TRPE - ECOLI - GREMLIN Contacts

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TRPE - Anthranilate synthase component 1

UniProt:	P00895	Sequences: MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSGNGEALLALLDNALPAGVESEQSPNCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFEDLPQLSAENNCPDFCFYLAETLMVIDHQKKSTRIQASLFAPNEEEKQRLTARLNELRQQLTEAAPPLPVVSVPHMRCECNQSDEEFGGVVRLLQKAIRAGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPSPYMFFMQDNDFTLFGASPESSLKYDATSRQIEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATVQAGAGVVLDSVPQSEADETRNKARAVLRAIATAHHAQETF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11028
Length:	520 (431)
Sequences:	4489 (2956)
Seq/√Len:	142.4

ECOLI - TRPE PABB MENF ENTC
BACSU - TRPE PABB MENF DHBC
HALSA - TRPE1 TRPE2 Q9HQN2
SULSO - TRPE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
128_R	412_D	4.508	1.00
378_T	406_E	4.359	1.00
426_L	450_G	4.340	1.00
377_C	405_G	4.102	1.00
378_T	409_H	3.698	1.00
242_D	246_G	3.520	1.00
320_Q	404_V	3.274	1.00
330_R	351_E	3.189	1.00
255_A	260_E	3.026	1.00
329_T	396_V	3.021	1.00
491_V	494_S	3.006	1.00
242_D	493_Q	2.967	1.00
385_A	404_V	2.932	1.00
271_S	477_I	2.904	1.00
122_S	418_R	2.812	1.00
122_S	125_D	2.766	1.00
246_G	493_Q	2.738	1.00
255_A	440_E	2.734	1.00
386_D	389_K	2.681	1.00
245_F	484_A	2.669	1.00
271_S	479_T	2.650	1.00
254_K	258_A	2.628	1.00
241_S	244_E	2.556	1.00
349_E	392_R	2.538	1.00
240_Q	248_V	2.466	1.00
273_P	477_I	2.411	1.00
408_R	411_L	2.396	1.00
346_S	350_L	2.342	1.00
320_Q	406_E	2.331	1.00
319_R	406_E	2.323	1.00
383_Y	404_V	2.309	1.00
350_L	354_T	2.308	1.00
152_Y	435_M	2.295	1.00
454_G	464_T	2.258	1.00
411_L	415_H	2.248	1.00
303_L	448_S	2.243	1.00
433_R	436_Q	2.241	1.00
247_G	250_R	2.230	1.00
335_R	343_D	2.214	1.00
252_L	264_V	2.211	1.00
261_I	264_V	2.153	1.00
373_L	377_C	2.126	1.00
353_R	399_L	2.100	1.00
277_P	302_T	2.071	1.00
336_A	346_S	1.994	1.00
332_R	345_D	1.988	1.00
294_F	305_G	1.950	1.00
346_S	349_E	1.924	1.00
390_V	399_L	1.907	1.00
493_Q	497_D	1.886	1.00
79_A	96_Q	1.833	1.00
437_L	441_A	1.813	1.00
250_R	253_Q	1.813	1.00
304_F	473_V	1.796	1.00
239_N	444_R	1.795	1.00
294_F	453_V	1.776	1.00
266_P	484_A	1.773	1.00
315_D	318_S	1.771	1.00
326_I	400_V	1.745	1.00
276_S	279_A	1.713	1.00
334_R	344_L	1.711	1.00
205_K	209_T	1.688	1.00
348_I	351_E	1.677	1.00
392_R	397_M	1.673	1.00
