GREMLIN Database
CYAA - Adenylate cyclase
UniProt: P00936 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10170
Length: 848 (803)
Sequences: 247 (151)
Seq/√Len: 5.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_I194_A6.1560.99
95_I119_V5.2110.98
156_I232_L4.7070.96
41_L140_L3.8160.89
140_L277_N3.6340.87
338_S369_D3.5960.86
64_Y70_Q3.1470.77
45_H390_M3.0340.74
194_A758_Y2.8470.69
248_L309_V2.8430.69
99_Y180_I2.7660.67
243_Y318_D2.7560.66
57_V323_D2.6730.64
35_Y105_S2.5280.59
248_L584_G2.4980.58
305_M309_V2.4860.58
95_I133_L2.4770.58
423_Y603_N2.4580.57
185_E260_K2.3360.53
42_L64_Y2.2900.51
337_L369_D2.2830.51
274_E351_L2.2590.50
102_G260_K2.2550.50
114_D260_K2.2540.50
328_C733_V2.2290.49
402_R809_Y2.2070.49
102_G185_E2.2040.49
140_L331_L2.1810.48
570_V764_N2.1780.48
119_V137_C2.1740.48
268_L617_I2.1670.47
260_K264_K2.1660.47
102_G264_K2.1640.47
114_D185_E2.1580.47
172_E277_N2.1530.47
114_D264_K2.1380.46
149_V414_D2.1310.46
614_Q618_E2.1280.46
102_G114_D2.1270.46
232_L779_L2.1160.46
331_L543_L2.1110.45
331_L700_L2.0960.45
185_E264_K2.0870.45
215_V441_S2.0870.45
331_L764_N2.0710.44
83_M222_G2.0680.44
538_P676_F2.0360.43
616_M654_V2.0280.43
190_A427_E2.0150.42
660_E724_T2.0020.42
199_L215_V2.0010.42
24_L36_S1.9890.41
282_A416_G1.9890.41
246_A733_V1.9790.41
263_L325_V1.9780.41
262_V274_E1.9630.41
157_D160_R1.9620.41
140_L555_I1.9620.41
107_V507_L1.9540.40
269_E420_R1.9450.40
97_G172_E1.9440.40
495_A532_P1.9430.40
182_L260_K1.9420.40
426_F657_L1.9280.39
355_V617_I1.9240.39
583_F591_V1.9180.39
737_A764_N1.9150.39
101_M260_K1.9150.39
101_M185_E1.9090.39
193_L268_L1.8910.38
433_V493_A1.8780.38
38_L141_E1.8650.37
71_R492_V1.8590.37
114_D182_L1.8550.37
182_L264_K1.8510.37
259_Y440_I1.8470.37
102_G182_L1.8420.37
274_E582_S1.8410.37
182_L185_E1.8400.37
335_E347_R1.8320.36
394_Y562_P1.8310.36
309_V423_Y1.8270.36
400_F758_Y1.8260.36
543_L764_N1.8250.36
509_I515_V1.8160.36
348_R369_D1.8080.36
365_L535_L1.8070.36
761_D765_R1.8070.36
610_F619_A1.8020.36
42_L719_S1.7960.35
250_Q397_L1.7950.35
414_D743_Q1.7900.35
101_M114_D1.7760.35
41_L679_L1.7720.35
249_W271_Y1.7600.34
740_G806_P1.7580.34
346_W369_D1.7560.34
276_P400_F1.7540.34
370_N373_N1.7530.34
42_L95_I1.7520.34
325_V393_S1.7440.34
391_M429_L1.7390.34
432_K464_W1.7270.33
189_T299_L1.7270.33
466_L520_L1.7200.33
108_G676_F1.7160.33
132_L140_L1.7120.33
120_C231_D1.6940.32
232_L556_V1.6930.32
154_F324_L1.6900.32
179_H204_P1.6850.32
5_I223_V1.6800.32
101_M264_K1.6680.32
369_D783_V1.6680.32
113_S258_P1.6670.32
681_V688_L1.6630.31
99_Y619_A1.6550.31
67_D193_L1.6510.31
609_H646_L1.6480.31
245_G600_N1.6450.31
127_S581_F1.6410.31
246_A788_S1.6330.31
