ASNA - ECOLI - GREMLIN Contacts

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ASNA - Aspartate--ammonia ligase

UniProt:	P00963	Sequences: MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10091
Length:	330 (311)
Sequences:	694 (398)
Seq/√Len:	22.5

ECOLI - ASNA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
174_L	207_D	4.849	1.00
171_Q	175_S	4.457	1.00
174_L	206_S	4.257	1.00
189_I	196_V	4.135	1.00
266_A	271_E	4.069	1.00
190_A	237_L	4.013	1.00
187_R	245_D	3.459	1.00
203_G	267_L	3.397	1.00
176_R	192_D	3.294	1.00
134_K	199_V	3.120	1.00
319_P	322_V	3.116	1.00
144_I	300_L	3.104	1.00
180_L	188_A	3.086	1.00
239_W	244_E	3.031	1.00
162_P	195_A	2.817	0.99
144_I	238_V	2.815	0.99
258_A	285_G	2.711	0.99
165_I	236_I	2.707	0.99
53_K	101_P	2.619	0.99
262_K	274_L	2.618	0.99
13_S	17_S	2.581	0.99
125_D	289_Q	2.569	0.99
238_V	249_L	2.524	0.98
274_L	283_L	2.488	0.98
320_A	324_E	2.487	0.98
166_H	189_I	2.429	0.98
216_P	273_R	2.399	0.98
121_R	136_T	2.392	0.98
8_K	307_L	2.342	0.97
49_S	213_V	2.341	0.97
86_F	92_L	2.230	0.96
204_K	267_L	2.229	0.96
170_S	198_L	2.201	0.96
282_L	285_G	2.194	0.96
263_H	267_L	2.188	0.96
58_K	101_P	2.165	0.96
166_H	193_L	2.156	0.95
171_Q	207_D	2.155	0.95
60_K	104_D	2.115	0.95
187_R	246_A	2.094	0.95
181_D	184_G	2.065	0.94
281_A	286_E	1.993	0.93
188_A	192_D	1.976	0.93
258_A	289_Q	1.971	0.93
203_G	222_S	1.944	0.92
109_L	245_D	1.936	0.92
130_F	200_G	1.913	0.92
196_V	237_L	1.912	0.92
53_K	58_K	1.875	0.91
275_E	280_Q	1.837	0.90
124_G	127_E	1.789	0.89
53_K	102_D	1.755	0.88
130_F	199_V	1.752	0.87
6_I	90_E	1.725	0.87
197_F	234_G	1.723	0.87
59_V	67_F	1.712	0.86
189_I	193_L	1.702	0.86
240_N	247_F	1.693	0.86
138_E	164_Q	1.686	0.85
271_E	274_L	1.684	0.85
200_G	222_S	1.667	0.85
160_F	306_Q	1.664	0.85
187_R	244_E	1.659	0.84
175_S	206_S	1.635	0.83
141_W	195_A	1.628	0.83
171_Q	174_L	1.623	0.83
88_A	124_G	1.613	0.83
160_F	241_P	1.595	0.82
169_H	199_V	1.589	0.82
157_L	306_Q	1.558	0.80
123_M	289_Q	1.541	0.80
22_Q	146_A	1.522	0.79
71_H	215_A	1.517	0.78
125_D	258_A	1.512	0.78
183_K	212_D	1.503	0.78
127_E	132_T	1.503	0.78
170_S	182_A	1.502	0.78
67_F	317_V	1.501	0.78
31_E	97_K	1.481	0.77
162_P	165_I	1.474	0.76
145_K	163_D	1.469	0.76
18_H	150_A	1.457	0.76
257_D	260_T	1.453	0.75
169_H	200_G	1.445	0.75
82_G	286_E	1.410	0.73
