GREMLIN Database
SDHD - D-serine dehydratase
UniProt: P00926 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10249
Length: 442 (335)
Sequences: 3360 (1816)
Seq/√Len: 99.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
255_L420_L4.6071.00
300_H359_G4.3931.00
179_S186_V4.3781.00
189_H226_A3.7061.00
367_T396_R3.5101.00
83_A102_Q3.4741.00
273_F302_F3.3841.00
196_A200_A3.1401.00
81_L420_L3.0771.00
53_H246_L2.9061.00
269_D418_T2.8631.00
274_V287_V2.8601.00
191_S195_R2.7171.00
249_S253_Q2.5981.00
83_A88_Q2.5851.00
185_K208_T2.5741.00
234_F285_G2.5621.00
90_R374_W2.5331.00
102_Q263_G2.5011.00
287_V422_W2.4291.00
187_T208_T2.3711.00
222_E225_K2.3631.00
73_T262_Q2.2671.00
273_F300_H2.2151.00
187_T210_V2.2061.00
162_S185_K2.1311.00
414_L417_T2.0991.00
126_V163_I2.0951.00
252_G290_G2.0321.00
83_A104_L2.0311.00
165_V188_V1.9971.00
232_N236_I1.9901.00
162_S187_T1.9821.00
259_F420_L1.9641.00
105_L375_L1.9291.00
307_T364_S1.9241.00
85_P89_K1.9231.00
86_A89_K1.9201.00
56_L131_E1.8931.00
274_V301_C1.8581.00
255_L287_V1.8561.00
257_A261_Q1.8321.00
239_E242_R1.8191.00
287_V301_C1.8161.00
162_S226_A1.8081.00
226_A230_D1.8011.00
214_Q217_G1.7881.00
391_M421_V1.7821.00
387_A423_A1.7641.00
401_V417_T1.7571.00
87_M391_M1.7241.00
336_A369_Y1.7121.00
232_N235_F1.7061.00
69_E73_T1.6881.00
102_Q418_T1.6861.00
225_K229_S1.6851.00
304_A393_G1.6691.00
316_V353_M1.6581.00
387_A424_T1.6361.00
251_A422_W1.6101.00
192_A213_E1.5981.00
114_S177_I1.5851.00
364_S367_T1.5711.00
304_A361_Y1.5701.00
302_F359_G1.5661.00
203_R208_T1.5511.00
372_L388_L1.5491.00
91_L395_Q1.5481.00
252_G287_V1.5391.00
62_Y66_A1.5301.00
79_S112_P1.5171.00
52_A55_R1.5051.00
326_V330_G1.5011.00
374_W395_Q1.4951.00
259_F418_T1.4911.00
316_V360_F1.4871.00
326_V331_I1.4871.00
310_P318_T1.4741.00
272_L417_T1.4721.00
292_K358_D1.4711.00
310_P314_L1.4691.00
392_A396_R1.4661.00
361_Y393_G1.4491.00
164_A233_C1.4441.00
167_S172_G1.4251.00
63_L66_A1.4241.00
194_A211_E1.3880.99
93_K101_G1.3830.99
274_V291_L1.3720.99
52_A61_P1.3670.99
351_R355_R1.3670.99
397_V400_S1.3660.99
82_V107_K1.3600.99
394_P421_V1.3330.99
371_M392_A1.3320.99
130_A184_F1.3230.99
433_E436_Q1.3140.99
275_Y302_F1.3130.99
163_I179_S1.3040.99
60_A64_A1.2960.99
85_P88_Q1.2950.99
383_L388_L1.2840.99
215_D218_V1.2740.99
321_H324_I1.2700.99
128_A243_T1.2700.99
276_L283_G1.2660.99
303_F360_F1.2660.99
104_L263_G1.2630.99
259_F263_G1.2620.99
273_F401_V1.2520.99
70_T182_I1.2520.99
199_K209_V1.2320.99
273_F419_H1.2290.99
191_S214_Q1.2290.99
90_R378_E1.2200.99
401_V414_L1.2130.99
84_I87_M1.2120.99
255_L422_W1.2050.99
390_G421_V1.1980.98
256_K260_A1.1950.98
78_E257_A1.1940.98
376_A382_R1.1940.98
51_D55_R1.1940.98