254_K	257_R	1.668	1.00
448_S	467_V	1.668	1.00
347_R	351_E	1.654	1.00
146_F	177_L	1.651	1.00
484_A	499_T	1.634	1.00
473_V	478_A	1.627	1.00
242_D	496_A	1.624	1.00
263_Q	485_G	1.614	1.00
250_R	492_P	1.611	1.00
236_C	272_L	1.602	1.00
378_T	408_R	1.574	1.00
323_I	369_A	1.555	1.00
164_L	439_A	1.540	1.00
376_I	419_A	1.540	1.00
321_I	377_C	1.515	1.00
497_D	501_N	1.510	1.00
391_D	400_V	1.509	1.00
471_A	478_A	1.498	1.00
423_M	466_I	1.491	1.00
180_T	211_R	1.479	1.00
252_L	266_P	1.473	1.00
333_G	344_L	1.472	1.00
324_Y	391_D	1.469	1.00
183_V	194_Q	1.460	1.00
255_A	433_R	1.457	1.00
344_L	347_R	1.450	1.00
246_G	250_R	1.443	1.00
297_Q	302_T	1.441	1.00
267_S	481_Q	1.441	1.00
294_F	303_L	1.422	1.00
374_A	380_G	1.419	1.00
494_S	497_D	1.411	1.00
244_E	443_G	1.408	1.00
251_L	440_E	1.402	1.00
193_I	212_L	1.400	1.00
255_A	437_L	1.398	1.00
153_D	439_A	1.398	1.00
417_Y	456_F	1.392	1.00
237_E	273_P	1.392	1.00
150_F	154_L	1.384	1.00
150_F	456_F	1.382	1.00
280_A	473_V	1.379	1.00
249_V	492_P	1.379	1.00
268_R	499_T	1.377	1.00
333_G	348_I	1.371	1.00
94_S	183_V	1.371	1.00
123_V	157_G	1.370	1.00
355_D	358_E	1.355	1.00
266_P	486_V	1.343	1.00
417_Y	464_T	1.330	1.00
496_A	500_R	1.330	1.00
366_V	387_L	1.330	1.00
433_R	440_E	1.317	1.00
193_I	216_R	1.314	1.00
246_G	492_P	1.313	1.00
247_G	251_L	1.295	1.00
274_C	473_V	1.290	1.00
385_A	402_R	1.288	1.00
448_S	472_L	1.286	1.00
373_L	405_G	1.280	1.00
244_E	247_G	1.279	1.00
153_D	445_R	1.275	1.00
126_A	129_L	1.271	1.00
343_D	347_R	1.268	1.00
335_R	344_L	1.263	1.00
265_V	483_G	1.259	1.00
497_D	500_R	1.258	1.00
321_I	373_L	1.254	1.00
91_G	185_D	1.247	1.00
349_E	390_V	1.244	1.00
128_R	132_N	1.235	1.00
315_D	461_D	1.235	1.00
314_Y	416_A	1.232	1.00
322_E	404_V	1.230	1.00
373_L	420_C	1.226	1.00
407_L	416_A	1.225	1.00
295_F	302_T	1.223	1.00
480_V	507_L	1.221	1.00
184_I	191_T	1.217	1.00
455_Y	463_D	1.216	1.00
378_T	381_S	1.214	1.00
471_A	506_V	1.209	1.00
310_S	463_D	1.207	1.00
414_L	456_F	1.207	1.00
359_L	388_T	1.199	1.00
244_E	248_V	1.197	1.00
180_T	195_A	1.195	1.00
243_E	247_G	1.182	1.00
249_V	486_V	1.180	1.00
242_D	497_D	1.175	1.00
363_L	387_L	1.174	1.00
238_C	268_R	1.164	1.00
305_G	465_C	1.161	1.00
324_Y	386_D	1.157	0.99
251_L	254_K	1.153	0.99
280_A	471_A	1.153	0.99
331_P	501_N	1.152	0.99
305_G	453_V	1.150	0.99
257_R	488_L	1.146	0.99
123_V	173_F	1.145	0.99
