ILVI - ECOLI - GREMLIN Contacts

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ILVI - Acetolactate synthase isozyme 3 large subunit

UniProt:	P00893	Sequences: MEMLSGAEMVVRSLIDQGVKQVFGYPGGAVLDIYDALHTVGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGATNAITGIATAYMDSIPLVVLSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPQVLKKAFWLAASGRPGPVVVDLPKDILNPANKLPYVWPESVSMRSYNPTTTGHKGQIKRALQTLVAAKKPVVYVGGGAITAGCHQQLKETVEALNLPVVCSLMGLGAFPATHRQALGMLGMHGTYEANMTMHNADVIFAVGVRFDDRTTNNLAKYCPNATVLHIDIDPTSISKTVTADIPIVGDARQVLEQMLELLSQESAHQPLDEIRDWWQQIEQWRARQCLKYDTHSEKIKPQAVIETLWRLTKGDAYVTSDVGQHQMFAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPEETVVCVTGDGSIQMNIQELSTALQYELPVLVVNLNNRYLGMVKQWQDMIYSGRHSQSYMQSLPDFVRLAEAYGHVGIQISHPHELESKLSEALEQVRNNRLVFVDVTVDGSEHVYPMQIRGGGMDEMWLSKTERT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10500
Length:	574 (535)
Sequences:	14254 (9071)
Seq/√Len:	392.2

ECOLI - ILVI GCL ILVB ILVG OXC POXB MEND
BACSU - ILVX ILVB YDAP IOLD MEND
HALSA - MEND
SULSO - Q7LXT8 Q97ZB3 Q97UP3 Q97U16 Q97XR3 Q980V7 Q97V62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
506_R	509_E	4.940	1.00
380_T	525_E	3.793	1.00
474_N	544_D	3.659	1.00
55_V	85_G	3.508	1.00
231_E	251_H	3.433	1.00
516_I	530_E	3.422	1.00
225_Q	329_E	3.267	1.00
20_K	67_E	3.105	1.00
520_H	523_E	3.071	1.00
517_Q	546_T	3.005	1.00
197_K	334_L	2.962	1.00
384_L	529_S	2.851	1.00
225_Q	325_R	2.751	1.00
15_I	42_G	2.689	1.00
64_A	437_L	2.682	1.00
322_G	327_V	2.649	1.00
250_T	409_D	2.616	1.00
213_V	226_L	2.579	1.00
516_I	541_V	2.574	1.00
514_V	539_R	2.544	1.00
380_T	383_R	2.501	1.00
21_Q	44_D	2.499	1.00
199_A	301_L	2.466	1.00
519_S	523_E	2.442	1.00
303_I	327_V	2.436	1.00
430_A	444_C	2.337	1.00
279_V	324_A	2.324	1.00
516_I	527_K	2.284	1.00
534_Q	539_R	2.251	1.00
273_A	276_I	2.226	1.00
503_D	506_R	2.213	1.00
68_V	150_A	2.160	1.00
517_Q	544_D	2.153	1.00
73_V	82_A	2.153	1.00
383_R	525_E	2.151	1.00
514_V	530_E	2.137	1.00
437_L	440_E	2.116	1.00
8_E	36_A	2.101	1.00
278_A	281_V	2.094	1.00
48_V	54_A	2.045	1.00
202_T	299_T	2.036	1.00
507_L	510_A	2.022	1.00
86_I	98_V	2.010	1.00
202_T	275_V	2.004	1.00
120_G	123_R	1.996	1.00
452_Q	511_Y	1.988	1.00
202_T	318_I	1.987	1.00
97_V	146_F	1.967	1.00
211_V	230_V	1.942	1.00
80_T	84_T	1.942	1.00
505_V	515_G	1.913	1.00
203_L	277_F	1.905	1.00
12_R	16_D	1.899	1.00
100_S	158_V	1.897	1.00
232_A	332_L	1.888	1.00
518_I	527_K	1.886	1.00
382_W	407_P	1.861	1.00
141_V	159_V	1.841	1.00
386_K	389_A	1.828	1.00
193_K	330_Q	1.827	1.00
