GREMLIN Database
PHR - Deoxyribodipyrimidine photo-lyase
UniProt: P00914 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10736
Length: 472 (415)
Sequences: 5591 (4292)
Seq/√Len: 210.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
310_N313_H4.0711.00
241_S246_G3.9281.00
326_I347_I3.7161.00
315_Q319_E3.6311.00
335_N366_Y3.4161.00
314_L318_Q3.3351.00
314_L362_E3.2711.00
297_P303_D3.2171.00
332_R422_E2.9931.00
212_L252_C2.9231.00
63_Q67_A2.9101.00
101_F129_F2.7511.00
330_A344_L2.6671.00
406_G416_I2.6221.00
58_Q246_G2.6181.00
99_H127_E2.5471.00
102_Y126_C2.5191.00
102_Y128_G2.4341.00
271_V274_N2.4291.00
63_Q72_P2.3911.00
87_I90_Q2.3801.00
15_H251_Q2.3761.00
335_N370_Q2.3731.00
324_Y351_F2.3411.00
205_E209_I2.3161.00
166_M169_C2.2991.00
61_G206_K2.2891.00
205_E251_Q2.2641.00
213_R255_R2.2161.00
333_Q337_T2.1811.00
17_N103_N2.1691.00
308_Q313_H2.1511.00
100_L121_L2.1441.00
209_I251_Q2.1411.00
344_L415_F2.1411.00
282_Y382_G2.1291.00
8_F33_A2.1091.00
404_T408_K2.0861.00
78_V87_I2.0681.00
6_V19_A2.0371.00
336_S419_W2.0111.00
6_V17_N1.9861.00
55_I244_T1.9481.00
323_G328_D1.9471.00
99_H125_V1.9371.00
337_T419_W1.9301.00
207_A210_A1.9091.00
366_Y370_Q1.9031.00
255_R258_A1.8841.00
212_L255_R1.8791.00
58_Q204_E1.8771.00
90_Q94_E1.8371.00
76_R87_I1.8371.00
178_S181_I1.8141.00
364_E380_N1.8081.00
34_L91_V1.7751.00
315_Q318_Q1.7571.00
401_N405_Q1.7381.00
65_A205_E1.7191.00
54_L244_T1.7171.00
332_R420_L1.7001.00
54_L241_S1.6981.00
155_K274_N1.6931.00
403_T406_G1.6521.00
216_C220_A1.6431.00
8_F66_L1.6421.00
92_C97_V1.6411.00
4_H27_S1.6291.00
169_C172_A1.6221.00
242_L252_C1.6121.00
282_Y381_G1.6091.00
230_P344_L1.6091.00
222_E226_Q1.6071.00
208_A247_L1.5961.00
155_K277_I1.5941.00
349_A386_A1.5881.00
85_V116_E1.5841.00
76_R94_E1.5821.00
165_G169_C1.5711.00
318_Q369_S1.5691.00
167_P170_V1.5641.00
333_Q415_F1.5611.00
352_L358_I1.5561.00
325_P329_A1.5471.00
79_D85_V1.5301.00
33_A71_I1.5201.00
251_Q255_R1.5081.00
61_G65_A1.5051.00
111_R115_V1.5021.00
154_F284_H1.4911.00
18_L131_D1.4771.00
291_S296_R1.4611.00
139_A161_R1.4561.00
368_M374_G1.4501.00
309_S362_E1.4411.00
362_E365_R1.4331.00
256_L269_G1.4231.00
324_Y355_D1.4221.00
21_A25_R1.4181.00
155_K159_L1.4151.00
316_A321_K1.4131.00
32_L74_L1.4131.00
67_A72_P1.4101.00
15_H209_I1.4091.00
34_L88_V1.4091.00
79_D86_E1.4061.00
107_E110_E1.3971.00
22_A25_R1.3891.00
38_T41_Q1.3881.00
253_L273_L1.3871.00
135_L158_W1.3831.00
150_V393_A1.3761.00
292_L380_N1.3741.00
151_F274_N1.3741.00
296_R303_D1.3681.00
236_S272_W1.3621.00
85_V89_K1.3621.00
238_L272_W1.3581.00
10_Q105_Q1.3531.00
352_L363_G1.3531.00