275_Y394_P1.1930.98
220_V235_F1.1910.98
191_S194_A1.1910.98
263_G418_T1.1880.98
373_G377_Q1.1870.98
221_E225_K1.1810.98
200_A204_S1.1780.98
60_A63_L1.1730.98
91_L399_A1.1620.98
166_G223_G1.1600.98
252_G291_L1.1590.98
225_K228_Q1.1570.98
75_G112_P1.1310.98
363_L392_A1.1250.98
371_M391_M1.1210.98
93_K103_L1.1130.98
164_A226_A1.1100.97
114_S119_A1.1070.97
54_A58_R1.0960.97
396_R399_A1.0950.97
91_L394_P1.0910.97
367_T392_A1.0840.97
50_Q54_A1.0720.97
177_I205_H1.0720.97
366_Q370_D1.0710.97
82_V109_S1.0670.97
369_Y385_P1.0660.97
278_C303_F1.0640.97
102_Q416_N1.0630.97
383_L387_A1.0620.97
263_G269_D1.0610.97
87_M374_W1.0600.97
393_G397_V1.0490.96
226_A229_S1.0470.96
191_S213_E1.0460.96
194_A203_R1.0350.96
104_L259_F1.0330.96
302_F397_V1.0280.96
375_L391_M1.0260.96
387_A390_G1.0240.96
288_A301_C1.0130.96
201_K205_H1.0120.96
275_Y304_A1.0090.96
396_R400_S1.0050.95
308_H332_D1.0000.95
349_V360_F0.9940.95
87_M103_L0.9930.95
273_F417_T0.9880.95
259_F268_A0.9880.95
117_I283_G0.9870.95
222_E226_A0.9840.95
192_A214_Q0.9780.95
273_F414_L0.9780.95
249_S290_G0.9530.94
91_L374_W0.9490.94
350_G353_M0.9360.93
47_Q50_Q0.9340.93
173_L201_K0.9340.93
56_L59_F0.9320.93
431_E435_N0.9320.93
270_N299_V0.9320.93
53_H57_S0.9320.93
192_A195_R0.9310.93
160_Q234_F0.9290.93
432_E436_Q0.9260.93
275_Y393_G0.9210.93
93_K398_C0.9180.93
214_Q218_V0.9160.93
88_Q101_G0.9130.93
220_V224_R0.9100.92
47_Q51_D0.9070.92
75_G79_S0.9050.92
57_S246_L0.9040.92
300_H358_D0.9000.92
104_L418_T0.9000.92
49_V293_L0.8890.92
126_V182_I0.8890.92
432_E435_N0.8880.91
255_L291_L0.8840.91
363_L396_R0.8810.91
70_T181_R0.8780.91
218_V221_E0.8770.91
259_F269_D0.8710.91
201_K382_R0.8700.91
130_A182_I0.8610.90
318_T321_H0.8590.90
373_G434_M0.8520.90
85_P181_R0.8510.90
382_R434_M0.8500.90
256_K296_G0.8500.90
54_A242_R0.8480.89
320_L324_I0.8450.89
92_E415_R0.8440.89
269_D416_N0.8420.89
122_G174_S0.8420.89
263_G268_A0.8390.89
375_L383_L0.8380.89
200_A203_R0.8350.89
54_A57_S0.8350.89
260_A263_G0.8340.89
253_Q290_G0.8300.88
122_G178_M0.8290.88
167_S384_E0.8270.88
302_F358_D0.8270.88
314_L319_G0.8220.88
370_D374_W0.8210.88
52_A56_L0.8150.88
251_A283_G0.8150.88
199_K211_E0.8150.88
314_L317_H0.8130.87
260_A270_N0.8130.87
309_S333_N0.8120.87
81_L259_F0.8070.87
195_R433_E0.8060.87
93_K419_H0.8050.87
394_P419_H0.8000.87
302_F393_G0.8000.87
389_A393_G0.7980.86
311_C345_A0.7960.86
374_W378_E0.7950.86
92_E416_N0.7940.86
119_A177_I0.7940.86
200_A431_E0.7930.86
285_G349_V0.7920.86
79_S116_S0.7900.86
304_A362_T0.7890.86
71_A75_G0.7860.86
273_F397_V0.7850.86
230_D233_C0.7840.85
70_T123_I0.7830.85
103_L398_C0.7830.85
59_F62_Y0.7780.85
235_F238_D0.7780.85
312_M360_F0.7770.85
198_K384_E0.7760.85
