_L122_V1.4681.00
83_A86_E1.4611.00
78_R111_I1.4131.00
94_T98_A1.4111.00
9_A12_S1.3981.00
19_L33_R1.3581.00
35_H39_K1.3301.00
19_L27_L1.3121.00
115_E134_A1.3001.00
39_K46_V1.2981.00
38_Q44_G1.2541.00
30_T35_H1.2170.99
92_L108_A1.2140.99
89_V121_T1.2140.99
55_M58_Y1.2000.99
78_R112_L1.1900.99
110_V135_I1.1400.99
108_A124_G1.1390.99
90_V95_L1.1360.99
35_H40_S1.1350.99
24_G27_L1.0990.99
51_E60_R1.0960.99
39_K44_G1.0880.99
110_V122_V1.0840.99
88_G118_T1.0800.99
79_L134_A1.0630.99
90_V120_V1.0460.98
8_P13_K1.0410.98
135_I140_G1.0170.98
74_T126_R1.0130.98
82_L120_V1.0060.98
8_P12_S1.0040.98
45_G48_R0.9960.98
87_G90_V0.9940.98
85_V88_G0.9940.98
111_I128_T0.9930.98
74_T107_F0.9920.98
15_A27_L0.9860.98
110_V127_V0.9810.97
16_G19_L0.9710.97
47_R58_Y0.9680.97
119_P141_K0.9650.97
75_A105_I0.9630.97
33_R40_S0.9630.97
86_E118_T0.9580.97
122_V135_I0.9350.97
96_K104_Q0.9330.97
127_V135_I0.9320.97
55_M59_R0.9300.97
38_Q46_V0.9050.96
19_L32_G0.9020.96
50_F54_Q0.9020.96
90_V94_T0.9010.96
81_D113_A0.8990.96
30_T36_K0.8980.96
101_I108_A0.8940.96
75_A107_F0.8910.96
68_S71_A0.8830.95
88_G98_A0.8760.95
78_R113_A0.8750.95
72_A107_F0.8730.95
92_L101_I0.8580.95
119_P138_A0.8530.94
51_E54_Q0.8470.94
57_L61_L0.8380.94
81_D100_I0.8380.94
102_G105_I0.8360.94
94_T97_A0.8360.94
1_M5_T0.8330.94
92_L96_K0.8300.94
121_T143_E0.8170.93
78_R128_T0.8150.93
20_G31_G0.8080.93
9_A13_K0.8050.92
132_R142_I0.8020.92
113_A134_A0.7880.92
75_A106_E0.7870.92
111_I131_A0.7840.91
29_K32_G0.7800.91
96_K103_I0.7800.91
27_L31_G0.7790.91
79_L112_L0.7730.91
90_V98_A0.7690.91
80_S83_A0.7680.91
16_G27_L0.7560.90
14_K27_L0.7550.90
122_V127_V0.7510.90
107_F126_R0.7340.89
124_G135_I0.7290.88
96_K101_I0.7270.88
72_A76_E0.7160.87
14_K17_K0.7090.87
40_S43_G0.7030.86
116_V119_P0.7010.86
23_I30_T0.7000.86
95_L101_I0.7000.86
23_I35_H0.6920.85
42_S45_G0.6880.85
87_G120_V0.6830.85
7_S12_S0.6820.85
76_E111_I0.6800.84
116_V138_A0.6770.84
64_F70_K0.6750.84
51_E56_P0.6690.84
104_Q107_F0.6670.83
56_P59_R0.6670.83
24_G64_F0.6600.83
65_G68_S0.6590.83
76_E126_R0.6590.83
79_L138_A0.6570.82
111_I114_G0.6570.82
75_A102_G0.6540.82
95_L99_N0.6530.82
44_G47_R0.6530.82
124_G142_I0.6480.82
89_V143_E0.6470.81
71_A74_T0.6430.81
15_A31_G0.6430.81
75_A101_I0.6420.81
92_L104_Q0.6400.81
77_I110_V0.6370.80
116_V135_I0.6320.80
79_L116_V0.6320.80
53_G56_P0.6310.80
77_I100_I0.6290.80
40_S44_G0.6270.79
95_L100_I0.6230.79
33_R39_K0.6190.79
132_R141_K0.6190.79
130_G134_A0.6120.78
43_G46_V0.6090.77
107_F125_L0.6080.77
91_D97_A0.6060.77
71_A76_E0.6030.77
123_R141_K0.6020.77
111_I134_A0.5910.75
79_L83_A0.5890.75
79_L122_V0.5860.75
121_T138_A0.5810.74
29_K64_F0.5810.74
73_I104_Q0.5800.74
14_K31_G0.5780.74
95_L124_G0.5720.73
85_V98_A0.5710.73
67_T70_K0.5680.72
12_S57_L0.5670.72
68_S74_T0.5670.72
9_A24_G0.5640.72
7_S10_E0.5630.72
42_S46_V0.5630.72
50_F53_G0.5620.72
92_L97_A0.5590.71
76_E110_V0.5530.70
79_L113_A0.5490.70
31_G35_H0.5490.70
25_S36_K0.5470.70
85_V94_T0.5450.69
103_I108_A0.5450.69
108_A112_L0.5450.69
87_G119_P0.5410.69
96_K105_I0.5360.68
87_G118_T0.5360.68
35_H43_G0.5350.68
112_L134_A0.5350.68
118_T121_T0.5340.68
114_G134_A0.5310.67
78_R114_G0.5300.67
109_K128_T0.5290.67
90_V122_V0.5270.67
31_G40_S0.5240.66
56_P60_R0.5130.65
33_R59_R0.5110.64
7_S11_G0.5060.64
35_H42_S0.5060.64
44_G55_M0.5050.63
1_M61_L0.5030.63
19_L25_S0.5020.63
51_E61_L0.5020.63
85_V118_T0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j3wL 1 1 100 0.061 Contact Map
1vw4J 1 0.9861 100 0.083 Contact Map
4tp9L 1 0.0139 100 0.084 Contact Map
2zjrI 1 0.9653 100 0.085 Contact Map
4rb6P 1 0.9792 100 0.088 Contact Map
3bboN 1 1 100 0.134 Contact Map
3j7yM 1 0.9722 100 0.151 Contact Map
1vq8L 1 0.8611 100 0.346 Contact Map
4a17K 1 0.9097 100 0.371 Contact Map
4ujrN 1 0.8681 100 0.392 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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