GREMLIN Database
SYGA - Glycine--tRNA ligase alpha subunit
UniProt: P00960 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10409
Length: 303 (280)
Sequences: 1036 (307)
Seq/√Len: 18.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_Q83_F4.9691.00
19_Y100_G4.6261.00
41_H60_Q4.6091.00
200_H204_V4.1831.00
55_A87_I3.8951.00
94_I161_G3.5711.00
52_E291_R3.4361.00
40_S123_N3.3531.00
78_Q210_N3.1290.99
221_T225_Q3.0660.99
108_D111_I2.9890.99
100_G103_K2.9850.99
201_Q205_E2.9350.99
123_N126_L2.8160.98
199_F202_N2.7220.98
77_L180_V2.5060.97
35_V60_Q2.4770.96
86_V160_T2.4730.96
12_L171_A2.4440.96
93_N97_L2.4100.96
48_E156_C2.3910.95
45_C284_A2.3870.95
222_C225_Q2.3580.95
213_Y238_N2.3440.95
227_E275_R2.2920.94
34_E250_K2.2810.94
81_Y199_F2.2490.94
112_H138_N2.1800.93
80_Y210_N2.1470.92
213_Y233_L2.1330.92
78_Q81_Y2.1200.91
8_T11_G2.1110.91
18_D22_R2.1070.91
40_S252_A2.0290.89
15_T104_E1.9930.89
202_N206_Q1.9900.89
206_Q246_E1.9690.88
142_V170_L1.9680.88
103_K109_P1.9440.87
184_V188_G1.9310.87
26_T193_T1.9290.87
87_I94_I1.9210.87
156_C159_V1.9170.87
12_L105_L1.8920.86
143_T163_I1.8760.85
56_A160_T1.8710.85
215_D232_Q1.8110.83
59_V62_S1.7790.82
170_L174_I1.7670.82
125_T273_I1.7660.82
81_Y210_N1.7490.81
49_L288_Y1.7310.80
216_V263_A1.7130.79
181_Y196_G1.7080.79
8_T187_D1.6820.78
103_K110_T1.6790.78
68_G211_F1.6680.78
51_P291_R1.6630.77
15_T18_D1.6480.77
184_V187_D1.6380.76
154_L288_Y1.6180.75
208_T213_Y1.6150.75
270_Q274_L1.5830.74
93_N163_I1.5750.73
17_Q29_Q1.5720.73
79_H210_N1.5690.73
109_P114_I1.5570.72
201_Q204_V1.5320.71
208_T212_E1.5220.71
230_A248_I1.5120.70
95_Q116_F1.4750.68
226_Y247_R1.4630.68
42_P246_E1.4470.67
40_S249_L1.4370.66
184_V194_T1.4130.65
32_D63_R1.3910.64
281_K285_E1.3840.63
123_N252_A1.3790.63
222_C226_Y1.3780.63
204_V208_T1.3760.63
56_A86_V1.3740.63
226_Y254_S1.3610.62
93_N96_E1.3580.62
31_L246_E1.3520.61
218_F225_Q1.3260.60
11_G15_T1.3090.59
98_Y102_L1.2840.57
9_F167_L1.2840.57
10_Q34_E1.2510.55
48_E86_V1.2420.55
14_L17_Q1.2370.54
202_N242_L1.2230.53
118_E150_Q1.2200.53
19_Y108_D1.2030.52
40_S126_L1.2000.52
108_D163_I1.1950.52
129_W155_E1.1910.51
60_Q246_E1.1710.50
13_I167_L1.1710.50
120_N284_A1.1670.50
80_Y199_F1.1560.49
35_V249_L1.1380.48
120_N274_L1.1260.47
8_T186_S1.1080.46
248_I283_V1.1050.46
219_L257_L1.1030.46
218_F222_C1.1000.46
239_P289_A1.0870.45
214_A257_L1.0770.44
180_V212_E1.0600.43
8_T184_V1.0350.42
41_H246_E1.0280.41
286_A289_A1.0270.41
188_G193_T1.0240.41
28_V41_H1.0220.41
117_V136_W1.0000.40
49_L234_L0.9970.40
151_V170_L0.9910.39
31_L138_N0.9790.38
129_W150_Q0.9790.38
66_T123_N0.9710.38
214_A263_A0.9670.38
183_L200_H0.9600.37
239_P286_A0.9540.37
247_R251_A0.9530.37
153_G281_K0.9520.37
234_L282_A0.9510.37
216_V220_F0.9480.37
35_V41_H0.9470.37
285_E289_A0.9420.36
206_Q242_L0.9380.36
28_V156_C0.9360.36
138_N229_E0.9280.36
251_A270_Q0.9220.35
117_V134_E0.9150.35
230_A279_L0.9130.35
57_A83_F0.9120.35
120_N275_R0.9090.34
90_S157_K0.9040.34
220_F224_E0.8940.34
62_S80_Y0.8890.33
