GREMLIN Database
TRPC - Tryptophan biosynthesis protein TrpCF
UniProt: P00909 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11026
Length: 453 (443)
Sequences: 529 (344)
Seq/√Len: 16.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_D146_Q4.7781.00
39_H42_D4.7761.00
21_K120_D4.4961.00
121_P149_Q4.3941.00
269_A300_V4.3791.00
144_D173_R3.8421.00
320_V342_Y3.7561.00
265_R268_D3.5981.00
118_I124_I3.5431.00
124_I135_C3.3760.99
213_I233_G3.2790.99
285_V291_C3.2490.99
171_Q206_L3.2300.99
85_I108_A3.1130.99
236_I253_V3.0870.99
182_V206_L3.0180.98
431_V446_V2.8700.98
310_G329_L2.8570.98
315_H319_D2.8540.98
104_V112_I2.7840.97
392_W417_A2.7750.97
409_L427_F2.7570.97
263_L280_G2.7450.97
414_C427_F2.5110.95
314_N337_N2.5100.95
4_T194_I2.4490.94
172_E205_K2.4180.94
175_I182_V2.4160.94
240_L246_L2.4030.94
12_D16_W2.3810.94
404_L424_G2.3610.93
427_F446_V2.3120.92
427_F450_L2.3110.92
200_R226_E2.2870.92
124_I158_E2.2590.92
221_Y225_R2.2290.91
433_S439_D2.2040.90
340_Q344_D2.2020.90
64_V95_Q2.1730.90
160_G181_V2.1620.90
40_F181_V2.1200.89
378_V404_L2.0960.88
70_D73_R2.0920.88
445_S449_T2.0420.87
12_D92_K2.0400.87
265_R437_I2.0360.87
125_Y153_V2.0310.86
280_G306_L2.0300.86
168_E205_K2.0090.86
300_V303_A1.9260.83
431_V443_L1.9070.83
169_E292_V1.9020.82
37_T105_S1.8940.82
17_V119_I1.8760.82
186_N199_T1.8720.81
171_Q203_A1.8710.81
206_L210_V1.8700.81
4_T190_R1.8530.81
258_N278_I1.8410.80
347_R356_I1.8230.80
12_D93_Y1.8210.79
29_F125_Y1.8160.79
128_R159_M1.8130.79
300_V304_A1.8130.79
196_L212_V1.8080.79
293_N296_Q1.8030.79
410_G430_A1.7960.79
339_E342_Y1.7950.78
181_V211_T1.7860.78
14_A146_Q1.7830.78
171_Q205_K1.7740.78
71_P107_I1.7690.77
4_T118_I1.7450.76
13_K90_D1.7380.76
269_A308_Y1.7320.76
320_V332_V1.7180.75
224_V236_I1.6770.73
58_A62_K1.6630.73
409_L425_L1.6330.71
13_K91_E1.6330.71
20_R24_Q1.6270.71
338_E358_K1.6250.71
427_F431_V1.6230.71
300_V308_Y1.6110.70
175_I210_V1.6050.70
75_A84_A1.5830.69
57_K100_F1.5690.68
362_V394_L1.5590.68
72_A107_I1.5310.66
7_A33_V1.5150.65
204_P233_G1.4990.65
151_A161_V1.4980.65
166_S190_R1.4870.64
16_W92_K1.4660.63
178_G206_L1.4490.62
301_M308_Y1.4470.62
418_A450_L1.4410.61
317_I321_V1.4400.61
66_R69_F1.3920.59
146_Q149_Q1.3850.58
294_V323_K1.3800.58
11_A14_A1.3760.58
26_L29_F1.3750.58
411_A414_C1.3730.58
167_N188_D1.3720.58
207_G210_V1.3690.57
282_L288_S1.3610.57
414_C418_A1.3570.57
265_R300_V1.3510.56
47_A158_E1.3470.56
409_L446_V1.3460.56
40_F160_G1.3410.56
314_N338_E1.3400.56
71_P75_A1.3380.56
271_A275_A1.3290.55
272_A277_A1.3260.55
146_Q419_Q1.3260.55
320_V324_A1.3190.54
285_V313_R1.2890.53
40_F157_L1.2890.53
245_D328_S1.2850.52
147_Y163_T1.2850.52
40_F84_A1.2840.52
197_N200_R1.2810.52
199_T213_I1.2750.52
260_V292_V1.2750.52
41_Y181_V1.2730.52
282_L297_A1.2700.52
57_K69_F1.2700.52
