GREMLIN Database
ILVH - Acetolactate synthase isozyme 3 small subunit
UniProt: P00894 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10499
Length: 163 (157)
Sequences: 2372 (1196)
Seq/√Len: 95.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_V44_S3.8281.00
111_Q123_Q3.7971.00
105_T122_V3.4951.00
134_F138_I3.3071.00
11_N42_T3.2261.00
87_M131_L2.7251.00
124_L134_F2.5131.00
89_V135_L2.3891.00
140_D143_K2.3781.00
31_E51_V2.2991.00
109_R130_K2.2641.00
58_E62_K2.1881.00
102_K112_I2.1261.00
33_L44_S2.0851.00
43_L71_L1.9531.00
9_L15_A1.9221.00
91_I138_I1.9201.00
148_A155_L1.9081.00
16_L35_V1.9051.00
16_L33_L1.8431.00
87_M124_L1.8351.00
85_E149_R1.8301.00
11_N44_S1.8191.00
103_R106_E1.7941.00
10_E69_D1.7841.00
99_D103_R1.7781.00
109_R133_A1.7341.00
34_T153_V1.7291.00
52_G56_V1.6811.00
86_I150_S1.6251.00
136_A139_R1.6031.00
89_V134_F1.5941.00
10_E71_L1.5881.00
130_K133_A1.5871.00
92_Q145_V1.5711.00
20_I46_M1.5521.00
12_E69_D1.4771.00
11_N37_P1.4721.00
32_S49_Q1.4200.99
107_I115_V1.4200.99
3_R75_E1.4000.99
35_V46_M1.3620.99
86_I153_V1.3440.99
63_Q66_K1.3440.99
109_R126_G1.3130.99
94_S97_G1.2910.99
90_K158_G1.2910.99
18_R67_L1.2900.99
133_A157_R1.2640.99
93_A101_V1.2630.99
105_T110_G1.2440.99
17_S24_S1.2340.99
109_R157_R1.2260.98
124_L131_L1.2170.98
21_G26_R1.2020.98
15_A46_M1.2010.98
119_L158_G1.1960.98
58_E72_R1.1730.98
102_K106_E1.1590.98
9_L46_M1.1510.98
9_L35_V1.1490.98
84_R123_Q1.1430.98
29_N35_V1.1410.98
34_T46_M1.1210.97
108_F133_A1.1140.97
50_T141_V1.1080.97
25_Q50_T1.1020.97
5_L13_S1.0980.97
150_S153_V1.0920.97
62_K65_H1.0880.97
6_S155_L1.0760.97
19_V46_M1.0750.97
50_T60_I1.0710.96
128_S132_D1.0650.96
17_S20_I1.0650.96
26_R66_K1.0640.96
2_R83_E1.0550.96
89_V138_I1.0320.96
97_G101_V1.0100.95
65_H72_R1.0090.95
110_G134_F1.0060.95
132_D136_A0.9930.95
100_E103_R0.9850.94
87_M147_V0.9730.94
5_L61_E0.9480.93
112_I122_V0.9480.93
11_N40_D0.9440.93
2_R90_K0.9430.93
125_A153_V0.9410.93
103_R120_Y0.9400.93
9_L19_V0.9390.93
7_V48_I0.9360.93
76_L156_S0.9310.93
25_Q66_K0.9290.92
6_S76_L0.9010.91
132_D149_R0.8990.91
102_K137_S0.8930.91
22_L28_Y0.8900.91
21_G24_S0.8890.91
15_A20_I0.8850.90
28_Y59_Q0.8830.90
87_M144_I0.8810.90
126_G130_K0.8740.90
84_R109_R0.8740.90
59_Q63_Q0.8720.90
114_D158_G0.8620.89
114_D119_L0.8570.89
121_T155_L0.8560.89
30_I150_S0.8390.88
11_N38_T0.8320.88
107_I112_I0.8300.87
102_K107_I0.8150.86
130_K157_R0.8100.86
104_N134_F0.8100.86
16_L30_I0.8050.86
109_R125_A0.8040.86
74_S156_S0.8000.85
118_S159_D0.7990.85
143_K154_G0.7970.85
2_R31_E0.7940.85
39_D45_R0.7850.84
84_R88_L0.7840.84
77_G80_A0.7840.84
13_S34_T0.7820.84