8_E	39_T	1.809	1.00
230_V	237_V	1.805	1.00
451_I	455_I	1.800	1.00
68_V	97_V	1.793	1.00
529_S	533_E	1.786	1.00
462_L	513_H	1.769	1.00
434_K	467_P	1.750	1.00
211_V	277_F	1.745	1.00
228_E	232_A	1.743	1.00
201_Q	205_A	1.743	1.00
232_A	336_S	1.742	1.00
525_E	529_S	1.730	1.00
227_K	231_E	1.720	1.00
514_V	541_V	1.720	1.00
192_H	195_Q	1.712	1.00
117_D	120_G	1.708	1.00
523_E	526_S	1.706	1.00
531_A	543_V	1.696	1.00
472_N	542_F	1.690	1.00
59_D	63_R	1.685	1.00
198_R	201_Q	1.681	1.00
379_E	383_R	1.670	1.00
519_S	546_T	1.667	1.00
390_Y	433_V	1.662	1.00
211_V	235_L	1.616	1.00
134_Q	137_D	1.612	1.00
509_E	514_V	1.607	1.00
279_V	303_I	1.595	1.00
381_L	445_V	1.587	1.00
425_F	429_A	1.573	1.00
394_D	446_T	1.564	1.00
224_Q	228_E	1.563	1.00
12_R	15_I	1.556	1.00
376_A	521_P	1.549	1.00
234_N	253_Q	1.538	1.00
526_S	530_E	1.537	1.00
310_I	321_V	1.536	1.00
384_L	525_E	1.531	1.00
126_V	158_V	1.530	1.00
130_F	159_V	1.524	1.00
394_D	450_S	1.510	1.00
203_L	275_V	1.508	1.00
195_Q	198_R	1.501	1.00
65_T	436_A	1.498	1.00
415_I	433_V	1.498	1.00
34_Y	45_H	1.490	1.00
434_K	466_L	1.487	1.00
505_V	517_Q	1.484	1.00
10_V	161_L	1.469	1.00
413_R	440_E	1.462	1.00
237_V	247_F	1.459	1.00
200_L	334_L	1.458	1.00
127_K	155_G	1.456	1.00
376_A	380_T	1.454	1.00
13_S	143_K	1.441	1.00
389_A	441_T	1.433	1.00
206_A	209_P	1.429	1.00
135_T	168_P	1.424	1.00
53_A	457_E	1.421	1.00
461_A	513_H	1.420	1.00
458_L	513_H	1.419	1.00
10_V	142_L	1.418	1.00
471_V	543_V	1.410	1.00
526_S	529_S	1.409	1.00
380_T	384_L	1.408	1.00
355_E	359_A	1.379	1.00
68_V	146_F	1.371	1.00
471_V	528_L	1.368	1.00
99_L	161_L	1.362	1.00
514_V	534_Q	1.361	1.00
387_G	409_D	1.359	1.00
461_A	468_V	1.359	1.00
17_Q	146_F	1.358	1.00
228_E	332_L	1.357	1.00
44_D	464_Y	1.354	1.00
200_L	331_M	1.352	1.00
24_G	45_H	1.351	1.00
275_V	301_L	1.350	1.00
377_V	545_V	1.344	1.00
21_Q	435_M	1.339	1.00
455_I	507_L	1.338	1.00
105_T	164_D	1.335	1.00
443_V	532_L	1.334	1.00
48_V	57_M	1.333	1.00
441_T	532_L	1.330	1.00
386_K	441_T	1.328	1.00
534_Q	541_V	1.327	1.00
347_I	351_W	1.319	1.00
82_A	98_V	1.316	1.00
191_G	327_V	1.312	1.00
390_Y	437_L	1.311	1.00
354_I	358_R	1.311	1.00
471_V	545_V	1.308	1.00
17_Q	143_K	1.305	1.00
97_V	149_A	1.304	1.00
229_T	233_L	1.295	1.00
229_T	332_L	1.294	1.00
385_T	443_V	1.294	1.00
435_M	466_L	1.293	1.00
206_A	275_V	1.293	1.00
86_I	96_L	1.292	1.00
15_I	41_G	1.290	1.00
299_T	317_D	1.289	1.00
434_K	441_T	1.284	1.00
505_V	509_E	1.280	1.00
469_L	531_A	1.274	1.00
325_R	329_E	1.271	1.00
272_N	353_Q	1.268	1.00
196_I	334_L	1.266	1.00
