GREMLIN Database
SYW - Tryptophan--tRNA ligase
UniProt: P00954 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11030
Length: 334 (316)
Sequences: 5633 (2802)
Seq/√Len: 157.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_D215_S4.5481.00
140_Q323_A3.7401.00
61_L303_Q3.7031.00
171_I327_A3.3411.00
291_R294_R3.2931.00
87_E314_S3.2631.00
87_E318_S3.2171.00
5_I36_H2.9991.00
38_I316_H2.9251.00
75_E308_D2.7231.00
301_F304_Q2.6241.00
286_T290_E2.6231.00
140_Q320_T2.6171.00
101_F126_F2.5701.00
265_F276_E2.4871.00
33_D76_K2.3911.00
7_F40_C2.2901.00
142_N173_K2.2701.00
283_G286_T2.2421.00
148_E185_R2.1651.00
217_V221_K2.1581.00
38_I78_T2.1551.00
259_P262_E2.1461.00
301_F305_V2.1201.00
211_E219_K2.1191.00
259_P263_K2.0571.00
260_E264_Q2.0561.00
262_E266_E2.0471.00
65_A296_R2.0361.00
105_S126_F2.0161.00
213_P282_S1.9961.00
140_Q173_K1.9931.00
290_E294_R1.9591.00
65_A302_L1.9571.00
94_A328_I1.9411.00
221_K275_G1.9361.00
256_Q264_Q1.9271.00
151_K177_P1.8941.00
256_Q260_E1.8711.00
52_D55_K1.8521.00
36_H78_T1.7891.00
70_C288_L1.7781.00
228_D240_K1.7731.00
257_S260_E1.7601.00
7_F42_V1.7561.00
123_A127_D1.7421.00
308_D311_E1.7391.00
151_K179_I1.7321.00
64_L306_M1.7281.00
91_L324_V1.7211.00
90_Q325_Y1.7211.00
211_E215_S1.7191.00
162_Q174_V1.7051.00
58_K62_D1.6931.00
263_K266_E1.6751.00
217_V278_A1.6551.00
188_S205_N1.6461.00
72_I77_S1.6401.00
213_P286_T1.6341.00
294_R298_D1.6321.00
68_L295_F1.6291.00
220_I281_V1.6201.00
268_K272_H1.6171.00
137_L161_A1.6131.00
216_V282_S1.6131.00
104_L123_A1.5861.00
80_F139_Y1.5841.00
315_A319_R1.5661.00
94_A324_V1.5591.00
298_D301_F1.5341.00
304_Q308_D1.5121.00
289_Q293_H1.5111.00
30_N34_D1.5071.00
318_S322_K1.5051.00
31_M178_F1.4761.00
29_V33_D1.4731.00
4_P142_N1.4711.00
41_I64_L1.4691.00
208_G211_E1.4551.00
247_L261_L1.4551.00
84_H310_A1.4471.00
10_A67_Y1.4161.00
55_K58_K1.4111.00
66_L292_Y1.4051.00
101_F105_S1.4051.00
88_H139_Y1.4031.00
133_A157_S1.3981.00
143_L178_F1.3911.00
64_L302_L1.3901.00
204_N222_R1.3881.00
308_D312_K1.3681.00
307_K311_E1.3661.00
300_A304_Q1.3601.00
96_N127_D1.3521.00
272_H275_G1.3411.00
258_I262_E1.3161.00
188_S200_D1.3091.00
12_P41_I1.3081.00
60_T81_V1.3021.00
217_V279_D1.3011.00
27_Q30_N1.2971.00
278_A282_S1.2901.00
264_Q276_E1.2851.00
26_R30_N1.2841.00
320_T324_V1.2711.00
236_D239_N1.2711.00
264_Q269_M1.2701.00
247_L258_I1.2661.00
55_K59_A1.2611.00
322_K326_E1.2601.00
44_Q89_A1.2571.00
253_V280_A1.2491.00
263_K267_G1.2471.00
26_R284_M1.2321.00
257_S276_E1.2311.00
260_E263_K1.2281.00