117_P136_A0.7770.84
108_F130_K0.7730.83
7_V64_L0.7730.83
88_L126_G0.7600.82
17_S21_G0.7530.82
61_E65_H0.7460.81
16_L46_M0.7390.81
30_I35_V0.7310.80
98_R130_K0.7260.79
91_I143_K0.7120.78
31_E37_P0.7110.78
39_D148_A0.7100.78
116_T119_L0.7080.78
128_S152_V0.7020.77
58_E74_S0.7010.77
30_I33_L0.6950.76
111_Q137_S0.6950.76
106_E130_K0.6930.76
114_D157_R0.6820.75
93_A115_V0.6810.75
28_Y60_I0.6800.75
139_R143_K0.6720.74
4_I14_G0.6710.74
7_V28_Y0.6670.73
15_A44_S0.6670.73
76_L121_T0.6660.73
5_L57_L0.6650.73
72_R145_V0.6560.72
37_P41_P0.6550.72
24_S34_T0.6540.72
22_L59_Q0.6540.72
17_S57_L0.6510.72
101_V141_V0.6490.71
114_D130_K0.6470.71
125_A130_K0.6420.71
18_R44_S0.6410.70
4_I83_E0.6360.70
5_L71_L0.6330.70
11_N31_E0.6310.69
126_G133_A0.6260.69
61_E145_V0.6240.68
106_E132_D0.6210.68
52_G149_R0.6210.68
52_G57_L0.6180.68
36_A132_D0.6170.68
10_E155_L0.6160.67
104_N137_S0.6150.67
90_K146_E0.6140.67
90_K121_T0.6120.67
45_R148_A0.6120.67
41_P53_D0.6090.67
82_V121_T0.6070.66
104_N119_L0.6010.66
101_V138_I0.6000.65
37_P121_T0.6000.65
73_V140_D0.5930.65
19_V67_L0.5920.64
3_R143_K0.5920.64
16_L44_S0.5920.64
36_A148_A0.5900.64
132_D135_L0.5870.64
93_A120_Y0.5850.63
79_G129_G0.5850.63
21_G30_I0.5810.63
89_V147_V0.5760.62
54_E75_E0.5740.62
36_A120_Y0.5720.62
78_Q92_Q0.5720.62
14_G23_F0.5700.61
23_F50_T0.5690.61
110_G122_V0.5680.61
62_K72_R0.5680.61
25_Q120_Y0.5650.61
38_T41_P0.5650.61
127_T136_A0.5620.60
52_G55_K0.5600.60
14_G21_G0.5550.59
29_N44_S0.5540.59
92_Q143_K0.5530.59
100_E104_N0.5510.59
113_I126_G0.5480.58
32_S148_A0.5470.58
85_E128_S0.5390.57
58_E65_H0.5380.57
4_I152_V0.5310.56
37_P60_I0.5300.56
132_D159_D0.5280.56
91_I122_V0.5280.56
50_T57_L0.5270.56
47_T66_K0.5260.55
15_A25_Q0.5240.55
141_V145_V0.5240.55
80_A129_G0.5220.55
39_D72_R0.5200.55
19_V64_L0.5200.55
68_V74_S0.5190.54
30_I113_I0.5160.54
83_E152_V0.5150.54
84_R108_F0.5140.54
45_R146_E0.5120.53
24_S128_S0.5110.53
53_D56_V0.5110.53
27_G52_G0.5110.53
6_S64_L0.5100.53
17_S25_Q0.5090.53
38_T42_T0.5080.53
28_Y40_D0.5060.53
11_N43_L0.5040.52
120_Y141_V0.5030.52
55_K155_L0.5020.52
5_L18_R0.5010.52
81_H118_S0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f1fA 4 0.9939 100 0.207 Contact Map
2pc6A 2 0.9939 100 0.21 Contact Map
2fgcA 2 0.9693 100 0.228 Contact Map
2lvwA 2 0.5521 99.2 0.773 Contact Map
1y7pA 5 0.9448 98.7 0.815 Contact Map
2ko1A 2 0.5153 98.4 0.829 Contact Map
1zpvA 3 0.5215 98.4 0.83 Contact Map
2f06A 4 0.8221 98.4 0.83 Contact Map
1u8sA 2 0.4969 98.2 0.838 Contact Map
2nyiA 2 0.4908 97.7 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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