507_L	511_Y	1.264	1.00
55_V	82_A	1.260	1.00
467_P	538_N	1.253	1.00
348_R	352_Q	1.251	1.00
279_V	328_L	1.250	1.00
23_F	61_L	1.245	1.00
444_C	470_V	1.243	1.00
431_L	461_A	1.243	1.00
132_V	138_I	1.239	1.00
197_K	201_Q	1.236	1.00
210_V	273_A	1.234	1.00
467_P	539_R	1.234	1.00
137_D	140_Q	1.231	1.00
350_W	354_I	1.227	1.00
79_A	100_S	1.224	1.00
351_W	355_E	1.223	1.00
534_Q	538_N	1.222	1.00
311_S	316_A	1.221	1.00
476_R	501_L	1.220	1.00
229_T	328_L	1.219	1.00
46_V	435_M	1.218	1.00
330_Q	333_E	1.211	1.00
227_K	248_P	1.210	1.00
22_V	37_L	1.209	1.00
61_L	436_A	1.206	1.00
323_D	326_Q	1.205	1.00
142_L	159_V	1.204	1.00
372_I	377_V	1.203	1.00
352_Q	355_E	1.202	1.00
13_S	142_L	1.198	1.00
372_I	545_V	1.198	1.00
140_Q	144_K	1.197	1.00
390_Y	442_V	1.197	1.00
352_Q	356_Q	1.196	1.00
226_L	328_L	1.195	1.00
326_Q	329_E	1.192	1.00
506_R	510_A	1.190	1.00
7_A	36_A	1.183	1.00
19_V	70_V	1.182	1.00
227_K	247_F	1.180	1.00
5_S	169_A	1.180	1.00
9_M	170_N	1.179	1.00
193_K	334_L	1.178	1.00
200_L	204_V	1.173	1.00
513_H	542_F	1.172	1.00
524_L	545_V	1.171	1.00
423_M	453_M	1.171	1.00
130_F	144_K	1.167	1.00
225_Q	332_L	1.164	1.00
353_Q	357_W	1.164	1.00
198_R	202_T	1.161	1.00
508_A	542_F	1.159	1.00
387_G	410_K	1.157	1.00
62_A	95_P	1.152	1.00
20_K	44_D	1.151	1.00
527_K	543_V	1.149	1.00
239_C	254_A	1.147	1.00
162_P	165_I	1.144	1.00
6_G	138_I	1.144	1.00
211_V	229_T	1.144	1.00
130_F	141_V	1.140	1.00
268_M	272_N	1.138	1.00
225_Q	228_E	1.133	1.00
217_A	226_L	1.131	1.00
530_E	534_Q	1.130	1.00
83_I	121_I	1.129	1.00
87_A	420_L	1.128	1.00
59_D	88_T	1.126	1.00
290_N	293_K	1.124	1.00
5_S	8_E	1.122	1.00
228_E	231_E	1.122	1.00
228_E	329_E	1.121	1.00
132_V	141_V	1.120	1.00
508_A	513_H	1.119	1.00
356_Q	360_R	1.119	1.00
255_L	269_T	1.117	1.00
64_A	433_V	1.113	1.00
83_I	125_V	1.098	1.00
204_V	336_S	1.095	1.00
208_K	272_N	1.093	1.00
36_A	39_T	1.091	1.00
230_V	247_F	1.086	1.00
59_D	94_I	1.085	1.00
190_T	330_Q	1.084	1.00
244_L	249_A	1.081	1.00
231_E	253_Q	1.080	1.00
121_I	125_V	1.074	1.00
516_I	543_V	1.072	1.00
106_S	164_D	1.072	1.00
200_L	335_L	1.071	1.00
209_P	274_D	1.069	1.00
459_S	463_Q	1.067	1.00
53_A	454_N	1.064	1.00
105_T	168_P	1.064	1.00
90_Y	156_P	1.063	1.00
80_T	121_I	1.063	1.00
227_K	251_H	1.061	1.00
388_D	440_E	1.058	1.00
211_V	226_L	1.057	1.00
434_K	438_P	1.055	1.00
247_F	251_H	1.052	1.00
524_L	528_L	1.052	1.00
238_V	255_L	1.050	1.00
508_A	515_G	1.050	1.00
204_V	338_E	1.047	1.00
205_A	299_T	1.046	1.00
148_L	157_V	1.042	1.00
476_R	546_T	1.038	1.00
230_V	253_Q	1.038	1.00
