GREMLIN Database
SYA - Alanine--tRNA ligase
UniProt: P00957 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10034
Length: 876 (854)
Sequences: 3998 (2372)
Seq/√Len: 81.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
483_I489_A5.7721.00
114_L121_F4.8911.00
464_L552_V4.3861.00
468_G494_D4.1371.00
519_F535_G4.0871.00
14_D17_H4.0091.00
105_H146_E3.9891.00
10_Q14_D3.9041.00
766_I868_K3.8931.00
565_S658_M3.8541.00
623_N673_R3.7891.00
827_K830_E3.7791.00
266_A269_K3.7491.00
563_N699_T3.6221.00
777_E861_P3.5641.00
493_L550_A3.4421.00
141_E145_K3.3991.00
280_S320_H3.3391.00
604_M612_V3.2751.00
632_D635_A3.2561.00
799_S821_D3.2521.00
507_G524_T3.1951.00
556_R560_I3.1421.00
604_M609_I3.0321.00
520_A538_A3.0311.00
336_G357_E2.9641.00
475_V487_Q2.9391.00
430_E434_R2.8851.00
421_D424_G2.8761.00
805_A860_L2.8691.00
410_A422_E2.8661.00
457_E495_Q2.8171.00
459_K466_L2.7731.00
428_A431_E2.7731.00
144_E151_R2.7281.00
717_V732_V2.7041.00
619_Q622_R2.6751.00
859_A862_A2.6421.00
395_A406_V2.6341.00
222_Q226_T2.5961.00
767_D770_G2.5881.00
19_K113_E2.5841.00
576_Q615_L2.5831.00
395_A420_V2.5651.00
739_T742_L2.5581.00
422_E426_E2.5301.00
467_N547_A2.5201.00
10_Q23_V2.4631.00
261_R265_Q2.4631.00
488_E536_K2.4571.00
11_A114_L2.4351.00
790_V817_G2.3941.00
767_D772_K2.3881.00
469_K547_A2.3831.00
294_L299_V2.3521.00
343_G350_K2.3451.00
222_Q228_E2.3321.00
630_I652_R2.3041.00
514_G517_F2.3031.00
465_E551_D2.3011.00
602_E608_E2.2711.00
378_L412_V2.2591.00
388_D419_K2.2561.00
635_A638_A2.2521.00
13_L23_V2.2461.00
302_S307_G2.2331.00
520_A536_K2.2301.00
623_N675_G2.2141.00
130_V149_I2.2021.00
671_A677_I2.1991.00
856_D859_A2.1851.00
577_V615_L2.1851.00
117_S125_K2.1851.00
512_L548_V2.1731.00
611_A614_D2.1731.00
616_V680_F2.1181.00
717_V728_L2.1171.00
390_L413_C2.1151.00
581_H600_H2.1141.00
746_L749_L2.0951.00
572_A576_Q2.0851.00
117_S120_W2.0651.00
137_D156_R2.0621.00
782_E785_M2.0601.00
328_E333_K2.0481.00
389_T419_K2.0351.00
221_R227_M2.0331.00
332_Y361_K2.0271.00
430_E433_R2.0201.00
27_S46_Q2.0191.00
469_K494_D2.0121.00
113_E117_S2.0021.00
509_K556_R1.9961.00
633_L637_K1.9871.00
431_E435_R1.9831.00
17_H23_V1.9731.00
88_H254_N1.9621.00
518_S539_A1.9311.00
605_K608_E1.9231.00
513_K551_D1.9191.00
866_S869_G1.9141.00
737_E741_Q1.9031.00
836_A852_A1.8991.00
456_S531_I1.8811.00
406_V422_E1.8751.00
608_E611_A1.8711.00
391_D394_T1.8681.00
366_Q369_R1.8641.00
211_I247_V1.8461.00
137_D141_E1.8391.00
838_Q859_A1.8351.00
141_E144_E1.8241.00