190_A	196_V	1.410	0.73
122_V	290_T	1.400	0.73
222_S	260_T	1.398	0.72
203_G	263_H	1.397	0.72
285_G	289_Q	1.379	0.71
270_D	273_R	1.378	0.71
14_F	154_E	1.376	0.71
16_K	95_H	1.332	0.69
280_Q	284_R	1.316	0.68
244_E	247_F	1.299	0.67
141_W	145_K	1.286	0.66
144_I	304_L	1.270	0.65
108_P	308_P	1.268	0.65
20_S	30_I	1.254	0.64
175_S	207_D	1.247	0.63
262_K	266_A	1.222	0.62
166_H	196_V	1.212	0.61
151_V	157_L	1.201	0.60
189_I	198_L	1.200	0.60
130_F	134_K	1.193	0.60
183_K	237_L	1.184	0.59
150_A	304_L	1.184	0.59
148_E	162_P	1.174	0.59
277_E	281_A	1.171	0.58
47_N	273_R	1.166	0.58
165_I	195_A	1.164	0.58
258_A	262_K	1.164	0.58
125_D	257_D	1.147	0.57
171_Q	200_G	1.132	0.56
323_R	326_V	1.121	0.55
39_R	42_D	1.116	0.55
109_L	247_F	1.112	0.54
14_F	150_A	1.111	0.54
222_S	263_H	1.105	0.54
160_F	303_L	1.104	0.54
141_W	303_L	1.100	0.54
18_H	304_L	1.092	0.53
141_W	165_I	1.084	0.53
20_S	33_Q	1.075	0.52
31_E	37_L	1.068	0.51
259_D	263_H	1.068	0.51
129_Q	134_K	1.062	0.51
148_E	159_P	1.057	0.51
157_L	160_F	1.056	0.51
108_P	243_L	1.053	0.50
144_I	249_L	1.051	0.50
187_R	239_W	1.045	0.50
148_E	161_L	1.044	0.50
138_E	163_D	1.042	0.50
204_K	210_R	1.039	0.49
198_L	237_L	1.023	0.48
11_Q	155_F	1.019	0.48
176_R	189_I	1.008	0.47
238_V	247_F	1.006	0.47
168_V	176_R	0.995	0.46
20_S	93_Y	0.991	0.46
81_L	288_P	0.990	0.46
89_G	127_E	0.985	0.46
121_R	139_A	0.984	0.46
58_K	64_D	0.971	0.45
148_E	195_A	0.961	0.44
216_P	270_D	0.959	0.44
59_V	112_V	0.956	0.44
28_G	90_E	0.952	0.43
26_R	146_A	0.950	0.43
262_K	271_E	0.939	0.43
190_A	239_W	0.938	0.43
26_R	143_G	0.936	0.42
67_F	112_V	0.933	0.42
168_V	177_Y	0.931	0.42
269_G	284_R	0.927	0.42
17_S	21_R	0.925	0.42
53_K	215_A	0.925	0.42
26_R	142_A	0.917	0.41
54_A	71_H	0.917	0.41
195_A	303_L	0.909	0.41
132_T	289_Q	0.909	0.41
82_G	281_A	0.907	0.40
79_Q	83_Q	0.904	0.40
198_L	246_A	0.901	0.40
222_S	267_L	0.897	0.40
121_R	132_T	0.896	0.40
189_I	237_L	0.895	0.40
44_T	277_E	0.892	0.39
141_W	194_G	0.890	0.39
141_W	162_P	0.887	0.39
132_T	136_T	0.885	0.39
45_Q	57_V	0.878	0.39
106_L	279_H	0.865	0.38
260_T	263_H	0.864	0.38
210_R	268_T	0.854	0.37
64_D	143_G	0.854	0.37
23_L	27_L	0.851	0.37
216_P	265_L	0.849	0.37
71_H	278_W	0.847	0.37
47_N	215_A	0.836	0.36
265_L	276_L	0.835	0.36
86_F	290_T	0.829	0.35
9_Q	53_K	0.828	0.35