385_T	391_V	1.038	1.00
213_V	217_A	1.034	1.00
55_V	71_V	1.034	1.00
515_G	542_F	1.032	1.00
71_V	82_A	1.030	1.00
441_T	469_L	1.029	1.00
391_V	406_Y	1.028	1.00
210_V	238_V	1.025	1.00
264_Y	268_M	1.024	1.00
199_A	318_I	1.023	1.00
199_A	320_I	1.022	1.00
469_L	541_V	1.021	1.00
108_I	131_L	1.021	1.00
434_K	442_V	1.020	1.00
10_V	99_L	1.020	1.00
60_G	64_A	1.015	1.00
21_Q	46_V	1.012	1.00
316_A	319_P	1.009	1.00
30_V	33_I	1.007	1.00
224_Q	227_K	1.004	1.00
46_V	464_Y	1.004	1.00
518_I	524_L	0.997	1.00
128_H	148_L	0.994	1.00
204_V	335_L	0.993	1.00
434_K	439_E	0.990	1.00
9_M	139_P	0.988	1.00
278_A	283_F	0.988	1.00
150_A	154_P	0.987	1.00
126_V	129_S	0.986	1.00
190_T	326_Q	0.986	1.00
232_A	337_Q	0.984	1.00
326_Q	330_Q	0.984	1.00
530_E	533_E	0.983	1.00
531_A	541_V	0.983	1.00
355_E	358_R	0.981	1.00
382_W	406_Y	0.981	1.00
191_G	330_Q	0.980	1.00
427_L	451_I	0.977	1.00
518_I	523_E	0.975	1.00
119_V	129_S	0.970	1.00
472_N	504_F	0.965	1.00
223_H	227_K	0.961	1.00
353_Q	356_Q	0.955	1.00
73_V	98_V	0.953	1.00
392_T	442_V	0.951	1.00
527_K	531_A	0.948	1.00
451_I	472_N	0.948	1.00
505_V	544_D	0.944	1.00
67_E	150_A	0.942	1.00
295_C	298_A	0.941	1.00
392_T	444_C	0.941	1.00
8_E	12_R	0.940	1.00
373_K	551_E	0.936	1.00
455_I	511_Y	0.936	1.00
55_V	96_L	0.936	1.00
378_I	445_V	0.935	1.00
426_G	444_C	0.935	1.00
458_L	542_F	0.934	1.00
10_V	33_I	0.931	1.00
229_T	335_L	0.931	1.00
201_Q	204_V	0.928	1.00
33_I	161_L	0.927	1.00
459_S	511_Y	0.927	1.00
206_A	274_D	0.927	1.00
194_G	197_K	0.926	1.00
129_S	158_V	0.925	1.00
79_A	122_S	0.924	1.00
128_H	141_V	0.922	1.00
458_L	470_V	0.921	1.00
350_W	357_W	0.919	1.00
22_V	70_V	0.918	1.00
102_Q	160_D	0.917	1.00
210_V	270_M	0.916	1.00
86_I	122_S	0.916	1.00
288_T	291_L	0.915	1.00
469_L	543_V	0.915	1.00
434_K	539_R	0.914	1.00
465_E	538_N	0.909	1.00
210_V	276_I	0.907	1.00
384_L	528_L	0.907	1.00
523_E	527_K	0.906	1.00
410_K	413_R	0.905	1.00
193_K	197_K	0.900	1.00
376_A	524_L	0.900	1.00
202_T	301_L	0.899	1.00
451_I	542_F	0.898	1.00
71_V	98_V	0.897	1.00
513_H	540_L	0.897	1.00
144_K	148_L	0.897	1.00
493_H	497_Y	0.896	1.00
473_L	547_V	0.896	1.00
461_A	470_V	0.896	1.00
469_L	532_L	0.892	1.00
63_R	94_I	0.888	1.00
119_V	131_L	0.885	1.00
228_E	336_S	0.884	1.00
120_G	124_P	0.881	1.00
80_T	87_A	0.881	1.00
6_G	135_T	0.881	1.00
377_V	473_L	0.879	1.00
389_A	443_V	0.875	1.00
354_I	357_W	0.872	1.00
211_V	279_V	0.869	1.00
384_L	532_L	0.867	1.00
205_A	275_V	0.866	1.00
201_Q	338_E	0.865	1.00
222_C	225_Q	0.864	1.00
199_A	275_V	0.864	1.00
320_I	327_V	0.863	1.00
