GREMLIN Database
THRC - Threonine synthase
UniProt: P00934 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11000
Length: 428 (418)
Sequences: 2567 (1588)
Seq/√Len: 77.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_A360_A4.0321.00
240_Q267_K3.9471.00
68_P120_H3.5491.00
341_R344_K3.5221.00
332_D335_T3.3591.00
78_A116_Q3.3561.00
227_F264_L3.3431.00
50_D53_T3.2521.00
126_P152_K3.1861.00
359_R363_D3.1451.00
342_E345_E3.1161.00
56_A73_E2.9571.00
298_S336_T2.9081.00
56_A76_V2.7451.00
60_S69_Q2.7181.00
183_D414_P2.6611.00
84_A109_F2.6071.00
159_R183_D2.5771.00
280_P328_Y2.5561.00
68_P71_I2.5121.00
256_G374_L2.4931.00
157_Y179_T2.4751.00
320_I324_K2.4131.00
350_S358_Y2.3791.00
14_S17_Q2.3311.00
39_S42_E2.3201.00
88_N94_G2.3031.00
164_P167_E2.2881.00
125_K207_G2.2511.00
337_Q388_A2.2181.00
297_L333_D2.2171.00
361_L371_G2.2171.00
49_L57_K2.2081.00
71_I120_H2.1461.00
387_E393_T2.1211.00
253_L271_A2.0901.00
243_V266_V2.0741.00
152_K178_E2.0661.00
342_E362_R2.0611.00
56_A69_Q2.0501.00
242_V267_K2.0451.00
12_Q33_H2.0261.00
335_T363_D2.0261.00
244_S371_G1.9141.00
185_D188_A1.9061.00
223_I258_L1.8881.00
275_V333_D1.8661.00
54_R228_E1.8631.00
182_I189_C1.8441.00
8_D11_E1.8421.00
94_G370_Y1.8341.00
192_L420_L1.8261.00
180_V413_L1.8191.00
113_F117_M1.8161.00
49_L54_R1.8031.00
241_L372_L1.7901.00
129_I145_F1.7831.00
2_K33_H1.7811.00
343_L350_S1.7791.00
354_A375_G1.7781.00
315_L319_K1.7761.00
244_S270_I1.7491.00
287_Q314_E1.7411.00
243_V372_L1.7401.00
147_G175_G1.7291.00
268_R327_G1.7191.00
95_C348_Y1.7161.00
228_E232_Q1.7131.00
402_E406_L1.7111.00
260_K266_V1.7011.00
270_I371_G1.6961.00
277_D281_R1.6881.00
79_A116_Q1.6741.00
280_P284_H1.6721.00
67_I71_I1.6661.00
329_A363_D1.6661.00
72_L76_V1.6461.00
297_L337_Q1.6411.00
416_D419_A1.6361.00
297_L336_T1.6351.00
339_T358_Y1.6331.00
54_R231_A1.6091.00
275_V294_Q1.6011.00
191_A195_Q1.5941.00
199_D421_R1.5931.00
56_A60_S1.5921.00
44_D237_T1.5921.00
86_V372_L1.5861.00
94_G233_L1.5851.00
243_V256_G1.5801.00
316_F319_K1.5770.99
173_L406_L1.5700.99
74_E78_A1.5690.99
267_K369_E1.5620.99
67_I120_H1.5590.99
350_S354_A1.5590.99
277_D330_A1.5540.99
184_G188_A1.5530.99
243_V374_L1.5380.99
253_L269_F1.5380.99
21_Q25_K1.5260.99
167_E408_L1.5230.99
331_V359_R1.5200.99
45_E57_K1.5170.99
7_K310_P1.4900.99
21_Q30_F1.4850.99
143_H146_Y1.4790.99
128_T154_V1.4650.99
87_A348_Y1.4640.99
47_L234_P1.4600.99
48_K235_Q1.4570.99
336_T356_V1.4570.99
159_R412_N1.4470.99
42_E61_A1.4390.99
69_Q73_E1.4260.99
42_E46_M1.4210.99
92_D368_G1.4180.99
322_Q325_E1.4070.99
67_I121_I1.3930.99
191_A305_Q1.3840.99
183_D412_N1.3830.99
88_N91_S1.3790.99