418_T422_W0.7740.85
256_K291_L0.7730.85
397_V401_V0.7710.84
316_V321_H0.7690.84
274_V420_L0.7650.84
175_I179_S0.7650.84
227_A233_C0.7600.84
188_V220_V0.7590.84
108_D424_T0.7570.83
86_A378_E0.7530.83
50_Q53_H0.7510.83
364_S396_R0.7500.83
270_N291_L0.7500.83
285_G289_F0.7490.83
364_S415_R0.7480.83
309_S312_M0.7480.83
325_S330_G0.7480.83
114_S428_M0.7470.83
312_M315_G0.7460.83
271_P420_L0.7430.82
376_A434_M0.7410.82
367_T370_D0.7410.82
363_L393_G0.7400.82
216_Y283_G0.7390.82
200_A435_N0.7340.81
168_T198_K0.7270.81
372_L434_M0.7260.81
278_C312_M0.7250.81
275_Y397_V0.7250.81
161_Y185_K0.7250.81
224_R228_Q0.7240.81
83_A263_G0.7160.80
101_G419_H0.7150.80
246_L249_S0.7150.80
388_L391_M0.7150.80
57_S60_A0.7140.80
289_F293_L0.7100.79
93_K401_V0.7100.79
180_A205_H0.7090.79
191_S332_D0.7080.79
103_L421_V0.7070.79
308_H365_D0.7060.79
81_L262_Q0.7040.79
316_V354_E0.7030.79
393_G396_R0.7000.78
321_H350_G0.6990.78
63_L67_F0.6990.78
321_H354_E0.6970.78
109_S424_T0.6960.78
383_L423_A0.6960.78
302_F361_Y0.6960.78
59_F63_L0.6910.77
313_L360_F0.6910.77
126_V175_I0.6870.77
101_G394_P0.6870.77
189_H222_E0.6840.77
260_A269_D0.6820.77
220_V333_N0.6800.76
186_V207_V0.6770.76
370_D395_Q0.6770.76
304_A363_L0.6770.76
224_R235_F0.6770.76
168_T384_E0.6750.76
315_G344_R0.6730.76
187_T233_C0.6700.75
128_A131_E0.6680.75
204_S373_G0.6670.75
89_K378_E0.6660.75
198_K338_D0.6660.75
114_S205_H0.6650.75
129_H240_N0.6640.75
51_D54_A0.6630.74
238_D242_R0.6620.74
58_R63_L0.6620.74
304_A388_L0.6590.74
400_S414_L0.6580.74
361_Y396_R0.6560.74
175_I188_V0.6550.74
163_I184_F0.6550.74
286_G349_V0.6540.73
315_G318_T0.6510.73
116_S122_G0.6500.73
309_S314_L0.6480.73
253_Q293_L0.6480.73
164_A189_H0.6470.73
57_S242_R0.6440.72
256_K290_G0.6430.72
370_D399_A0.6430.72
298_H358_D0.6430.72
107_K423_A0.6400.72
62_Y65_K0.6400.72
162_S233_C0.6400.72
202_L207_V0.6390.72
256_K293_L0.6390.72
363_L368_M0.6380.72
287_V420_L0.6370.72
237_D248_Y0.6350.71
164_A212_Y0.6340.71
353_M357_L0.6320.71
203_R435_N0.6310.71
278_C345_A0.6290.71
381_I423_A0.6290.71
320_L323_Q0.6290.71
160_Q232_N0.6280.70
88_Q93_K0.6280.70
88_Q102_Q0.6260.70
307_T362_T0.6230.70
400_S415_R0.6220.70
310_P315_G0.6210.70
130_A161_Y0.6190.69
179_S187_T0.6190.69
58_R61_P0.6180.69
178_M182_I0.6170.69
220_V433_E0.6160.69
93_K415_R0.6160.69
303_F357_L0.6140.69
105_L423_A0.6130.69
67_F71_A0.6130.69
325_S331_I0.6110.68
129_H234_F0.6110.68
292_K352_A0.6110.68
129_H163_I0.6110.68
394_P398_C0.6090.68
248_Y387_A0.6060.68
395_Q399_A0.6040.68
245_F285_G0.6030.67
67_F257_A0.6030.67
315_G319_G0.6020.67
337_A425_G0.6010.67
220_V240_N0.6000.67
253_Q257_A0.5980.67
75_G123_I0.5980.67
172_G281_G0.5980.67
61_P66_A0.5960.66
367_T371_M0.5960.66
