GREMLIN Database
TRPE - Anthranilate synthase component 1
UniProt: P00895 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11028
Length: 520 (431)
Sequences: 4489 (2956)
Seq/√Len: 142.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_R412_D4.5081.00
378_T406_E4.3591.00
426_L450_G4.3401.00
377_C405_G4.1021.00
378_T409_H3.6981.00
242_D246_G3.5201.00
320_Q404_V3.2741.00
330_R351_E3.1891.00
255_A260_E3.0261.00
329_T396_V3.0211.00
491_V494_S3.0061.00
242_D493_Q2.9671.00
385_A404_V2.9321.00
271_S477_I2.9041.00
122_S418_R2.8121.00
122_S125_D2.7661.00
246_G493_Q2.7381.00
255_A440_E2.7341.00
386_D389_K2.6811.00
245_F484_A2.6691.00
271_S479_T2.6501.00
254_K258_A2.6281.00
241_S244_E2.5561.00
349_E392_R2.5381.00
240_Q248_V2.4661.00
273_P477_I2.4111.00
408_R411_L2.3961.00
346_S350_L2.3421.00
320_Q406_E2.3311.00
319_R406_E2.3231.00
383_Y404_V2.3091.00
350_L354_T2.3081.00
152_Y435_M2.2951.00
454_G464_T2.2581.00
411_L415_H2.2481.00
303_L448_S2.2431.00
433_R436_Q2.2411.00
247_G250_R2.2301.00
335_R343_D2.2141.00
252_L264_V2.2111.00
261_I264_V2.1531.00
373_L377_C2.1261.00
353_R399_L2.1001.00
277_P302_T2.0711.00
336_A346_S1.9941.00
332_R345_D1.9881.00
294_F305_G1.9501.00
346_S349_E1.9241.00
390_V399_L1.9071.00
493_Q497_D1.8861.00
79_A96_Q1.8331.00
437_L441_A1.8131.00
250_R253_Q1.8131.00
304_F473_V1.7961.00
239_N444_R1.7951.00
294_F453_V1.7761.00
266_P484_A1.7731.00
315_D318_S1.7711.00
326_I400_V1.7451.00
276_S279_A1.7131.00
334_R344_L1.7111.00
205_K209_T1.6881.00
348_I351_E1.6771.00
392_R397_M1.6731.00
254_K257_R1.6681.00
448_S467_V1.6681.00
347_R351_E1.6541.00
146_F177_L1.6511.00
484_A499_T1.6341.00
473_V478_A1.6271.00
242_D496_A1.6241.00
263_Q485_G1.6141.00
250_R492_P1.6111.00
236_C272_L1.6021.00
378_T408_R1.5741.00
323_I369_A1.5551.00
164_L439_A1.5401.00
376_I419_A1.5401.00
321_I377_C1.5151.00
497_D501_N1.5101.00
391_D400_V1.5091.00
471_A478_A1.4981.00
423_M466_I1.4911.00
180_T211_R1.4791.00
252_L266_P1.4731.00
333_G344_L1.4721.00
324_Y391_D1.4691.00
183_V194_Q1.4601.00
255_A433_R1.4571.00
344_L347_R1.4501.00
246_G250_R1.4431.00
297_Q302_T1.4411.00
267_S481_Q1.4411.00
294_F303_L1.4221.00
374_A380_G1.4191.00
494_S497_D1.4111.00
244_E443_G1.4081.00
251_L440_E1.4021.00
193_I212_L1.4001.00
255_A437_L1.3981.00
153_D439_A1.3981.00
417_Y456_F1.3921.00
237_E273_P1.3921.00
150_F154_L1.3841.00
150_F456_F1.3821.00
280_A473_V1.3791.00
249_V492_P1.3791.00
268_R499_T1.3771.00
333_G348_I1.3711.00
94_S183_V1.3711.00
123_V157_G1.3701.00
355_D358_E1.3551.00
266_P486_V1.3431.00
417_Y464_T1.3301.00
496_A500_R1.3301.00
366_V387_L1.3301.00
433_R440_E1.3171.00
193_I216_R1.3141.00
246_G492_P1.3131.00
247_G251_L1.2951.00
274_C473_V1.2901.00
385_A402_R1.2881.00
448_S472_L1.2861.00
373_L405_G1.2801.00
