GREMLIN Database
PABA - Aminodeoxychorismate synthase component 2
UniProt: P00903 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10682
Length: 187 (173)
Sequences: 12041 (6663)
Seq/√Len: 506.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_A132_V3.0201.00
94_V133_E2.9381.00
85_M162_L2.6661.00
119_A176_Q2.5011.00
92_K133_E2.3721.00
142_D156_R2.2811.00
22_L182_A2.2601.00
144_T156_R2.2541.00
86_A155_I2.2401.00
19_F48_V2.2321.00
35_T38_D2.2221.00
21_E178_H2.2171.00
57_D87_Q2.2081.00
157_H160_W2.2031.00
3_L29_K2.1961.00
142_D158_R2.1011.00
143_V152_I2.0921.00
63_L88_A1.9991.00
66_I84_A1.9771.00
176_Q179_Q1.9731.00
92_K136_S1.9551.00
18_Y178_H1.8911.00
4_L16_Y1.8661.00
63_L87_Q1.8501.00
145_A154_G1.8211.00
82_H164_G1.7121.00
157_H161_D1.7071.00
133_E136_S1.7021.00
7_N49_I1.6741.00
29_K34_L1.6671.00
27_L42_L1.6411.00
112_E156_R1.6281.00
94_V131_V1.6041.00
38_D41_A1.5771.00
140_C159_Q1.5731.00
179_Q182_A1.5441.00
40_D68_H1.4531.00
155_I164_G1.4361.00
101_H129_S1.4231.00
143_V146_W1.4201.00
15_L78_V1.3901.00
40_D72_R1.3891.00
132_V155_I1.3741.00
156_R163_E1.3641.00
4_L48_V1.3591.00
85_M164_G1.3431.00
49_I62_S1.3331.00
97_A151_E1.3321.00
8_Y32_D1.3181.00
89_F162_L1.3021.00
67_R70_A1.2781.00
140_C158_R1.2601.00
57_D92_K1.2571.00
46_K184_F1.2541.00
34_L38_D1.2501.00
24_A185_L1.2451.00
64_D67_R1.2371.00
82_H132_V1.2261.00
115_F154_G1.2131.00
86_A91_G1.2101.00
48_V76_L1.1991.00
59_A84_A1.1991.00
7_N62_S1.1971.00
27_L44_P1.1891.00
141_F157_H1.1881.00
141_F155_I1.1881.00
131_V151_E1.1791.00
2_I46_K1.1701.00
36_L40_D1.1471.00
64_D68_H1.1461.00
112_E144_T1.1431.00
70_A160_W1.1101.00
108_T146_W1.1001.00
18_Y21_E1.0791.00
15_L181_L1.0781.00
47_I65_V1.0621.00
110_N146_W1.0581.00
96_A131_V1.0441.00
37_A41_A1.0321.00
137_L143_V1.0301.00
110_N142_D1.0301.00
93_V132_V1.0181.00
22_L181_L1.0151.00
140_C157_H1.0091.00
67_R88_A1.0081.00
16_Y20_C0.9881.00
5_I65_V0.9871.00
37_A40_D0.9831.00
14_N17_Q0.9811.00
37_A68_H0.9811.00
49_I75_I0.9791.00
158_R161_D0.9761.00
86_A138_P0.9751.00
72_R160_W0.9741.00
3_L39_I0.9741.00
146_W150_R0.9561.00
76_L165_V0.9541.00
34_L42_L0.9531.00
40_D71_G0.9521.00
113_G156_R0.9501.00
89_F141_F0.9471.00
79_C168_H0.9461.00
91_G138_P0.9441.00
3_L42_L0.9421.00
2_I24_A0.9421.00
119_A175_E0.9401.00
70_A162_L0.9341.00
82_H155_I0.9331.00
54_C58_E0.9271.00
22_L178_H0.9241.00
55_T58_E0.9161.00
47_I73_L0.9141.00
95_R99_V0.9141.00
118_L176_Q0.9031.00
46_K185_L0.9001.00
65_V69_Y0.8921.00
109_H146_W0.8901.00
4_L11_F0.8891.00
65_V68_H0.8891.00
147_S151_E0.8801.00
78_V165_V0.8791.00
137_L152_I0.8761.00
34_L39_I0.8751.00
20_C26_V0.8731.00
17_Q20_C0.8701.00
91_G136_S0.8681.00
113_G163_E0.8641.00
63_L84_A0.8531.00
167_F180_L0.8521.00
5_I29_K0.8481.00
22_L185_L0.8461.00
98_K149_T0.8421.00
8_Y30_R0.8341.00
29_K38_D0.8301.00
145_A167_F0.8241.00
115_F167_F0.8221.00
