GREMLIN Database
MANA - Mannose-6-phosphate isomerase
UniProt: P00946 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10566
Length: 391 (365)
Sequences: 1470 (1029)
Seq/√Len: 53.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_V262_A5.3551.00
65_D68_T4.9261.00
140_T243_P4.2181.00
141_P242_N4.1281.00
102_K130_N3.9351.00
102_K106_E3.8641.00
48_V61_V3.3451.00
93_P223_F3.2861.00
273_L290_N3.2431.00
12_A279_P3.2191.00
107_I111_K3.0091.00
112_E124_R3.0011.00
359_L367_A2.9621.00
3_K365_E2.9071.00
20_T33_M2.8251.00
245_E302_L2.8071.00
38_M342_I2.7931.00
6_N366_S2.7731.00
98_V290_N2.7391.00
137_F323_F2.6661.00
38_M366_S2.6391.00
6_N38_M2.5391.00
17_T20_T2.5001.00
126_Y286_E2.4721.00
163_G205_A2.4631.00
143_L240_K2.3981.00
85_F265_V2.3891.00
216_T238_V2.3741.00
87_V263_L2.3501.00
184_F232_S2.3391.00
131_H267_A2.2381.00
103_H106_E2.2231.00
12_A92_Q2.2091.00
143_L238_V2.2001.00
242_N245_E2.1891.00
311_E324_S2.1541.00
143_L219_L2.1501.00
57_S60_D2.1291.00
85_F323_F2.1261.00
248_F318_V2.1101.00
98_V291_V2.1081.00
112_E125_N2.1001.00
25_M33_M2.0761.00
61_V69_L2.0341.00
131_H320_D2.0251.00
77_R319_D2.0231.00
145_M258_L1.9821.00
163_G201_I1.9541.00
85_F263_L1.9231.00
311_E326_H1.9171.00
112_E281_Y1.8960.99
361_L367_A1.8820.99
72_E76_K1.8800.99
7_S44_S1.8770.99
20_T23_Y1.8260.99
104_N290_N1.8100.99
62_I65_D1.8030.99
17_T21_E1.7880.99
98_V275_A1.7820.99
265_V323_F1.7570.99
112_E127_K1.7310.99
95_S274_R1.7250.99
9_Q44_S1.6990.99
6_N46_S1.6980.99
216_T220_I1.6440.99
23_Y363_P1.6380.98
11_Y34_A1.6320.98
98_V273_L1.6150.98
75_A79_G1.6040.98
149_R157_L1.5930.98
184_F188_L1.5870.98
66_K71_G1.5760.98
345_C348_G1.5660.98
368_F371_A1.5620.98
273_L286_E1.5520.98
69_L370_A1.5390.98
69_L368_F1.5350.98
199_L230_L1.5350.98
102_K131_H1.5340.98
141_P240_K1.5320.98
19_L262_A1.5240.98
80_E129_P1.5230.98
349_D360_Q1.5190.97
48_V51_A1.5170.97
254_P275_A1.5110.97
274_R280_K1.5010.97
56_V64_S1.4970.97
18_A261_V1.4800.97
92_Q223_F1.4340.96
286_E289_A1.4040.96
89_C261_V1.3990.96
250_F253_T1.3910.96
224_Y230_L1.3870.96
20_T25_M1.3810.96
354_K373_E1.3710.95
87_V261_V1.3670.95
10_N31_Q1.3640.95
95_S280_K1.3640.95
23_Y33_M1.3590.95
110_A129_P1.3540.95
347_E383_R1.3520.95
101_N104_N1.3520.95
127_K272_V1.3470.95
17_T22_L1.3370.95
73_A338_Q1.3310.95
136_V247_M1.3240.94
350_A367_A1.3230.94
106_E110_A1.3140.94
274_R278_T1.3060.94
62_I70_L1.3020.94
145_M238_V1.3010.94
108_G124_R1.2960.94
124_R281_Y1.2790.93
16_K30_S1.2650.93
38_M85_F1.2620.93
220_I224_Y1.2570.93
253_T292_K1.2560.93
351_T358_Q1.2540.93
123_E281_Y1.2390.92
9_Q43_K1.2370.92
352_L367_A1.2370.92
219_L238_V1.2360.92
92_Q224_Y1.2150.91
369_I376_V1.2100.91
108_G112_E1.2090.91
51_A56_V1.1980.91
95_S278_T1.1870.90
341_A376_V1.1850.90
2_Q48_V1.1740.90
103_H107_I1.1700.90
181_S185_A1.1550.89
125_N273_L1.1490.89
131_H266_M1.1360.88
146_N247_M1.1220.88
124_R127_K1.1220.88
68_T372_N1.1180.88