100_Y103_E1.2281.00
279_D283_G1.2101.00
250_L277_V1.2051.00
213_P289_Q1.1851.00
61_L299_E1.1841.00
277_V280_A1.1791.00
5_I38_I1.1781.00
73_D76_K1.1741.00
292_Y296_R1.1601.00
158_R175_P1.1551.00
5_I316_H1.1511.00
16_L67_Y1.1471.00
92_G96_N1.1431.00
101_F110_F1.1421.00
235_Y244_S1.1411.00
293_H296_R1.1361.00
25_L70_C1.1361.00
43_D83_S1.1331.00
261_L265_F1.1321.00
62_D296_R1.1281.00
21_Y26_R1.1261.00
43_D84_H1.1241.00
108_T112_D1.1241.00
216_V285_L1.1231.00
314_S318_S1.1231.00
319_R322_K1.1181.00
298_D304_Q1.1121.00
10_A25_L1.1111.00
233_V236_D1.1051.00
311_E315_A1.0930.99
54_Q58_K1.0870.99
7_F38_I1.0870.99
94_A325_Y1.0850.99
217_V282_S1.0840.99
8_S23_G1.0790.99
321_L325_Y1.0700.99
240_K243_V1.0600.99
36_H312_K1.0520.99
214_K217_V1.0390.99
7_F141_T1.0380.99
9_G40_C1.0380.99
68_L305_V1.0340.99
88_H91_L1.0310.99
102_G106_R1.0280.99
207_I220_I1.0140.99
32_Q77_S1.0140.99
236_D244_S1.0140.99
99_T160_I1.0090.99
22_M252_A1.0070.99
86_P90_Q1.0060.99
255_G264_Q1.0040.99
194_K200_D0.9980.99
22_M253_V0.9970.99
63_T67_Y0.9840.99
4_P143_L0.9800.99
218_K222_R0.9780.99
192_P242_G0.9750.99
4_P35_Y0.9750.99
265_F273_L0.9680.99
162_Q166_A0.9560.99
78_T312_K0.9540.99
16_L63_T0.9530.99
215_S218_K0.9450.98
136_I157_S0.9390.98
187_M245_N0.9370.98
123_A130_V0.9350.98
163_R167_L0.9310.98
244_S265_F0.9230.98
10_A28_W0.9210.98
43_D60_T0.9210.98
180_P184_A0.9200.98
276_E280_A0.9190.98
172_F324_V0.9160.98
254_T280_A0.9100.98
253_V284_M0.9100.98
209_L285_L0.9070.98
319_R323_A0.9010.98
10_A23_G0.8990.98
87_E317_A0.8990.98
212_D293_H0.8980.98
12_P46_A0.8920.98
62_D292_Y0.8890.98
104_L130_V0.8890.98
247_L262_E0.8850.98
8_S28_W0.8800.98
221_K278_A0.8740.97
323_A327_A0.8700.97
234_R239_N0.8680.97
4_P34_D0.8660.97
15_E59_A0.8650.97
293_H297_N0.8600.97
200_D205_N0.8570.97
323_A326_E0.8530.97
161_A174_V0.8500.97
320_T323_A0.8430.97
18_I253_V0.8400.97
96_N123_A0.8390.97
95_L137_L0.8370.97
311_E314_S0.8360.97
28_W39_Y0.8210.96
154_L177_P0.8190.96
290_E293_H0.8190.96
91_L134_A0.8110.96
6_V143_L0.8080.96
80_F84_H0.8050.96
256_Q261_L0.8010.96
208_G219_K0.8000.96
217_V275_G0.7990.96
81_V84_H0.7980.96
264_Q267_G0.7910.95
171_I324_V0.7870.95
275_G279_D0.7860.95
75_E312_K0.7840.95
271_G275_G0.7770.95
238_Q244_S0.7760.95
161_A165_N0.7740.95
254_T257_S0.7740.95
169_G327_A0.7710.95
66_L210_L0.7660.95
251_S261_L0.7640.94
189_L219_K0.7610.94
6_V35_Y0.7610.94
20_N24_A0.7570.94
164_F168_Y0.7570.94
300_A315_A0.7530.94
287_E290_E0.7530.94
9_G42_V0.7520.94
282_S289_Q0.7510.94
159_D162_Q0.7500.94