59_A63_L0.8201.00
69_Y75_I0.8201.00
59_A62_S0.8181.00
5_I39_I0.8171.00
7_N31_N0.8171.00
144_T154_G0.8151.00
66_I75_I0.8131.00
36_L68_H0.8061.00
3_L44_P0.7961.00
39_I44_P0.7841.00
118_L179_Q0.7661.00
165_V169_P0.7601.00
156_R183_N0.7601.00
29_K42_L0.7601.00
57_D63_L0.7591.00
19_F181_L0.7591.00
71_G160_W0.7581.00
105_S148_E0.7581.00
36_L65_V0.7581.00
114_V163_E0.7561.00
163_E184_F0.7561.00
110_N144_T0.7531.00
19_F24_A0.7531.00
4_L19_F0.7521.00
55_T130_L0.7431.00
40_D73_L0.7411.00
63_L67_R0.7401.00
57_D93_V0.7371.00
19_F185_L0.7321.00
107_I146_W0.7301.00
13_W16_Y0.7291.00
89_F157_H0.7271.00
178_H182_A0.7261.00
23_G26_V0.7261.00
79_C83_Q0.7231.00
69_Y73_L0.7221.00
89_F160_W0.7201.00
11_F16_Y0.7191.00
112_E142_D0.7151.00
31_N60_G0.7141.00
126_R153_M0.7121.00
144_T163_E0.7111.00
116_R177_G0.7101.00
24_A46_K0.7101.00
12_T28_V0.7091.00
6_D12_T0.7091.00
118_L180_L0.6941.00
55_T95_R0.6931.00
61_I65_V0.6891.00
116_R179_Q0.6881.00
48_V184_F0.6841.00
66_I88_A0.6831.00
61_I64_D0.6781.00
2_I19_F0.6761.00
68_H71_G0.6761.00
44_P73_L0.6751.00
66_I70_A0.6671.00
17_Q21_E0.6611.00
108_T148_E0.6591.00
55_T87_Q0.6541.00
112_E163_E0.6481.00
38_D42_L0.6471.00
16_Y28_V0.6461.00
14_N18_Y0.6451.00
54_C57_D0.6441.00
117_G179_Q0.6441.00
87_Q92_K0.6421.00
127_Y130_L0.6421.00
47_I75_I0.6411.00
91_G132_V0.6391.00
100_M147_S0.6391.00
157_H162_L0.6351.00
43_K73_L0.6311.00
12_T50_S0.6291.00
62_S84_A0.6261.00
99_V129_S0.6211.00
4_L12_T0.6211.00
18_Y181_L0.6111.00
4_L50_S0.6101.00
136_S139_A0.6071.00
93_V130_L0.6020.99
3_L27_L0.6010.99
167_F177_G0.6000.99
4_L26_V0.5970.99
101_H127_Y0.5960.99
52_G80_L0.5930.99
76_L180_L0.5830.99
46_K76_L0.5820.99
5_I34_L0.5810.99
117_G183_N0.5760.99
110_N156_R0.5750.99
165_V180_L0.5740.99
75_I85_M0.5720.99
70_A89_F0.5680.99
111_G183_N0.5680.99
109_H112_E0.5550.99
49_I66_I0.5550.99
64_D69_Y0.5530.99
131_V150_R0.5480.99
32_D61_I0.5470.99
31_N61_I0.5460.99
115_F145_A0.5360.99
46_K74_P0.5340.99
175_E178_H0.5330.99
83_Q166_Q0.5320.99
152_I155_I0.5290.99
31_N62_S0.5280.99
2_I45_Q0.5280.99
109_H113_G0.5280.99
39_I65_V0.5280.99
131_V149_T0.5240.99
51_P79_C0.5190.98
96_A99_V0.5190.98
60_G63_L0.5180.98
68_H72_R0.5180.98
7_N84_A0.5150.98
94_V151_E0.5090.98
3_L34_L0.5090.98
84_A88_A0.5090.98
111_G156_R0.5070.98
76_L163_E0.5040.98
55_T93_V0.5030.98
64_D84_A0.5000.98
182_A185_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqiA 3 0.9091 100 0.196 Contact Map
2ywbA 4 0.9626 100 0.205 Contact Map
1gpmA 3 0.984 100 0.21 Contact Map
2vxoA 2 0.9626 100 0.221 Contact Map
3uowA 2 0.9786 100 0.258 Contact Map
1a9xB 1 0.9519 100 0.281 Contact Map
1qdlB 2 0.9893 100 0.287 Contact Map
1i1qB 1 0.9519 100 0.299 Contact Map
3r75A 2 0.9519 100 0.301 Contact Map
2vpiA 1 0.9305 100 0.306 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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