4_L342_I1.1150.87
96_I254_P1.1140.87
19_L89_C1.1120.87
131_H318_V1.1100.87
351_T379_K1.1080.87
144_A247_M1.1080.87
261_V265_V1.0990.87
148_F236_L1.0990.87
353_W358_Q1.0790.86
353_W356_S1.0720.85
125_N286_E1.0680.85
36_L87_V1.0680.85
195_K228_S1.0660.85
149_R236_L1.0640.85
340_A368_F1.0450.84
313_D324_S1.0390.83
353_W377_T1.0310.83
20_T29_S1.0270.83
249_L287_L1.0130.82
19_L136_V1.0090.82
130_N267_A1.0030.81
149_R154_I1.0020.81
43_K270_D1.0020.81
16_K91_A0.9970.81
56_V350_A0.9960.81
353_W379_K0.9850.80
202_L205_A0.9800.80
347_E363_P0.9790.80
104_N108_G0.9790.80
74_V78_F0.9750.79
316_I320_D0.9740.79
217_I234_L0.9730.79
101_N252_E0.9720.79
62_I69_L0.9680.79
266_M272_V0.9660.79
126_Y229_G0.9640.78
40_A80_E0.9630.78
249_L253_T0.9550.78
155_V172_L0.9530.78
361_L365_E0.9460.77
349_D362_K0.9420.77
91_A259_Q0.9390.77
188_L232_S0.9390.77
207_D222_E0.9350.76
174_Q179_R0.9340.76
60_D64_S0.9330.76
90_A258_L0.9330.76
36_L83_F0.9210.75
265_V279_P0.9160.75
95_S287_L0.9120.75
183_L233_P0.9100.74
107_I289_A0.9090.74
354_K357_Q0.9060.74
300_Q303_T0.9060.74
202_L231_F0.9040.74
206_L214_W0.9040.74
185_A189_N0.9030.74
137_F325_L0.9030.74
6_N33_M0.9010.74
98_V253_T0.9010.74
248_F317_P0.9010.74
104_N252_E0.9000.74
46_S246_A0.9000.74
236_L287_L0.9000.74
175_P178_E0.8970.73
66_K70_L0.8960.73
126_Y280_K0.8940.73
296_K299_N0.8940.73
183_L186_S0.8930.73
232_S235_L0.8920.73
102_K129_P0.8900.73
241_L245_E0.8900.73
216_T219_L0.8880.73
125_N281_Y0.8850.72
93_P345_C0.8830.72
198_A202_L0.8800.72
274_R287_L0.8780.72
351_T360_Q0.8780.72
2_Q50_N0.8770.72
247_M382_G0.8690.71
144_A239_V0.8670.71
212_E240_K0.8640.70
80_E101_N0.8640.70
290_N293_F0.8610.70
146_N236_L0.8580.70
184_F236_L0.8580.70
178_E181_S0.8570.70
90_A262_A0.8520.69
141_P243_P0.8510.69
87_V161_V0.8490.69
25_M29_S0.8460.69
133_P267_A0.8430.69
16_K20_T0.8400.68
38_M87_V0.8390.68
101_N232_S0.8370.68
47_R57_S0.8360.68
198_A231_F0.8350.68
166_P201_I0.8340.68
96_I230_L0.8330.68
130_N318_V0.8330.68
135_L265_V0.8320.68
73_A110_A0.8320.68
326_H378_V0.8310.67
20_T30_S0.8290.67
89_C262_A0.8280.67
43_K263_L0.8280.67
151_F155_V0.8180.66
109_F123_E0.8150.66
109_F350_A0.8140.66
135_L268_N0.8140.66
103_H110_A0.8140.66
135_L301_L0.8130.66
146_N249_L0.8080.65
189_N285_P0.8080.65
90_A261_V0.8050.65
9_Q34_A0.8050.65
108_G123_E0.8030.65
253_T293_F0.8000.64
203_K221_S0.8000.64
230_L277_L0.7990.64
243_P371_A0.7990.64
153_E156_S0.7970.64
126_Y287_L0.7960.64
21_E363_P0.7960.64
83_F319_D0.7930.64
373_E376_V0.7900.63
108_G281_Y0.7890.63
125_N283_D0.7880.63
60_D63_E0.7870.63
185_A285_P0.7850.63
83_F91_A0.7820.63
193_E197_R0.7810.63
23_Y291_V0.7760.62
149_R153_E0.7760.62
314_F325_L0.7750.62
58_L71_G0.7710.62
352_L358_Q0.7700.61
154_I233_P0.7680.61
58_L62_I0.7650.61
28_P33_M0.7630.61
135_L316_I0.7630.61
19_L23_Y0.7620.61
127_K281_Y0.7620.61
102_K320_D0.7600.60
192_G196_S0.7590.60