15_F19_K1.8181.00
381_E390_L1.8041.00
803_V816_A1.8011.00
491_V542_L1.8011.00
111_A214_I1.7951.00
128_L185_I1.7881.00
195_G203_E1.7781.00
423_A426_E1.7711.00
121_F248_L1.7641.00
296_A356_V1.7631.00
271_T326_A1.7631.00
115_L211_I1.7511.00
760_N763_S1.7501.00
610_R614_D1.7471.00
321_G330_F1.7441.00
268_A281_L1.7361.00
556_R591_D1.7361.00
820_K824_D1.7341.00
818_V822_V1.7321.00
353_Q357_E1.7281.00
861_P865_A1.7271.00
194_W202_E1.7231.00
381_E394_T1.7161.00
339_I353_Q1.7081.00
489_A519_F1.6971.00
265_Q268_A1.6971.00
42_A45_N1.6961.00
629_N639_K1.6871.00
764_K776_S1.6871.00
106_D109_Q1.6831.00
13_L63_T1.6801.00
144_E154_I1.6761.00
742_L746_L1.6751.00
105_H109_Q1.6711.00
482_A543_K1.6691.00
562_L621_R1.6661.00
491_V512_L1.6611.00
803_V867_V1.6551.00
15_F110_F1.6531.00
790_V815_I1.6501.00
140_Y156_R1.6441.00
195_G205_G1.6391.00
109_Q146_E1.6321.00
473_L491_V1.6291.00
18_S120_W1.6291.00
467_N549_Q1.6201.00
634_E638_A1.6191.00
400_D432_Q1.6121.00
838_Q866_S1.6071.00
361_K365_E1.6051.00
575_R583_S1.6001.00
543_K546_D1.5921.00
267_V281_L1.5921.00
382_L418_I1.5831.00
262_T341_V1.5831.00
291_C314_I1.5811.00
50_V57_R1.5711.00
23_V63_T1.5631.00
229_P233_P1.5621.00
497_P550_A1.5531.00
519_F542_L1.5521.00
434_R438_E1.5471.00
129_W155_I1.5360.99
631_M639_K1.5220.99
251_V256_D1.5140.99
117_S122_A1.5060.99
489_A535_G1.5050.99
105_H145_K1.5040.99
814_L839_V1.5000.99
427_A431_E1.4980.99
639_K663_T1.4950.99
336_G353_Q1.4920.99
266_A337_P1.4860.99
464_L554_E1.4840.99
468_G495_Q1.4820.99
626_I658_M1.4670.99
423_A427_A1.4660.99
493_L512_L1.4660.99
273_A277_S1.4580.99
797_L800_T1.4560.99
378_L382_L1.4500.99
479_A544_V1.4480.99
482_A541_S1.4410.99
521_V535_G1.4390.99
83_Y414_R1.4380.99
490_V532_G1.4360.99
745_E750_K1.4340.99
542_L548_V1.4330.99
614_D618_T1.4300.99
132_V156_R1.4290.99
61_R101_D1.4270.99
488_E522_E1.4240.99
17_H22_Q1.4230.99
140_Y144_E1.4190.99
502_S526_K1.4180.99
522_E535_G1.4160.99
575_R642_M1.4120.99
672_S676_D1.4040.99
195_G200_S1.3980.99
11_A120_W1.3970.99
518_S538_A1.3960.99
657_S663_T1.3940.99
314_I360_L1.3930.99
114_L248_L1.3900.99
513_K518_S1.3840.99
140_Y151_R1.3840.99
837_Q842_K1.3810.99
468_G550_A1.3800.99
627_E657_S1.3750.99
393_E428_A1.3730.99
701_E705_A1.3680.99
134_E158_G1.3650.99
106_D110_F1.3640.99
610_R712_D1.3640.99
8_I245_A1.3560.99
569_L616_V1.3550.99
720_L733_R1.3550.99
493_L548_V1.3500.99
19_K110_F1.3490.99
209_I246_A1.3440.99
832_I852_A1.3430.99
738_R743_E1.3430.99
807_V810_G1.3390.99