52_I213_I1.2690.52
25_P29_F1.2690.52
26_L125_Y1.2660.51
142_L165_V1.2590.51
260_V391_D1.2570.51
19_A23_Q1.2450.50
263_L438_K1.2440.50
145_D148_R1.2410.50
72_A103_I1.2390.50
297_A334_L1.2310.49
125_Y157_L1.2210.49
190_R240_L1.2180.49
312_F329_L1.2160.48
121_P146_Q1.2140.48
214_S227_L1.2090.48
286_A369_R1.2060.48
239_A381_N1.1980.47
70_D435_P1.1980.47
196_L224_V1.1880.47
74_I241_M1.1860.47
412_D445_S1.1750.46
347_R375_D1.1740.46
6_L9_I1.1690.46
271_A443_L1.1540.45
285_V315_H1.1540.45
17_V450_L1.1460.44
246_L250_V1.1450.44
16_W84_A1.1370.44
298_Q326_V1.1360.44
167_N198_R1.1260.43
274_D416_E1.1240.43
312_F334_L1.1210.43
270_K303_A1.1190.43
270_K299_E1.1180.43
221_Y439_D1.1160.43
155_H180_K1.1120.42
151_A155_H1.1070.42
379_L403_V1.1070.42
381_N414_C1.0990.42
30_Q125_Y1.0960.41
178_G182_V1.0880.41
5_V169_E1.0840.41
286_A315_H1.0760.40
286_A319_D1.0720.40
62_K89_T1.0710.40
288_S438_K1.0680.40
414_C450_L1.0670.40
247_H250_V1.0620.40
17_V231_A1.0580.39
362_V377_Y1.0580.39
39_H155_H1.0580.39
81_Y147_Y1.0580.39
316_D320_V1.0570.39
284_F288_S1.0560.39
425_L428_N1.0560.39
152_A156_S1.0540.39
396_N399_S1.0500.39
116_D438_K1.0460.39
228_S279_Y1.0450.39
75_A113_L1.0440.39
283_I311_V1.0430.38
169_E172_E1.0400.38
175_I206_L1.0330.38
101_L254_L1.0310.38
321_V342_Y1.0240.37
310_G338_E1.0210.37
182_V210_V1.0200.37
4_T439_D1.0180.37
171_Q199_T1.0180.37
75_A181_V1.0180.37
81_Y138_M1.0150.37
91_E214_S1.0120.37
135_C283_I1.0110.37
49_T65_I1.0090.37
248_A278_I1.0080.37
50_A285_V1.0020.36
46_G232_N1.0010.36
169_E332_V0.9990.36
138_M192_L0.9990.36
269_A303_A0.9930.36
122_Y241_M0.9930.36
52_I215_E0.9880.35
197_N226_E0.9860.35
138_M147_Y0.9850.35
332_V346_L0.9850.35
263_L306_L0.9840.35
250_V253_V0.9830.35
182_V254_L0.9820.35
172_E176_A0.9780.35
40_F159_M0.9740.35
84_A198_R0.9740.35
10_V119_I0.9720.35
418_A427_F0.9690.34
425_L446_V0.9680.34
97_S129_Y0.9650.34
316_D319_D0.9580.34
182_V253_V0.9570.34
340_Q411_A0.9550.34
199_T231_A0.9540.34
165_V171_Q0.9520.34
366_L395_L0.9510.34
294_V298_Q0.9470.33
284_F392_W0.9450.33
317_I320_V0.9410.33
194_I242_A0.9370.33
367_P395_L0.9350.33
252_R257_E0.9350.33
112_I239_A0.9310.32
193_S359_A0.9270.32
270_K273_Y0.9260.32
184_I358_K0.9260.32
12_D29_F0.9250.32
141_V177_L0.9210.32
50_A160_G0.9210.32
261_C407_G0.9150.32
173_R280_G0.9100.31
307_Q330_A0.9060.31
378_V398_Q0.9050.31
314_N334_L0.9050.31
27_A292_V0.9050.31
184_I200_R0.9040.31
5_V206_L0.9030.31
51_F255_L0.9020.31
273_Y305_P0.9000.31
321_V346_L0.8910.30
16_W160_G0.8890.30
3_Q194_I0.8880.30
411_A431_V0.8870.30
81_Y163_T0.8860.30
188_D242_A0.8860.30
85_I212_V0.8860.30
272_A276_G0.8850.30
11_A106_Q0.8820.30
90_D214_S0.8820.30
147_Y238_S0.8800.30
46_G411_A0.8800.30
412_D449_T0.8790.30
16_W90_D0.8760.30
15_I92_K0.8690.29
138_M238_S0.8680.29