111_L	114_E	1.139	0.99
141_R	315_D	1.136	0.99
270_F	500_R	1.131	0.99
278_L	295_F	1.129	0.99
252_L	261_I	1.126	0.99
482_A	503_A	1.126	0.99
153_D	156_A	1.120	0.99
177_L	458_A	1.120	0.99
277_P	473_V	1.120	0.99
496_A	499_T	1.115	0.99
281_Y	285_K	1.114	0.99
457_T	461_D	1.113	0.99
288_N	306_A	1.110	0.99
156_A	163_Q	1.105	0.99
193_I	215_L	1.103	0.99
168_N	444_R	1.102	0.99
150_F	175_F	1.101	0.99
324_Y	402_R	1.097	0.99
236_C	507_L	1.097	0.99
314_Y	407_L	1.096	0.99
280_A	304_F	1.089	0.99
274_C	280_A	1.085	0.99
352_M	390_V	1.082	0.99
112_L	115_D	1.079	0.99
161_L	436_Q	1.078	0.99
294_F	465_C	1.077	0.99
283_V	512_T	1.076	0.99
122_S	157_G	1.075	0.99
155_V	435_M	1.075	0.99
484_A	494_S	1.060	0.99
453_V	467_V	1.058	0.99
204_E	207_R	1.051	0.99
165_S	439_A	1.048	0.99
268_R	500_R	1.042	0.99
205_K	208_L	1.040	0.99
240_Q	443_G	1.039	0.99
170_C	472_L	1.034	0.99
314_Y	321_I	1.033	0.99
349_E	397_M	1.033	0.99
452_A	464_T	1.029	0.99
264_V	438_I	1.028	0.99
330_R	348_I	1.026	0.99
212_L	216_R	1.025	0.99
347_R	350_L	1.025	0.99
128_R	415_H	1.024	0.99
327_A	425_T	1.024	0.99
272_L	478_A	1.023	0.99
480_V	503_A	1.021	0.99
264_V	437_L	1.016	0.99
142_E	147_G	1.014	0.99
100_C	179_E	1.012	0.99
269_R	479_T	1.011	0.99
167_E	445_R	0.998	0.98
175_F	464_T	0.995	0.98
426_L	468_I	0.994	0.98
209_T	213_N	0.993	0.98
237_E	271_S	0.992	0.98
268_R	496_A	0.990	0.98
156_A	439_A	0.983	0.98
508_R	511_A	0.982	0.98
350_L	353_R	0.978	0.98
158_F	421_M	0.976	0.98
265_V	426_L	0.975	0.98
96_Q	147_G	0.974	0.98
252_L	486_V	0.972	0.98
322_E	402_R	0.970	0.98
273_P	476_G	0.969	0.98
311_S	323_I	0.964	0.98
353_R	390_V	0.961	0.98
238_C	499_T	0.960	0.98
214_E	218_Q	0.958	0.98
217_Q	221_E	0.956	0.98
283_V	513_A	0.954	0.98
319_R	409_H	0.954	0.98
327_A	362_H	0.949	0.98
174_C	301_F	0.948	0.98
182_M	191_T	0.947	0.98
344_L	348_I	0.947	0.98
101_R	130_L	0.947	0.98
327_A	365_L	0.945	0.98
290_S	293_M	0.944	0.98
365_L	425_T	0.943	0.98
250_R	257_R	0.941	0.98
331_P	494_S	0.939	0.98
293_M	306_A	0.935	0.98
261_I	434_A	0.934	0.98
100_C	177_L	0.933	0.98
274_C	478_A	0.929	0.98
251_L	255_A	0.927	0.98
363_L	388_T	0.924	0.98
290_S	395_Y	0.924	0.98
336_A	343_D	0.923	0.97
181_L	194_Q	0.921	0.97
417_Y	462_L	0.921	0.97
204_E	208_L	0.920	0.97
300_D	474_E	0.920	0.97
174_C	298_D	0.917	0.97
128_R	418_R	0.911	0.97
362_H	365_L	0.908	0.97
303_L	467_V	0.906	0.97