432_G	436_A	0.862	1.00
64_A	415_I	0.862	1.00
13_S	17_Q	0.861	1.00
37_L	43_I	0.859	1.00
128_H	145_A	0.859	1.00
21_Q	61_L	0.853	1.00
208_K	274_D	0.853	1.00
35_D	38_H	0.850	1.00
452_Q	455_I	0.850	1.00
149_A	157_V	0.848	1.00
225_Q	328_L	0.848	1.00
463_Q	500_S	0.847	1.00
509_E	515_G	0.847	1.00
516_I	534_Q	0.846	1.00
191_G	196_I	0.845	1.00
60_G	429_A	0.845	1.00
527_K	530_E	0.845	1.00
199_A	202_T	0.845	1.00
461_A	540_L	0.843	1.00
445_V	473_L	0.842	1.00
468_V	540_L	0.842	1.00
303_I	320_I	0.835	1.00
13_S	16_D	0.834	1.00
476_R	549_G	0.834	1.00
494_S	497_Y	0.833	1.00
388_D	410_K	0.832	1.00
249_A	254_A	0.831	1.00
161_L	166_L	0.830	1.00
32_D	167_N	0.829	1.00
93_S	153_R	0.828	1.00
402_A	445_V	0.827	1.00
356_Q	359_A	0.825	1.00
218_I	246_A	0.824	1.00
196_I	330_Q	0.824	1.00
349_D	353_Q	0.824	1.00
378_I	473_L	0.820	1.00
380_T	524_L	0.817	1.00
57_M	461_A	0.815	1.00
349_D	352_Q	0.815	1.00
449_G	478_L	0.810	1.00
258_L	270_M	0.810	1.00
135_T	139_P	0.809	1.00
84_T	422_T	0.808	1.00
275_V	299_T	0.807	1.00
70_V	97_V	0.805	1.00
83_I	122_S	0.805	1.00
443_V	471_V	0.803	1.00
310_I	319_P	0.801	1.00
307_P	321_V	0.800	1.00
503_D	509_E	0.799	1.00
5_S	36_A	0.792	1.00
351_W	354_I	0.789	1.00
378_I	406_Y	0.788	1.00
198_R	318_I	0.788	1.00
503_D	517_Q	0.788	1.00
248_P	409_D	0.787	1.00
64_A	436_A	0.785	1.00
469_L	538_N	0.785	1.00
233_L	335_L	0.781	1.00
20_K	61_L	0.779	1.00
35_D	492_R	0.778	1.00
222_C	325_R	0.776	1.00
213_V	237_V	0.776	1.00
250_T	387_G	0.775	1.00
474_N	546_T	0.772	1.00
199_A	327_V	0.770	1.00
213_V	239_C	0.768	1.00
430_A	468_V	0.768	1.00
48_V	53_A	0.767	1.00
19_V	146_F	0.767	1.00
493_H	496_S	0.767	1.00
522_H	526_S	0.764	1.00
431_L	466_L	0.763	1.00
128_H	144_K	0.763	1.00
127_K	157_V	0.762	1.00
372_I	521_P	0.762	1.00
330_Q	334_L	0.761	1.00
56_H	422_T	0.760	1.00
390_Y	440_E	0.760	1.00
382_W	409_D	0.760	1.00
15_I	20_K	0.756	1.00
131_L	160_D	0.754	1.00
22_V	72_L	0.753	1.00
217_A	246_A	0.752	1.00
223_H	411_P	0.752	1.00
462_L	540_L	0.747	1.00
61_L	67_E	0.746	1.00
17_Q	150_A	0.745	1.00
462_L	512_G	0.745	1.00
97_V	150_A	0.744	1.00
393_S	416_N	0.743	1.00
87_A	125_V	0.743	1.00
393_S	414_W	0.742	1.00
357_W	360_R	0.740	1.00
72_L	99_L	0.740	1.00
427_L	470_V	0.739	1.00
309_S	312_K	0.737	1.00
204_V	334_L	0.737	1.00
204_V	333_E	0.736	1.00
62_A	94_I	0.736	1.00
147_W	151_S	0.732	1.00
515_G	544_D	0.730	1.00
128_H	157_V	0.729	1.00
398_H	450_S	0.728	1.00
26_P	47_L	0.727	1.00
190_T	193_K	0.727	1.00
277_F	303_I	0.726	1.00
239_C	249_A	0.725	1.00
221_G	412_R	0.724	1.00
127_K	148_L	0.724	1.00