375_L423_A0.5950.66
50_Q242_R0.5940.66
70_T73_T0.5940.66
245_F346_S0.5930.66
64_A71_A0.5900.66
101_G416_N0.5890.66
56_L61_P0.5880.65
376_A383_L0.5830.65
120_R248_Y0.5820.65
337_A368_M0.5820.65
167_S198_K0.5820.65
384_E425_G0.5810.65
75_G119_A0.5810.65
173_L202_L0.5810.65
314_L323_Q0.5790.64
171_L244_L0.5780.64
87_M375_L0.5770.64
171_L248_Y0.5760.64
383_L391_M0.5730.63
316_V324_I0.5720.63
93_K394_P0.5720.63
199_K203_R0.5660.63
312_M316_V0.5650.62
68_P71_A0.5650.62
202_L209_V0.5650.62
87_M90_R0.5630.62
365_D369_Y0.5630.62
278_C424_T0.5630.62
233_C236_I0.5630.62
119_A181_R0.5600.62
274_V299_V0.5570.61
48_D289_F0.5570.61
289_F348_F0.5560.61
86_A379_E0.5540.61
308_H334_L0.5510.60
90_R377_Q0.5510.60
187_T226_A0.5510.60
372_L385_P0.5510.60
168_T280_V0.5490.60
186_V205_H0.5470.60
216_Y280_V0.5470.60
89_K261_Q0.5450.60
366_Q369_Y0.5440.59
309_S313_L0.5440.59
310_P362_T0.5430.59
309_S315_G0.5430.59
122_G385_P0.5430.59
361_Y400_S0.5420.59
288_A356_L0.5420.59
243_T247_G0.5400.59
84_I105_L0.5400.59
186_V415_R0.5390.59
89_K253_Q0.5390.59
300_H417_T0.5380.59
303_F349_V0.5370.59
198_K386_S0.5360.58
225_K325_S0.5360.58
189_H220_V0.5360.58
168_T386_S0.5340.58
333_N341_A0.5340.58
48_D55_R0.5320.58
109_S423_A0.5320.58
112_P177_I0.5310.58
55_R58_R0.5310.58
363_L389_A0.5310.58
79_S119_A0.5290.57
245_F348_F0.5290.57
262_Q268_A0.5280.57
82_V85_P0.5280.57
180_A377_Q0.5270.57
336_A365_D0.5270.57
127_L131_E0.5260.57
121_G247_G0.5260.57
287_V290_G0.5250.57
212_Y219_A0.5250.57
89_K229_S0.5250.57
68_P72_A0.5230.57
49_V53_H0.5200.56
374_W400_S0.5180.56
69_E85_P0.5170.56
273_F400_S0.5170.56
316_V320_L0.5170.56
168_T216_Y0.5160.56
268_A298_H0.5160.56
180_A186_V0.5150.55
259_F262_Q0.5150.55
60_A68_P0.5150.55
255_L259_F0.5140.55
237_D244_L0.5120.55
166_G283_G0.5100.55
398_C401_V0.5100.55
194_A282_G0.5090.55
61_P64_A0.5090.55
58_R68_P0.5080.54
307_T365_D0.5070.54
310_P419_H0.5060.54
171_L241_S0.5050.54
220_V233_C0.5040.54
123_I178_M0.5030.54
370_D373_G0.5030.54
105_L387_A0.5030.54
292_K301_C0.5030.54
304_A389_A0.5030.54
270_N296_G0.5020.54
299_V357_L0.5020.54
168_T339_G0.5020.54
312_M323_Q0.5010.53
104_L262_Q0.5000.53
269_D272_L0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ss7X 1 0.9796 100 0.237 Contact Map
1tdjA 2 0.7421 100 0.399 Contact Map
1e5xA 2 0.819 100 0.419 Contact Map
2zsjA 2 0.7353 100 0.426 Contact Map
2d1fA 2 0.7376 100 0.427 Contact Map
1v71A 2 0.7195 100 0.428 Contact Map
3aeyA 2 0.7308 100 0.428 Contact Map
2gn0A 2 0.7421 100 0.43 Contact Map
2rkbA 2 0.7036 100 0.433 Contact Map
4h27A 1 0.7036 100 0.437 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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