97_E100_H1.3630.99
10_N30_F1.3510.98
398_K402_E1.3510.98
16_A121_I1.3430.98
59_L113_F1.3330.98
317_R321_W1.3250.98
96_L229_A1.3170.98
229_A372_L1.3130.98
339_T362_R1.2980.98
333_D336_T1.2940.98
52_V77_R1.2890.98
339_T359_R1.2860.98
86_V233_L1.2790.98
337_Q389_I1.2790.98
334_E338_Q1.2770.98
57_K61_A1.2730.98
343_L358_Y1.2650.98
275_V296_T1.2600.97
398_K401_A1.2560.97
19_V121_I1.2530.97
349_T390_L1.2520.97
273_T280_P1.2490.97
403_R406_L1.2410.97
154_V180_V1.2380.97
57_K69_Q1.2260.97
15_F63_I1.2210.97
335_T359_R1.2150.97
116_Q148_L1.2150.97
17_Q21_Q1.2130.97
42_E57_K1.2050.97
153_V177_I1.2030.97
293_T304_S1.1990.97
52_V76_V1.1970.97
75_R120_H1.1960.97
244_S252_D1.1830.96
232_Q235_Q1.1810.96
242_V371_G1.1790.96
8_D12_Q1.1760.96
93_V373_F1.1640.96
5_N26_N1.1540.96
254_T258_L1.1530.96
230_V234_P1.1500.96
159_R167_E1.1470.96
242_V369_E1.1380.95
122_A127_V1.1380.95
47_L237_T1.1370.95
182_I413_L1.1350.95
419_A422_K1.1320.95
33_H37_E1.1320.95
89_V95_C1.1320.95
196_A421_R1.1270.95
36_P262_L1.1260.95
352_P385_S1.1230.95
201_E204_V1.1230.95
46_M49_L1.1220.95
252_D374_L1.1200.95
357_A373_F1.1170.95
9_H12_Q1.1170.95
126_P150_N1.1160.95
252_D256_G1.1140.95
70_E74_E1.1130.95
90_E345_E1.1120.95
418_A421_R1.1010.95
335_T338_Q1.0900.94
25_K30_F1.0890.94
73_E77_R1.0780.94
164_P168_K1.0760.94
111_G144_A1.0720.94
40_L44_D1.0670.94
290_P305_Q1.0660.94
200_E203_K1.0610.93
146_Y174_G1.0610.93
186_F190_Q1.0590.93
130_L196_A1.0580.93
51_F224_C1.0570.93
13_V18_A1.0540.93
361_L373_F1.0500.93
11_E30_F1.0470.93
364_Q369_E1.0430.93
129_I209_N1.0410.93
281_R291_K1.0400.93
4_Y33_H1.0360.93
44_D47_L1.0360.93
90_E362_R1.0330.92
230_V264_L1.0260.92
414_P419_A1.0230.92
62_F220_L1.0200.92
124_D150_N1.0200.92
38_F46_M1.0150.92
298_S356_V1.0140.92
233_L372_L1.0130.92
43_I227_F1.0120.92
42_E45_E1.0090.92
89_V343_L1.0050.91
62_F262_L1.0010.91
192_L417_F0.9990.91
200_E204_V0.9970.91
257_L326_L0.9970.91
119_T149_P0.9950.91
418_A422_K0.9950.91
145_F153_V0.9820.90
338_Q341_R0.9810.90
402_E405_D0.9790.90
13_V30_F0.9760.90
275_V332_D0.9760.90
3_L62_F0.9680.90
154_V178_E0.9670.90
331_V356_V0.9650.90
55_S224_C0.9550.89
273_T328_Y0.9550.89
131_T155_I0.9540.89
32_P62_F0.9510.89
84_A96_L0.9500.89
277_D280_P0.9470.89
53_T57_K0.9460.89
31_F258_L0.9460.89
88_N92_D0.9450.89
53_T73_E0.9390.88
2_K14_S0.9370.88
364_Q367_P0.9360.88
102_P112_R0.9340.88
35_L62_F0.9330.88
415_A419_A0.9280.88
84_A228_E0.9230.87
95_C350_S0.9200.87
234_P237_T0.9180.87
54_R58_I0.9130.87
35_L258_L0.9100.87
56_A77_R0.9060.86
417_F421_R0.9040.86
57_K60_S0.9040.86
90_E93_V0.9010.86
56_A72_L0.9000.86
37_E261_S0.8990.86