99_N158_E0.8670.29
428_N446_V0.8650.29
297_A312_F0.8600.29
13_K16_W0.8600.29
27_A445_S0.8600.29
153_V161_V0.8570.29
7_A340_Q0.8570.29
49_T159_M0.8570.29
186_N241_M0.8560.29
134_A215_E0.8560.29
121_P165_V0.8550.29
12_D15_I0.8520.29
268_D437_I0.8520.29
3_Q190_R0.8510.29
175_I379_L0.8510.29
319_D323_K0.8500.28
236_I250_V0.8460.28
224_V320_V0.8440.28
16_W181_V0.8440.28
291_C315_H0.8440.28
31_N211_T0.8420.28
160_G236_I0.8410.28
312_F338_E0.8370.28
238_S428_N0.8370.28
186_N214_S0.8360.28
121_P161_V0.8360.28
114_C127_A0.8340.28
163_T428_N0.8320.28
11_A124_I0.8310.28
138_M234_F0.8300.28
273_Y304_A0.8290.27
138_M163_T0.8270.27
33_V129_Y0.8270.27
362_V379_L0.8250.27
382_G386_S0.8230.27
71_P105_S0.8220.27
223_Q226_E0.8210.27
49_T245_D0.8200.27
361_S383_Q0.8190.27
360_L377_Y0.8190.27
150_L240_L0.8190.27
191_D277_A0.8170.27
380_D387_G0.8150.27
360_L381_N0.8140.27
409_L418_A0.8130.27
131_Q250_V0.8120.27
446_V450_L0.8120.27
177_L202_L0.8090.27
17_V369_R0.8080.27
188_D265_R0.8030.26
41_Y180_K0.7970.26
334_L338_E0.7970.26
302_A318_A0.7950.26
104_V143_D0.7900.26
240_L254_L0.7900.26
318_A345_T0.7880.26
153_V156_S0.7870.26
105_S381_N0.7850.25
135_C154_A0.7820.25
7_A83_S0.7750.25
167_N273_Y0.7730.25
20_R29_F0.7730.25
291_C316_D0.7730.25
139_L234_F0.7720.25
194_I220_T0.7710.25
232_N331_A0.7690.25
128_R133_D0.7660.25
39_H127_A0.7660.25
155_H160_G0.7650.25
127_A181_V0.7640.25
340_Q374_V0.7640.25
79_K105_S0.7640.25
186_N338_E0.7630.25
81_Y247_H0.7610.24
25_P122_Y0.7610.24
73_R386_S0.7600.24
331_A357_W0.7570.24
346_L412_D0.7560.24
312_F320_V0.7560.24
16_W131_Q0.7540.24
305_P309_V0.7540.24
116_D392_W0.7520.24
49_T224_V0.7520.24
288_S359_A0.7500.24
293_N315_H0.7490.24
55_C163_T0.7480.24
139_L147_Y0.7470.24
243_H253_V0.7450.24
97_S112_I0.7450.24
363_G410_G0.7450.24
182_V205_K0.7450.24
260_V447_F0.7430.24
147_Y428_N0.7420.24
114_C126_L0.7400.24
174_A312_F0.7400.24
341_L419_Q0.7400.24
172_E245_D0.7350.23
45_Q232_N0.7320.23
278_I405_L0.7310.23
247_H251_R0.7300.23
58_A309_V0.7300.23
118_I231_A0.7290.23
446_V449_T0.7290.23
225_R255_L0.7270.23
199_T227_L0.7250.23
236_I386_S0.7230.23
180_K224_V0.7230.23
163_T238_S0.7220.23
155_H159_M0.7210.23
233_G414_C0.7200.23
244_D302_A0.7190.23
404_L423_A0.7150.22
184_I199_T0.7130.22
391_D431_V0.7120.22
135_C161_V0.7090.22
243_H252_R0.7090.22
148_R344_D0.7090.22
287_T291_C0.7080.22
300_V445_S0.7070.22
145_D266_G0.7070.22
261_C408_G0.7070.22
264_T356_I0.7070.22
414_C449_T0.7010.22
71_P275_A0.7010.22
229_H448_Q0.7000.22
71_P382_G0.6970.22
340_Q372_Q0.6960.22
118_I253_V0.6950.22
45_Q299_E0.6950.22
186_N312_F0.6940.22
114_C258_N0.6940.22
42_D314_N0.6920.22
322_D388_Q0.6910.22
114_C138_M0.6880.21
178_G425_L0.6860.21
163_T184_I0.6850.21
204_P341_L0.6850.21
219_N239_A0.6830.21
144_D176_A0.6820.21
13_K57_K0.6820.21
