GREMLIN Database
METB - Cystathionine gamma-synthase
UniProt: P00935 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10582
Length: 386 (378)
Sequences: 10586 (5881)
Seq/√Len: 302.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_N186_A3.3951.00
93_L120_L3.1491.00
131_R165_E3.0671.00
267_Q282_E3.0261.00
67_G212_I3.0141.00
66_G186_A2.9371.00
377_E381_R2.8391.00
6_A368_D2.8191.00
273_K305_D2.7131.00
260_Q264_K2.7011.00
93_L135_A2.5331.00
61_L210_V2.4841.00
321_F332_S2.4511.00
4_K368_D2.4121.00
347_P351_A2.3721.00
157_A291_R2.3501.00
274_K303_E2.3361.00
157_A161_H2.3281.00
286_H290_A2.2791.00
140_L171_V2.2451.00
8_I63_E2.2091.00
265_Y373_I2.2081.00
265_Y377_E2.1631.00
253_E257_R2.1301.00
181_L256_Q2.1291.00
160_C170_S2.0081.00
127_E158_K1.9911.00
126_D129_A1.9561.00
154_V159_I1.9371.00
55_D59_R1.9131.00
234_G237_D1.9101.00
6_A249_V1.9091.00
164_R190_D1.9011.00
118_R135_A1.9001.00
303_E358_T1.8701.00
57_V241_L1.8501.00
196_C208_A1.8481.00
92_D139_K1.8361.00
262_I373_I1.8311.00
254_L257_R1.8271.00
199_Y298_A1.8211.00
172_V189_A1.8081.00
336_H339_T1.8061.00
161_H165_E1.7881.00
89_K114_R1.7781.00
120_L135_A1.7361.00
70_A212_I1.6841.00
255_A298_A1.6821.00
369_G373_I1.6791.00
164_R170_S1.6681.00
261_A369_G1.6611.00
347_P357_E1.6561.00
128_Q131_R1.6521.00
350_R357_E1.6521.00
258_N369_G1.6491.00
5_Q180_A1.6431.00
36_T40_E1.6191.00
264_K281_P1.6171.00
303_E356_S1.6071.00
261_A373_I1.6041.00
54_R238_S1.5931.00
96_A108_F1.5901.00
73_T82_L1.5741.00
65_E194_H1.5671.00
93_L118_R1.5601.00
183_N294_K1.5591.00
261_A264_K1.5571.00
131_R166_V1.5541.00
67_G185_L1.5491.00
318_L334_I1.5491.00
127_E162_L1.5461.00
44_H50_G1.5441.00
141_V159_I1.5411.00
170_S189_A1.5241.00
83_V171_V1.5171.00
122_V133_A1.5161.00
313_R317_G1.4991.00
317_G382_A1.4971.00
308_E312_R1.4941.00
141_V163_A1.4771.00
304_L314_F1.4641.00
319_S378_N1.4401.00
346_A349_A1.4351.00
262_I364_T1.4261.00
273_K358_T1.4221.00
208_A233_G1.4211.00
261_A370_E1.4191.00
176_F327_L1.4171.00
158_K161_H1.4161.00
4_K370_E1.4151.00
93_L138_P1.4141.00
196_C241_L1.4101.00
62_A70_A1.4091.00
12_S63_E1.4091.00
265_Y269_Q1.4031.00
57_V72_L1.3981.00
308_E357_E1.3871.00
29_L236_F1.3771.00
70_A210_V1.3681.00
273_K303_E1.3611.00
93_L137_K1.3611.00
196_C210_V1.3571.00
281_P286_H1.3531.00
134_L141_V1.3521.00
37_G40_E1.3481.00
321_F376_L1.3371.00
44_H55_D1.3301.00
250_P366_I1.3301.00
134_L168_A1.3231.00