292_Y	310_S	0.904	0.97
314_Y	413_A	0.904	0.97
125_D	129_L	0.902	0.97
318_S	461_D	0.902	0.97
110_P	113_D	0.898	0.97
265_V	427_S	0.897	0.97
80_L	83_L	0.896	0.97
439_A	445_R	0.892	0.97
208_L	212_L	0.890	0.97
170_C	448_S	0.887	0.97
310_S	322_E	0.884	0.97
125_D	128_R	0.882	0.97
288_N	395_Y	0.880	0.97
127_F	175_F	0.877	0.97
323_I	373_L	0.877	0.97
323_I	420_C	0.876	0.97
154_L	173_F	0.876	0.97
331_P	334_R	0.875	0.97
110_P	115_D	0.875	0.97
270_F	507_L	0.873	0.96
151_S	172_D	0.871	0.96
243_E	246_G	0.868	0.96
413_A	462_L	0.864	0.96
265_V	450_G	0.858	0.96
157_G	172_D	0.858	0.96
310_S	324_Y	0.855	0.96
260_E	433_R	0.852	0.96
504_R	508_R	0.850	0.96
321_I	416_A	0.848	0.96
155_V	158_F	0.848	0.96
206_Q	210_A	0.847	0.96
163_Q	439_A	0.846	0.96
246_G	491_V	0.845	0.96
250_R	254_K	0.845	0.96
433_R	437_L	0.844	0.96
124_F	154_L	0.844	0.96
301_F	474_E	0.842	0.96
162_P	436_Q	0.838	0.96
234_M	273_P	0.838	0.96
423_M	465_C	0.837	0.96
252_L	441_A	0.832	0.95
202_E	206_Q	0.832	0.95
213_N	216_R	0.831	0.95
393_Y	400_V	0.829	0.95
102_V	174_C	0.828	0.95
79_A	83_L	0.826	0.95
79_A	82_A	0.819	0.95
331_P	348_I	0.817	0.95
99_N	178_A	0.816	0.95
142_E	145_F	0.812	0.95
170_C	301_F	0.810	0.95
324_Y	389_K	0.809	0.95
210_A	214_E	0.808	0.95
128_R	414_L	0.805	0.94
81_L	84_L	0.805	0.94
248_V	252_L	0.804	0.94
134_L	458_A	0.804	0.94
253_Q	488_L	0.797	0.94
169_N	474_E	0.796	0.94
248_V	266_P	0.796	0.94
132_N	412_D	0.795	0.94
381_S	406_E	0.793	0.94
109_S	114_E	0.791	0.94
211_R	215_L	0.790	0.94
288_N	505_A	0.789	0.94
98_P	180_T	0.787	0.94
118_L	121_L	0.787	0.94
255_A	436_Q	0.787	0.94
239_N	268_R	0.786	0.94
277_P	295_F	0.786	0.94
355_D	494_S	0.785	0.94
165_S	168_N	0.782	0.94
150_F	173_F	0.782	0.94
213_N	217_Q	0.781	0.94
394_S	505_A	0.780	0.94
253_Q	257_R	0.779	0.93
384_V	387_L	0.778	0.93
149_L	448_S	0.777	0.93
374_A	379_P	0.776	0.93
154_L	157_G	0.775	0.93
302_T	473_V	0.775	0.93
104_R	174_C	0.771	0.93
386_D	402_R	0.769	0.93
156_A	162_P	0.765	0.93
147_G	296_M	0.762	0.93
369_A	465_C	0.760	0.93
395_Y	505_A	0.760	0.93
314_Y	319_R	0.758	0.93
245_F	499_T	0.758	0.93
77_G	102_V	0.754	0.92
79_A	178_A	0.753	0.92
314_Y	462_L	0.753	0.92
103_L	126_A	0.751	0.92
311_S	420_C	0.750	0.92
214_E	217_Q	0.749	0.92
208_L	219_L	0.748	0.92
421_M	466_I	0.748	0.92
206_Q	209_T	0.747	0.92
275_P	476_G	0.747	0.92
79_A	147_G	0.747	0.92