5_V278_I0.6800.21
170_E253_V0.6800.21
184_I212_V0.6790.21
265_R299_E0.6780.21
80_H439_D0.6780.21
362_V390_F0.6770.21
207_G429_S0.6770.21
138_M256_G0.6770.21
18_E119_I0.6760.21
84_A181_V0.6750.21
122_Y126_L0.6750.21
199_T241_M0.6750.21
73_R121_P0.6740.21
105_S133_D0.6730.21
207_G271_A0.6720.21
287_T313_R0.6720.21
263_L377_Y0.6720.21
176_A368_A0.6700.21
152_A415_V0.6700.21
145_D195_D0.6700.21
123_Q150_L0.6690.21
214_S231_A0.6680.21
362_V403_V0.6680.21
381_N395_L0.6670.21
64_V67_D0.6650.21
113_L132_A0.6650.21
118_I123_Q0.6640.20
186_N231_A0.6640.20
324_A334_L0.6630.20
89_T336_G0.6630.20
192_L238_S0.6630.20
286_A291_C0.6630.20
425_L450_L0.6620.20
227_L240_L0.6600.20
295_E326_V0.6580.20
409_L430_A0.6570.20
90_D354_V0.6560.20
58_A95_Q0.6550.20
65_I384_G0.6540.20
198_R201_E0.6530.20
188_D381_N0.6530.20
291_C342_Y0.6530.20
261_C406_A0.6520.20
55_C192_L0.6480.20
126_L163_T0.6470.20
282_L287_T0.6450.20
201_E332_V0.6450.20
196_L375_D0.6440.20
175_I208_H0.6430.20
220_T225_R0.6430.20
79_K159_M0.6430.20
52_I84_A0.6430.20
171_Q202_L0.6410.20
292_V318_A0.6380.20
163_T192_L0.6350.19
111_P312_F0.6350.19
3_Q409_L0.6340.19
79_K188_D0.6340.19
89_T329_L0.6330.19
241_M312_F0.6330.19
378_V415_V0.6330.19
116_D140_S0.6320.19
55_C69_F0.6310.19
355_A396_N0.6290.19
128_R199_T0.6290.19
182_V449_T0.6290.19
47_A443_L0.6280.19
276_G306_L0.6280.19
100_F230_F0.6270.19
204_P207_G0.6260.19
290_R407_G0.6240.19
265_R377_Y0.6240.19
395_L400_L0.6230.19
443_L450_L0.6230.19
414_C425_L0.6230.19
264_T435_P0.6210.19
10_V141_V0.6200.19
382_G429_S0.6200.19
293_N439_D0.6200.19
138_M278_I0.6200.19
158_E427_F0.6200.19
165_V443_L0.6200.19
201_E206_L0.6190.19
105_S188_D0.6150.19
68_D222_A0.6140.19
3_Q361_S0.6130.19
80_H293_N0.6130.19
165_V360_L0.6120.19
145_D169_E0.6110.19
209_N251_R0.6110.19
139_L163_T0.6110.19
277_A447_F0.6100.18
440_A445_S0.6090.18
322_D326_V0.6090.18
69_F100_F0.6080.18
385_G407_G0.6070.18
44_L211_T0.6050.18
428_N450_L0.6030.18
83_S100_F0.6030.18
224_V427_F0.6020.18
222_A396_N0.6020.18
55_C138_M0.6010.18
62_K95_Q0.6010.18
134_A154_A0.6000.18
188_D322_D0.5980.18
434_Q437_I0.5980.18
221_Y246_L0.5980.18
116_D288_S0.5960.18
155_H161_V0.5950.18
84_A159_M0.5940.18
155_H443_L0.5940.18
114_C306_L0.5940.18
79_K292_V0.5930.18
99_N156_S0.5930.18
124_I153_V0.5910.18
21_K404_L0.5910.18
14_A18_E0.5910.18
365_T412_D0.5890.18
415_V427_F0.5880.18
198_R276_G0.5880.18
53_L138_M0.5870.18
30_Q45_Q0.5870.18
290_R408_G0.5860.18
124_I295_E0.5850.18
21_K122_Y0.5840.18
332_V410_G0.5830.18
270_K302_A0.5830.18
54_E60_P0.5820.18
56_K60_P0.5820.18
84_A194_I0.5810.17
17_V129_Y0.5800.17
195_D269_A0.5800.17
312_F336_G0.5800.17
181_V313_R0.5790.17
16_W98_F0.5780.17
17_V188_D0.5780.17
297_A329_L0.5780.17
167_N205_K0.5770.17
147_Y234_F0.5750.17
364_E367_P0.5750.17