244_E247_G1.2791.00
153_D445_R1.2751.00
126_A129_L1.2711.00
343_D347_R1.2681.00
335_R344_L1.2631.00
265_V483_G1.2591.00
497_D500_R1.2581.00
321_I373_L1.2541.00
91_G185_D1.2471.00
349_E390_V1.2441.00
128_R132_N1.2351.00
315_D461_D1.2351.00
314_Y416_A1.2321.00
322_E404_V1.2301.00
373_L420_C1.2261.00
407_L416_A1.2251.00
295_F302_T1.2231.00
480_V507_L1.2211.00
184_I191_T1.2171.00
455_Y463_D1.2161.00
378_T381_S1.2141.00
471_A506_V1.2091.00
310_S463_D1.2071.00
414_L456_F1.2071.00
359_L388_T1.1991.00
244_E248_V1.1971.00
180_T195_A1.1951.00
243_E247_G1.1821.00
249_V486_V1.1801.00
242_D497_D1.1751.00
363_L387_L1.1741.00
238_C268_R1.1641.00
305_G465_C1.1611.00
324_Y386_D1.1570.99
251_L254_K1.1530.99
280_A471_A1.1530.99
331_P501_N1.1520.99
305_G453_V1.1500.99
257_R488_L1.1460.99
123_V173_F1.1450.99
111_L114_E1.1390.99
141_R315_D1.1360.99
270_F500_R1.1310.99
278_L295_F1.1290.99
252_L261_I1.1260.99
482_A503_A1.1260.99
153_D156_A1.1200.99
177_L458_A1.1200.99
277_P473_V1.1200.99
496_A499_T1.1150.99
281_Y285_K1.1140.99
457_T461_D1.1130.99
288_N306_A1.1100.99
156_A163_Q1.1050.99
193_I215_L1.1030.99
168_N444_R1.1020.99
150_F175_F1.1010.99
324_Y402_R1.0970.99
236_C507_L1.0970.99
314_Y407_L1.0960.99
280_A304_F1.0890.99
274_C280_A1.0850.99
352_M390_V1.0820.99
112_L115_D1.0790.99
161_L436_Q1.0780.99
294_F465_C1.0770.99
283_V512_T1.0760.99
122_S157_G1.0750.99
155_V435_M1.0750.99
484_A494_S1.0600.99
453_V467_V1.0580.99
204_E207_R1.0510.99
165_S439_A1.0480.99
268_R500_R1.0420.99
205_K208_L1.0400.99
240_Q443_G1.0390.99
170_C472_L1.0340.99
314_Y321_I1.0330.99
349_E397_M1.0330.99
452_A464_T1.0290.99
264_V438_I1.0280.99
330_R348_I1.0260.99
212_L216_R1.0250.99
347_R350_L1.0250.99
128_R415_H1.0240.99
327_A425_T1.0240.99
272_L478_A1.0230.99
480_V503_A1.0210.99
264_V437_L1.0160.99
142_E147_G1.0140.99
100_C179_E1.0120.99
269_R479_T1.0110.99
167_E445_R0.9980.98
175_F464_T0.9950.98
426_L468_I0.9940.98
209_T213_N0.9930.98
237_E271_S0.9920.98
268_R496_A0.9900.98
156_A439_A0.9830.98
508_R511_A0.9820.98
350_L353_R0.9780.98
158_F421_M0.9760.98
265_V426_L0.9750.98
96_Q147_G0.9740.98
252_L486_V0.9720.98
322_E402_R0.9700.98
273_P476_G0.9690.98
311_S323_I0.9640.98
353_R390_V0.9610.98
238_C499_T0.9600.98
214_E218_Q0.9580.98
217_Q221_E0.9560.98
283_V513_A0.9540.98
319_R409_H0.9540.98
327_A362_H0.9490.98
174_C301_F0.9480.98
182_M191_T0.9470.98
344_L348_I0.9470.98
101_R130_L0.9470.98
327_A365_L0.9450.98
290_S293_M0.9440.98
365_L425_T0.9430.98
250_R257_R0.9410.98
331_P494_S0.9390.98
293_M306_A0.9350.98
261_I434_A0.9340.98
100_C177_L0.9330.98
274_C478_A0.9290.98
251_L255_A0.9270.98
363_L388_T0.9240.98
290_S395_Y0.9240.98
336_A343_D0.9230.97
181_L194_Q0.9210.97
417_Y462_L0.9210.97
204_E208_L0.9200.97
300_D474_E0.9200.97
