ILVG - ECOLI - GREMLIN Contacts

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ILVG - Acetolactate synthase isozyme 2 large subunit

UniProt:	P00892	Sequences: MNGAQWVVHALRAQGVNTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIATSGPGATNLITGLADALLDSIPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLEELPRIMAEAFDVACSGRPGPVLVDIPKDIQLASGDLEPWFTTVENEVTFPHAEVEQARQMLAKAQKPMLYVGGGVGMAQAVPALREFLAATKMPATCTLKGLGAVEADYPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPHASVIHMDIDPAEMNKLRQAHVALQGDLNALLPALQQPLNQYDWQQHCAQLRDEHSWRYDHPGDAIYAPLLLKQLSDRKPADCVVTTDVGQHQMWAAQHIAHTRPENFITSSGLGTMGFGLPAAVGAQVARPNDTVVCISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTDNPDFLMLASAFGIHGQHITRKDQVEAALDTMLNSDGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10498
Length:	548 (528)
Sequences:	14140 (8998)
Seq/√Len:	391.6

ECOLI - ILVG ILVB ILVI GCL OXC POXB MEND
BACSU - ILVX ILVB MEND IOLD YDAP
HALSA - MEND
SULSO - Q7LXT8 Q97ZB3 Q97UP3 Q97U16 Q97V62 Q97XR3 Q980V7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
486_M	489_S	4.937	1.00
454_D	521_H	3.811	1.00
360_Q	505_E	3.698	1.00
51_A	81_G	3.629	1.00
221_A	241_Y	3.470	1.00
496_Q	510_T	3.441	1.00
215_A	319_P	3.214	1.00
17_N	63_K	3.133	1.00
500_R	503_Q	3.042	1.00
497_H	523_S	2.984	1.00
187_E	324_P	2.857	1.00
215_A	315_N	2.814	1.00
364_R	509_D	2.727	1.00
312_G	317_L	2.700	1.00
203_V	216_L	2.673	1.00
12_R	38_G	2.670	1.00
60_A	417_R	2.654	1.00
496_Q	518_Y	2.565	1.00
240_D	389_T	2.531	1.00
360_Q	363_D	2.497	1.00
494_H	516_G	2.485	1.00
189_A	291_I	2.456	1.00
18_T	40_E	2.450	1.00
293_M	317_L	2.440	1.00
499_T	503_Q	2.411	1.00
269_V	314_L	2.342	1.00
410_A	424_C	2.307	1.00
496_Q	507_A	2.295	1.00
69_A	78_L	2.295	1.00
263_C	266_L	2.284	1.00
483_D	486_M	2.167	1.00
497_H	521_H	2.159	1.00
363_D	505_E	2.144	1.00
64_T	146_C	2.143	1.00
432_M	491_F	2.088	1.00
5_Q	33_A	2.081	1.00
417_R	420_D	2.080	1.00
268_A	271_A	2.078	1.00
76_T	80_T	2.076	1.00
44_C	50_A	2.057	1.00
494_H	510_T	2.054	1.00
93_V	142_F	2.032	1.00
82_L	94_A	2.015	1.00
487_L	490_A	2.010	1.00
192_M	308_V	1.989	1.00
192_M	289_S	1.953	1.00
96_T	154_L	1.947	1.00
201_L	220_L	1.943	1.00
116_G	119_L	1.930	1.00
192_M	265_L	1.904	1.00
137_I	155_V	1.893	1.00
9_H	13_A	1.892	1.00
485_L	495_G	1.887	1.00
498_I	507_A	1.861	1.00
366_P	369_C	1.848	1.00
222_A	322_Q	1.836	1.00
362_S	387_A	1.833	1.00
64_T	93_V	1.825	1.00
193_L	267_I	1.819	1.00
414_Q	447_P	1.816	1.00
55_I	59_R	1.815	1.00
442_K	493_I	1.811	1.00
431_F	435_V	1.811	1.00
220_L	227_A	1.788	1.00
509_D	513_N	1.774	1.00
183_H	320_A	1.764	1.00
222_A	326_N	1.738	1.00
218_E	222_A	1.737	1.00
5_Q	36_D	1.736	1.00
188_Q	191_Q	1.717	1.00