49_T255_L0.5740.17
364_E449_T0.5740.17
102_P106_Q0.5730.17
196_L424_G0.5700.17
148_R152_A0.5700.17
24_Q210_V0.5700.17
298_Q302_A0.5700.17
201_E443_L0.5690.17
233_G289_P0.5690.17
326_V419_Q0.5680.17
263_L282_L0.5670.17
112_I359_A0.5670.17
385_G408_G0.5670.17
393_S444_A0.5650.17
214_S356_I0.5630.17
122_Y314_N0.5620.17
76_A443_L0.5610.17
140_S395_L0.5600.17
270_K274_D0.5590.17
83_S108_A0.5580.17
158_E366_L0.5570.17
147_Y161_V0.5570.17
376_K404_L0.5570.17
29_F153_V0.5560.17
75_A132_A0.5550.17
362_V395_L0.5540.17
139_L177_L0.5540.17
139_L192_L0.5540.17
142_L167_N0.5530.17
324_A332_V0.5530.17
192_L242_A0.5510.17
300_V360_L0.5500.16
99_N220_T0.5490.16
101_L223_Q0.5490.16
66_R192_L0.5480.16
111_P186_N0.5480.16
126_L129_Y0.5470.16
46_G49_T0.5470.16
140_S282_L0.5430.16
168_E199_T0.5430.16
251_R260_V0.5420.16
32_E35_P0.5420.16
318_A405_L0.5420.16
81_Y192_L0.5420.16
138_M161_V0.5410.16
267_Q273_Y0.5410.16
97_S206_L0.5410.16
85_I275_A0.5410.16
447_F450_L0.5400.16
212_V303_A0.5390.16
93_Y215_E0.5390.16
344_D445_S0.5390.16
11_A101_L0.5390.16
72_A105_S0.5380.16
85_I379_L0.5380.16
261_C385_G0.5370.16
323_K354_V0.5370.16
154_A392_W0.5350.16
155_H386_S0.5340.16
406_A430_A0.5340.16
178_G274_D0.5340.16
200_R230_F0.5330.16
13_K110_Q0.5330.16
92_K241_M0.5330.16
117_F311_V0.5320.16
186_N297_A0.5310.16
100_F253_V0.5300.16
234_F428_N0.5300.16
45_Q152_A0.5300.16
90_D166_S0.5290.16
53_L57_K0.5270.16
296_Q332_V0.5270.16
278_I318_A0.5270.16
29_F130_Y0.5270.16
135_C220_T0.5270.16
221_Y257_E0.5270.16
52_I55_C0.5260.16
7_A11_A0.5250.16
143_D149_Q0.5240.16
336_G358_K0.5240.16
112_I198_R0.5200.16
13_K93_Y0.5200.16
244_D318_A0.5190.15
5_V67_D0.5190.15
7_A14_A0.5180.15
182_V209_N0.5180.15
264_T268_D0.5180.15
175_I220_T0.5170.15
114_C163_T0.5150.15
318_A323_K0.5150.15
250_V254_L0.5140.15
97_S100_F0.5140.15
131_Q160_G0.5120.15
84_A236_I0.5120.15
416_E420_T0.5110.15
42_D343_I0.5110.15
16_W20_R0.5110.15
206_L209_N0.5080.15
192_L278_I0.5070.15
93_Y105_S0.5050.15
52_I447_F0.5050.15
4_T119_I0.5050.15
46_G293_N0.5040.15
153_V157_L0.5040.15
261_C290_R0.5030.15
324_A329_L0.5030.15
252_R378_V0.5020.15
163_T234_F0.5020.15
107_I450_L0.5020.15
72_A172_E0.5010.15
29_F122_Y0.5010.15
279_Y400_L0.5010.15
280_G428_N0.5010.15
258_N424_G0.5000.15
13_K214_S0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1piiA 1 0.9978 100 0.298 Contact Map
3tsmA 2 0.5585 100 0.665 Contact Map
1i4nA 1 0.5497 100 0.672 Contact Map
1v5xA 2 0.426 100 0.676 Contact Map
4aajA 1 0.404 100 0.69 Contact Map
3qjaA 1 0.5497 100 0.696 Contact Map
1vc4A 2 0.5519 100 0.697 Contact Map
4a29A 1 0.5342 100 0.7 Contact Map
1nsjA 2 0.4305 100 0.721 Contact Map
4wuiA 1 0.426 100 0.741 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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