174_C298_D0.9170.97
128_R418_R0.9110.97
362_H365_L0.9080.97
303_L467_V0.9060.97
292_Y310_S0.9040.97
314_Y413_A0.9040.97
125_D129_L0.9020.97
318_S461_D0.9020.97
110_P113_D0.8980.97
265_V427_S0.8970.97
80_L83_L0.8960.97
439_A445_R0.8920.97
208_L212_L0.8900.97
170_C448_S0.8870.97
310_S322_E0.8840.97
125_D128_R0.8820.97
288_N395_Y0.8800.97
127_F175_F0.8770.97
323_I373_L0.8770.97
323_I420_C0.8760.97
154_L173_F0.8760.97
331_P334_R0.8750.97
110_P115_D0.8750.97
270_F507_L0.8730.96
151_S172_D0.8710.96
243_E246_G0.8680.96
413_A462_L0.8640.96
265_V450_G0.8580.96
157_G172_D0.8580.96
310_S324_Y0.8550.96
260_E433_R0.8520.96
504_R508_R0.8500.96
321_I416_A0.8480.96
155_V158_F0.8480.96
206_Q210_A0.8470.96
163_Q439_A0.8460.96
246_G491_V0.8450.96
250_R254_K0.8450.96
433_R437_L0.8440.96
124_F154_L0.8440.96
301_F474_E0.8420.96
162_P436_Q0.8380.96
234_M273_P0.8380.96
423_M465_C0.8370.96
252_L441_A0.8320.95
202_E206_Q0.8320.95
213_N216_R0.8310.95
393_Y400_V0.8290.95
102_V174_C0.8280.95
79_A83_L0.8260.95
79_A82_A0.8190.95
331_P348_I0.8170.95
99_N178_A0.8160.95
142_E145_F0.8120.95
170_C301_F0.8100.95
324_Y389_K0.8090.95
210_A214_E0.8080.95
128_R414_L0.8050.94
81_L84_L0.8050.94
248_V252_L0.8040.94
134_L458_A0.8040.94
253_Q488_L0.7970.94
169_N474_E0.7960.94
248_V266_P0.7960.94
132_N412_D0.7950.94
381_S406_E0.7930.94
109_S114_E0.7910.94
211_R215_L0.7900.94
288_N505_A0.7890.94
98_P180_T0.7870.94
118_L121_L0.7870.94
255_A436_Q0.7870.94
239_N268_R0.7860.94
277_P295_F0.7860.94
355_D494_S0.7850.94
165_S168_N0.7820.94
150_F173_F0.7820.94
213_N217_Q0.7810.94
394_S505_A0.7800.94
253_Q257_R0.7790.93
384_V387_L0.7780.93
149_L448_S0.7770.93
374_A379_P0.7760.93
154_L157_G0.7750.93
302_T473_V0.7750.93
104_R174_C0.7710.93
386_D402_R0.7690.93
156_A162_P0.7650.93
147_G296_M0.7620.93
369_A465_C0.7600.93
395_Y505_A0.7600.93
314_Y319_R0.7580.93
245_F499_T0.7580.93
77_G102_V0.7540.92
79_A178_A0.7530.92
314_Y462_L0.7530.92
103_L126_A0.7510.92
311_S420_C0.7500.92
214_E217_Q0.7490.92
208_L219_L0.7480.92
421_M466_I0.7480.92
206_Q209_T0.7470.92
275_P476_G0.7470.92
79_A147_G0.7470.92
362_H450_G0.7470.92
359_L387_L0.7440.92
369_A423_M0.7440.92
362_H397_M0.7430.92
471_A480_V0.7350.91
86_N90_A0.7340.91
78_E82_A0.7340.91
330_R358_E0.7340.91
171_P301_F0.7320.91
145_F458_A0.7320.91
216_R220_T0.7300.91
331_P497_D0.7270.91
130_L146_F0.7260.91
362_H425_T0.7260.91
129_L132_N0.7240.91
190_S286_K0.7240.91
261_I437_L0.7220.91
367_D370_R0.7200.90
426_L466_I0.7200.90
436_Q440_E0.7180.90
197_L208_L0.7170.90
319_R378_T0.7170.90
240_Q244_E0.7140.90
111_L116_A0.7140.90
249_V253_Q0.7120.90
158_F418_R0.7110.90
159_E375_R0.7110.90
124_F158_F0.7090.90
298_D301_F0.7080.90
83_L93_E0.7010.89
167_E269_R0.6990.89
369_A450_G0.6980.89