300_A303_Q0.7500.94
78_T81_V0.7490.94
282_S286_T0.7490.94
97_C124_G0.7470.94
250_L280_A0.7460.94
81_V306_M0.7440.94
54_Q57_R0.7440.94
234_R262_E0.7430.94
130_V160_I0.7410.94
204_N218_K0.7400.94
315_A318_S0.7400.94
280_A283_G0.7360.93
213_P217_V0.7350.93
296_R302_L0.7330.93
241_A244_S0.7320.93
270_Y273_L0.7310.93
133_A160_I0.7290.93
294_R297_N0.7290.93
317_A320_T0.7270.93
220_I277_V0.7270.93
295_F301_F0.7240.93
95_L130_V0.7210.93
78_T316_H0.7200.93
213_P285_L0.7190.93
272_H276_E0.7170.92
242_G262_E0.7160.92
85_V317_A0.7150.92
280_A284_M0.7140.92
133_A137_L0.7040.92
241_A266_E0.7040.92
28_W67_Y0.7010.92
234_R237_V0.7010.92
233_V237_V0.7010.92
264_Q270_Y0.6970.91
117_Y120_N0.6960.91
100_Y122_N0.6960.91
303_Q307_K0.6950.91
138_L321_L0.6920.91
225_T246_L0.6900.91
180_P183_G0.6890.91
88_H138_L0.6880.91
164_F171_I0.6850.91
56_L60_T0.6820.90
304_Q307_K0.6820.90
61_L302_L0.6820.90
209_L288_L0.6800.90
287_E291_R0.6790.90
86_P321_L0.6790.90
251_S258_I0.6750.90
110_F114_S0.6750.90
210_L292_Y0.6720.90
240_K244_S0.6710.90
56_L59_A0.6700.90
80_F88_H0.6660.89
315_A323_A0.6640.89
189_L222_R0.6630.89
40_C80_F0.6630.89
11_Q49_V0.6630.89
214_K218_K0.6620.89
142_N176_E0.6620.89
242_G277_V0.6590.89
31_M143_L0.6570.89
299_E302_L0.6540.89
164_F328_I0.6480.88
98_Y328_I0.6470.88
15_E210_L0.6460.88
47_I51_Q0.6450.88
234_R244_S0.6450.88
67_Y79_I0.6450.88
189_L223_A0.6450.88
279_D282_S0.6440.88
95_L160_I0.6430.88
36_H316_H0.6430.88
15_E62_D0.6420.88
247_L273_L0.6420.88
35_Y143_L0.6400.87
38_I80_F0.6400.87
295_F299_E0.6390.87
229_E269_M0.6380.87
96_N122_N0.6370.87
250_L273_L0.6360.87
65_A68_L0.6360.87
24_A28_W0.6350.87
8_S39_Y0.6350.87
294_R301_F0.6350.87
186_V252_A0.6330.87
304_Q311_E0.6330.87
282_S285_L0.6280.86
108_T152_Q0.6280.86
98_Y167_L0.6280.86
248_D251_S0.6280.86
96_N130_V0.6280.86
18_I281_V0.6270.86
30_N33_D0.6260.86
196_M199_S0.6260.86
318_S321_L0.6240.86
316_H320_T0.6240.86
59_A62_D0.6240.86
92_G127_D0.6220.86
98_Y160_I0.6220.86
265_F268_K0.6210.86
321_L324_V0.6210.86
170_E173_K0.6200.86
102_G108_T0.6200.86
295_F298_D0.6180.86
237_V244_S0.6160.85
31_M37_C0.6160.85
311_E322_K0.6140.85
11_Q63_T0.6140.85
53_A56_L0.6080.85
226_D229_E0.6060.84
85_V310_A0.6050.84
316_H319_R0.6050.84
64_L79_I0.6050.84
239_N244_S0.6040.84
29_V32_Q0.6040.84
103_E163_R0.6040.84
257_S280_A0.6030.84
310_A314_S0.6030.84
275_G278_A0.6020.84
312_K315_A0.6020.84
161_A172_F0.6000.84
57_R61_L0.5990.84
45_H131_L0.5980.84
285_L289_Q0.5980.84
67_Y70_C0.5980.84
103_E159_D0.5980.84