142_I147_V1.3380.99
124_P127_R1.3380.99
15_F113_E1.3360.99
632_D652_R1.3350.99
512_L550_A1.3340.99
292_A335_V1.3330.99
14_D23_V1.3280.98
506_V560_I1.3280.98
11_A121_F1.3230.98
689_A692_V1.3230.98
519_F537_L1.3220.98
124_P187_Y1.3200.98
465_E549_Q1.3180.98
65_S346_G1.3180.98
197_P200_S1.3170.98
727_N730_D1.3140.98
517_F542_L1.3140.98
777_E807_V1.3120.98
865_A868_K1.3110.98
801_I826_V1.3100.98
838_Q862_A1.3030.98
40_T45_N1.2970.98
354_A357_E1.2900.98
842_K855_T1.2900.98
6_A344_S1.2860.98
37_L41_N1.2840.98
183_T235_V1.2830.98
358_Q602_E1.2820.98
129_W153_R1.2820.98
14_D18_S1.2820.98
522_E536_K1.2750.98
350_K353_Q1.2670.98
121_F244_I1.2650.98
514_G548_V1.2640.98
623_N676_D1.2630.98
266_A270_V1.2620.98
559_R700_G1.2610.98
812_V857_A1.2560.98
525_Q534_I1.2560.98
386_S416_R1.2550.98
600_H608_E1.2530.98
571_H642_M1.2520.98
830_E833_G1.2500.98
620_I680_F1.2480.98
590_N593_V1.2470.98
773_L871_V1.2460.98
628_T656_L1.2460.98
679_L707_V1.2380.98
834_M866_S1.2360.98
840_G856_D1.2320.97
615_L661_F1.2310.97
470_V491_V1.2310.97
702_G705_A1.2290.97
105_H142_I1.2230.97
560_I591_D1.2220.97
865_A869_G1.2220.97
183_T214_I1.2190.97
139_A183_T1.2140.97
765_A774_L1.2140.97
459_K495_Q1.2120.97
558_A561_R1.2100.97
40_T46_Q1.2090.97
839_V859_A1.2090.97
625_P673_R1.2080.97
142_I146_E1.2070.97
826_V871_V1.2070.97
127_R187_Y1.2050.97
470_V542_L1.2050.97
800_T819_S1.2050.97
485_A539_A1.2040.97
619_Q624_L1.2040.97
484_N487_Q1.2030.97
631_M635_A1.2020.97
268_A271_T1.1980.97
827_K847_P1.1950.97
406_V420_V1.1950.97
820_K848_D1.1930.97
407_D411_D1.1920.97
559_R701_E1.1910.97
792_D795_N1.1880.97
22_Q59_Y1.1840.97
10_Q17_H1.1830.97
132_V140_Y1.1810.97
634_E637_K1.1770.97
833_G837_Q1.1730.97
424_G428_A1.1730.97
200_S205_G1.1720.97
594_L697_A1.1710.97
429_M432_Q1.1710.97
774_L793_L1.1700.97
862_A865_A1.1700.97
762_S765_A1.1680.97
585_K599_S1.1650.96
200_S203_E1.1620.96
619_Q661_F1.1610.96
818_V828_A1.1580.96
799_S819_S1.1550.96
512_L521_V1.1500.96
833_G842_K1.1490.96
682_I695_I1.1480.96
511_E518_S1.1470.96
681_R711_S1.1470.96
463_H552_V1.1410.96
123_L247_V1.1400.96
607_E611_A1.1400.96
24_V64_T1.1390.96
799_S822_V1.1330.96
517_F548_V1.1300.96
28_S32_H1.1280.96
41_N173_M1.1260.96
862_A866_S1.1230.96
790_V802_I1.1220.96
64_T97_F1.1220.96
483_I519_F1.1210.96
115_L128_L1.1200.96
220_N228_E1.1200.96
822_V826_V1.1190.96
500_A531_I1.1180.96
56_K60_S1.1160.96
614_D708_H1.1150.95
431_E434_R1.1100.95
491_V535_G1.1000.95
22_Q62_A1.0960.95
268_A274_T1.0950.95