160_C164_R1.3171.00
80_I142_L1.3151.00
233_G238_S1.3131.00
157_A292_Q1.3111.00
25_P56_V1.3111.00
57_V210_V1.3011.00
143_V156_I1.2961.00
262_I376_L1.2821.00
185_L214_K1.2821.00
84_T140_L1.2791.00
252_M255_A1.2731.00
269_Q377_E1.2721.00
83_V191_L1.2681.00
89_K92_D1.2671.00
118_R137_K1.2671.00
134_L162_L1.2661.00
290_A296_F1.2631.00
84_T108_F1.2601.00
143_V170_S1.2591.00
96_A100_C1.2581.00
88_L94_L1.2521.00
155_D158_K1.2471.00
128_Q132_A1.2361.00
4_K374_A1.2321.00
334_I360_L1.2231.00
182_Q187_L1.2201.00
213_A219_V1.2181.00
321_F372_L1.2171.00
171_V193_L1.2121.00
362_I376_L1.2091.00
160_C189_A1.2051.00
69_G219_V1.2021.00
217_D221_E1.1981.00
83_V211_V1.1951.00
61_L212_I1.1941.00
73_T211_V1.1941.00
258_N366_I1.1931.00
82_L231_V1.1891.00
37_G316_G1.1871.00
262_I372_L1.1861.00
206_V241_L1.1861.00
267_Q280_L1.1811.00
301_S359_L1.1791.00
71_V219_V1.1781.00
169_V218_V1.1741.00
259_A263_V1.1691.00
263_V280_L1.1671.00
216_P220_T1.1651.00
78_S231_V1.1621.00
34_N322_T1.1611.00
320_L372_L1.1601.00
249_V253_E1.1601.00
151_L278_P1.1531.00
256_Q295_G1.1531.00
157_A187_L1.1481.00
130_L159_I1.1421.00
287_E290_A1.1421.00
279_S296_F1.1411.00
109_D121_F1.1321.00
108_F119_V1.1291.00
5_Q183_N1.1271.00
200_L245_L1.1261.00
196_C200_L1.1251.00
81_H85_T1.1251.00
9_A249_V1.1221.00
254_L258_N1.1221.00
39_N316_G1.1191.00
201_N206_V1.1191.00
134_L166_V1.1161.00
163_A170_S1.1141.00
286_H296_F1.1071.00
330_V366_I1.1071.00
95_V133_A1.1031.00
285_G288_I1.0931.00
205_D243_R1.0911.00
264_K267_Q1.0871.00
84_T88_L1.0831.00
98_H152_R1.0821.00
109_D113_K1.0801.00
206_V237_D1.0781.00
257_R261_A1.0681.00
71_V223_A1.0641.00
68_A216_P1.0631.00
61_L200_L1.0621.00
129_A132_A1.0611.00
161_H164_R1.0611.00
289_A296_F1.0571.00
373_I377_E1.0551.00
151_L300_L1.0541.00
131_R162_L1.0501.00
181_L295_G1.0451.00
23_V322_T1.0421.00
141_V168_A1.0361.00
262_I369_G1.0331.00
211_V222_L1.0311.00
208_A241_L1.0291.00
287_E291_R1.0191.00
250_P254_L1.0161.00
68_A215_D1.0131.00
217_D220_T1.0131.00
60_A242_L1.0111.00
39_N312_R1.0101.00
306_G310_T1.0061.00
193_L211_V1.0011.00
55_D58_Q1.0011.00
60_A245_L1.0001.00
81_H107_L1.0001.00
374_A377_E0.9951.00
38_F316_G0.9921.00
263_V275_L0.9851.00
236_F240_L0.9811.00
177_L293_Q0.9781.00
256_Q260_Q0.9721.00
143_V172_V0.9641.00
349_A352_A0.9621.00
125_G285_G0.9611.00
265_Y380_F0.9601.00
49_R227_N0.9571.00
88_L92_D0.9561.00
82_L225_W0.9541.00
156_I189_A0.9541.00