357_E701_E1.6310.30
417_V556_V1.6290.30
458_R811_I1.6280.30
337_L348_R1.6280.30
194_A702_N1.6230.30
103_S249_W1.6140.30
103_S271_Y1.6140.30
34_V193_L1.6130.30
8_L515_V1.6090.30
252_Y421_K1.6040.30
238_L471_P1.6010.30
103_S258_P1.6010.30
216_M380_R1.5940.29
150_E239_S1.5900.29
193_L345_G1.5900.29
16_N19_R1.5820.29
245_G394_Y1.5770.29
206_D415_I1.5740.29
263_L426_F1.5740.29
51_G595_D1.5650.29
67_D92_E1.5610.29
188_R302_Y1.5570.28
594_V614_Q1.5550.28
249_W258_P1.5540.28
258_P271_Y1.5540.28
490_K581_F1.5540.28
101_M182_L1.5530.28
260_K321_R1.5520.28
183_L242_E1.5480.28
80_Y99_Y1.5470.28
282_A759_I1.5420.28
181_L240_A1.5420.28
120_C432_K1.5410.28
203_V235_L1.5390.28
113_S188_R1.5370.28
113_S302_Y1.5370.28
21_D151_V1.5350.28
306_L310_T1.5350.28
238_L290_H1.5350.28
232_L566_F1.5340.28
42_L133_L1.5300.28
258_P264_K1.5280.28
103_S113_S1.5260.28
51_G181_L1.5240.28
308_R406_L1.5200.27
307_E597_L1.5170.27
188_R258_P1.5160.27
258_P302_Y1.5160.27
277_N317_E1.5110.27
284_D311_E1.5070.27
188_R249_W1.5030.27
188_R271_Y1.5030.27
249_W302_Y1.5030.27
271_Y302_Y1.5030.27
116_D602_W1.4950.27
114_D321_R1.4900.27
75_N140_L1.4890.27
354_L426_F1.4790.26
803_F806_P1.4780.26
23_A507_L1.4710.26
239_S686_W1.4710.26
282_A314_T1.4680.26
154_F424_A1.4660.26
375_K440_I1.4660.26
103_S188_R1.4630.26
103_S302_Y1.4630.26
185_E321_R1.4590.26
351_L705_E1.4520.26
666_L714_K1.4520.26
127_S224_L1.4510.26
113_S249_W1.4480.26
113_S271_Y1.4480.26
119_V132_L1.4430.25
269_E321_R1.4410.25
31_F201_N1.4400.25
264_K321_R1.4380.25
97_G789_S1.4350.25
120_C431_G1.4350.25
281_L733_V1.4340.25
250_Q437_N1.4320.25
99_Y243_Y1.4310.25
108_G243_Y1.4260.25
102_G321_R1.4250.25
99_Y465_Y1.4240.25
46_H579_D1.4210.25
451_F690_F1.4100.25
228_E359_G1.4000.24
247_S617_I1.3980.24
395_R425_A1.3960.24
64_Y400_F1.3960.24
13_D197_R1.3950.24
244_F495_A1.3950.24
710_I766_V1.3870.24
581_F769_Y1.3830.24
180_I597_L1.3770.24
113_S264_K1.3750.24
19_R184_D1.3740.24
55_G194_A1.3700.24
597_L733_V1.3680.24
397_L561_D1.3670.24
482_L738_S1.3640.23
444_L562_P1.3620.23
66_P653_R1.3550.23
215_V400_F1.3540.23
282_A613_E1.3500.23
26_A582_S1.3490.23
248_L743_Q1.3480.23
338_S348_R1.3340.23
203_V702_N1.3330.23
282_A292_G1.3320.23
262_V423_Y1.3290.23
64_Y109_Q1.3280.23
231_D286_K1.3280.23
341_R351_L1.3260.23
166_S256_D1.3210.22
102_G113_S1.3200.22
137_C403_R1.3200.22
518_P597_L1.3190.22
172_E176_S1.3190.22
204_P239_S1.3180.22
189_T708_G1.3110.22
492_V787_Y1.3070.22
105_S301_P1.3070.22
231_D464_W1.3060.22
194_A352_S1.3040.22
185_E249_W1.3020.22
185_E271_Y1.3020.22
595_D603_N1.3010.22
103_S264_K1.2990.22
419_T471_P1.2940.22
106_S549_I1.2930.22
623_I658_V1.2910.22
141_E556_V1.2910.22