65_A206_K1.3441.00
285_L391_T1.3421.00
53_E57_A1.3341.00
224_E271_V1.3311.00
86_E90_Q1.3301.00
57_A203_V1.3261.00
5_L97_V1.3141.00
91_V95_N1.3041.00
275_E378_A1.2991.00
229_F232_V1.2931.00
214_Q218_N1.2841.00
111_R287_T1.2811.00
222_E225_Q1.2761.00
204_E207_A1.2731.00
413_G417_R1.2691.00
8_F62_L1.2661.00
326_I406_G1.2621.00
118_E128_G1.2621.00
226_Q234_G1.2591.00
66_L71_I1.2561.00
271_V275_E1.2531.00
188_T191_Y1.2491.00
178_S184_S1.2361.00
92_C95_N1.2311.00
132_S283_R1.2291.00
255_R259_E1.2231.00
107_E376_L1.2221.00
89_K120_A1.2171.00
4_H26_N1.2171.00
314_L358_I1.2161.00
4_H101_F1.2161.00
37_A42_W1.2141.00
258_A262_Q1.2131.00
414_E417_R1.2131.00
334_L371_L1.2021.00
170_V173_P1.1991.00
330_A415_F1.1971.00
9_R114_D1.1961.00
250_R254_H1.1951.00
26_N29_A1.1911.00
92_C124_V1.1831.00
92_C100_L1.1801.00
40_R79_D1.1791.00
376_L380_N1.1771.00
256_L273_L1.1721.00
238_L252_C1.1691.00
105_Q110_E1.1541.00
363_G383_W1.1511.00
256_L272_W1.1491.00
181_I184_S1.1491.00
179_G184_S1.1471.00
167_P175_V1.1461.00
404_T407_E1.1391.00
204_E208_A1.1291.00
36_I88_V1.1281.00
158_W277_I1.1271.00
227_R275_E1.1261.00
312_A362_E1.1261.00
226_Q232_V1.1261.00
333_Q339_W1.1251.00
318_Q366_Y1.1211.00
204_E246_G1.1151.00
26_N99_H1.1141.00
34_L76_R1.1121.00
39_P77_E1.1091.00
74_L91_V1.1081.00
286_I377_A1.1081.00
65_A69_K1.0991.00
253_L277_I1.0971.00
108_V112_A1.0961.00
4_H29_A1.0951.00
54_L240_A1.0941.00
165_G170_V1.0911.00
237_R339_W1.0881.00
89_K93_A1.0871.00
35_Y59_L1.0841.00
35_Y55_I1.0801.00
64_I68_E1.0741.00
327_V331_M1.0721.00
323_G414_E1.0701.00
257_L273_L1.0671.00
311_P362_E1.0671.00
36_I84_S1.0661.00
56_N60_N1.0441.00
222_E268_A1.0421.00
14_L69_K1.0411.00
182_E185_P1.0391.00
115_V119_R1.0371.00
7_W117_V1.0341.00
312_A316_A1.0321.00
157_A160_K1.0311.00
112_A116_E1.0241.00
32_L95_N1.0211.00
216_C256_L1.0211.00
151_F154_F1.0171.00
382_G386_A1.0171.00
32_L97_V1.0141.00
327_V347_I1.0101.00
100_L126_C0.9951.00
314_L352_L0.9891.00
134_I158_W0.9861.00
92_C121_L0.9861.00
214_Q219_G0.9811.00
202_P207_A0.9791.00
172_A175_V0.9781.00
112_A115_V0.9761.00
221_G259_E0.9701.00
47_M51_Q0.9691.00
61_G203_V0.9681.00
121_L124_V0.9621.00
36_I87_I0.9611.00
359_D362_E0.9611.00
15_H205_E0.9601.00
133_V283_R0.9591.00
104_Y137_P0.9561.00
50_R370_Q0.9511.00
203_V207_A0.9470.99
159_L270_S0.9450.99
267_G270_S0.9440.99
233_E237_R0.9370.99
143_G157_A0.9370.99
277_I280_E0.9350.99
60_N64_I0.9260.99
213_R217_Q0.9240.99
235_T339_W0.9240.99
141_M288_Y0.9200.99
102_Y118_E0.9200.99
309_S313_H0.9170.99
332_R336_S0.9160.99
406_G413_G0.9110.99
89_K92_C0.9080.99
76_R90_Q0.9070.99
317_W331_M0.9050.99