80_I193_L0.9531.00
310_T358_T0.9521.00
314_F360_L0.9511.00
286_H289_A0.9481.00
73_T226_A0.9461.00
314_F334_I0.9461.00
276_Y303_E0.9461.00
217_D222_L0.9451.00
69_G223_A0.9431.00
283_N286_H0.9431.00
314_F376_L0.9391.00
77_M80_I0.9341.00
204_S329_G0.9341.00
309_Q313_R0.9341.00
249_V254_L0.9321.00
66_G183_N0.9301.00
54_R233_G0.9291.00
375_D378_N0.9281.00
201_N241_L0.9261.00
21_G36_T0.9261.00
105_Y109_D0.9251.00
75_T207_V0.9251.00
120_L133_A0.9251.00
185_L192_V0.9231.00
271_L305_D0.9171.00
124_Q130_L0.9151.00
10_V366_I0.9151.00
96_A121_F0.9151.00
179_P194_H0.9141.00
302_F362_I0.9121.00
338_A350_R0.9101.00
143_V154_V0.9081.00
262_I362_I0.9061.00
142_L171_V0.9021.00
191_L213_A0.9021.00
156_I160_C0.9001.00
99_D152_R0.8951.00
321_F362_I0.8901.00
69_G216_P0.8881.00
72_L210_V0.8781.00
176_F299_M0.8761.00
163_A168_A0.8751.00
96_A119_V0.8741.00
27_I236_F0.8731.00
123_D129_A0.8651.00
197_T207_V0.8651.00
266_L302_F0.8641.00
269_Q380_F0.8631.00
180_A253_E0.8621.00
156_I182_Q0.8601.00
259_A277_H0.8601.00
218_V222_L0.8591.00
54_R72_L0.8581.00
47_S54_R0.8561.00
264_K280_L0.8541.00
159_I170_S0.8491.00
218_V221_E0.8491.00
15_N59_R0.8461.00
68_A213_A0.8451.00
315_L334_I0.8441.00
378_N382_A0.8401.00
271_L380_F0.8391.00
71_V222_L0.8331.00
246_R331_E0.8321.00
260_Q295_G0.8311.00
153_V285_G0.8301.00
6_A254_L0.8281.00
146_P182_Q0.8281.00
370_E374_A0.8271.00
317_G379_G0.8271.00
113_K118_R0.8221.00
312_R316_G0.8201.00
87_F218_V0.8201.00
196_C233_G0.8171.00
162_L166_V0.8151.00
140_L169_V0.8141.00
191_L211_V0.8141.00
143_V159_I0.8121.00
156_I187_L0.8111.00
127_E131_R0.8071.00
180_A252_M0.8051.00
81_H229_I0.8041.00
25_P242_L0.8031.00
260_Q277_H0.7981.00
95_V122_V0.7951.00
274_K358_T0.7951.00
220_T223_A0.7931.00
309_Q312_R0.7921.00
142_L193_L0.7901.00
321_F334_I0.7901.00
8_I12_S0.7880.99
88_L140_L0.7870.99
27_I239_Y0.7860.99
182_Q292_Q0.7860.99
153_V288_I0.7840.99
249_V368_D0.7840.99
83_V193_L0.7800.99
271_L310_T0.7760.99
94_L140_L0.7710.99
258_N262_I0.7710.99
269_Q381_R0.7700.99
68_A214_K0.7690.99
73_T78_S0.7680.99
310_T313_R0.7660.99
260_Q267_Q0.7660.99
300_L362_I0.7650.99
83_V87_F0.7650.99
88_L117_Y0.7640.99
69_G215_D0.7610.99
200_L241_L0.7590.99
114_R221_E0.7580.99
191_L218_V0.7560.99
190_D214_K0.7540.99
69_G213_A0.7540.99
261_A265_Y0.7530.99
7_T320_L0.7520.99
258_N364_T0.7460.99
265_Y376_L0.7440.99
17_D20_Y0.7430.99
257_R369_G0.7420.99
264_K268_T0.7400.99
