GREMLIN Database
XYLA - Xylose isomerase
UniProt: P00944 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11074
Length: 440 (428)
Sequences: 953 (379)
Seq/√Len: 18.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_Y130_Q4.8031.00
28_N31_E4.7941.00
127_A179_K4.4561.00
170_V212_F4.4221.00
31_E368_K4.1731.00
37_R40_E3.5971.00
247_A265_L3.5561.00
207_E257_F3.5111.00
124_D179_K3.4621.00
83_A126_L3.3391.00
358_G431_N3.1520.99
222_K406_A3.1320.99
396_Q400_K3.0290.99
98_Y126_L3.0280.99
34_L371_A2.9850.99
204_Q391_N2.9650.99
175_E219_H2.9360.99
14_E20_N2.9020.99
184_N230_L2.8950.99
140_G177_T2.7670.98
177_T182_G2.7140.98
33_V368_K2.6810.98
155_A212_F2.5830.97
89_F353_F2.5350.97
382_R429_L2.5260.97
26_H368_K2.4360.96
247_A267_I2.4270.96
90_F135_V2.4240.96
84_D129_K2.4210.96
39_E96_P2.4070.96
24_F360_M2.3910.95
208_Q399_L2.3880.95
123_V176_A2.3530.95
251_Y291_L2.3140.94
46_A95_V2.2990.94
295_V325_I2.2980.94
371_A375_E2.2880.94
32_L37_R2.2730.94
13_Y16_S2.2630.94
25_R435_H2.2370.93
52_F86_A2.2190.93
86_A90_F2.2050.93
287_I328_A2.2020.93
91_H135_V2.1900.93
30_D37_R2.1210.91
46_A52_F2.1070.91
381_K385_Q2.0880.91
404_S407_D2.0660.90
97_F183_E2.0450.90
318_N362_T2.0340.90
283_I295_V2.0120.89
397_Q402_Q1.9980.89
46_A93_L1.9800.88
62_V148_P1.9210.87
326_L367_L1.9160.86
157_N390_W1.9150.86
52_F90_F1.8840.86
80_K121_Q1.8670.85
28_N368_K1.8570.85
203_R256_Q1.8280.84
310_Q430_E1.8260.84
30_D39_E1.7700.82
129_K132_E1.7650.81
123_V179_K1.7610.81
140_G182_G1.7590.81
128_G132_E1.7280.80
38_M367_L1.7100.79
48_Y86_A1.7080.79
403_M407_D1.7040.79
111_S114_E1.7040.79
92_K353_F1.6810.78
156_T213_M1.6750.78
251_Y255_K1.6650.77
173_A177_T1.6500.77
428_Q432_L1.6420.76
96_P135_V1.5990.74
103_V115_Y1.5840.74
214_Q258_G1.5840.74
109_G118_N1.5810.74
187_L216_V1.5800.74
240_K301_D1.5520.72
204_Q208_Q1.5510.72
255_K260_E1.5410.72
202_L285_T1.5300.71
76_L121_Q1.5280.71
22_L354_Y1.5250.71
328_A331_F1.5140.70
140_G173_A1.5080.70
269_A279_F1.5040.70
395_G398_I1.4950.69
124_D127_A1.4930.69
206_R248_A1.4910.69
46_A90_F1.4860.69
323_Y373_M1.4810.68
195_E345_Q1.4800.68
204_Q399_L1.4780.68
217_V262_E1.4670.68
252_G255_K1.4590.67
295_V336_L1.4560.67
220_K229_L1.4470.67
47_C356_H1.4440.66
127_A131_E1.4410.66
123_V127_A1.4400.66
229_L263_I1.4390.66
236_Q304_L1.4280.66
103_V116_I1.4150.65
217_V221_H1.4040.64
186_V230_L1.3980.64
379_L433_V1.3890.63
106_S118_N1.3830.63
410_K414_E1.3750.63
409_A413_Q1.3650.62
221_H262_E1.3610.62
160_P389_G1.3600.62
163_F390_W1.3600.62
18_S25_R1.3590.62
206_R257_F1.3530.61
113_K117_N1.3520.61
20_N23_A1.3500.61
53_C82_K1.3420.61
214_Q218_E1.3360.60
250_V265_L1.3350.60
292_F331_F1.3290.60
41_H45_A1.3290.60
44_F360_M1.3220.59