120_N183_L0.8870.33
10_Q250_K0.8860.33
120_N156_C0.8830.33
87_I161_G0.8780.33
140_M173_Y0.8770.33
103_K108_D0.8750.33
11_G107_M0.8750.33
115_R136_W0.8730.32
23_Q93_N0.8720.32
35_V78_Q0.8690.32
9_F12_L0.8680.32
49_L154_L0.8580.32
123_N276_I0.8550.31
28_V170_L0.8530.31
18_D107_M0.8530.31
204_V210_N0.8520.31
62_S77_L0.8510.31
152_G284_A0.8490.31
55_A93_N0.8450.31
155_E274_L0.8400.31
221_T224_E0.8400.31
207_S245_Y0.8380.31
197_D286_A0.8330.30
123_N145_F0.8320.30
81_Y202_N0.8250.30
224_E276_I0.8160.29
27_I57_A0.8120.29
278_T281_K0.8100.29
19_Y201_Q0.8080.29
45_C137_L0.8070.29
63_R125_T0.7980.29
48_E151_V0.7960.28
107_M114_I0.7960.28
254_S257_L0.7950.28
240_L243_P0.7940.28
268_E275_R0.7940.28
120_N206_Q0.7930.28
97_L131_L0.7900.28
35_V62_S0.7890.28
234_L237_E0.7880.28
154_L248_I0.7840.28
11_G14_L0.7840.28
212_E242_L0.7800.28
120_N270_Q0.7770.27
30_P118_E0.7760.27
200_H234_L0.7660.27
66_T105_L0.7650.27
66_T80_Y0.7650.27
78_Q204_V0.7630.27
52_E292_E0.7610.27
289_A292_E0.7570.26
45_C233_L0.7530.26
224_E272_Y0.7530.26
138_N267_T0.7490.26
174_I216_V0.7480.26
160_T284_A0.7420.26
226_Y251_A0.7420.26
252_A276_I0.7410.26
129_W270_Q0.7400.26
135_V152_G0.7400.26
66_T210_N0.7380.26
17_Q27_I0.7360.25
105_L163_I0.7350.25
266_V281_K0.7350.25
45_C280_T0.7300.25
131_L276_I0.7250.25
100_G104_E0.7230.25
194_T279_L0.7220.25
159_V275_R0.7210.25
220_F272_Y0.7200.25
181_Y211_F0.7190.25
267_T291_R0.7180.25
68_G181_Y0.7170.25
201_Q291_R0.7140.24
171_A211_F0.7100.24
117_V140_M0.7070.24
232_Q238_N0.7070.24
177_V184_V0.7030.24
18_D21_A0.7030.24
148_F211_F0.7020.24
241_P290_S0.7010.24
227_E250_K0.6970.24
96_E150_Q0.6940.24
120_N137_L0.6930.24
8_T174_I0.6910.23
129_W153_G0.6900.23
12_L176_G0.6900.23
273_I276_I0.6900.23
143_T175_Q0.6900.23
220_F264_I0.6890.23
23_Q97_L0.6890.23
143_T229_E0.6860.23
137_L251_A0.6860.23
33_M41_H0.6850.23
252_A280_T0.6850.23
205_E242_L0.6830.23
66_T270_Q0.6820.23
83_F174_I0.6740.23
41_H219_L0.6730.23
57_A105_L0.6720.23
156_C213_Y0.6720.23
46_L54_M0.6700.22
156_C161_G0.6700.22
63_R211_F0.6690.22
137_L248_I0.6680.22
155_E159_V0.6670.22
62_S263_A0.6660.22
142_V216_V0.6650.22
58_Y249_L0.6650.22
35_V248_I0.6630.22
196_G291_R0.6600.22
33_M111_I0.6600.22
108_D238_N0.6590.22
90_S248_I0.6580.22
188_G224_E0.6570.22
81_Y177_V0.6550.22
244_A283_V0.6550.22
138_N185_W0.6520.22
213_Y246_E0.6510.22
151_V156_C0.6500.22
8_T251_A0.6500.22
171_A183_L0.6500.22
40_S80_Y0.6500.22
43_M172_M0.6480.22
123_N230_A0.6470.22
254_S281_K0.6450.21
47_R54_M0.6440.21
62_S81_Y0.6420.21
114_I248_I0.6410.21
179_S283_V0.6400.21
161_G251_A0.6370.21
170_L176_G0.6360.21
19_Y97_L0.6360.21
33_M66_T0.6350.21
221_T228_K0.6350.21
28_V43_M0.6340.21
15_T217_D0.6340.21
210_N257_L0.6330.21
45_C185_W0.6300.21
185_W287_Y0.6280.21
138_N184_V0.6280.21
218_F228_K0.6280.21
179_S182_D0.6280.21
151_V216_V0.6280.21
55_A86_V0.6260.21
66_T126_L0.6240.21
72_E215_D0.6240.21
218_F232_Q0.6230.21
94_I151_V0.6200.20
201_Q290_S0.6190.20
125_T183_L0.6170.20
16_L20_W0.6170.20