362_H	450_G	0.747	0.92
359_L	387_L	0.744	0.92
369_A	423_M	0.744	0.92
362_H	397_M	0.743	0.92
471_A	480_V	0.735	0.91
86_N	90_A	0.734	0.91
78_E	82_A	0.734	0.91
330_R	358_E	0.734	0.91
171_P	301_F	0.732	0.91
145_F	458_A	0.732	0.91
216_R	220_T	0.730	0.91
331_P	497_D	0.727	0.91
130_L	146_F	0.726	0.91
362_H	425_T	0.726	0.91
129_L	132_N	0.724	0.91
190_S	286_K	0.724	0.91
261_I	437_L	0.722	0.91
367_D	370_R	0.720	0.90
426_L	466_I	0.720	0.90
436_Q	440_E	0.718	0.90
197_L	208_L	0.717	0.90
319_R	378_T	0.717	0.90
240_Q	244_E	0.714	0.90
111_L	116_A	0.714	0.90
249_V	253_Q	0.712	0.90
158_F	418_R	0.711	0.90
159_E	375_R	0.711	0.90
124_F	158_F	0.709	0.90
298_D	301_F	0.708	0.90
83_L	93_E	0.701	0.89
167_E	269_R	0.699	0.89
369_A	450_G	0.698	0.89
472_L	479_T	0.697	0.89
390_V	397_M	0.696	0.89
265_V	369_A	0.695	0.89
266_P	441_A	0.694	0.89
351_E	354_T	0.693	0.89
109_S	112_L	0.693	0.89
362_H	369_A	0.693	0.89
294_F	423_M	0.690	0.89
249_V	484_A	0.690	0.89
305_G	423_M	0.689	0.88
508_R	512_T	0.688	0.88
130_L	133_L	0.688	0.88
305_G	426_L	0.686	0.88
406_E	409_H	0.684	0.88
235_R	511_A	0.684	0.88
252_L	437_L	0.683	0.88
353_R	359_L	0.681	0.88
358_E	494_S	0.679	0.88
106_P	172_D	0.679	0.88
207_R	210_A	0.678	0.88
444_R	481_Q	0.677	0.88
269_R	444_R	0.676	0.88
267_S	483_G	0.675	0.87
284_L	506_V	0.675	0.87
359_L	399_L	0.672	0.87
321_I	405_G	0.671	0.87
165_S	443_G	0.671	0.87
100_C	458_A	0.669	0.87
93_E	96_Q	0.667	0.87
500_R	504_R	0.667	0.87
109_S	113_D	0.666	0.87
246_G	249_V	0.665	0.87
94_S	147_G	0.665	0.87
265_V	423_M	0.665	0.87
78_E	83_L	0.664	0.87
330_R	501_N	0.664	0.87
153_D	435_M	0.663	0.87
156_A	172_D	0.662	0.86
303_L	453_V	0.662	0.86
311_S	369_A	0.659	0.86
287_S	395_Y	0.657	0.86
296_M	453_V	0.657	0.86
437_L	440_E	0.653	0.86
304_F	471_A	0.653	0.86
412_D	415_H	0.653	0.86
365_L	484_A	0.653	0.86
471_A	509_A	0.653	0.86
182_M	193_I	0.652	0.86
269_R	481_Q	0.652	0.86
330_R	397_M	0.652	0.86
312_L	416_A	0.652	0.86
160_D	436_Q	0.651	0.86
331_P	344_L	0.651	0.86
456_F	462_L	0.650	0.85
324_Y	393_Y	0.650	0.85
207_R	211_R	0.649	0.85
423_M	450_G	0.645	0.85
159_E	432_V	0.643	0.85
108_V	120_S	0.643	0.85
196_S	458_A	0.642	0.85
85_D	88_L	0.642	0.85
82_A	285_K	0.641	0.85
367_D	372_D	0.640	0.85
132_N	135_N	0.639	0.84
163_Q	445_R	0.638	0.84
501_N	504_R	0.636	0.84
358_E	425_T	0.636	0.84
319_R	407_L	0.635	0.84
203_E	207_R	0.635	0.84