338_Q342_E0.8980.86
2_K12_Q0.8980.86
327_G364_Q0.8970.86
202_L208_L0.8920.86
58_I227_F0.8880.85
4_Y12_Q0.8870.85
25_K204_V0.8870.85
93_V365_L0.8850.85
123_G150_N0.8830.85
38_F42_E0.8820.85
39_S43_I0.8810.85
281_R285_D0.8780.85
194_K214_I0.8770.85
312_V326_L0.8740.84
99_F375_G0.8740.84
53_T77_R0.8740.84
122_A150_N0.8700.84
95_C358_Y0.8690.84
71_I74_E0.8640.84
148_L151_V0.8620.84
234_P238_R0.8620.84
134_S194_K0.8620.84
160_G167_E0.8600.83
32_P36_P0.8590.83
220_L223_I0.8560.83
171_C408_L0.8490.83
286_G320_I0.8490.83
190_Q225_Y0.8470.82
267_K366_N0.8450.82
196_A208_L0.8440.82
366_N369_E0.8310.81
297_L385_S0.8310.81
46_M54_R0.8300.81
74_E120_H0.8290.81
229_A243_V0.8290.81
358_Y362_R0.8170.80
7_K27_Q0.8160.80
53_T318_R0.8150.80
334_E337_Q0.8130.80
167_E171_C0.8120.80
128_T152_K0.8110.80
86_V96_L0.8090.80
37_E262_L0.8080.79
399_E406_L0.8070.79
190_Q194_K0.8040.79
254_T257_L0.8020.79
243_V252_D0.8020.79
3_L216_I0.8000.79
244_S373_F0.7990.79
186_F249_N0.7990.79
133_T138_G0.7980.79
321_W324_K0.7970.78
241_L266_V0.7970.78
167_E220_L0.7960.78
241_L267_K0.7950.78
27_Q310_P0.7920.78
396_L404_A0.7920.78
74_E77_R0.7890.78
146_Y175_G0.7890.78
195_Q417_F0.7840.77
225_Y249_N0.7810.77
401_A404_A0.7800.77
339_T343_L0.7780.77
119_T148_L0.7770.77
161_K295_A0.7720.76
272_A360_A0.7710.76
8_D13_V0.7700.76
249_N307_N0.7660.76
278_T281_R0.7650.76
159_R181_A0.7630.75
242_V367_P0.7630.75
256_G269_F0.7530.74
52_V94_G0.7510.74
199_D202_L0.7500.74
281_R289_S0.7480.74
94_G372_L0.7410.73
11_E25_K0.7410.73
112_R216_I0.7400.73
157_Y167_E0.7380.73
212_N218_R0.7360.73
54_R232_Q0.7350.73
358_Y373_F0.7340.73
92_D365_L0.7330.72
111_G282_F0.7310.72
168_K408_L0.7310.72
190_Q307_N0.7270.72
67_I72_L0.7230.71
272_A340_M0.7230.71
59_L63_I0.7230.71
244_S361_L0.7220.71
185_D293_T0.7210.71
89_V346_L0.7200.71
104_L400_L0.7190.71
411_H418_A0.7190.71
194_K225_Y0.7180.71
334_E388_A0.7180.71
395_D398_K0.7180.71
242_V270_I0.7140.70
180_V412_N0.7140.70
113_F221_A0.7070.70
164_P384_E0.7050.70
52_V56_A0.7040.69
345_E393_T0.7030.69
51_F55_S0.7010.69
283_L323_L0.7000.69
316_F323_L0.6990.69
192_L195_Q0.6980.69
391_G394_L0.6970.69
116_Q119_T0.6950.68
197_F208_L0.6940.68
225_Y307_N0.6940.68
153_V179_T0.6900.68
186_F225_Y0.6870.68
189_C192_L0.6870.68
38_F227_F0.6870.68
318_R321_W0.6860.67
131_T210_S0.6850.67
343_L346_L0.6840.67
190_Q249_N0.6840.67
186_F194_K0.6810.67
97_E348_Y0.6800.67
115_A145_F0.6800.67
13_V21_Q0.6800.67
397_P406_L0.6790.67
244_S272_A0.6790.67
164_P404_A0.6770.66
131_T216_I0.6770.66
5_N24_G0.6750.66
34_D37_E0.6750.66
6_L310_P0.6740.66
42_E58_I0.6740.66
139_A300_A0.6730.66
331_V336_T0.6730.66