472_L479_T0.6970.89
390_V397_M0.6960.89
265_V369_A0.6950.89
266_P441_A0.6940.89
351_E354_T0.6930.89
109_S112_L0.6930.89
362_H369_A0.6930.89
294_F423_M0.6900.89
249_V484_A0.6900.89
305_G423_M0.6890.88
508_R512_T0.6880.88
130_L133_L0.6880.88
305_G426_L0.6860.88
406_E409_H0.6840.88
235_R511_A0.6840.88
252_L437_L0.6830.88
353_R359_L0.6810.88
358_E494_S0.6790.88
106_P172_D0.6790.88
207_R210_A0.6780.88
444_R481_Q0.6770.88
269_R444_R0.6760.88
267_S483_G0.6750.87
284_L506_V0.6750.87
359_L399_L0.6720.87
321_I405_G0.6710.87
165_S443_G0.6710.87
100_C458_A0.6690.87
93_E96_Q0.6670.87
500_R504_R0.6670.87
109_S113_D0.6660.87
246_G249_V0.6650.87
94_S147_G0.6650.87
265_V423_M0.6650.87
78_E83_L0.6640.87
330_R501_N0.6640.87
153_D435_M0.6630.87
156_A172_D0.6620.86
303_L453_V0.6620.86
311_S369_A0.6590.86
287_S395_Y0.6570.86
296_M453_V0.6570.86
437_L440_E0.6530.86
304_F471_A0.6530.86
412_D415_H0.6530.86
365_L484_A0.6530.86
471_A509_A0.6530.86
182_M193_I0.6520.86
269_R481_Q0.6520.86
330_R397_M0.6520.86
312_L416_A0.6520.86
160_D436_Q0.6510.86
331_P344_L0.6510.86
456_F462_L0.6500.85
324_Y393_Y0.6500.85
207_R211_R0.6490.85
423_M450_G0.6450.85
159_E432_V0.6430.85
108_V120_S0.6430.85
196_S458_A0.6420.85
85_D88_L0.6420.85
82_A285_K0.6410.85
367_D372_D0.6400.85
132_N135_N0.6390.84
163_Q445_R0.6380.84
501_N504_R0.6360.84
358_E425_T0.6360.84
319_R407_L0.6350.84
203_E207_R0.6350.84
503_A507_L0.6350.84
426_L506_V0.6340.84
370_R429_A0.6340.84
238_C482_A0.6340.84
83_L91_G0.6330.84
509_A513_A0.6320.84
97_S180_T0.6310.84
150_F464_T0.6290.84
473_V476_G0.6290.84
281_Y304_F0.6270.83
507_L511_A0.6250.83
323_I403_V0.6240.83
432_V435_M0.6230.83
108_V157_G0.6230.83
420_C465_C0.6230.83
311_S362_H0.6220.83
467_V470_S0.6210.83
260_E371_N0.6210.83
450_G465_C0.6200.83
311_S327_A0.6190.83
486_V494_S0.6180.82
265_V305_G0.6170.82
150_F417_Y0.6150.82
423_M426_L0.6150.82
141_R313_K0.6130.82
279_A283_V0.6130.82
146_F458_A0.6090.82
362_H366_V0.6080.81
277_P297_Q0.6080.81
239_N271_S0.6060.81
211_R214_E0.6050.81
167_E474_E0.6030.81
358_E365_L0.6030.81
265_V434_A0.6000.81
346_S392_R0.6000.81
421_M450_G0.5980.80
321_I407_L0.5980.80
268_R470_S0.5970.80
100_C146_F0.5970.80
321_I376_I0.5960.80
330_R355_D0.5960.80
425_T484_A0.5960.80
362_H392_R0.5940.80
197_L204_E0.5940.80
398_H485_G0.5930.80
121_L129_L0.5920.80
327_A484_A0.5900.79
142_E463_D0.5880.79
264_V434_A0.5870.79
113_D116_A0.5870.79
364_M372_D0.5860.79
474_E479_T0.5860.79
265_V465_C0.5860.79
248_V443_G0.5850.79
144_M457_T0.5840.79
389_K402_R0.5830.79
368_L424_G0.5820.79
312_L420_C0.5810.78
105_F157_G0.5800.78
305_G369_A0.5800.78
90_A93_E0.5790.78
262_F370_R0.5790.78
92_V95_E0.5780.78
311_S365_L0.5780.78
80_L93_E0.5770.78
294_F470_S0.5770.78
432_V436_Q0.5770.78
353_R356_H0.5750.78