503_A	507_L	0.635	0.84
426_L	506_V	0.634	0.84
370_R	429_A	0.634	0.84
238_C	482_A	0.634	0.84
83_L	91_G	0.633	0.84
509_A	513_A	0.632	0.84
97_S	180_T	0.631	0.84
150_F	464_T	0.629	0.84
473_V	476_G	0.629	0.84
281_Y	304_F	0.627	0.83
507_L	511_A	0.625	0.83
323_I	403_V	0.624	0.83
432_V	435_M	0.623	0.83
108_V	157_G	0.623	0.83
420_C	465_C	0.623	0.83
311_S	362_H	0.622	0.83
467_V	470_S	0.621	0.83
260_E	371_N	0.621	0.83
450_G	465_C	0.620	0.83
311_S	327_A	0.619	0.83
486_V	494_S	0.618	0.82
265_V	305_G	0.617	0.82
150_F	417_Y	0.615	0.82
423_M	426_L	0.615	0.82
141_R	313_K	0.613	0.82
279_A	283_V	0.613	0.82
146_F	458_A	0.609	0.82
362_H	366_V	0.608	0.81
277_P	297_Q	0.608	0.81
239_N	271_S	0.606	0.81
211_R	214_E	0.605	0.81
167_E	474_E	0.603	0.81
358_E	365_L	0.603	0.81
265_V	434_A	0.600	0.81
346_S	392_R	0.600	0.81
421_M	450_G	0.598	0.80
321_I	407_L	0.598	0.80
268_R	470_S	0.597	0.80
100_C	146_F	0.597	0.80
321_I	376_I	0.596	0.80
330_R	355_D	0.596	0.80
425_T	484_A	0.596	0.80
362_H	392_R	0.594	0.80
197_L	204_E	0.594	0.80
398_H	485_G	0.593	0.80
121_L	129_L	0.592	0.80
327_A	484_A	0.590	0.79
142_E	463_D	0.588	0.79
264_V	434_A	0.587	0.79
113_D	116_A	0.587	0.79
364_M	372_D	0.586	0.79
474_E	479_T	0.586	0.79
265_V	465_C	0.586	0.79
248_V	443_G	0.585	0.79
144_M	457_T	0.584	0.79
389_K	402_R	0.583	0.79
368_L	424_G	0.582	0.79
312_L	420_C	0.581	0.78
105_F	157_G	0.580	0.78
305_G	369_A	0.580	0.78
90_A	93_E	0.579	0.78
262_F	370_R	0.579	0.78
92_V	95_E	0.578	0.78
311_S	365_L	0.578	0.78
80_L	93_E	0.577	0.78
294_F	470_S	0.577	0.78
432_V	436_Q	0.577	0.78
353_R	356_H	0.575	0.78
287_S	508_R	0.574	0.78
280_A	478_A	0.574	0.78
105_F	123_V	0.574	0.78
241_S	246_G	0.572	0.77
255_A	258_A	0.572	0.77
208_L	211_R	0.572	0.77
110_P	114_E	0.571	0.77
239_N	269_R	0.571	0.77
178_A	181_L	0.571	0.77
434_A	485_G	0.570	0.77
358_E	484_A	0.569	0.77
482_A	499_T	0.568	0.77
360_S	489_D	0.568	0.77
83_L	90_A	0.568	0.77
112_L	116_A	0.567	0.77
287_S	509_A	0.566	0.77
99_N	471_A	0.565	0.77
253_Q	489_D	0.564	0.76
369_A	425_T	0.563	0.76
195_A	211_R	0.561	0.76
206_Q	214_E	0.558	0.76
265_V	398_H	0.558	0.76
423_M	434_A	0.557	0.76
159_E	162_P	0.556	0.75
270_F	482_A	0.554	0.75
267_S	425_T	0.553	0.75
93_E	186_H	0.553	0.75
359_L	363_L	0.553	0.75
349_E	353_R	0.553	0.75
130_L	134_L	0.553	0.75
335_R	347_R	0.552	0.75
243_E	250_R	0.552	0.75
91_G	95_E	0.549	0.74