49_S	52_E	0.826	0.35
13_S	24_E	0.824	0.35
184_G	187_R	0.824	0.35
37_L	99_L	0.822	0.35
149_A	159_P	0.821	0.35
60_K	71_H	0.816	0.35
11_Q	80_T	0.813	0.34
161_L	238_V	0.812	0.34
190_A	198_L	0.812	0.34
68_E	93_Y	0.805	0.34
20_S	300_L	0.803	0.34
263_H	266_A	0.803	0.34
101_P	109_L	0.798	0.33
198_L	236_I	0.795	0.33
276_L	282_L	0.791	0.33
92_L	138_E	0.789	0.33
24_E	93_Y	0.788	0.33
39_R	67_F	0.780	0.32
47_N	53_K	0.771	0.32
56_Q	66_Q	0.770	0.32
188_A	191_K	0.769	0.32
262_K	283_L	0.768	0.32
238_V	326_V	0.760	0.31
166_H	190_A	0.756	0.31
125_D	285_G	0.749	0.31
142_A	146_A	0.746	0.30
143_G	147_T	0.744	0.30
148_E	160_F	0.742	0.30
47_N	68_E	0.738	0.30
10_R	150_A	0.738	0.30
189_I	194_G	0.738	0.30
212_D	243_L	0.735	0.30
102_D	276_L	0.734	0.30
39_R	62_L	0.733	0.30
15_V	147_T	0.732	0.30
98_A	117_W	0.723	0.29
152_S	160_F	0.722	0.29
22_Q	25_E	0.722	0.29
303_L	306_Q	0.721	0.29
129_Q	270_D	0.721	0.29
15_V	156_G	0.719	0.29
148_E	306_Q	0.717	0.29
6_I	30_I	0.709	0.28
170_S	200_G	0.708	0.28
20_S	31_E	0.707	0.28
83_Q	323_R	0.705	0.28
103_E	106_L	0.704	0.28
266_A	274_L	0.701	0.28
148_E	165_I	0.700	0.28
41_G	65_A	0.699	0.28
141_W	161_L	0.697	0.28
14_F	18_H	0.695	0.27
152_S	159_P	0.695	0.27
71_H	136_T	0.695	0.27
5_Y	82_G	0.695	0.27
15_V	154_E	0.691	0.27
5_Y	319_P	0.691	0.27
270_D	291_I	0.691	0.27
265_L	273_R	0.686	0.27
240_N	245_D	0.686	0.27
31_E	34_A	0.686	0.27
16_K	27_L	0.685	0.27
113_Y	140_I	0.682	0.27
57_V	95_H	0.680	0.27
33_Q	97_K	0.680	0.27
45_Q	49_S	0.680	0.27
259_D	285_G	0.680	0.27
182_A	209_H	0.678	0.27
37_L	57_V	0.676	0.26
152_S	241_P	0.676	0.26
41_G	44_T	0.675	0.26
171_Q	206_S	0.674	0.26
97_K	300_L	0.673	0.26
11_Q	57_V	0.671	0.26
28_G	127_E	0.670	0.26
273_R	276_L	0.669	0.26
41_G	194_G	0.668	0.26
16_K	23_L	0.664	0.26
257_D	263_H	0.663	0.26
83_Q	281_A	0.659	0.26
13_S	93_Y	0.658	0.26
240_N	243_L	0.656	0.25
261_L	282_L	0.655	0.25
176_R	193_L	0.652	0.25
85_D	90_E	0.652	0.25
144_I	277_E	0.650	0.25
134_K	138_E	0.650	0.25
9_Q	240_N	0.649	0.25
10_R	148_E	0.645	0.25
201_I	211_H	0.644	0.25
38_S	57_V	0.643	0.25
59_V	65_A	0.643	0.25
280_Q	286_E	0.643	0.25
81_L	122_V	0.642	0.25
176_R	180_L	0.642	0.25
45_Q	67_F	0.641	0.25
61_A	106_L	0.641	0.25
87_S	168_V	0.641	0.25
28_G	150_A	0.640	0.25
30_I	86_F	0.639	0.25
125_D	130_F	0.639	0.25
33_Q	45_Q	0.636	0.24