134_S307_N0.6730.66
83_P399_E0.6730.66
181_A410_S0.6720.66
349_T386_V0.6720.66
46_M57_K0.6710.66
216_I219_L0.6710.66
73_E76_V0.6710.66
247_S252_D0.6670.65
153_V157_Y0.6650.65
331_V360_A0.6640.65
339_T350_S0.6640.65
401_A405_D0.6640.65
104_L399_E0.6630.65
271_A279_V0.6620.65
141_V299_N0.6610.65
18_A216_I0.6610.65
173_L409_L0.6600.64
245_V256_G0.6590.64
132_A186_F0.6590.64
216_I228_E0.6570.64
89_V93_V0.6550.64
24_G30_F0.6530.64
19_V67_I0.6520.63
187_D194_K0.6510.63
392_E395_D0.6500.63
227_F231_A0.6500.63
8_D24_G0.6490.63
111_G210_S0.6440.63
268_R369_E0.6420.62
75_R78_A0.6420.62
8_D26_N0.6410.62
47_L54_R0.6390.62
25_K200_E0.6370.62
96_L374_L0.6370.62
228_E231_A0.6370.62
385_S389_I0.6350.61
283_L324_K0.6350.61
387_E391_G0.6350.61
47_L231_A0.6340.61
350_S375_G0.6330.61
50_D73_E0.6320.61
186_F189_C0.6320.61
19_V144_A0.6310.61
132_A190_Q0.6290.61
144_A162_I0.6280.61
324_K342_E0.6270.60
122_A216_I0.6270.60
45_E48_K0.6270.60
417_F420_L0.6260.60
74_E205_A0.6250.60
76_V79_A0.6220.60
278_T304_S0.6200.60
273_T306_P0.6190.60
93_V362_R0.6190.60
84_A229_A0.6180.59
59_L220_L0.6160.59
242_V361_L0.6140.59
223_I300_A0.6140.59
244_S360_A0.6140.59
118_L127_V0.6140.59
38_F61_A0.6130.59
339_T342_E0.6130.59
75_R79_A0.6120.59
146_Y173_L0.6100.58
227_F256_G0.6090.58
266_V370_Y0.6090.58
245_V269_F0.6090.58
353_H377_A0.6080.58
187_D190_Q0.6070.58
57_K73_E0.6070.58
407_P411_H0.6060.58
307_N310_P0.6050.58
166_Q382_F0.6040.58
253_L326_L0.6030.58
194_K307_N0.6030.58
250_F273_T0.6020.57
23_L198_D0.6020.57
411_H415_A0.6020.57
137_T213_S0.5990.57
105_A134_S0.5990.57
143_H149_P0.5980.57
165_L383_K0.5970.57
338_Q392_E0.5960.57
218_R249_N0.5960.57
106_F251_G0.5950.57
53_T56_A0.5940.56
99_F378_H0.5940.56
182_I192_L0.5930.56
377_A382_F0.5890.56
211_A221_A0.5890.56
196_A417_F0.5890.56
407_P410_S0.5880.56
183_D415_A0.5880.56
331_V363_D0.5870.56
175_G409_L0.5870.56
157_Y171_C0.5860.55
122_A151_V0.5860.55
30_F52_V0.5860.55
262_L265_P0.5860.55
315_L320_I0.5850.55
343_L362_R0.5850.55
6_L31_F0.5840.55
285_D289_S0.5840.55
269_F328_Y0.5830.55
351_E375_G0.5820.55
75_R113_F0.5810.55
142_A177_I0.5800.55
134_S137_T0.5780.54
54_R227_F0.5770.54
20_T122_A0.5760.54
323_L410_S0.5760.54
105_A301_M0.5750.54
166_Q353_H0.5730.54
134_S190_Q0.5730.54
340_M386_V0.5710.53
188_A415_A0.5700.53
121_I219_L0.5700.53
175_G325_E0.5700.53
114_M351_E0.5690.53
129_I151_V0.5690.53
299_N303_V0.5680.53
252_D288_W0.5670.53
241_L370_Y0.5660.53
57_K347_G0.5660.53
194_K249_N0.5650.53
194_K301_M0.5630.52
137_T187_D0.5630.52
321_W325_E0.5620.52
59_L224_C0.5610.52
242_V364_Q0.5580.52
106_F134_S0.5570.52
253_L300_A0.5570.52