432_Q435_R1.0940.95
288_I334_L1.0900.95
24_V62_A1.0880.95
146_E149_I1.0860.95
7_E11_A1.0820.95
217_M234_S1.0770.95
470_V548_V1.0770.95
239_M244_I1.0730.94
658_M674_T1.0720.94
264_I268_A1.0720.94
314_I318_V1.0700.94
389_T421_D1.0700.94
257_I262_T1.0670.94
736_L739_T1.0590.94
335_V339_I1.0590.94
778_L781_V1.0570.94
33_N55_D1.0530.94
807_V860_L1.0510.94
65_S94_L1.0510.94
788_T792_D1.0500.94
391_D395_A1.0500.94
10_Q344_S1.0480.94
573_A615_L1.0470.94
379_D416_R1.0470.94
724_D727_N1.0430.94
379_D383_A1.0420.94
413_C420_V1.0420.94
511_E551_D1.0350.93
657_S660_D1.0330.93
488_E534_I1.0330.93
189_H209_I1.0300.93
626_I671_A1.0290.93
629_N635_A1.0280.93
339_I350_K1.0260.93
506_V591_D1.0220.93
814_L832_I1.0200.93
189_H246_A1.0180.93
115_L185_I1.0160.93
741_Q745_E1.0160.93
744_K747_Q1.0160.93
381_E384_K1.0160.93
537_L542_L1.0150.93
110_F113_E1.0110.92
567_T594_L1.0110.92
71_A78_L1.0100.92
266_A333_K1.0100.92
732_V735_V1.0080.92
22_Q58_N1.0070.92
783_P813_S1.0070.92
434_R437_R1.0070.92
816_A835_V1.0060.92
765_A772_K1.0050.92
189_H252_N1.0030.92
292_A338_L1.0030.92
685_E693_R1.0020.92
576_Q661_F1.0010.92
470_V493_L0.9990.92
196_G199_G0.9990.92
141_E146_E0.9980.92
484_N541_S0.9970.92
698_V706_T0.9970.92
717_V721_L0.9960.92
834_M837_Q0.9950.92
442_F445_D0.9930.92
78_L313_I0.9930.92
61_R110_F0.9930.92
172_Q221_R0.9910.92
794_K817_G0.9890.92
507_G523_D0.9880.92
413_C418_I0.9870.92
705_A709_A0.9870.92
576_Q611_A0.9860.92
604_M608_E0.9860.92
188_D207_R0.9840.91
4_S7_E0.9830.91
611_A615_L0.9820.91
426_E430_E0.9800.91
745_E748_Q0.9800.91
352_Q355_Q0.9790.91
359_V601_N0.9760.91
295_I359_V0.9740.91
748_Q751_E0.9740.91
509_K560_I0.9710.91
572_A642_M0.9680.91
728_L732_V0.9670.91
483_I487_Q0.9660.91
698_V703_A0.9660.91
49_D54_L0.9660.91
428_A435_R0.9650.91
385_L391_D0.9650.91
778_L789_M0.9620.90
725_S729_A0.9610.90
563_N702_G0.9610.90
404_F409_T0.9590.90
465_E554_E0.9570.90
429_M436_A0.9570.90
818_V823_T0.9560.90
5_T257_I0.9550.90
673_R676_D0.9550.90
814_L835_V0.9540.90
513_K549_Q0.9520.90
490_V534_I0.9500.90
777_E864_L0.9490.90
805_A864_L0.9490.90
271_T281_L0.9480.90
498_F550_A0.9480.90
468_G548_V0.9440.90
129_W208_Y0.9440.90
69_V290_S0.9440.90
335_V357_E0.9410.89
384_K394_T0.9410.89
319_R415_E0.9410.89
775_V864_L0.9410.89
505_Q669_T0.9400.89
509_K522_E0.9370.89
618_T622_R0.9360.89
867_V871_V0.9360.89
137_D140_Y0.9360.89
59_Y62_A0.9360.89
29_L294_L0.9340.89
709_A712_D0.9300.89
109_Q147_V0.9270.89
463_H466_L0.9240.89
273_A281_L0.9160.88