54_A	198_L	0.636	0.24
129_Q	132_T	0.635	0.24
176_R	280_Q	0.633	0.24
145_K	195_A	0.633	0.24
308_P	326_V	0.632	0.24
37_L	71_H	0.632	0.24
62_L	319_P	0.630	0.24
97_K	108_P	0.629	0.24
31_E	113_Y	0.628	0.24
203_G	278_W	0.627	0.24
173_L	246_A	0.627	0.24
6_I	86_F	0.625	0.24
6_I	319_P	0.625	0.24
137_V	254_I	0.621	0.24
166_H	240_N	0.621	0.24
129_Q	321_A	0.619	0.24
11_Q	45_Q	0.619	0.24
130_F	269_G	0.618	0.23
136_T	170_S	0.617	0.23
6_I	9_Q	0.616	0.23
135_S	157_L	0.614	0.23
213_V	270_D	0.613	0.23
5_Y	30_I	0.612	0.23
319_P	325_S	0.612	0.23
165_I	238_V	0.611	0.23
42_D	80_T	0.606	0.23
25_E	28_G	0.605	0.23
7_A	30_I	0.603	0.23
80_T	122_V	0.601	0.23
45_Q	97_K	0.600	0.23
57_V	278_W	0.600	0.23
180_L	187_R	0.600	0.23
31_E	38_S	0.600	0.23
79_Q	82_G	0.599	0.23
22_Q	26_R	0.599	0.23
71_H	129_Q	0.597	0.22
60_K	215_A	0.595	0.22
145_K	162_P	0.594	0.22
57_V	99_L	0.594	0.22
40_V	67_F	0.594	0.22
7_A	51_C	0.593	0.22
23_L	147_T	0.593	0.22
52_E	103_E	0.590	0.22
238_V	303_L	0.590	0.22
56_Q	65_A	0.589	0.22
158_A	306_Q	0.589	0.22
58_K	169_H	0.588	0.22
239_W	303_L	0.586	0.22
41_G	47_N	0.586	0.22
103_E	173_L	0.586	0.22
68_E	244_E	0.585	0.22
236_I	247_F	0.584	0.22
132_T	291_I	0.584	0.22
149_A	153_E	0.584	0.22
168_V	189_I	0.580	0.22
15_V	301_T	0.580	0.22
39_R	49_S	0.579	0.22
155_F	317_V	0.579	0.22
194_G	261_L	0.578	0.22
159_P	306_Q	0.576	0.21
249_L	303_L	0.573	0.21
216_P	272_D	0.573	0.21
259_D	267_L	0.573	0.21
136_T	139_A	0.571	0.21
270_D	276_L	0.570	0.21
86_F	90_E	0.570	0.21
140_I	156_G	0.569	0.21
34_A	215_A	0.567	0.21
150_A	153_E	0.567	0.21
39_R	65_A	0.567	0.21
157_L	300_L	0.566	0.21
153_E	166_H	0.565	0.21
232_L	254_I	0.565	0.21
68_E	190_A	0.564	0.21
155_F	303_L	0.561	0.21
34_A	300_L	0.558	0.21
61_A	64_D	0.558	0.21
12_I	97_K	0.554	0.20
263_H	285_G	0.554	0.20
212_D	265_L	0.554	0.20
249_L	300_L	0.552	0.20
11_Q	15_V	0.552	0.20
7_A	83_Q	0.552	0.20
278_W	291_I	0.551	0.20
170_S	236_I	0.551	0.20
36_I	42_D	0.550	0.20
96_M	117_W	0.550	0.20
13_S	20_S	0.549	0.20
269_G	319_P	0.549	0.20
282_L	286_E	0.549	0.20
151_V	236_I	0.548	0.20
41_G	259_D	0.546	0.20
13_S	301_T	0.546	0.20
61_A	239_W	0.544	0.20
10_R	30_I	0.542	0.20
22_Q	315_C	0.542	0.20
140_I	279_H	0.542	0.20
13_S	31_E	0.541	0.20
59_V	62_L	0.541	0.20
146_A	198_L	0.541	0.20
148_E	194_G	0.540	0.20
145_K	303_L	0.539	0.20