452_Q	502_P	0.722	1.00
247_F	254_A	0.722	1.00
329_E	333_E	0.721	1.00
20_K	42_G	0.721	1.00
482_K	486_D	0.718	1.00
445_V	471_V	0.717	1.00
392_T	415_I	0.716	1.00
52_Q	81_N	0.715	1.00
62_A	96_L	0.714	1.00
73_V	100_S	0.714	1.00
86_I	125_V	0.713	1.00
14_L	70_V	0.708	1.00
35_D	39_T	0.706	1.00
188_T	323_D	0.704	1.00
252_R	355_E	0.702	1.00
441_T	467_P	0.701	1.00
215_G	242_M	0.696	1.00
394_D	426_G	0.696	1.00
119_V	123_R	0.695	1.00
462_L	500_S	0.694	1.00
209_P	235_L	0.693	1.00
329_E	332_L	0.693	1.00
248_P	251_H	0.692	1.00
470_V	513_H	0.689	0.99
347_I	350_W	0.689	0.99
259_G	262_G	0.688	0.99
25_Y	82_A	0.687	0.99
105_T	133_K	0.686	0.99
385_T	389_A	0.684	0.99
100_S	160_D	0.683	0.99
80_T	83_I	0.683	0.99
55_V	98_V	0.683	0.99
220_A	323_D	0.681	0.99
30_V	72_L	0.679	0.99
135_T	170_N	0.677	0.99
461_A	466_L	0.676	0.99
144_K	147_W	0.676	0.99
44_D	438_P	0.675	0.99
90_Y	127_K	0.675	0.99
452_Q	504_F	0.674	0.99
94_I	425_F	0.674	0.99
327_V	330_Q	0.674	0.99
443_V	469_L	0.673	0.99
139_P	143_K	0.672	0.99
80_T	116_C	0.672	0.99
211_V	237_V	0.671	0.99
372_I	520_H	0.670	0.99
358_R	361_Q	0.670	0.99
74_T	114_Q	0.668	0.99
207_K	274_D	0.668	0.99
471_V	524_L	0.667	0.99
268_M	271_H	0.665	0.99
202_T	205_A	0.664	0.99
195_Q	320_I	0.664	0.99
30_V	34_Y	0.662	0.99
427_L	446_T	0.662	0.99
333_E	336_S	0.661	0.99
122_S	158_V	0.661	0.99
21_Q	67_E	0.660	0.99
89_A	96_L	0.659	0.99
209_P	275_V	0.658	0.99
234_N	252_R	0.658	0.99
141_V	144_K	0.658	0.99
191_G	326_Q	0.658	0.99
477_Y	482_K	0.656	0.99
451_I	504_F	0.655	0.99
212_Y	278_A	0.655	0.99
377_V	471_V	0.655	0.99
392_T	433_V	0.655	0.99
148_L	153_R	0.653	0.99
33_I	166_L	0.652	0.99
513_H	539_R	0.652	0.99
435_M	464_Y	0.651	0.99
430_A	442_V	0.651	0.99
61_L	69_G	0.651	0.99
195_Q	199_A	0.649	0.99
32_D	166_L	0.648	0.99
427_L	457_E	0.648	0.99
310_I	316_A	0.647	0.99
291_L	294_Y	0.646	0.99
135_T	165_I	0.643	0.99
61_L	65_T	0.642	0.99
23_F	57_M	0.642	0.99
518_I	543_V	0.642	0.99
302_H	316_A	0.641	0.99
33_I	72_L	0.640	0.99
216_G	304_D	0.639	0.99
196_I	331_M	0.638	0.99
378_I	402_A	0.637	0.99
444_C	450_S	0.636	0.99
244_L	408_F	0.636	0.99
332_L	336_S	0.635	0.99
431_L	460_T	0.634	0.99
491_G	495_Q	0.633	0.99
30_V	101_G	0.633	0.99
304_D	309_S	0.632	0.99
392_T	426_G	0.631	0.99
278_A	300_V	0.630	0.99
467_P	540_L	0.629	0.99
226_L	230_V	0.626	0.99
81_N	84_T	0.625	0.99
145_A	159_V	0.625	0.99
370_E	520_H	0.624	0.99
233_L	253_Q	0.621	0.99
502_P	510_A	0.621	0.99
381_L	471_V	0.618	0.99
132_V	162_P	0.617	0.99
20_K	65_T	0.616	0.99
428_P	457_E	0.615	0.99