100_T177_T1.2850.22
281_L723_E1.2780.21
582_S758_Y1.2760.21
102_G258_P1.2690.21
177_T410_A1.2680.21
114_D188_R1.2640.21
114_D302_Y1.2640.21
103_S604_E1.2620.21
366_A591_V1.2600.21
249_W264_K1.2550.21
264_K271_Y1.2550.21
174_C184_D1.2510.21
609_H643_S1.2500.21
119_V126_D1.2470.21
54_D59_K1.2440.21
769_Y803_F1.2440.21
279_R365_L1.2410.21
61_I275_Y1.2390.21
52_Y172_E1.2390.21
185_E188_R1.2380.21
185_E302_Y1.2380.21
11_R39_P1.2360.21
581_F654_V1.2360.21
93_L362_E1.2350.20
371_R379_V1.2340.20
583_F650_I1.2340.20
426_F617_I1.2340.20
20_V35_Y1.2310.20
528_S581_F1.2280.20
119_V386_L1.2270.20
250_Q346_W1.2230.20
379_V440_I1.2230.20
38_L554_I1.2210.20
103_S185_E1.2210.20
193_L808_F1.2210.20
15_I230_L1.2200.20
188_R264_K1.2200.20
264_K302_Y1.2200.20
309_V433_V1.2180.20
145_A232_L1.2170.20
114_D258_P1.2170.20
247_S396_N1.2160.20
102_G188_R1.2140.20
102_G302_Y1.2140.20
261_A334_C1.2120.20
114_D249_W1.2020.20
114_D271_Y1.2020.20
23_A331_L1.2000.20
113_S185_E1.2000.20
105_S243_Y1.1950.20
176_S757_I1.1930.20
102_G249_W1.1930.20
102_G271_Y1.1930.20
67_D359_G1.1910.20
103_S267_L1.1890.20
249_W260_K1.1850.19
260_K271_Y1.1850.19
430_P783_V1.1830.19
107_V172_E1.1820.19
177_T214_Y1.1810.19
575_F764_N1.1780.19
594_V781_R1.1780.19
588_N687_G1.1760.19
32_Q151_V1.1740.19
182_L321_R1.1680.19
119_V761_D1.1660.19
113_S332_K1.1650.19
71_R74_L1.1620.19
185_E258_P1.1620.19
188_R332_K1.1620.19
302_Y332_K1.1620.19
250_Q368_L1.1610.19
581_F593_S1.1610.19
759_I768_V1.1610.19
103_S114_D1.1540.19
107_V569_Q1.1480.19
249_W267_L1.1480.19
267_L271_Y1.1480.19
443_D556_V1.1430.19
230_L569_Q1.1400.18
450_T682_S1.1390.18
548_E610_F1.1380.18
117_I500_L1.1370.18
269_E446_E1.1360.18
328_C605_V1.1350.18
328_C531_F1.1330.18
117_I493_A1.1330.18
188_R260_K1.1320.18
260_K302_Y1.1320.18
263_L336_K1.1320.18
625_G758_Y1.1310.18
94_P134_Q1.1300.18
286_K390_M1.1280.18
251_L437_N1.1260.18
481_P507_L1.1240.18
611_N757_I1.1190.18
301_P507_L1.1190.18
249_W604_E1.1160.18
271_Y604_E1.1160.18
183_L188_R1.1140.18
183_L302_Y1.1140.18
188_R242_E1.1140.18
242_E302_Y1.1140.18
170_G571_V1.1120.18
18_L603_N1.1120.18
50_P60_G1.1110.18
64_Y618_E1.1110.18
113_S183_L1.1100.18
113_S242_E1.1100.18
609_H727_V1.1090.18
232_L347_R1.1070.18
232_L416_G1.1030.18
209_E351_L1.1020.18
188_R267_L1.1020.18
267_L302_Y1.1020.18
258_P604_E1.1000.18
103_S260_K1.0980.18
258_P332_K1.0970.18
418_L505_T1.0970.18
444_L634_P1.0970.18
113_S260_K1.0920.18
57_V201_N1.0920.18
106_S545_S1.0900.18
64_Y230_L1.0880.17
561_D743_Q1.0870.17
393_S426_F1.0860.17
414_D431_G1.0860.17
116_D374_W1.0860.17
374_W602_W1.0860.17
156_I261_A1.0820.17
730_P804_N1.0820.17
38_L761_D1.0770.17
93_L594_V1.0760.17