503_Q	506_A	1.714	1.00
511_M	520_L	1.712	1.00
201_L	267_I	1.709	1.00
191_Q	195_K	1.706	1.00
217_R	221_A	1.697	1.00
452_L	519_L	1.689	1.00
201_L	225_M	1.685	1.00
370_V	413_A	1.669	1.00
505_E	509_D	1.663	1.00
494_H	518_Y	1.656	1.00
374_D	426_S	1.650	1.00
359_K	363_D	1.640	1.00
113_D	116_G	1.640	1.00
499_T	523_S	1.613	1.00
405_F	409_A	1.597	1.00
361_L	425_I	1.597	1.00
130_S	133_E	1.590	1.00
21_G	41_H	1.573	1.00
269_V	293_M	1.571	1.00
374_D	430_S	1.570	1.00
489_S	494_H	1.566	1.00
214_P	218_E	1.565	1.00
182_P	185_E	1.563	1.00
9_H	12_R	1.556	1.00
31_Y	41_H	1.553	1.00
262_E	333_H	1.535	1.00
122_T	154_L	1.532	1.00
126_F	155_V	1.513	1.00
196_A	199_P	1.511	1.00
395_I	413_A	1.501	1.00
185_E	188_Q	1.498	1.00
356_L	501_K	1.493	1.00
61_T	416_A	1.491	1.00
10_A	139_A	1.490	1.00
414_Q	446_L	1.485	1.00
364_R	505_E	1.483	1.00
506_A	510_T	1.482	1.00
224_K	243_Y	1.480	1.00
333_H	337_L	1.479	1.00
300_M	311_Q	1.477	1.00
123_K	151_G	1.476	1.00
393_N	420_D	1.474	1.00
227_A	237_V	1.457	1.00
506_A	509_D	1.454	1.00
356_L	360_Q	1.454	1.00
369_C	421_T	1.448	1.00
485_L	497_H	1.446	1.00
190_R	324_P	1.446	1.00
193_L	265_L	1.445	1.00
441_V	493_I	1.443	1.00
49_G	437_E	1.433	1.00
438_L	493_I	1.429	1.00
78_L	94_A	1.416	1.00
7_V	157_I	1.416	1.00
451_V	520_L	1.413	1.00
441_V	448_L	1.402	1.00
7_V	138_M	1.398	1.00
451_V	508_L	1.397	1.00
335_A	338_R	1.390	1.00
95_I	157_I	1.387	1.00
218_E	322_Q	1.387	1.00
131_L	164_A	1.386	1.00
360_Q	364_R	1.379	1.00
265_L	291_I	1.374	1.00
190_R	321_L	1.373	1.00
44_C	53_A	1.369	1.00
93_V	145_A	1.363	1.00
330_W	334_C	1.362	1.00
101_A	160_D	1.357	1.00
357_L	522_V	1.356	1.00
366_P	421_T	1.350	1.00
435_V	487_L	1.337	1.00
186_V	324_P	1.330	1.00
336_Q	340_E	1.330	1.00
365_K	423_V	1.329	1.00
82_L	92_V	1.327	1.00
14_Q	142_F	1.325	1.00
64_T	142_F	1.325	1.00
219_F	223_T	1.322	1.00
423_V	512_L	1.321	1.00
451_V	522_V	1.320	1.00
289_S	307_H	1.313	1.00
40_E	444_K	1.313	1.00
75_A	96_T	1.307	1.00
449_K	511_M	1.305	1.00
415_V	446_L	1.302	1.00
196_A	265_L	1.298	1.00
12_R	37_G	1.297	1.00
370_V	417_R	1.289	1.00
219_F	322_Q	1.288	1.00
219_F	318_L	1.285	1.00
367_A	389_T	1.283	1.00
18_T	415_V	1.282	1.00
14_Q	139_A	1.280	1.00
128_V	134_L	1.279	1.00
485_L	489_S	1.277	1.00
487_L	491_F	1.271	1.00
187_E	191_Q	1.271	1.00
411_V	441_V	1.271	1.00
51_A	78_L	1.270	1.00
403_M	433_M	1.267	1.00
352_I	522_V	1.265	1.00
315_N	319_P	1.265	1.00
414_Q	421_T	1.257	1.00
200_M	263_C	1.254	1.00
447_P	516_G	1.253	1.00
421_T	512_L	1.253	1.00
269_V	318_L	1.252	1.00
190_R	325_L	1.246	1.00
332_Q	336_Q	1.245	1.00
217_R	238_E	1.241	1.00
133_E	136_R	1.239	1.00
352_I	357_L	1.238	1.00
4_A	33_A	1.223	1.00
136_R	140_E	1.212	1.00
55_I	84_D	1.208	1.00