84_D125_V1.3210.59
251_Y289_L1.2900.57
43_R97_F1.2900.57
359_A362_T1.2870.57
372_R436_Y1.2840.57
14_E23_A1.2800.57
120_A172_T1.2770.57
312_P359_A1.2740.56
174_M220_K1.2710.56
11_V353_F1.2690.56
283_I321_V1.2650.56
212_F405_L1.2610.56
103_V169_Q1.2600.56
177_T227_G1.2550.55
397_Q407_D1.2520.55
391_N399_L1.2440.55
256_Q289_L1.2400.54
156_T206_R1.2390.54
378_E436_Y1.2380.54
279_F321_V1.2360.54
126_L130_Q1.2300.54
202_L248_A1.2180.53
115_Y165_W1.2180.53
108_E165_W1.2150.53
318_N366_A1.1810.51
314_S317_E1.1810.51
14_E18_S1.1790.51
384_A391_N1.1750.50
28_N33_V1.1700.50
108_E115_Y1.1670.50
350_Y425_R1.1650.50
178_H223_I1.1610.50
152_A345_Q1.1590.49
350_Y354_Y1.1560.49
46_A94_H1.1540.49
249_T285_T1.1520.49
91_H132_E1.1470.49
160_P394_L1.1410.48
354_Y431_N1.1370.48
111_S115_Y1.1360.48
327_K380_D1.1230.47
270_N300_G1.1210.47
284_A324_E1.1180.47
29_P94_H1.1170.47
72_P75_A1.1090.46
228_T333_T1.1080.46
173_A182_G1.0990.46
22_L103_V1.0970.46
36_K41_H1.0840.45
398_I408_L1.0840.45
32_L35_G1.0810.45
299_R313_N1.0760.44
280_H314_S1.0700.44
26_H31_E1.0640.44
210_G214_Q1.0630.43
236_Q303_Q1.0620.43
184_N332_T1.0610.43
91_H133_S1.0600.43
248_A285_T1.0600.43
136_K183_E1.0500.43
41_H367_L1.0480.43
228_T264_K1.0470.42
159_D422_Q1.0390.42
155_A209_L1.0380.42
174_M229_L1.0370.42
426_Q430_E1.0360.42
112_L412_A1.0350.42
326_L374_I1.0280.41
108_E147_N1.0270.41
11_V357_I1.0240.41
44_F363_M1.0220.41
107_P118_N1.0180.41
427_E430_E1.0160.41
354_Y425_R1.0140.41
80_K122_M1.0060.40
80_K125_V1.0020.40
230_L332_T0.9970.39
140_G430_E0.9970.39
11_V24_F0.9900.39
159_D421_H0.9880.39
252_G285_T0.9830.39
11_V22_L0.9720.38
122_M126_L0.9710.38
315_V362_T0.9710.38
75_A78_L0.9700.38
119_F176_A0.9680.38
247_A251_Y0.9650.38
140_G310_Q0.9650.38
216_V229_L0.9640.38
56_G240_K0.9620.37
327_K374_I0.9600.37
65_F342_V0.9530.37
63_G148_P0.9480.37
178_H220_K0.9480.37
178_H226_Q0.9470.37
206_R209_L0.9460.37
214_Q217_V0.9440.36
115_Y168_T0.9370.36
209_L213_M0.9360.36
51_T342_V0.9340.36
125_V129_K0.9290.36
18_S21_P0.9270.35
35_G371_A0.9260.35
394_L411_Y0.9130.35
51_T352_L0.9100.34
220_K262_E0.9100.34
26_H435_H0.9090.34
13_Y28_N0.9070.34
374_I380_D0.9030.34
201_D204_Q0.9000.34
255_K289_L0.9000.34
97_F136_K0.8980.34
12_R414_E0.8940.34
322_M336_L0.8930.34
41_H326_L0.8910.33
45_A245_Y0.8900.33
53_C75_A0.8890.33
29_P39_E0.8870.33
160_P393_E0.8840.33
36_K40_E0.8830.33
211_R399_L0.8830.33
382_R428_Q0.8800.33
94_H134_G0.8760.33
265_L291_L0.8740.32
38_M326_L0.8740.32
144_C166_A0.8730.32
319_A369_I0.8710.32
208_Q391_N0.8700.32
183_E333_T0.8670.32
43_R333_T0.8610.32
83_A125_V0.8600.32
33_V367_L0.8600.32
230_L333_T0.8540.31
94_H133_S0.8490.31
163_F398_I0.8490.31