116_D188_R1.0710.17
116_D302_Y1.0710.17
188_R602_W1.0710.17
302_Y602_W1.0710.17
251_L394_Y1.0710.17
308_R500_L1.0710.17
482_L641_C1.0690.17
312_Y328_C1.0680.17
67_D513_G1.0620.17
146_S156_I1.0600.17
394_Y561_D1.0590.17
451_F469_R1.0590.17
414_D562_P1.0540.17
113_S267_L1.0520.17
38_L591_V1.0500.17
224_L227_N1.0480.17
645_H808_F1.0460.17
129_E616_M1.0460.17
183_L258_P1.0450.17
242_E258_P1.0450.17
249_W332_K1.0410.17
271_Y332_K1.0410.17
41_L155_L1.0400.17
556_V670_R1.0360.16
415_I501_L1.0350.16
238_L410_A1.0340.16
300_D332_K1.0340.16
398_I758_Y1.0340.16
437_N440_I1.0330.16
406_L419_T1.0330.16
177_T554_I1.0320.16
277_N587_Q1.0310.16
152_S243_Y1.0300.16
255_I423_Y1.0290.16
250_Q369_D1.0290.16
433_V633_P1.0290.16
341_R594_V1.0280.16
103_S332_K1.0270.16
525_A594_V1.0260.16
787_Y806_P1.0240.16
513_G597_L1.0240.16
196_K609_H1.0230.16
108_G151_V1.0210.16
174_C811_I1.0210.16
156_I466_L1.0200.16
125_L184_D1.0200.16
252_Y420_R1.0180.16
101_M321_R1.0180.16
113_S604_E1.0170.16
433_V495_A1.0160.16
79_L224_L1.0150.16
79_L331_L1.0150.16
140_L145_A1.0140.16
526_D640_F1.0130.16
550_R603_N1.0130.16
421_K451_F1.0120.16
589_C620_L1.0090.16
495_A714_K1.0090.16
520_L743_Q1.0070.16
258_P267_L1.0060.16
113_S116_D1.0050.16
113_S602_W1.0050.16
115_L412_P1.0050.16
183_L300_D1.0050.16
242_E300_D1.0050.16
723_E761_D1.0050.16
183_L249_W1.0000.16
183_L271_Y1.0000.16
242_E249_W1.0000.16
242_E271_Y1.0000.16
528_S593_S1.0000.16
116_D258_P0.9990.16
258_P602_W0.9990.16
579_D583_F0.9980.16
255_I507_L0.9970.16
161_F252_Y0.9940.16
115_L660_E0.9930.16
556_V790_S0.9920.16
138_S552_L0.9910.16
152_S325_V0.9910.16
100_T519_K0.9870.16
437_N562_P0.9870.16
154_F260_K0.9840.16
103_S175_G0.9840.16
567_R589_C0.9820.16
130_R482_L0.9820.16
331_L664_L0.9810.15
234_G501_L0.9790.15
66_P71_R0.9780.15
354_L375_K0.9740.15
17_Q507_L0.9710.15
258_P300_D0.9680.15
175_G249_W0.9670.15
175_G271_Y0.9670.15
175_G258_P0.9660.15
248_L764_N0.9640.15
145_A266_L0.9630.15
321_R374_W0.9630.15
591_V650_I0.9620.15
274_E308_R0.9610.15
414_D626_K0.9610.15
584_G724_T0.9580.15
342_A648_G0.9580.15
16_N388_D0.9570.15
113_S175_G0.9570.15
305_M384_N0.9550.15
31_F239_S0.9550.15
194_A344_V0.9550.15
116_D253_K0.9530.15
253_K602_W0.9530.15
247_S268_L0.9510.15
626_K739_E0.9510.15
150_E153_F0.9500.15
116_D249_W0.9500.15
116_D271_Y0.9500.15
249_W602_W0.9500.15
271_Y602_W0.9500.15
351_L702_N0.9490.15
175_G188_R0.9490.15
175_G302_Y0.9490.15
22_R247_S0.9480.15
185_E267_L0.9450.15
273_W433_V0.9440.15
188_R604_E0.9440.15
302_Y604_E0.9440.15
103_S183_L0.9430.15
103_S242_E0.9430.15
41_L157_D0.9400.15
141_E512_N0.9360.15
101_M328_C0.9340.15
259_Y375_K0.9340.15
119_V151_V0.9330.15