275_E346_M0.9040.99
5_L92_C0.9030.99
401_N404_T0.8990.99
22_A26_N0.8970.99
416_I420_L0.8950.99
398_R405_Q0.8870.99
216_C259_E0.8870.99
22_A129_F0.8840.99
104_Y128_G0.8790.99
33_A66_L0.8780.99
54_L246_G0.8720.99
172_A176_R0.8700.99
207_A211_Q0.8700.99
27_S30_R0.8690.99
39_P43_A0.8690.99
37_A59_L0.8690.99
398_R401_N0.8660.99
216_C255_R0.8630.99
84_S89_K0.8630.99
103_N131_D0.8620.99
26_N101_F0.8600.99
252_C272_W0.8580.99
170_V175_V0.8580.99
210_A214_Q0.8550.99
403_T407_E0.8530.99
300_A303_D0.8530.99
318_Q362_E0.8520.99
146_E149_K0.8510.99
18_L22_A0.8480.99
88_V92_C0.8460.99
166_M172_A0.8410.99
130_D136_P0.8390.99
74_L95_N0.8390.99
37_A75_F0.8380.99
349_A367_F0.8370.99
282_Y391_T0.8330.99
105_Q113_R0.8330.99
78_V86_E0.8280.99
66_L73_L0.8270.99
283_R378_A0.8260.99
100_L117_V0.8240.99
39_P42_W0.8230.99
297_P389_T0.8230.99
24_C172_A0.8230.99
54_L203_V0.8190.99
54_L204_E0.8190.99
320_G331_M0.8170.98
358_I362_E0.8160.98
328_D332_R0.8150.98
343_R405_Q0.8150.98
50_R201_F0.8150.98
74_L94_E0.8130.98
101_F127_E0.8120.98
166_M171_A0.8110.98
4_H30_R0.8020.98
14_L66_L0.8020.98
149_K289_H0.7990.98
65_A68_E0.7960.98
182_E186_S0.7950.98
159_L277_I0.7920.98
324_Y403_T0.7900.98
54_L58_Q0.7900.98
321_K420_L0.7900.98
201_F237_R0.7890.98
115_V118_E0.7880.98
110_E113_R0.7860.98
136_P139_A0.7850.98
47_M52_A0.7840.98
135_L277_I0.7840.98
212_L247_L0.7810.98
106_Y133_V0.7800.98
134_I253_L0.7780.98
24_C31_V0.7770.98
106_Y136_P0.7770.98
57_A61_G0.7770.98
393_A397_F0.7760.98
292_L298_F0.7730.98
338_G372_I0.7730.98
325_P328_D0.7720.98
35_Y41_Q0.7720.98
260_Q270_S0.7720.98
238_L247_L0.7700.98
76_R91_V0.7700.98
5_L91_V0.7670.98
224_E268_A0.7660.98
367_F379_N0.7620.98
220_A256_L0.7620.98
317_W353_V0.7600.98
334_L340_M0.7550.97
240_A372_I0.7530.97
302_T305_V0.7520.97
406_G423_L0.7510.97
333_Q419_W0.7500.97
203_V208_A0.7490.97
189_L192_P0.7480.97
174_K177_S0.7460.97
4_H99_H0.7460.97
293_C376_L0.7430.97
309_S358_I0.7420.97
289_H298_F0.7390.97
228_D275_E0.7380.97
16_D250_R0.7370.97
169_C173_P0.7360.97
35_Y38_T0.7350.97
33_A36_I0.7350.97
152_T156_N0.7310.97
5_L34_L0.7280.97
61_G204_E0.7280.97
319_E335_N0.7280.97
151_F158_W0.7280.97
166_M170_V0.7220.97
217_Q259_E0.7220.97
104_Y138_G0.7210.97
142_T146_E0.7200.97
118_E126_C0.7190.97
173_P176_R0.7170.97
169_C175_V0.7170.97
138_G288_Y0.7160.97
61_G246_G0.7150.97
7_W84_S0.7130.96
400_F405_Q0.7120.96
274_N278_W0.7110.96
274_N277_I0.7100.96
122_R125_V0.7090.96
150_V153_P0.7080.96
41_Q45_H0.7080.96
46_N369_S0.7060.96
175_V178_S0.7040.96
104_Y136_P0.7030.96
88_V117_V0.7010.96
201_F240_A0.7010.96
340_M371_L0.7010.96