99_C359_A0.8470.31
365_L369_I0.8450.31
155_A170_V0.8420.31
135_V166_A0.8410.31
378_E381_K0.8390.31
169_Q173_A0.8380.31
89_F92_K0.8370.30
216_V405_L0.8360.30
46_A86_A0.8350.30
374_I436_Y0.8340.30
140_G185_Y0.8340.30
279_F283_I0.8330.30
17_K32_L0.8320.30
313_N359_A0.8300.30
287_I324_E0.8290.30
160_P390_W0.8250.30
94_H135_V0.8250.30
313_N358_G0.8240.30
144_C150_Y0.8220.30
299_R310_Q0.8220.30
207_E256_Q0.8190.30
378_E382_R0.8170.29
202_L284_A0.8080.29
394_L398_I0.8070.29
154_A426_Q0.8060.29
336_L363_M0.8040.29
12_R17_K0.8040.29
130_Q134_G0.8010.29
120_A179_K0.8010.29
202_L288_A0.8000.29
247_A286_A0.7980.28
255_K291_L0.7950.28
412_A415_H0.7930.28
201_D384_A0.7900.28
151_G421_H0.7870.28
69_W79_A0.7850.28
34_L374_I0.7840.28
12_R261_K0.7830.28
105_V125_V0.7820.28
106_S125_V0.7800.28
247_A282_E0.7760.27
328_A332_T0.7760.27
249_T252_G0.7720.27
134_G404_S0.7710.27
110_A114_E0.7700.27
196_T429_L0.7690.27
103_V109_G0.7660.27
15_G20_N0.7660.27
231_I263_I0.7640.27
116_I172_T0.7640.27
172_T175_E0.7640.27
185_Y290_G0.7620.27
37_R96_P0.7610.27
377_G380_D0.7610.27
112_L120_A0.7600.27
47_C99_C0.7600.27
8_L350_Y0.7590.27
411_Y415_H0.7580.27
187_L229_L0.7580.27
251_Y285_T0.7570.26
15_G18_S0.7570.26
56_G65_F0.7550.26
270_N273_T0.7540.26
230_L331_F0.7490.26
62_V146_T0.7490.26
22_L350_Y0.7470.26
90_F95_V0.7470.26
52_F89_F0.7470.26
38_M368_K0.7460.26
67_R342_V0.7460.26
161_E411_Y0.7450.26
77_A81_R0.7450.26
12_R396_Q0.7440.26
88_E326_L0.7400.26
19_S435_H0.7360.25
359_A427_E0.7360.25
206_R285_T0.7350.25
106_S109_G0.7350.25
99_C283_I0.7340.25
25_R32_L0.7320.25
143_N146_T0.7320.25
89_F93_L0.7310.25
112_L116_I0.7300.25
30_D40_E0.7280.25
202_L289_L0.7270.25
30_D55_N0.7260.25
252_G289_L0.7250.25
385_Q422_Q0.7240.25
304_L398_I0.7240.25
29_P37_R0.7240.25
115_Y172_T0.7230.25
76_L107_P0.7220.25
393_E396_Q0.7200.25
313_N362_T0.7200.25
177_T225_F0.7200.25
45_A99_C0.7180.25
394_L397_Q0.7170.25
113_K414_E0.7170.25
383_I404_S0.7150.24
195_E304_L0.7120.24
120_A176_A0.7110.24
12_R39_E0.7100.24
250_V310_Q0.7090.24
318_N363_M0.7080.24
184_N331_F0.7080.24
34_L37_R0.7020.24
9_D12_R0.7000.24
9_D19_S0.7000.24
228_T303_Q0.7000.24
303_Q317_E0.6990.24
372_R376_D0.6980.24
269_A302_A0.6970.24
272_A282_E0.6970.24
112_L172_T0.6970.24
142_A150_Y0.6960.24
19_S378_E0.6910.23
269_A273_T0.6910.23
24_F336_L0.6900.23
19_S402_Q0.6900.23
43_R96_P0.6900.23
354_Y358_G0.6880.23
315_V365_L0.6880.23
210_G256_Q0.6870.23
11_V20_N0.6860.23
52_F135_V0.6860.23
109_G114_E0.6850.23
113_K413_Q0.6850.23
196_T345_Q0.6850.23
42_L336_L0.6850.23
209_L437_L0.6820.23
342_V352_L0.6820.23
299_R358_G0.6820.23
77_A133_S0.6810.23
10_R39_E0.6810.23
250_V430_E0.6780.23
251_Y390_W0.6760.23