447_P	515_D	1.208	1.00
424_C	450_I	1.206	1.00
504_V	522_V	1.203	1.00
367_A	390_R	1.202	1.00
58_A	91_P	1.200	1.00
20_F	57_Y	1.199	1.00
57_Y	416_A	1.198	1.00
216_L	318_L	1.196	1.00
138_M	155_V	1.193	1.00
456_Q	481_N	1.190	1.00
42_L	415_V	1.189	1.00
493_I	519_L	1.184	1.00
301_N	306_A	1.183	1.00
188_Q	192_M	1.176	1.00
486_M	490_A	1.168	1.00
19_V	34_L	1.166	1.00
488_A	493_I	1.164	1.00
507_A	520_L	1.162	1.00
10_A	138_M	1.161	1.00
370_V	422_V	1.161	1.00
245_L	259_A	1.159	1.00
320_A	323_Q	1.157	1.00
338_R	342_S	1.154	1.00
439_G	443_R	1.153	1.00
316_A	319_P	1.150	1.00
199_P	264_D	1.150	1.00
102_P	160_D	1.148	1.00
79_I	117_L	1.144	1.00
229_C	244_Y	1.144	1.00
83_A	400_L	1.142	1.00
17_N	40_E	1.141	1.00
126_F	137_I	1.139	1.00
126_F	140_E	1.136	1.00
158_P	161_I	1.136	1.00
313_D	316_A	1.135	1.00
488_A	519_L	1.130	1.00
183_H	324_P	1.130	1.00
217_R	237_V	1.125	1.00
207_V	216_L	1.125	1.00
335_A	339_D	1.125	1.00
258_F	262_E	1.124	1.00
67_C	78_L	1.119	1.00
332_Q	335_A	1.119	1.00
194_A	328_Y	1.116	1.00
16_V	66_V	1.115	1.00
60_A	413_A	1.111	1.00
215_A	322_Q	1.109	1.00
201_L	219_F	1.104	1.00
55_I	90_I	1.104	1.00
215_A	218_E	1.101	1.00
234_L	239_A	1.098	1.00
6_W	166_G	1.094	1.00
190_R	194_A	1.092	1.00
414_Q	418_P	1.089	1.00
189_A	310_L	1.080	1.00
218_E	319_P	1.077	1.00
117_L	121_C	1.074	1.00
504_V	508_L	1.071	1.00
79_I	121_C	1.071	1.00
86_L	152_P	1.070	1.00
76_T	117_L	1.070	1.00
144_V	153_V	1.069	1.00
181_F	317_L	1.069	1.00
218_E	221_A	1.069	1.00
189_A	308_V	1.069	1.00
101_A	164_A	1.068	1.00
494_H	514_S	1.068	1.00
198_K	262_E	1.068	1.00
203_V	207_V	1.067	1.00
56_G	60_A	1.067	1.00
221_A	243_Y	1.064	1.00
488_A	495_G	1.058	1.00
33_A	36_D	1.054	1.00
496_Q	520_L	1.054	1.00
49_G	434_N	1.054	1.00
171_W	174_T	1.053	1.00
495_G	519_L	1.047	1.00
18_T	42_L	1.047	1.00
122_T	125_S	1.046	1.00
219_F	325_L	1.044	1.00
194_A	326_N	1.044	1.00
195_K	289_S	1.041	1.00
330_W	333_H	1.040	1.00
368_D	420_D	1.040	1.00
181_F	320_A	1.034	1.00
51_A	67_C	1.033	1.00
128_V	137_I	1.032	1.00
510_T	513_N	1.031	1.00
414_Q	422_V	1.027	1.00
220_L	243_Y	1.027	1.00
254_K	258_F	1.024	1.00
331_Q	335_A	1.022	1.00
371_V	386_I	1.021	1.00
27_I	30_V	1.016	1.00
449_K	518_Y	1.016	1.00
6_W	135_P	1.015	1.00
237_V	241_Y	1.014	1.00
220_L	237_V	1.014	1.00
421_T	449_K	1.014	1.00
200_M	228_T	1.013	1.00
104_I	127_L	1.013	1.00
498_I	504_V	1.008	1.00
201_L	216_L	1.007	1.00
3_G	134_L	1.007	1.00
280_K	283_T	1.006	1.00
42_L	444_K	1.006	1.00
228_T	245_L	1.006	1.00
180_T	320_A	1.005	1.00
456_Q	523_S	0.998	1.00
69_A	94_A	0.997	1.00
194_A	325_L	0.997	1.00
7_V	95_I	0.993	1.00
115_L	125_S	0.993	1.00
214_P	217_R	0.992	1.00
217_R	241_Y	0.991	1.00