96_I232_S0.7570.60
74_V339_S0.7560.60
252_E286_E0.7530.60
12_A31_Q0.7520.60
220_I233_P0.7510.60
135_L320_D0.7480.59
312_L325_L0.7440.59
220_I223_F0.7430.59
197_R367_A0.7420.59
126_Y279_P0.7410.59
280_K287_L0.7410.59
214_W234_L0.7390.58
200_A360_Q0.7350.58
190_M195_K0.7340.58
158_L161_V0.7280.57
104_N107_I0.7240.57
275_A293_F0.7210.56
8_V38_M0.7200.56
5_I47_R0.7190.56
7_S26_E0.7130.56
135_L246_A0.7130.56
18_A89_C0.7110.55
199_L206_L0.7100.55
230_L282_I0.7090.55
254_P318_V0.7040.55
148_F293_F0.7030.55
251_A279_P0.7010.54
127_K266_M0.7000.54
220_I230_L0.7000.54
350_A382_G0.6990.54
48_V56_V0.6980.54
143_L259_Q0.6970.54
184_F288_V0.6970.54
96_I220_I0.6970.54
15_S20_T0.6960.54
197_R377_T0.6960.54
336_S374_S0.6950.54
52_A56_V0.6900.53
370_A373_E0.6880.53
292_K320_D0.6860.53
362_K365_E0.6840.53
151_F179_R0.6840.53
64_S159_Q0.6830.52
178_E327_D0.6790.52
91_A150_E0.6780.52
33_M89_C0.6730.51
340_A346_V0.6720.51
239_V298_A0.6710.51
180_L293_F0.6690.51
196_S226_E0.6680.51
189_N248_F0.6650.51
136_V196_S0.6640.50
109_F112_E0.6620.50
59_R80_E0.6600.50
51_A72_E0.6590.50
63_E110_A0.6580.50
349_D380_G0.6580.50
41_H132_K0.6580.50
236_L249_L0.6560.50
216_T258_L0.6550.49
94_L97_Q0.6530.49
236_L254_P0.6530.49
204_S207_D0.6520.49
2_Q368_F0.6510.49
215_Q218_R0.6510.49
263_L344_F0.6500.49
87_V344_F0.6490.49
252_E290_N0.6480.49
78_F83_F0.6470.49
314_F320_D0.6470.49
154_I157_L0.6470.49
267_A320_D0.6440.48
19_L252_E0.6440.48
144_A258_L0.6440.48
219_L259_Q0.6430.48
337_Q341_A0.6430.48
294_E319_D0.6420.48
96_I287_L0.6420.48
343_L369_I0.6410.48
4_L21_E0.6400.48
128_D255_H0.6400.48
218_R221_S0.6380.48
127_K283_D0.6370.48
176_D295_A0.6370.48
193_E201_I0.6360.47
137_F266_M0.6350.47
59_R63_E0.6320.47
62_I248_F0.6320.47
356_S379_K0.6310.47
278_T287_L0.6310.47
182_E207_D0.6300.47
38_M46_S0.6300.47
181_S188_L0.6290.47
280_K283_D0.6280.47
6_N137_F0.6230.46
64_S72_E0.6230.46
130_N317_P0.6220.46
93_P224_Y0.6210.46
220_I240_K0.6210.46
107_I330_D0.6200.46
195_K198_A0.6180.46
96_I274_R0.6170.45
129_P144_A0.6140.45
154_I183_L0.6140.45
15_S18_A0.6140.45
52_A72_E0.6140.45
80_E130_N0.6100.45
334_T365_E0.6090.45
330_D376_V0.6090.45
18_A23_Y0.6080.44
43_K46_S0.6070.44
108_G261_V0.6050.44
242_N258_L0.6040.44
11_Y14_G0.6040.44
70_L340_A0.6020.44
74_V77_R0.6010.44
32_P249_L0.6010.44
154_I295_A0.6000.44
63_E203_K0.6000.44
23_Y137_F0.6000.44
12_A135_L0.5980.43
29_S377_T0.5980.43
16_K26_E0.5970.43
34_A37_W0.5970.43
197_R201_I0.5970.43
29_S33_M0.5950.43
131_H237_N0.5950.43
20_T291_V0.5950.43
193_E200_A0.5940.43
144_A249_L0.5920.43
330_D378_V0.5920.43
190_M239_V0.5920.43
131_H317_P0.5910.43
46_S85_F0.5900.43
215_Q219_L0.5900.43
268_N339_S0.5890.42
148_F158_L0.5840.42
265_V268_N0.5840.42
38_M266_M0.5840.42
262_A265_V0.5830.42
224_Y256_A0.5820.42
144_A272_V0.5820.42
246_A291_V0.5820.42
152_S156_S0.5780.41
191_Q198_A0.5770.41
107_I285_P0.5770.41
31_Q263_L0.5770.41