502_S565_S0.9150.88
835_V867_V0.9130.88
831_L870_W0.9120.88
834_M838_Q0.9100.88
322_N372_E0.9090.88
629_N657_S0.9070.88
27_S40_T0.9050.88
42_A68_C0.9050.88
8_I121_F0.9050.88
773_L868_K0.9030.87
555_A701_E0.8990.87
733_R737_E0.8990.87
464_L561_R0.8940.87
15_F117_S0.8940.87
19_K120_W0.8920.87
784_K842_K0.8920.87
737_E740_R0.8890.87
452_V479_A0.8890.87
123_L127_R0.8880.87
109_Q113_E0.8880.87
732_V736_L0.8860.86
218_Q229_P0.8860.86
814_L852_A0.8820.86
13_L17_H0.8820.86
614_D705_A0.8810.86
553_D556_R0.8790.86
710_D714_L0.8780.86
570_M594_L0.8780.86
182_C186_F0.8770.86
491_V519_F0.8770.86
263_L338_L0.8760.86
730_D733_R0.8750.86
706_T710_D0.8750.86
839_V854_G0.8740.86
466_L495_Q0.8730.86
391_D424_G0.8720.86
567_T587_S0.8720.86
266_A334_L0.8710.86
69_V294_L0.8710.86
475_V480_V0.8700.85
111_A185_I0.8680.85
445_D449_M0.8670.85
189_H193_I0.8660.85
489_A537_L0.8660.85
198_P201_P0.8640.85
712_D716_E0.8640.85
842_K852_A0.8610.85
195_G199_G0.8600.85
292_A349_L0.8600.85
50_V58_N0.8590.85
812_V855_T0.8570.85
270_V326_A0.8560.85
716_E719_H0.8550.84
830_E847_P0.8540.84
393_E431_E0.8540.84
803_V835_V0.8540.84
265_Q269_K0.8530.84
249_Q258_D0.8520.84
389_T423_A0.8510.84
211_I244_I0.8510.84
339_I356_V0.8490.84
759_A792_D0.8480.84
88_H260_F0.8470.84
221_R224_D0.8460.84
157_I167_S0.8460.84
812_V839_V0.8460.84
561_R669_T0.8430.84
572_A661_F0.8420.84
144_E147_V0.8410.83
750_K782_E0.8410.83
835_V863_A0.8400.83
337_P340_D0.8400.83
393_E424_G0.8380.83
729_A732_V0.8350.83
502_S531_I0.8340.83
716_E729_A0.8340.83
780_G806_T0.8320.83
671_A676_D0.8310.83
779_S807_V0.8300.83
23_V64_T0.8290.83
430_E437_R0.8290.83
251_V261_R0.8280.83
716_E733_R0.8280.83
711_S715_S0.8270.82
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443_G446_Y0.5400.51
608_E612_V0.5390.51
803_V870_W0.5390.51
48_K173_M0.5390.51
750_K785_M0.5390.51
196_G201_P0.5380.51
476_D487_Q0.5380.51
393_E427_A0.5370.51
131_T147_V0.5370.51
155_I203_E0.5370.51
709_A726_N0.5370.51
407_D692_V0.5370.51
448_A451_R0.5360.51
147_V151_R0.5360.51
201_P208_Y0.5360.51
312_R404_F0.5360.51
321_G325_G0.5360.51
5_T246_A0.5360.51
744_K748_Q0.5360.51
42_A65_S0.5350.50
199_G205_G0.5340.50
11_A18_S0.5340.50
447_N451_R0.5330.50
45_N173_M0.5330.50
318_V372_E0.5330.50
456_S460_G0.5330.50
195_G202_E0.5320.50
197_P205_G0.5320.50
455_A460_G0.5320.50
112_W130_V0.5310.50
257_I261_R0.5310.50
552_V561_R0.5300.50
735_V739_T0.5300.50
743_E747_Q0.5300.50
189_H206_D0.5300.50
832_I839_V0.5290.50
511_E538_A0.5290.50