370_E373_I0.7400.99
22_C28_H0.7310.99
124_Q154_V0.7300.99
146_P292_Q0.7280.99
181_L252_M0.7270.99
89_K139_K0.7240.99
194_H212_I0.7230.99
233_G241_L0.7210.99
94_L108_F0.7190.99
57_V196_C0.7190.99
122_V129_A0.7180.99
315_L360_L0.7180.99
147_S152_R0.7180.99
85_T115_G0.7160.99
332_S362_I0.7160.99
347_P350_R0.7130.99
276_Y283_N0.7130.99
5_Q8_I0.7130.99
155_D291_R0.7100.99
110_S224_W0.7090.99
129_A133_A0.7080.99
164_R168_A0.7050.99
104_S142_L0.7040.99
321_F364_T0.6990.99
174_N184_P0.6980.99
95_V138_P0.6960.99
256_Q298_A0.6960.99
217_D223_A0.6940.99
127_E130_L0.6920.99
74_N231_V0.6910.99
88_L139_K0.6880.99
314_F318_L0.6880.99
93_L136_E0.6880.99
29_L206_V0.6840.99
61_L72_L0.6810.99
92_D137_K0.6810.99
57_V200_L0.6800.99
272_V302_F0.6790.98
240_L243_R0.6790.98
200_L248_L0.6790.98
82_L211_V0.6780.98
152_R285_G0.6780.98
61_L196_C0.6770.98
277_H300_L0.6760.98
306_G309_Q0.6750.98
236_F239_Y0.6750.98
260_Q279_S0.6730.98
218_V223_A0.6730.98
45_D49_R0.6720.98
271_L381_R0.6690.98
153_V289_A0.6680.98
147_S150_L0.6660.98
262_I265_Y0.6640.98
293_Q296_F0.6600.98
187_L292_Q0.6590.98
50_G55_D0.6570.98
65_E192_V0.6560.98
72_L233_G0.6550.98
181_L294_K0.6550.98
120_L137_K0.6530.98
219_V223_A0.6460.98
313_R316_G0.6450.98
374_A378_N0.6450.98
272_V380_F0.6440.98
108_F142_L0.6440.98
158_K162_L0.6430.98
257_R295_G0.6430.98
131_R158_K0.6380.98
174_N194_H0.6380.98
29_L239_Y0.6370.98
24_V239_Y0.6370.98
379_G382_A0.6360.98
302_F360_L0.6340.98
271_L304_L0.6340.98
86_V222_L0.6330.98
171_V191_L0.6330.98
145_S174_N0.6320.98
276_Y301_S0.6310.98
87_F171_V0.6310.98
59_R63_E0.6270.97
125_G152_R0.6250.97
256_Q296_F0.6250.97
122_V130_L0.6250.97
73_T231_V0.6250.97
153_V283_N0.6240.97
314_F380_F0.6230.97
156_I170_S0.6210.97
74_N232_T0.6200.97
174_N177_L0.6200.97
130_L141_V0.6180.97
90_P116_C0.6180.97
94_L119_V0.6170.97
141_V164_R0.6160.97
126_D132_A0.6130.97
5_Q9_A0.6120.97
71_V211_V0.6120.97
263_V300_L0.6090.97
351_A356_S0.6050.97
30_S33_Y0.6050.97
58_Q72_L0.6040.97
56_V242_L0.6040.97
179_P200_L0.6030.97
32_T326_S0.6030.97
141_V162_L0.6020.97
334_I362_I0.6000.97
376_L380_F0.5990.97
99_D147_S0.5990.97
75_T232_T0.5970.97
80_I104_S0.5970.97
20_Y28_H0.5940.97
314_F379_G0.5940.97
348_E352_A0.5890.96
332_S372_L0.5890.96
177_L289_A0.5890.96
313_R382_A0.5880.96
317_G378_N0.5880.96
338_A357_E0.5880.96
8_I66_G0.5870.96
199_Y299_M0.5850.96
311_L358_T0.5850.96
97_P124_Q0.5840.96