104_Y130_D0.7010.96
30_R33_A0.7000.96
201_F372_I0.6970.96
332_R335_N0.6940.96
259_E263_A0.6920.96
253_L276_L0.6920.96
364_E383_W0.6910.96
240_A339_W0.6890.96
148_Y153_P0.6880.96
8_F14_L0.6880.96
167_P171_A0.6870.96
169_C176_R0.6870.96
230_P409_F0.6870.96
117_V121_L0.6850.96
389_T394_A0.6850.96
284_H288_Y0.6840.96
394_A397_F0.6840.96
185_P188_T0.6830.95
225_Q268_A0.6830.95
37_A77_E0.6830.95
317_W358_I0.6800.95
230_P326_I0.6800.95
165_G172_A0.6790.95
415_F419_W0.6790.95
410_D413_G0.6790.95
151_F155_K0.6790.95
179_G183_P0.6780.95
167_P172_A0.6780.95
165_G173_P0.6780.95
385_W398_R0.6750.95
6_V101_F0.6750.95
224_E267_G0.6740.95
33_A37_A0.6740.95
308_Q357_L0.6730.95
92_C120_A0.6700.95
169_C174_K0.6690.95
19_A103_N0.6680.95
205_E208_A0.6650.95
141_M145_H0.6650.95
325_P416_I0.6630.95
224_E228_D0.6620.95
285_L292_L0.6610.95
130_D133_V0.6590.95
283_R375_D0.6580.94
170_V174_K0.6580.94
31_V35_Y0.6570.94
209_I213_R0.6560.94
186_S189_L0.6550.94
260_Q269_G0.6540.94
165_G171_A0.6530.94
195_S336_S0.6530.94
90_Q93_A0.6530.94
115_V128_G0.6500.94
378_A382_G0.6460.94
211_Q237_R0.6460.94
118_E122_R0.6450.94
102_Y114_D0.6430.94
247_L252_C0.6430.94
23_A101_F0.6430.94
320_G328_D0.6420.94
159_L274_N0.6410.94
236_S273_L0.6410.94
6_V33_A0.6390.94
368_M376_L0.6390.94
61_G64_I0.6390.94
313_H358_I0.6390.94
179_G182_E0.6370.93
166_M174_K0.6330.93
67_A71_I0.6290.93
88_V91_V0.6280.93
86_E89_K0.6270.93
269_G273_L0.6270.93
157_A161_R0.6260.93
191_Y194_Q0.6250.93
22_A127_E0.6240.93
349_A379_N0.6230.93
178_S183_P0.6210.93
281_F391_T0.6210.93
168_E176_R0.6200.93
7_W102_Y0.6190.93
169_C177_S0.6140.92
310_N362_E0.6130.92
331_M348_T0.6130.92
197_D200_H0.6130.92
235_T341_H0.6120.92
326_I344_L0.6090.92
252_C255_R0.6080.92
212_L216_C0.6080.92
225_Q228_D0.6080.92
343_R398_R0.6060.92
153_P157_A0.6050.92
379_N383_W0.6050.92
385_W390_G0.6050.92
5_L88_V0.6020.91
22_A101_F0.6020.91
333_Q336_S0.6010.91
103_N130_D0.6000.91
58_Q203_V0.5990.91
64_I206_K0.5990.91
114_D117_V0.5990.91
41_Q44_T0.5980.91
350_S386_A0.5940.91
178_S182_E0.5940.91
116_E119_R0.5930.91
21_A24_C0.5910.91
297_P302_T0.5910.91
278_W381_G0.5900.91
64_I67_A0.5880.90
363_G384_Q0.5860.90
307_W310_N0.5860.90
50_R53_E0.5850.90
84_S110_E0.5830.90
27_S31_V0.5830.90
317_W349_A0.5830.90
38_T42_W0.5820.90
265_D268_A0.5820.90
180_S183_P0.5810.90
111_R137_P0.5770.90
79_D84_S0.5770.90
226_Q229_F0.5770.90
192_P196_F0.5770.90
154_F280_E0.5770.90
361_R364_E0.5760.90
231_A234_G0.5740.89
116_E120_A0.5740.89
248_S251_Q0.5730.89
321_K422_E0.5720.89
256_L259_E0.5710.89
346_M400_F0.5700.89
227_R346_M0.5690.89
220_A269_G0.5690.89