406_V426_E0.5290.50
381_E391_D0.5290.50
566_A697_A0.5290.50
293_F346_G0.5280.50
603_A606_P0.5280.50
12_F36_T0.5280.50
709_A713_R0.5270.49
69_V310_L0.5270.49
575_R582_V0.5270.49
79_E279_K0.5270.49
509_K524_T0.5270.49
192_H252_N0.5270.49
816_A867_V0.5270.49
40_T173_M0.5250.49
746_L753_A0.5250.49
807_V812_V0.5250.49
578_L600_H0.5250.49
47_F59_Y0.5240.49
761_L793_L0.5230.49
203_E206_D0.5230.49
354_A580_T0.5230.49
770_G825_R0.5230.49
679_L703_A0.5220.49
492_V532_G0.5220.49
190_G193_I0.5220.49
425_F429_M0.5210.49
85_A253_S0.5210.49
559_R563_N0.5210.49
41_N45_N0.5210.49
121_F211_I0.5210.49
598_F604_M0.5210.49
513_K552_V0.5200.49
819_S822_V0.5190.48
130_V154_I0.5190.48
452_V530_A0.5190.48
758_S762_S0.5180.48
358_Q601_N0.5180.48
686_S696_E0.5180.48
713_R717_V0.5180.48
412_V415_E0.5180.48
628_T654_R0.5160.48
593_V683_I0.5160.48
704_I707_V0.5160.48
217_M221_R0.5160.48
572_A575_R0.5150.48
432_Q439_A0.5150.48
867_V870_W0.5150.48
251_V265_Q0.5150.48
52_L173_M0.5150.48
517_F541_S0.5150.48
123_L248_L0.5150.48
736_L740_R0.5140.48
189_H235_V0.5140.48
202_E209_I0.5140.48
713_R716_E0.5130.48
490_V535_G0.5130.48
681_R698_V0.5130.48
157_I203_E0.5130.48
19_K117_S0.5120.47
275_D278_N0.5120.47
176_T221_R0.5120.47
512_L547_A0.5110.47
125_K131_T0.5110.47
457_E630_I0.5110.47
561_R672_S0.5100.47
65_S345_A0.5100.47
131_T186_F0.5100.47
194_W197_P0.5090.47
45_N227_M0.5090.47
464_L560_I0.5090.47
97_F110_F0.5080.47
30_V299_V0.5080.47
555_A618_T0.5070.47
48_K175_D0.5070.47
135_S156_R0.5070.47
47_F64_T0.5070.47
765_A797_L0.5070.47
157_I186_F0.5060.47
529_Q650_D0.5060.47
140_Y167_S0.5050.47
11_A122_A0.5050.47
855_T859_A0.5040.46
770_G799_S0.5040.46
20_G59_Y0.5040.46
179_C224_D0.5030.46
33_N437_R0.5030.46
445_D452_V0.5020.46
330_F368_A0.5020.46
47_F189_H0.5020.46
45_N67_R0.5010.46
173_M176_T0.5010.46
571_H644_L0.5010.46
39_F227_M0.5010.46
521_V531_I0.5010.46
803_V814_L0.5010.46
560_I590_N0.5000.46
637_K643_A0.5000.46
274_T277_S0.5000.46
621_R703_A0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wqyA 2 0.8847 100 0.257 Contact Map
2zzeA 1 0.6644 100 0.351 Contact Map
2ztgA 1 0.6986 100 0.357 Contact Map
3hy0A 1 0.5034 100 0.427 Contact Map
1yfsA 1 0.5034 100 0.43 Contact Map
3kewA 1 0.258 100 0.825 Contact Map
2e1bA 1 0.2409 100 0.836 Contact Map
1nyrA 2 0.4121 100 0.908 Contact Map
4ce4c 1 0.2603 100 0.91 Contact Map
1tkeA 1 0.2363 100 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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