101_P	169_H	0.539	0.20
131_S	179_D	0.539	0.20
88_A	291_I	0.538	0.20
282_L	287_M	0.538	0.20
42_D	317_V	0.537	0.20
292_G	296_G	0.537	0.20
154_E	157_L	0.537	0.20
175_S	268_T	0.536	0.20
187_R	302_M	0.536	0.20
9_Q	315_C	0.535	0.20
154_E	321_A	0.535	0.20
9_Q	20_S	0.534	0.20
79_Q	282_L	0.533	0.20
17_S	20_S	0.532	0.19
31_E	57_V	0.532	0.19
87_S	194_G	0.532	0.19
45_Q	301_T	0.531	0.19
168_V	278_W	0.530	0.19
216_P	276_L	0.530	0.19
6_I	10_R	0.529	0.19
155_F	164_Q	0.529	0.19
132_T	240_N	0.529	0.19
13_S	18_H	0.529	0.19
175_S	200_G	0.528	0.19
182_A	192_D	0.528	0.19
155_F	306_Q	0.527	0.19
130_F	192_D	0.527	0.19
129_Q	281_A	0.527	0.19
47_N	59_V	0.526	0.19
49_S	270_D	0.526	0.19
307_L	312_Q	0.526	0.19
40_V	269_G	0.525	0.19
175_S	284_R	0.524	0.19
172_E	206_S	0.524	0.19
242_V	306_Q	0.523	0.19
145_K	148_E	0.523	0.19
20_S	108_P	0.523	0.19
23_L	124_G	0.523	0.19
152_S	306_Q	0.522	0.19
168_V	192_D	0.521	0.19
31_E	95_H	0.521	0.19
31_E	93_Y	0.521	0.19
17_S	304_L	0.520	0.19
190_A	240_N	0.520	0.19
135_S	198_L	0.520	0.19
5_Y	57_V	0.519	0.19
97_K	301_T	0.519	0.19
86_F	238_V	0.519	0.19
22_Q	79_Q	0.518	0.19
40_V	59_V	0.517	0.19
26_R	139_A	0.517	0.19
25_E	135_S	0.517	0.19
13_S	304_L	0.517	0.19
135_S	139_A	0.516	0.19
151_V	154_E	0.515	0.19
14_F	210_R	0.514	0.19
21_R	69_V	0.511	0.19
40_V	47_N	0.511	0.19
6_I	106_L	0.510	0.19
106_L	322_V	0.510	0.19
58_K	102_D	0.509	0.19
279_H	326_V	0.509	0.19
17_S	93_Y	0.509	0.19
161_L	195_A	0.509	0.19
79_Q	239_W	0.508	0.18
16_K	159_P	0.508	0.18
99_L	278_W	0.508	0.18
6_I	87_S	0.506	0.18
18_H	22_Q	0.505	0.18
18_H	144_I	0.505	0.18
86_F	122_V	0.504	0.18
165_I	303_L	0.504	0.18
6_I	148_E	0.504	0.18
19_F	93_Y	0.504	0.18
126_G	207_D	0.503	0.18
142_A	163_D	0.502	0.18
13_S	319_P	0.501	0.18
268_T	272_D	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
12asA	2	0.9909	100	0.002	Contact Map
4lnsA	2	0.9152	100	0.021	Contact Map
3m4pA	2	0.8515	100	0.827	Contact Map
3nemA	2	0.8606	99.9	0.847	Contact Map
1wydA	2	0.8606	99.9	0.851	Contact Map
1n9wA	2	0.7121	99.4	0.909	Contact Map
2xgtA	2	0.8667	99.2	0.92	Contact Map
1e1oA	2	0.8788	98.9	0.928	Contact Map
4j15A	2	0.7121	98.9	0.928	Contact Map
4ex5A	2	0.8818	98.8	0.931	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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