74_P305_V0.5970.84
93_W97_C0.5960.83
320_T327_A0.5940.83
157_S175_P0.5940.83
144_V154_L0.5930.83
57_R60_T0.5910.83
304_Q315_A0.5910.83
324_V327_A0.5870.83
255_G259_P0.5850.82
15_E208_G0.5830.82
156_L160_I0.5830.82
103_E106_R0.5830.82
62_D65_A0.5830.82
27_Q180_P0.5820.82
224_V242_G0.5810.82
78_T313_A0.5790.82
307_K318_S0.5780.82
168_Y328_I0.5780.82
171_I320_T0.5780.82
11_Q20_N0.5760.81
191_E194_K0.5760.81
299_E303_Q0.5730.81
85_V88_H0.5720.81
47_I57_R0.5720.81
10_A16_L0.5710.81
286_T289_Q0.5710.81
65_A292_Y0.5700.81
16_L66_L0.5670.80
187_M248_D0.5640.80
64_L67_Y0.5640.80
164_F324_V0.5640.80
173_K323_A0.5630.80
245_N248_D0.5630.80
13_S51_Q0.5620.80
269_M272_H0.5610.80
138_L317_A0.5600.80
241_A262_E0.5590.79
217_V220_I0.5570.79
213_P216_V0.5530.79
246_L273_L0.5530.79
44_Q94_A0.5520.79
84_H307_K0.5510.78
309_G313_A0.5510.78
148_E181_K0.5500.78
21_Y284_M0.5480.78
92_G130_V0.5470.78
127_D130_V0.5460.78
192_P277_V0.5450.78
123_A126_F0.5440.78
314_S317_A0.5440.78
245_N249_I0.5440.78
16_L20_N0.5430.77
114_S117_Y0.5430.77
25_L77_S0.5420.77
39_Y77_S0.5420.77
107_M152_Q0.5420.77
109_Q113_K0.5410.77
109_Q152_Q0.5400.77
143_L176_E0.5400.77
281_V284_M0.5370.77
220_I278_A0.5360.77
47_I94_A0.5350.76
250_L276_E0.5320.76
110_F113_K0.5300.76
244_S273_L0.5300.76
158_R176_E0.5290.76
306_M310_A0.5280.75
4_P176_E0.5280.75
16_L25_L0.5270.75
297_N300_A0.5270.75
50_R167_L0.5260.75
96_N120_N0.5220.75
35_Y142_N0.5220.75
307_K315_A0.5210.75
300_A311_E0.5210.75
243_V262_E0.5200.74
164_F172_F0.5200.74
107_M156_L0.5170.74
235_Y248_D0.5170.74
99_T156_L0.5150.74
213_P278_A0.5150.74
92_G95_L0.5150.74
98_Y164_F0.5140.74
127_D131_L0.5130.73
39_Y72_I0.5120.73
212_D216_V0.5120.73
224_V227_S0.5120.73
140_Q316_H0.5120.73
256_Q259_P0.5110.73
11_Q113_K0.5110.73
311_E318_S0.5100.73
92_G123_A0.5080.73
40_C141_T0.5080.73
88_H93_W0.5080.73
291_R295_F0.5080.73
90_Q321_L0.5070.73
244_S258_I0.5070.73
95_L173_K0.5030.72
85_V138_L0.5030.72
250_L265_F0.5020.72
250_L261_L0.5010.72
228_D234_R0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n9iA 2 0.994 100 0.115 Contact Map
2yy5A 2 0.985 100 0.126 Contact Map
3sz3A 2 1 100 0.136 Contact Map
3prhA 2 0.9461 100 0.138 Contact Map
1i6kA 2 0.976 100 0.142 Contact Map
2el7A 2 0.9281 100 0.222 Contact Map
2g36A 2 0.9461 100 0.248 Contact Map
3tzlA 2 0.9461 100 0.25 Contact Map
1yi8B 2 0.9701 100 0.251 Contact Map
2dlcX 2 0.8353 100 0.299 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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