99_N	496_A	0.548	0.74
445_R	479_T	0.547	0.74
365_L	369_A	0.546	0.74
238_C	496_A	0.546	0.74
299_N	302_T	0.546	0.74
367_D	371_N	0.545	0.74
215_L	219_L	0.545	0.74
94_S	181_L	0.544	0.74
210_A	213_N	0.544	0.74
83_L	282_Y	0.543	0.74
138_K	461_D	0.543	0.74
248_V	441_A	0.542	0.74
262_F	371_N	0.542	0.74
84_L	87_A	0.541	0.73
292_Y	505_A	0.541	0.73
306_A	395_Y	0.540	0.73
369_A	397_M	0.539	0.73
153_D	450_G	0.536	0.73
152_Y	439_A	0.536	0.73
263_Q	365_L	0.536	0.73
121_L	125_D	0.536	0.73
156_A	445_R	0.536	0.73
265_V	294_F	0.536	0.73
371_N	489_D	0.536	0.73
262_F	267_S	0.536	0.73
164_L	445_R	0.535	0.73
82_A	93_E	0.534	0.72
310_S	400_V	0.533	0.72
75_G	297_Q	0.532	0.72
327_A	397_M	0.531	0.72
278_L	282_Y	0.530	0.72
343_D	346_S	0.529	0.72
152_Y	427_S	0.529	0.72
105_F	126_A	0.528	0.72
252_L	438_I	0.528	0.72
82_A	86_N	0.528	0.72
131_Q	456_F	0.526	0.71
168_N	269_R	0.526	0.71
155_V	425_T	0.526	0.71
253_Q	492_P	0.524	0.71
374_A	377_C	0.524	0.71
464_T	507_L	0.523	0.71
364_M	367_D	0.521	0.71
253_Q	491_V	0.521	0.71
186_H	189_K	0.520	0.70
343_D	409_H	0.520	0.70
91_G	94_S	0.519	0.70
435_M	438_I	0.519	0.70
97_S	215_L	0.519	0.70
266_P	483_G	0.518	0.70
238_C	270_F	0.517	0.70
150_F	421_M	0.515	0.70
291_P	436_Q	0.514	0.70
263_Q	487_V	0.514	0.70
426_L	488_L	0.513	0.69
500_R	507_L	0.511	0.69
326_I	468_I	0.511	0.69
168_N	479_T	0.510	0.69
289_P	306_A	0.510	0.69
327_A	369_A	0.508	0.69
255_A	360_S	0.508	0.69
355_D	362_H	0.508	0.69
495_E	498_E	0.506	0.68
110_P	116_A	0.506	0.68
149_L	472_L	0.505	0.68
129_L	133_L	0.505	0.68
203_E	206_Q	0.505	0.68
347_R	354_T	0.504	0.68
365_L	395_Y	0.504	0.68
427_S	435_M	0.504	0.68
376_I	416_A	0.504	0.68
288_N	482_A	0.504	0.68
252_L	265_V	0.503	0.68
371_N	375_R	0.502	0.68
80_L	91_G	0.502	0.68
155_V	365_L	0.501	0.68
109_S	116_A	0.501	0.68
172_D	445_R	0.500	0.68
277_P	304_F	0.500	0.68
151_S	154_L	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1i1qA	2	0.9846	100	0.223	Contact Map
1k0eA	1	0.825	100	0.269	Contact Map
4grhA	1	0.8269	100	0.281	Contact Map
1qdlA	1	0.7865	100	0.288	Contact Map
3logA	1	0.85	100	0.318	Contact Map
3h9mA	1	0.7462	100	0.33	Contact Map
2fn0A	2	0.7865	100	0.356	Contact Map
3gseA	1	0.7923	100	0.401	Contact Map
3bzmA	1	0.8115	100	0.434	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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