287_S508_R0.5740.78
280_A478_A0.5740.78
105_F123_V0.5740.78
241_S246_G0.5720.77
255_A258_A0.5720.77
208_L211_R0.5720.77
110_P114_E0.5710.77
239_N269_R0.5710.77
178_A181_L0.5710.77
434_A485_G0.5700.77
358_E484_A0.5690.77
482_A499_T0.5680.77
360_S489_D0.5680.77
83_L90_A0.5680.77
112_L116_A0.5670.77
287_S509_A0.5660.77
99_N471_A0.5650.77
253_Q489_D0.5640.76
369_A425_T0.5630.76
195_A211_R0.5610.76
206_Q214_E0.5580.76
265_V398_H0.5580.76
423_M434_A0.5570.76
159_E162_P0.5560.75
270_F482_A0.5540.75
267_S425_T0.5530.75
93_E186_H0.5530.75
359_L363_L0.5530.75
349_E353_R0.5530.75
130_L134_L0.5530.75
335_R347_R0.5520.75
243_E250_R0.5520.75
91_G95_E0.5490.74
99_N496_A0.5480.74
445_R479_T0.5470.74
365_L369_A0.5460.74
238_C496_A0.5460.74
299_N302_T0.5460.74
367_D371_N0.5450.74
215_L219_L0.5450.74
94_S181_L0.5440.74
210_A213_N0.5440.74
83_L282_Y0.5430.74
138_K461_D0.5430.74
248_V441_A0.5420.74
262_F371_N0.5420.74
84_L87_A0.5410.73
292_Y505_A0.5410.73
306_A395_Y0.5400.73
369_A397_M0.5390.73
153_D450_G0.5360.73
152_Y439_A0.5360.73
263_Q365_L0.5360.73
121_L125_D0.5360.73
156_A445_R0.5360.73
265_V294_F0.5360.73
371_N489_D0.5360.73
262_F267_S0.5360.73
164_L445_R0.5350.73
82_A93_E0.5340.72
310_S400_V0.5330.72
75_G297_Q0.5320.72
327_A397_M0.5310.72
278_L282_Y0.5300.72
343_D346_S0.5290.72
152_Y427_S0.5290.72
105_F126_A0.5280.72
252_L438_I0.5280.72
82_A86_N0.5280.72
131_Q456_F0.5260.71
168_N269_R0.5260.71
155_V425_T0.5260.71
253_Q492_P0.5240.71
374_A377_C0.5240.71
464_T507_L0.5230.71
364_M367_D0.5210.71
253_Q491_V0.5210.71
186_H189_K0.5200.70
343_D409_H0.5200.70
91_G94_S0.5190.70
435_M438_I0.5190.70
97_S215_L0.5190.70
266_P483_G0.5180.70
238_C270_F0.5170.70
150_F421_M0.5150.70
291_P436_Q0.5140.70
263_Q487_V0.5140.70
426_L488_L0.5130.69
500_R507_L0.5110.69
326_I468_I0.5110.69
168_N479_T0.5100.69
289_P306_A0.5100.69
327_A369_A0.5080.69
255_A360_S0.5080.69
355_D362_H0.5080.69
495_E498_E0.5060.68
110_P116_A0.5060.68
149_L472_L0.5050.68
129_L133_L0.5050.68
203_E206_Q0.5050.68
347_R354_T0.5040.68
365_L395_Y0.5040.68
427_S435_M0.5040.68
376_I416_A0.5040.68
288_N482_A0.5040.68
252_L265_V0.5030.68
371_N375_R0.5020.68
80_L91_G0.5020.68
155_V365_L0.5010.68
109_S116_A0.5010.68
172_D445_R0.5000.68
277_P304_F0.5000.68
151_S154_L0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i1qA 2 0.9846 100 0.223 Contact Map
1k0eA 1 0.825 100 0.269 Contact Map
4grhA 1 0.8269 100 0.281 Contact Map
1qdlA 1 0.7865 100 0.288 Contact Map
3logA 1 0.85 100 0.318 Contact Map
3h9mA 1 0.7462 100 0.33 Contact Map
2fn0A 2 0.7865 100 0.356 Contact Map
3gseA 1 0.7923 100 0.401 Contact Map
3bzmA 1 0.8115 100 0.434 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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