257_L260_K0.5560.52
342_E358_Y0.5560.52
139_A143_H0.5560.52
113_F189_C0.5540.51
163_S225_Y0.5530.51
119_T122_A0.5530.51
257_L312_V0.5520.51
233_L237_T0.5520.51
109_F273_T0.5520.51
387_E392_E0.5490.51
40_L43_I0.5490.51
214_I307_N0.5480.51
36_P61_A0.5470.50
415_A418_A0.5470.50
93_V361_L0.5460.50
346_L349_T0.5460.50
229_A232_Q0.5450.50
139_A179_T0.5450.50
3_L109_F0.5440.50
3_L25_K0.5430.50
275_V297_L0.5430.50
314_E317_R0.5430.50
363_D421_R0.5400.50
173_L407_P0.5400.50
201_E205_A0.5390.49
214_I225_Y0.5390.49
70_E73_E0.5380.49
134_S382_F0.5380.49
127_V209_N0.5380.49
364_Q371_G0.5370.49
168_K172_T0.5360.49
124_D406_L0.5360.49
37_E123_G0.5350.49
144_A148_L0.5350.49
147_G174_G0.5340.49
299_N306_P0.5340.49
250_F272_A0.5340.49
106_F187_D0.5330.49
122_A389_I0.5330.49
111_G145_F0.5320.49
4_Y8_D0.5320.49
95_C354_A0.5320.49
276_N353_H0.5320.49
398_K405_D0.5310.48
281_R293_T0.5310.48
35_L262_L0.5300.48
113_F121_I0.5300.48
136_D166_Q0.5280.48
75_R116_Q0.5280.48
170_F303_V0.5270.48
190_Q193_V0.5270.48
212_N249_N0.5270.48
132_A225_Y0.5270.48
87_A198_D0.5260.48
121_I300_A0.5260.48
144_A348_Y0.5260.48
99_F349_T0.5250.48
67_I117_M0.5250.48
278_T306_P0.5250.48
114_M217_S0.5220.47
304_S390_L0.5220.47
134_S225_Y0.5220.47
204_V407_P0.5210.47
115_A139_A0.5200.47
112_R131_T0.5200.47
411_H414_P0.5200.47
4_Y25_K0.5200.47
214_I226_Y0.5190.47
325_E407_P0.5180.47
396_L399_E0.5180.47
15_F67_I0.5170.47
136_D301_M0.5170.47
320_I323_L0.5170.47
134_S377_A0.5160.46
254_T306_P0.5160.46
123_G149_P0.5160.46
84_A231_A0.5150.46
106_F225_Y0.5140.46
204_V207_G0.5140.46
270_I364_Q0.5120.46
282_F315_L0.5120.46
209_N221_A0.5120.46
88_N370_Y0.5110.46
413_L419_A0.5110.46
74_E116_Q0.5110.46
240_Q370_Y0.5100.46
187_D212_N0.5100.46
71_I123_G0.5100.46
214_I249_N0.5090.46
254_T279_V0.5090.46
163_S214_I0.5080.45
134_S214_I0.5080.45
357_A375_G0.5060.45
120_H123_G0.5060.45
186_F193_V0.5050.45
87_A99_F0.5050.45
10_N123_G0.5050.45
284_H324_K0.5050.45
34_D314_E0.5040.45
413_L420_L0.5040.45
77_R368_G0.5020.45
43_I237_T0.5010.45
387_E390_L0.5010.45
384_E393_T0.5010.45
51_F109_F0.5010.45
288_W376_T0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kl7A 1 0.9953 100 0.216 Contact Map
3v7nA 1 0.9603 100 0.232 Contact Map
1vb3A 1 1 100 0.235 Contact Map
4f4fA 1 0.9977 100 0.238 Contact Map
1e5xA 2 0.8808 100 0.472 Contact Map
4qysB 2 0.8364 100 0.541 Contact Map
3iauA 1 0.8154 100 0.551 Contact Map
2o2eA 2 0.6916 100 0.553 Contact Map
1x1qA 2 0.8201 100 0.556 Contact Map
4negA 2 0.7126 100 0.562 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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