GREMLIN Database
RS6 - 30S ribosomal protein S6
UniProt: P02358 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10905
Length: 135 (115)
Sequences: 1323 (703)
Seq/√Len: 65.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_I34_G6.0431.00
9_M57_A4.8041.00
35_K65_E4.4911.00
27_A31_G3.4441.00
51_I86_R3.0571.00
7_V61_L2.7711.00
26_T30_T2.6281.00
73_E76_T2.3671.00
23_E26_T2.1461.00
66_A71_I2.0821.00
26_T39_L2.0181.00
68_Q72_D1.9781.00
75_E89_V1.9291.00
30_T35_K1.8101.00
67_P70_V1.7871.00
23_E27_A1.7531.00
111_E115_D1.7351.00
108_E111_E1.6790.99
41_D58_H1.6620.99
75_E87_S1.6470.99
27_A30_T1.6100.99
10_V84_V1.5560.99
8_F60_V1.5480.99
109_R112_R1.5170.99
2_R91_R1.5150.99
76_T80_F1.5010.99
6_I64_V1.4870.99
11_H54_L1.4070.98
112_R115_D1.4040.98
9_M92_T1.3850.98
99_A103_V1.2920.96
32_A70_V1.2810.96
6_I78_F1.2800.96
6_I89_V1.2750.96
37_H65_E1.2670.96
46_Q56_K1.2130.95
63_N95_A1.2010.95
78_F84_V1.1940.94
47_L85_I1.1820.94
8_F78_F1.1760.94
64_V89_V1.1230.92
10_V21_M1.1210.92
106_K109_R1.1090.92
32_A67_P1.0980.91
25_Y78_F1.0720.90
23_E39_L1.0600.90
111_E114_D1.0570.90
29_I70_V1.0560.90
7_V88_M1.0490.89
19_P41_D1.0440.89
74_L78_F1.0210.88
110_R113_R1.0030.87
9_M54_L0.9990.87
45_R102_M0.9910.87
107_D110_R0.9840.86
109_R113_R0.9830.86
44_R56_K0.9750.86
40_E61_L0.9460.84
28_A77_T0.9250.82
26_T36_I0.9180.82
12_P50_P0.8920.80
21_M83_A0.8900.80
12_P54_L0.8700.78
22_I61_L0.8650.78
38_R57_A0.8580.77
25_Y46_Q0.8340.75
98_E101_P0.8280.75
10_V34_G0.8170.74
66_A70_V0.8120.73
10_V54_L0.7920.72
26_T91_R0.7910.72
28_A105_A0.7810.71
72_D109_R0.7760.70
92_T96_V0.7700.69
31_G93_K0.7680.69
13_D18_V0.7620.69
72_D76_T0.7600.68
9_M75_E0.7550.68
64_V78_F0.7530.68
29_I64_V0.7520.68
77_T82_D0.7500.67
11_H83_A0.7470.67
42_W85_I0.7400.66
22_I60_V0.7310.65
24_R81_N0.7290.65
73_E77_T0.7190.64
69_E72_D0.7160.64
11_H55_H0.7160.64
45_R59_Y0.7150.64
31_G106_K0.7060.63
59_Y114_D0.7040.63
53_K112_R0.7040.63
14_Q45_R0.7030.62
99_A107_D0.7010.62
34_G84_V0.7000.62
50_P81_N0.6980.62
71_I79_R0.6970.62
17_Q20_G0.6960.62
10_V88_M0.6920.61
62_M90_M0.6900.61
39_L55_H0.6820.60
56_K100_S0.6810.60
28_A76_T0.6810.60
57_A102_M0.6790.60
71_I89_V0.6760.59
50_P55_H0.6670.58
36_I90_M0.6670.58
3_H65_E0.6670.58
52_N85_I0.6650.58
25_Y41_D0.6620.58
2_R24_R0.6600.58
41_D44_R0.6550.57
19_P22_I0.6480.56
46_Q54_L0.6460.56
18_V58_H0.6430.56
21_M81_N0.6400.55
25_Y74_L0.6400.55
28_A32_A0.6390.55
8_F26_T0.6390.55
32_A69_E0.6350.55
105_A111_E0.6320.54
6_I74_L0.6270.54
71_I74_L0.6160.52
87_S90_M0.6160.52
79_R87_S0.6140.52
41_D60_V0.6110.52
25_Y77_T0.6070.51
42_W61_L0.6050.51
71_I75_E0.6010.51
63_N97_T0.6010.51
100_S103_V0.5920.50
71_I84_V0.5850.49
7_V58_H0.5840.49
26_T62_M0.5740.48
9_M30_T0.5740.48
38_R41_D0.5730.47
14_Q87_S0.5720.47
25_Y81_N0.5700.47
12_P78_F0.5650.46
45_R86_R0.5590.46
3_H100_S0.5580.46
67_P79_R0.5580.46
40_E103_V0.5560.45
12_P79_R0.5530.45
110_R114_D0.5530.45
12_P21_M0.5520.45
13_D17_Q0.5490.45
14_Q48_A0.5470.44
30_T94_H0.5450.44
108_E112_R0.5410.44
39_L62_M0.5370.43
56_K81_N0.5340.43
71_I76_T0.5320.43
23_E59_Y0.5300.42
36_I78_F0.5290.42
8_F61_L0.5270.42
8_F62_M0.5260.42
108_E113_R0.5250.42
9_M72_D0.5230.42
17_Q63_N0.5210.41
68_Q75_E0.5200.41
105_A110_R0.5190.41
98_E105_A0.5190.41
2_R10_V0.5190.41
66_A75_E0.5100.40
3_H95_A0.5090.40
1_M4_Y0.5080.40
95_A98_E0.5030.39
41_D62_M0.5030.39
39_L53_K0.5020.39
50_P53_K0.5020.39
73_E90_M0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kiyF 1 0.7556 100 0.155 Contact Map
1vmbA 1 0.7704 100 0.204 Contact Map
4tp8F 1 0.7407 100 0.219 Contact Map
2j5aA 1 0.7407 100 0.233 Contact Map
1cqmA 1 0.7185 100 0.235 Contact Map
3r3tA 3 0.6889 100 0.242 Contact Map
3bbnF 1 0.7185 100 0.248 Contact Map
5aj3F 1 0.8741 100 0.282 Contact Map
2kjwA 1 0.3926 99.8 0.528 Contact Map
3zzpA 1 0.5259 99 0.705 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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