80_Y173_Y0.6160.20
30_P150_Q0.6130.20
142_V185_W0.6130.20
137_L185_W0.6110.20
45_C174_I0.6110.20
125_T128_A0.6080.20
137_L284_A0.6080.20
131_L245_Y0.6070.20
163_I278_T0.6070.20
40_S246_E0.6050.20
262_K274_L0.6030.20
49_L201_Q0.6030.20
193_T217_D0.6030.20
86_V170_L0.6020.20
217_D237_E0.5990.20
114_I134_E0.5990.20
40_S276_I0.5970.19
224_E228_K0.5960.19
54_M118_E0.5930.19
204_V287_Y0.5930.19
13_I59_V0.5930.19
229_E232_Q0.5930.19
43_M123_N0.5910.19
18_D97_L0.5910.19
222_C251_A0.5860.19
23_Q100_G0.5850.19
51_P158_P0.5830.19
14_L27_I0.5820.19
97_L100_G0.5820.19
66_T78_Q0.5820.19
23_Q87_I0.5810.19
155_E257_L0.5800.19
160_T177_V0.5800.19
40_S66_T0.5770.19
272_Y276_I0.5730.19
101_S165_Y0.5730.19
107_M193_T0.5730.19
9_F183_L0.5720.19
83_F131_L0.5710.18
40_S120_N0.5670.18
59_V232_Q0.5670.18
134_E272_Y0.5670.18
86_V186_S0.5650.18
21_A55_A0.5650.18
79_H120_N0.5640.18
48_E288_Y0.5630.18
206_Q241_P0.5620.18
112_H173_Y0.5610.18
160_T262_K0.5610.18
268_E276_I0.5600.18
274_L278_T0.5580.18
13_I29_Q0.5570.18
242_L283_V0.5550.18
23_Q55_A0.5550.18
19_Y58_Y0.5540.18
210_N273_I0.5540.18
49_L138_N0.5530.18
170_L206_Q0.5530.18
249_L254_S0.5520.18
205_E291_R0.5520.18
230_A276_I0.5520.18
68_G182_D0.5520.18
154_L159_V0.5510.18
60_Q291_R0.5510.18
50_G87_I0.5510.18
215_D228_K0.5490.18
75_N177_V0.5480.18
38_G62_S0.5480.18
66_T125_T0.5470.18
12_L174_I0.5450.18
207_S263_A0.5450.18
32_D125_T0.5440.18
79_H199_F0.5440.18
239_P293_A0.5430.17
173_Y180_V0.5430.17
63_R273_I0.5430.17
77_L207_S0.5420.17
175_Q184_V0.5410.17
290_S293_A0.5390.17
122_E246_E0.5360.17
226_Y230_A0.5350.17
142_V217_D0.5350.17
26_T60_Q0.5350.17
271_R274_L0.5340.17
78_Q199_F0.5340.17
123_N224_E0.5330.17
118_E219_L0.5330.17
60_Q199_F0.5330.17
10_Q35_V0.5310.17
46_L152_G0.5280.17
129_W233_L0.5280.17
49_L86_V0.5260.17
105_L201_Q0.5260.17
48_E281_K0.5250.17
148_F284_A0.5250.17
138_N246_E0.5230.17
47_R246_E0.5230.17
22_R104_E0.5210.17
125_T255_F0.5210.17
33_M254_S0.5200.17
47_R238_N0.5190.17
111_I138_N0.5190.17
55_A268_E0.5190.17
260_A263_A0.5180.17
79_H204_V0.5170.17
156_C219_L0.5170.17
9_F131_L0.5170.17
159_V187_D0.5160.17
48_E161_G0.5140.16
83_F152_G0.5130.16
90_S158_P0.5130.16
120_N248_I0.5110.16
95_Q161_G0.5100.16
177_V226_Y0.5100.16
40_S156_C0.5090.16
28_V86_V0.5090.16
90_S145_F0.5080.16
95_Q138_N0.5080.16
13_I17_Q0.5080.16
29_Q78_Q0.5060.16
66_T90_S0.5050.16
26_T228_K0.5030.16
77_L181_Y0.5030.16
204_V293_A0.5020.16
218_F247_R0.5020.16
78_Q202_N0.5010.16
93_N181_Y0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j5wA 2 0.9241 100 0.032 Contact Map
3rf1A 2 0.9538 100 0.036 Contact Map
2zzeA 1 0.8845 100 0.711 Contact Map
2ztgA 1 0.9307 100 0.721 Contact Map
3wqyA 2 0.9307 100 0.802 Contact Map
3dsqA 2 0.6007 95.9 0.962 Contact Map
4cs4A 2 0.5941 95.6 0.963 Contact Map
3hy0A 1 0.8251 95.4 0.964 Contact Map
1yfsA 1 0.8053 94.7 0.965 Contact Map
1n9wA 2 0.5083 79 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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