109_F124_R0.5770.41
15_S29_S0.5760.41
349_D381_H0.5760.41
78_F139_L0.5760.41
144_A262_A0.5750.41
226_E336_S0.5750.41
186_S203_K0.5750.41
108_G286_E0.5740.41
326_H379_K0.5740.41
352_L378_V0.5720.41
152_S362_K0.5720.41
144_A224_Y0.5700.41
19_L261_V0.5680.40
11_Y265_V0.5670.40
3_K49_Q0.5640.40
60_D76_K0.5630.40
196_S200_A0.5630.40
207_D221_S0.5630.40
91_A261_V0.5620.40
199_L247_M0.5620.40
60_D347_E0.5610.40
277_L318_V0.5600.40
7_S46_S0.5590.39
63_E76_K0.5570.39
304_Q315_P0.5570.39
51_A258_L0.5570.39
186_S191_Q0.5570.39
7_S47_R0.5570.39
182_E185_A0.5570.39
239_V247_M0.5560.39
219_L223_F0.5550.39
139_L346_V0.5530.39
252_E292_K0.5520.39
137_F265_V0.5500.38
247_M275_A0.5490.38
101_N220_I0.5490.38
127_K256_A0.5480.38
208_S359_L0.5470.38
44_S59_R0.5460.38
158_L293_F0.5450.38
275_A341_A0.5440.38
48_V57_S0.5440.38
296_K300_Q0.5430.38
52_A245_E0.5430.38
268_N320_D0.5430.38
137_F246_A0.5430.38
209_Q294_E0.5420.38
14_G35_E0.5420.38
164_A167_A0.5410.38
197_R342_I0.5410.38
229_G339_S0.5410.38
267_A318_V0.5400.37
78_F317_P0.5400.37
148_F248_F0.5400.37
184_F314_F0.5380.37
16_K191_Q0.5380.37
160_P164_A0.5380.37
200_A204_S0.5370.37
159_Q172_L0.5370.37
361_L374_S0.5360.37
88_L276_G0.5360.37
176_D179_R0.5350.37
32_P280_K0.5340.37
343_L352_L0.5340.37
130_N320_D0.5330.37
50_N57_S0.5330.37
283_D287_L0.5330.37
153_E240_K0.5320.37
79_G371_A0.5320.37
330_D377_T0.5320.37
203_K217_I0.5310.37
13_W34_A0.5300.36
135_L274_R0.5280.36
175_P179_R0.5280.36
274_R277_L0.5280.36
90_A275_A0.5280.36
108_G136_V0.5270.36
209_Q214_W0.5270.36
108_G265_V0.5260.36
126_Y283_D0.5260.36
229_G267_A0.5260.36
184_F339_S0.5260.36
93_P106_E0.5240.36
140_T317_P0.5230.36
98_V104_N0.5230.36
325_L328_L0.5220.36
22_L87_V0.5220.36
177_A204_S0.5210.36
324_S341_A0.5210.36
275_A299_N0.5180.35
233_P268_N0.5180.35
213_P216_T0.5160.35
278_T283_D0.5160.35
294_E325_L0.5140.35
4_L263_L0.5130.35
98_V216_T0.5130.35
88_L238_V0.5130.35
317_P320_D0.5120.35
307_K327_D0.5120.35
8_V33_M0.5120.35
250_F254_P0.5120.35
235_L367_A0.5120.35
87_V329_S0.5110.35
3_K359_L0.5100.35
43_K344_F0.5090.34
356_S377_T0.5090.34
338_Q378_V0.5080.34
216_T224_Y0.5070.34
183_L340_A0.5050.34
137_F263_L0.5030.34
265_V342_I0.5030.34
274_R283_D0.5020.34
95_S283_D0.5010.34
39_G133_P0.5010.34
71_G84_L0.5010.34
62_I243_P0.5010.34
124_R268_N0.5010.34
151_F171_F0.5000.34
111_K199_L0.5000.34
111_K125_N0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wfpA 1 0.9872 100 0.2 Contact Map
1pmiA 1 0.9668 100 0.242 Contact Map
1zx5A 1 0.7417 100 0.486 Contact Map
1qwrA 1 0.7647 100 0.522 Contact Map
3rnsA 1 0.5013 98.7 0.923 Contact Map
3myxA 1 0.5473 98 0.936 Contact Map
1sq4A 5 0.6061 98 0.937 Contact Map
3h7jA 1 0.5294 97.9 0.938 Contact Map
3es4A 2 0.2788 97.8 0.939 Contact Map
1y3tA 2 0.5729 97.7 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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