318_L321_F0.5830.96
303_E359_L0.5830.96
55_D69_G0.5820.96
288_I292_Q0.5820.96
279_S286_H0.5810.96
305_D310_T0.5790.96
233_G237_D0.5790.96
325_E335_S0.5760.96
32_T324_A0.5740.96
58_Q70_A0.5720.96
163_A166_V0.5710.96
57_V242_L0.5700.96
146_P177_L0.5700.96
207_V232_T0.5690.96
206_V244_G0.5670.95
109_D349_A0.5670.95
68_A219_V0.5670.95
23_V34_N0.5650.95
5_Q249_V0.5640.95
288_I291_R0.5640.95
98_H123_D0.5640.95
194_H210_V0.5640.95
267_Q283_N0.5630.95
134_L138_P0.5620.95
82_L229_I0.5620.95
29_L234_G0.5600.95
156_I172_V0.5600.95
255_A258_N0.5580.95
105_Y121_F0.5580.95
36_T42_R0.5570.95
95_V124_Q0.5570.95
106_R110_S0.5570.95
299_M327_L0.5560.95
132_A136_E0.5530.95
246_R330_V0.5530.95
62_A69_G0.5510.95
348_E351_A0.5510.95
268_T377_E0.5500.95
304_L380_F0.5470.95
85_T229_I0.5450.94
351_A357_E0.5440.94
157_A186_A0.5420.94
332_S376_L0.5410.94
213_A218_V0.5410.94
11_R322_T0.5400.94
260_Q280_L0.5390.94
135_A138_P0.5370.94
83_V140_L0.5370.94
111_L228_N0.5360.94
263_V279_S0.5360.94
86_V225_W0.5350.94
145_S182_Q0.5340.94
120_L136_E0.5340.94
111_L229_I0.5330.94
319_S382_A0.5330.94
324_A333_L0.5310.94
253_E256_Q0.5300.94
123_D126_D0.5290.94
4_K8_I0.5280.93
280_L286_H0.5280.93
164_R167_G0.5280.93
203_H243_R0.5270.93
71_V226_A0.5270.93
334_I376_L0.5240.93
177_L182_Q0.5240.93
312_R339_T0.5240.93
114_R224_W0.5230.93
162_L165_E0.5230.93
38_F312_R0.5220.93
102_G342_H0.5210.93
226_A232_T0.5190.93
180_A249_V0.5180.93
151_L301_S0.5170.93
345_M349_A0.5150.93
311_L336_H0.5140.93
154_V288_I0.5130.92
258_N261_A0.5120.92
17_D22_C0.5120.92
20_Y44_H0.5110.92
95_V120_L0.5090.92
95_V141_V0.5090.92
346_A350_R0.5090.92
59_R62_A0.5090.92
51_N54_R0.5080.92
256_Q259_A0.5080.92
335_S340_M0.5060.92
199_Y255_A0.5060.92
18_E28_H0.5040.92
53_T242_L0.5040.92
345_M353_A0.5040.92
15_N18_E0.5020.92
319_S375_D0.5010.92
112_A117_Y0.5010.92
220_T224_W0.5000.91
273_K304_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ibjA 4 0.9845 100 0.383 Contact Map
1qgnA 4 0.9896 100 0.399 Contact Map
3cogA 4 0.9974 100 0.424 Contact Map
3ri6A 4 0.8601 100 0.427 Contact Map
4iy7A 4 0.9819 100 0.433 Contact Map
4kamA 4 0.9197 100 0.443 Contact Map
4itxA 4 0.9819 100 0.452 Contact Map
1e5eA 4 0.9845 100 0.46 Contact Map
3ndnA 4 0.9819 100 0.48 Contact Map
4oc9A 5 0.9819 100 0.485 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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