203_L	233_L	0.615	0.99
137_D	141_V	0.615	0.99
538_N	541_V	0.615	0.99
102_Q	108_I	0.614	0.99
6_G	9_M	0.612	0.99
520_H	526_S	0.612	0.99
91_M	420_L	0.608	0.99
49_R	463_Q	0.608	0.99
446_T	470_V	0.607	0.99
527_K	541_V	0.607	0.99
433_V	442_V	0.607	0.99
230_V	233_L	0.607	0.99
105_T	162_P	0.606	0.99
227_K	410_K	0.605	0.99
350_W	353_Q	0.604	0.99
272_N	349_D	0.602	0.99
56_H	88_T	0.600	0.99
218_I	412_R	0.597	0.99
136_E	171_K	0.597	0.99
15_I	43_I	0.596	0.99
393_S	426_G	0.596	0.99
212_Y	281_V	0.594	0.98
11_V	41_G	0.592	0.98
232_A	335_L	0.591	0.98
102_Q	131_L	0.591	0.98
60_G	432_G	0.589	0.98
57_M	435_M	0.589	0.98
327_V	331_M	0.589	0.98
516_I	526_S	0.589	0.98
389_A	440_E	0.588	0.98
370_E	521_P	0.588	0.98
164_D	168_P	0.587	0.98
503_D	544_D	0.586	0.98
225_Q	229_T	0.586	0.98
415_I	425_F	0.584	0.98
267_N	271_H	0.584	0.98
376_A	525_E	0.581	0.98
130_F	157_V	0.580	0.98
482_K	498_M	0.579	0.98
371_K	548_D	0.578	0.98
68_V	149_A	0.578	0.98
109_G	115_E	0.577	0.98
105_T	134_Q	0.576	0.98
59_D	429_A	0.575	0.98
334_L	338_E	0.575	0.98
44_D	435_M	0.575	0.98
427_L	461_A	0.574	0.98
50_H	81_N	0.574	0.98
146_F	150_A	0.573	0.98
245_G	249_A	0.573	0.98
446_T	454_N	0.572	0.98
451_I	470_V	0.571	0.98
64_A	390_Y	0.571	0.98
212_Y	240_S	0.569	0.98
234_N	351_W	0.569	0.98
255_L	266_A	0.567	0.98
377_V	524_L	0.565	0.98
347_I	354_I	0.565	0.98
301_L	318_I	0.564	0.98
9_M	172_L	0.563	0.98
87_A	116_C	0.562	0.98
100_S	118_M	0.562	0.98
398_H	473_L	0.562	0.98
16_D	172_L	0.562	0.98
242_M	418_G	0.561	0.98
191_G	322_G	0.559	0.98
38_H	492_R	0.559	0.98
196_I	320_I	0.559	0.98
469_L	539_R	0.559	0.98
357_W	361_Q	0.558	0.98
227_K	230_V	0.556	0.98
486_D	493_H	0.556	0.98
239_C	244_L	0.556	0.98
241_L	403_A	0.556	0.98
502_P	507_L	0.555	0.98
492_R	496_S	0.555	0.98
105_T	165_I	0.554	0.98
334_L	337_Q	0.554	0.98
95_P	149_A	0.554	0.98
13_S	139_P	0.553	0.98
97_V	157_V	0.553	0.98
153_R	306_D	0.552	0.98
97_V	159_V	0.552	0.98
54_A	71_V	0.551	0.98
335_L	338_E	0.551	0.98
455_I	510_A	0.550	0.98
348_R	351_W	0.549	0.97
188_T	192_H	0.548	0.97
228_E	333_E	0.548	0.97
263_T	363_L	0.548	0.97
288_T	292_A	0.546	0.97
127_K	153_R	0.545	0.97
390_Y	415_I	0.544	0.97
462_L	465_E	0.544	0.97
99_L	142_L	0.543	0.97
530_E	541_V	0.543	0.97
491_G	496_S	0.542	0.97
482_K	549_G	0.541	0.97
210_V	269_T	0.541	0.97
70_V	146_F	0.541	0.97
194_G	198_R	0.539	0.97
62_A	68_V	0.539	0.97
452_Q	456_Q	0.538	0.97
491_G	494_S	0.537	0.97
234_N	337_Q	0.537	0.97
393_S	402_A	0.537	0.97
528_L	532_L	0.537	0.97
446_T	450_S	0.536	0.97
385_T	406_Y	0.536	0.97