559_E780_V0.9320.15
11_R675_R0.9320.15
543_L743_Q0.9310.15
261_A407_S0.9290.15
279_R742_I0.9290.15
211_Y231_D0.9290.15
486_R589_C0.9290.15
42_L727_V0.9280.15
167_G417_V0.9280.15
154_F185_E0.9250.15
337_L601_S0.9240.15
581_F618_E0.9230.15
436_V486_R0.9200.14
262_V417_V0.9190.14
102_G332_K0.9170.14
394_Y397_L0.9140.14
193_L308_R0.9130.14
5_I83_M0.9090.14
169_L235_L0.9080.14
153_F205_C0.9080.14
55_G433_V0.9080.14
346_W491_L0.9060.14
151_V261_A0.9060.14
152_S278_P0.9030.14
38_L105_S0.9020.14
238_L484_Y0.9010.14
15_I584_G0.9010.14
103_S116_D0.9010.14
103_S602_W0.9010.14
268_L643_S0.8990.14
15_I64_Y0.8980.14
301_P706_F0.8970.14
397_L505_T0.8960.14
189_T511_G0.8950.14
108_G288_R0.8930.14
15_I664_L0.8920.14
573_F594_V0.8920.14
114_D332_K0.8900.14
268_L441_S0.8900.14
5_I125_L0.8890.14
12_L723_E0.8880.14
346_W562_P0.8880.14
215_V597_L0.8850.14
29_P584_G0.8840.14
34_V423_Y0.8830.14
134_Q670_R0.8820.14
113_S300_D0.8820.14
408_V473_I0.8820.14
185_E332_K0.8820.14
309_V334_C0.8820.14
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304_M380_R0.5240.09
251_L393_S0.5230.09
106_S794_F0.5230.09
482_L576_R0.5220.09
58_P99_Y0.5220.09
441_S808_F0.5220.09
169_L312_Y0.5210.09
379_V532_P0.5190.09
410_A463_G0.5180.09
25_A591_V0.5180.09
27_M152_S0.5170.09
240_A552_L0.5160.09
275_Y400_F0.5150.09
441_S587_Q0.5150.09
14_A292_G0.5150.09
178_Q188_R0.5140.09
178_Q302_Y0.5140.09
28_G500_L0.5140.09
169_L597_L0.5140.09
244_F610_F0.5140.09
325_V545_S0.5140.09
31_F310_T0.5130.09
365_L438_P0.5130.09
291_D378_Q0.5130.09
561_D740_G0.5120.09
98_V292_G0.5120.09
174_C789_S0.5120.09
202_M281_L0.5110.09
263_L304_M0.5110.09
177_T489_N0.5100.09
549_I628_H0.5100.09
45_H231_D0.5100.09
95_I205_C0.5100.09
450_T764_N0.5100.09
429_L549_I0.5090.09
254_S438_P0.5080.09
156_I486_R0.5080.09
247_S654_V0.5080.09
18_L293_E0.5050.09
42_L299_L0.5050.09
17_Q466_L0.5050.09
144_A286_K0.5040.09
181_L218_L0.5040.09
389_A660_E0.5040.09
70_Q739_E0.5030.09
213_D433_V0.5030.09
400_F475_S0.5020.09
253_K374_W0.5020.09
289_L555_I0.5020.09
641_C762_E0.5010.09
6_E466_L0.5000.09
53_L761_D0.5000.09
126_D163_H0.5000.09
23_A378_Q0.5000.09
42_L110_S0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cs6A 1 0.263 94.4 0.982 Contact Map
2rffA 1 0.1297 92.6 0.983 Contact Map
1wotA 1 0.1156 87.2 0.985 Contact Map
1ylqA 2 0.1073 86.4 0.985 Contact Map
1no5A 4 0.1203 77.5 0.986 Contact Map
4ebjA 2 0.2677 37.5 0.989 Contact Map
1knyA 2 0.2748 37.1 0.989 Contact Map
2cr7A 1 0.0719 12.9 0.991 Contact Map
1rpuA 2 0.0495 12 0.992 Contact Map
2ggtA 1 0.1533 11.6 0.992 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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