85_V117_V0.5680.89
51_Q243_A0.5680.89
236_S239_S0.5680.89
171_A174_K0.5680.89
392_D398_R0.5670.89
330_A340_M0.5660.89
202_P241_S0.5660.89
106_Y137_P0.5620.88
199_A203_V0.5570.88
282_Y285_L0.5570.88
40_R85_V0.5550.88
7_W88_V0.5550.88
209_I255_R0.5540.88
200_H237_R0.5520.88
270_S274_N0.5520.88
208_A241_S0.5520.88
105_Q243_A0.5510.87
24_C27_S0.5500.87
79_D116_E0.5500.87
275_E342_N0.5500.87
138_G287_T0.5480.87
251_Q254_H0.5470.87
135_L139_A0.5470.87
176_R179_G0.5470.87
39_P45_H0.5460.87
350_S383_W0.5460.87
135_L140_V0.5450.87
42_W52_A0.5420.87
342_N346_M0.5420.87
38_T84_S0.5410.86
211_Q219_G0.5410.86
162_L253_L0.5400.86
175_V179_G0.5400.86
63_Q73_L0.5370.86
309_S359_D0.5370.86
238_L242_L0.5360.86
268_A271_V0.5360.86
297_P300_A0.5350.86
211_Q214_Q0.5350.86
8_F12_L0.5350.86
346_M409_F0.5330.86
216_C219_G0.5310.85
283_R377_A0.5310.85
140_V143_G0.5300.85
329_A333_Q0.5300.85
173_P177_S0.5290.85
128_G136_P0.5290.85
330_A348_T0.5280.85
227_R342_N0.5280.85
189_L194_Q0.5270.85
352_L356_L0.5270.85
5_L95_N0.5260.85
193_R370_Q0.5240.85
354_K397_F0.5230.85
335_N369_S0.5220.85
42_W56_N0.5210.84
141_M146_E0.5200.84
134_I248_S0.5200.84
38_T78_V0.5200.84
109_N113_R0.5200.84
36_I41_Q0.5190.84
320_G420_L0.5190.84
172_A177_S0.5190.84
134_I250_R0.5190.84
59_L63_Q0.5190.84
14_L205_E0.5190.84
230_P418_Q0.5180.84
317_W352_L0.5170.84
351_F354_K0.5160.84
324_Y406_G0.5160.84
158_W161_R0.5160.84
340_M348_T0.5150.84
229_F234_G0.5150.84
33_A38_T0.5140.84
354_K398_R0.5140.84
237_R240_A0.5130.83
215_F236_S0.5130.83
364_E368_M0.5120.83
300_A304_R0.5120.83
131_D250_R0.5120.83
231_A333_Q0.5110.83
275_E278_W0.5110.83
340_M367_F0.5110.83
170_V176_R0.5100.83
84_S113_R0.5100.83
252_C256_L0.5100.83
260_Q266_G0.5090.83
329_A332_R0.5090.83
26_N30_R0.5080.83
108_V376_L0.5080.83
308_Q311_P0.5080.83
382_G393_A0.5080.83
55_I59_L0.5080.83
6_V23_A0.5080.83
133_V284_H0.5050.83
325_P423_L0.5050.83
349_A353_V0.5050.83
403_T423_L0.5050.83
147_M289_H0.5040.82
399_I402_P0.5020.82
105_Q114_D0.5020.82
417_R423_L0.5020.82
147_M288_Y0.5010.82
63_Q66_L0.5000.82
50_R338_G0.5000.82
36_I78_V0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u63A 1 0.9767 100 0.054 Contact Map
1dnpA 1 0.9746 100 0.059 Contact Map
1u3dA 1 0.9767 100 0.064 Contact Map
1np7A 1 0.964 100 0.067 Contact Map
1owlA 1 0.9661 100 0.07 Contact Map
3fy4A 1 0.9788 100 0.072 Contact Map
4gu5A 1 0.9873 100 0.084 Contact Map
4k0rA 1 0.9343 100 0.085 Contact Map
4mlpC 1 0.9767 100 0.086 Contact Map
2wq7A 1 0.9809 100 0.094 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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