193_K	333_E	0.536	0.97
199_A	277_F	0.536	0.97
324_A	329_E	0.535	0.97
465_E	539_R	0.535	0.97
521_P	525_E	0.534	0.97
49_R	459_S	0.534	0.97
459_S	502_P	0.533	0.97
113_F	421_G	0.533	0.97
204_V	207_K	0.533	0.97
224_Q	231_E	0.533	0.97
388_D	441_T	0.532	0.97
359_A	363_L	0.532	0.97
218_I	223_H	0.532	0.97
378_I	382_W	0.530	0.97
19_V	68_V	0.530	0.97
99_L	159_V	0.530	0.97
11_V	37_L	0.529	0.97
132_V	159_V	0.529	0.97
503_D	510_A	0.529	0.97
55_V	86_I	0.529	0.97
90_Y	126_V	0.528	0.97
470_V	542_F	0.528	0.97
148_L	151_S	0.528	0.97
375_Q	551_E	0.527	0.97
457_E	460_T	0.527	0.97
338_E	341_H	0.527	0.97
212_Y	276_I	0.526	0.97
82_A	100_S	0.525	0.97
195_Q	318_I	0.525	0.97
82_A	85_G	0.524	0.97
222_C	324_A	0.524	0.97
311_S	319_P	0.524	0.97
368_H	522_H	0.524	0.97
135_T	138_I	0.524	0.97
23_F	435_M	0.523	0.97
460_T	466_L	0.521	0.97
118_M	158_V	0.521	0.97
18_G	67_E	0.521	0.97
188_T	326_Q	0.521	0.97
63_R	92_D	0.521	0.97
62_A	69_G	0.520	0.97
291_L	314_V	0.520	0.97
6_G	168_P	0.519	0.96
217_A	222_C	0.519	0.96
374_P	401_F	0.519	0.96
13_S	146_F	0.518	0.96
341_H	348_R	0.518	0.96
139_P	142_L	0.518	0.96
25_Y	478_L	0.517	0.96
365_Y	379_E	0.517	0.96
518_I	545_V	0.517	0.96
502_P	511_Y	0.516	0.96
239_C	246_A	0.516	0.96
192_H	326_Q	0.516	0.96
28_G	74_T	0.515	0.96
518_I	526_S	0.515	0.96
462_L	539_R	0.514	0.96
360_R	363_L	0.514	0.96
427_L	455_I	0.513	0.96
303_I	322_G	0.513	0.96
474_N	504_F	0.513	0.96
46_V	460_T	0.512	0.96
90_Y	155_G	0.512	0.96
376_A	379_E	0.511	0.96
300_V	314_V	0.511	0.96
481_V	485_Q	0.508	0.96
467_P	534_Q	0.508	0.96
408_F	413_R	0.507	0.96
27_G	74_T	0.507	0.96
68_V	71_V	0.507	0.96
104_A	107_L	0.506	0.96
248_P	410_K	0.505	0.96
362_C	407_P	0.505	0.96
147_W	150_A	0.505	0.96
306_D	309_S	0.505	0.96
358_R	407_P	0.505	0.96
385_T	532_L	0.504	0.96
458_L	462_L	0.504	0.96
88_T	92_D	0.504	0.96
392_T	429_A	0.504	0.96
428_P	454_N	0.503	0.96
458_L	461_A	0.502	0.96
303_I	324_A	0.502	0.96
227_K	253_Q	0.502	0.96
196_I	199_A	0.501	0.96
218_I	221_G	0.501	0.96
410_K	440_E	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ybhA	4	0.9826	100	0.16	Contact Map
2panA	3	0.9861	100	0.165	Contact Map
1ozhA	4	0.9512	100	0.165	Contact Map
2uz1A	4	0.9512	100	0.173	Contact Map
2pgnA	4	0.9617	100	0.175	Contact Map
1t9bA	2	0.9774	100	0.176	Contact Map
2ihtA	4	0.9443	100	0.177	Contact Map
4rjjA	5	0.9634	100	0.18	Contact Map
3eyaA	5	0.9199	100	0.183	Contact Map
2x7jA	4	0.9808	100	0.187	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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