217_V263_I0.6760.23
380_D383_I0.6730.23
183_E226_Q0.6730.23
147_N165_W0.6710.23
354_Y428_Q0.6710.23
52_F358_G0.6650.22
133_S276_G0.6620.22
385_Q388_S0.6620.22
432_L435_H0.6610.22
369_I436_Y0.6610.22
150_Y166_A0.6610.22
32_L402_Q0.6610.22
72_P81_R0.6580.22
187_L262_E0.6580.22
208_Q211_R0.6580.22
217_V220_K0.6570.22
247_A285_T0.6550.22
105_V122_M0.6540.22
369_I437_L0.6530.22
160_P398_I0.6520.22
314_S319_A0.6520.22
34_L326_L0.6500.22
17_K410_K0.6490.22
112_L165_W0.6490.22
24_F44_F0.6490.22
90_F96_P0.6470.21
20_N283_I0.6470.21
109_G147_N0.6460.21
115_Y176_A0.6440.21
33_V371_A0.6440.21
108_E114_E0.6430.21
250_V267_I0.6420.21
15_G23_A0.6410.21
11_V392_S0.6410.21
112_L176_A0.6400.21
230_L264_K0.6390.21
47_C53_C0.6380.21
251_Y265_L0.6370.21
98_Y134_G0.6370.21
174_M202_L0.6370.21
42_L276_G0.6360.21
347_T421_H0.6360.21
48_Y83_A0.6340.21
177_T430_E0.6330.21
215_M407_D0.6320.21
59_M70_Q0.6300.21
349_K354_Y0.6290.21
219_H404_S0.6280.21
13_Y355_G0.6260.21
37_R43_R0.6260.21
39_E134_G0.6250.21
300_G304_L0.6250.21
14_E21_P0.6250.21
72_P78_L0.6250.21
75_A173_A0.6240.21
91_H130_Q0.6220.20
207_E410_K0.6210.20
260_E291_L0.6210.20
10_R91_H0.6210.20
313_N427_E0.6210.20
245_Y276_G0.6190.20
19_S117_N0.6180.20
132_E135_V0.6170.20
228_T292_F0.6170.20
48_Y52_F0.6160.20
319_A326_L0.6160.20
116_I120_A0.6150.20
71_Q81_R0.6150.20
75_A106_S0.6120.20
61_G136_K0.6120.20
93_L379_L0.6120.20
47_C220_K0.6100.20
203_R287_I0.6100.20
306_W310_Q0.6100.20
32_L295_V0.6090.20
326_L370_A0.6080.20
32_L39_E0.6070.20
54_W345_Q0.6050.20
19_S261_K0.6040.20
312_P323_Y0.6040.20
310_Q426_Q0.6010.20
397_Q403_M0.6010.20
196_T343_R0.6000.20
292_F332_T0.6000.20
71_Q78_L0.6000.20
210_G260_E0.5990.20
13_Y314_S0.5990.20
343_R427_E0.5980.20
415_H419_P0.5970.19
156_T432_L0.5960.19
15_G21_P0.5960.19
410_K413_Q0.5960.19
407_D410_K0.5960.19
85_V92_K0.5950.19
378_E432_L0.5950.19
63_G151_G0.5940.19
142_A170_V0.5930.19
37_R62_V0.5930.19
126_L176_A0.5930.19
85_V321_V0.5910.19
267_I295_V0.5900.19
258_G291_L0.5900.19
138_L322_M0.5890.19
98_Y404_S0.5880.19
8_L353_F0.5860.19
112_L207_E0.5860.19
280_H321_V0.5850.19
184_N228_T0.5820.19
19_S376_D0.5820.19
112_L168_T0.5820.19
103_V110_A0.5820.19
78_L107_P0.5810.19
196_T217_V0.5810.19
138_L335_G0.5800.19
105_V221_H0.5800.19
395_G408_L0.5790.19
116_I409_A0.5780.19
22_L34_L0.5760.19
187_L221_H0.5760.19
46_A51_T0.5750.19
206_R256_Q0.5750.19
213_M321_V0.5730.19
390_W393_E0.5720.19
155_A174_M0.5720.19
214_Q257_F0.5710.18
172_T176_A0.5710.18
54_W65_F0.5710.18
89_F352_L0.5710.18
284_A299_R0.5710.18
126_L161_E0.5700.18
91_H134_G0.5700.18
103_V108_E0.5700.18
287_I292_F0.5690.18
295_V331_F0.5680.18
187_L213_M0.5680.18
37_R41_H0.5680.18
150_Y169_Q0.5670.18
280_H320_L0.5670.18
213_M217_V0.5660.18
18_S23_A0.5640.18
8_L22_L0.5640.18
44_F322_M0.5640.18
109_G115_Y0.5630.18
138_L259_L0.5630.18
239_T301_D0.5620.18
103_V107_P0.5610.18
228_T331_F0.5590.18
32_L41_H0.5580.18
144_C239_T0.5570.18
32_L371_A0.5560.18
297_A363_M0.5550.18
103_V106_S0.5550.18
86_A135_V0.5550.18
376_D429_L0.5530.18
152_A347_T0.5520.18
290_G333_T0.5520.18
353_F357_I0.5510.18
378_E435_H0.5510.18
295_V302_A0.5500.18
231_I250_V0.5500.18
315_V437_L0.5500.18
46_A356_H0.5500.18
314_S320_L0.5490.18
25_R371_A0.5480.18
392_S407_D0.5470.18
144_C174_M0.5470.18
97_F181_G0.5470.18
373_M378_E0.5470.18
28_N410_K0.5450.18
40_E161_E0.5450.18
106_S251_Y0.5440.17
42_L333_T0.5440.17
94_H166_A0.5440.17
76_L106_S0.5440.17
30_D121_Q0.5430.17
16_S25_R0.5430.17
270_N304_L0.5410.17
65_F352_L0.5410.17
196_T426_Q0.5400.17
143_N279_F0.5390.17
110_A115_Y0.5390.17
13_Y66_N0.5370.17
267_I283_I0.5360.17
236_Q245_Y0.5350.17
120_A175_E0.5350.17
171_V175_E0.5340.17
74_E121_Q0.5320.17
115_Y144_C0.5310.17
280_H317_E0.5300.17
91_H385_Q0.5290.17
152_A262_E0.5280.17
376_D436_Y0.5280.17
285_T289_L0.5280.17
33_V365_L0.5280.17
55_N63_G0.5280.17
90_F356_H0.5270.17
43_R332_T0.5270.17
166_A206_R0.5250.17
36_K367_L0.5250.17
320_L324_E0.5240.17
320_L374_I0.5220.17
97_F312_P0.5210.17
34_L375_E0.5210.17
245_Y303_Q0.5210.17
119_F123_V0.5210.17
117_N121_Q0.5210.17
11_V103_V0.5210.17
22_L45_A0.5200.17
201_D208_Q0.5200.17
174_M221_H0.5190.17
99_C357_I0.5180.17
175_E207_E0.5180.17
177_T310_Q0.5170.17
392_S405_L0.5170.17
320_L323_Y0.5170.17
108_E149_R0.5160.17
175_E406_A0.5150.16
173_A280_H0.5150.16
380_D384_A0.5140.16
178_H221_H0.5140.16
324_E328_A0.5140.16
419_P430_E0.5140.16
72_P146_T0.5130.16
137_L180_L0.5130.16
251_Y260_E0.5130.16
10_R264_K0.5130.16
270_N322_M0.5120.16
10_R422_Q0.5110.16
230_L378_E0.5100.16
108_E111_S0.5090.16
147_N169_Q0.5090.16
288_A292_F0.5080.16
391_N396_Q0.5080.16
99_C185_Y0.5080.16
53_C71_Q0.5070.16
85_V353_F0.5060.16
106_S336_L0.5060.16
269_A379_L0.5060.16
376_D383_I0.5050.16
162_V180_L0.5050.16
368_K372_R0.5030.16
396_Q403_M0.5030.16
40_E414_E0.5010.16
98_Y245_Y0.5010.16
103_V433_V0.5000.16
342_V355_G0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0cA 4 0.9932 100 0.481 Contact Map
1ximA 4 0.8659 100 0.699 Contact Map
1muwA 4 0.8659 100 0.705 Contact Map
1xlaA 4 0.8659 100 0.705 Contact Map
1bxbA 4 0.8659 100 0.72 Contact Map
3p14A 2 0.8841 100 0.727 Contact Map
3m0mA 4 0.8682 100 0.835 Contact Map
1d8wA 4 0.8432 100 0.837 Contact Map
3ktcA 4 0.7455 100 0.842 Contact Map
3cqjA 2 0.6205 99.5 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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