268_A	273_F	0.990	1.00
67_C	94_A	0.987	1.00
180_T	316_A	0.985	1.00
365_K	371_V	0.982	1.00
498_I	503_Q	0.982	1.00
125_S	154_L	0.980	1.00
306_A	309_A	0.979	1.00
406_G	424_C	0.974	1.00
336_Q	339_D	0.970	1.00
414_Q	419_N	0.967	1.00
514_S	518_Y	0.967	1.00
196_A	264_D	0.966	1.00
19_V	66_V	0.966	1.00
353_Y	528_E	0.963	1.00
390_R	393_N	0.961	1.00
316_A	320_A	0.960	1.00
452_L	484_F	0.960	1.00
407_L	431_F	0.958	1.00
146_C	150_P	0.957	1.00
98_Q	156_D	0.954	1.00
431_F	452_L	0.953	1.00
372_T	424_C	0.948	1.00
75_A	118_S	0.947	1.00
438_L	519_L	0.946	1.00
333_H	336_Q	0.944	1.00
30_V	157_I	0.942	1.00
124_H	144_V	0.937	1.00
82_L	118_S	0.937	1.00
511_M	518_Y	0.935	1.00
213_V	217_R	0.931	1.00
362_S	386_I	0.930	1.00
5_Q	9_H	0.930	1.00
293_M	310_L	0.928	1.00
438_L	450_I	0.928	1.00
435_V	491_F	0.926	1.00
222_A	327_Q	0.926	1.00
200_M	260_V	0.926	1.00
485_L	521_H	0.924	1.00
51_A	92_V	0.924	1.00
200_M	266_L	0.923	1.00
124_H	137_I	0.922	1.00
358_L	425_I	0.920	1.00
441_V	450_I	0.916	1.00
372_T	422_V	0.915	1.00
507_A	511_M	0.913	1.00
338_R	341_H	0.911	1.00
453_L	524_I	0.908	1.00
59_R	90_I	0.908	1.00
449_K	512_L	0.904	1.00
357_L	453_L	0.904	1.00
449_K	520_L	0.904	1.00
184_A	187_E	0.904	1.00
170_P	173_T	0.903	1.00
414_Q	516_G	0.902	1.00
493_I	517_P	0.902	1.00
189_A	192_M	0.901	1.00
7_V	30_V	0.900	1.00
445_Q	515_D	0.899	1.00
63_K	146_C	0.897	1.00
337_L	341_H	0.894	1.00
89_S	149_R	0.893	1.00
364_R	508_L	0.891	1.00
198_K	264_D	0.891	1.00
191_Q	194_A	0.891	1.00
183_H	187_E	0.890	1.00
439_G	491_F	0.889	1.00
215_A	318_L	0.888	1.00
339_D	343_W	0.885	1.00
195_K	265_L	0.883	1.00
10_A	14_Q	0.877	1.00
432_M	435_V	0.876	1.00
431_F	519_L	0.875	1.00
140_E	144_V	0.871	1.00
124_H	141_A	0.871	1.00
53_A	441_V	0.867	1.00
412_G	416_A	0.867	1.00
285_A	288_A	0.865	1.00
145_A	153_V	0.863	1.00
32_D	35_Y	0.862	1.00
76_T	83_A	0.862	1.00
503_Q	507_A	0.860	1.00
218_E	326_N	0.855	1.00
189_A	265_L	0.855	1.00
116_G	120_A	0.852	1.00
186_V	320_A	0.852	1.00
189_A	317_L	0.848	1.00
310_L	317_L	0.847	1.00
356_L	504_V	0.845	1.00
34_L	39_V	0.844	1.00
56_G	409_A	0.842	1.00
191_Q	328_Y	0.842	1.00
441_V	517_P	0.841	1.00
334_C	341_H	0.837	1.00
369_C	423_V	0.836	1.00
448_L	517_P	0.835	1.00
18_T	57_Y	0.835	1.00
60_A	395_I	0.835	1.00
115_L	127_L	0.834	1.00
425_I	453_L	0.834	1.00
382_A	425_I	0.832	1.00
489_S	495_G	0.832	1.00
429_G	458_L	0.831	1.00
278_T	281_L	0.830	1.00
3_G	131_L	0.830	1.00
223_T	325_L	0.829	1.00
157_I	162_Q	0.829	1.00
334_C	337_L	0.828	1.00
360_Q	504_V	0.823	1.00
66_V	93_V	0.823	1.00
358_L	453_L	0.821	1.00
80_T	402_T	0.821	1.00
79_I	118_S	0.821	1.00
507_A	510_T	0.820	1.00
456_Q	526_E	0.819	1.00
265_L	289_S	0.815	1.00
239_A	244_Y	0.815	1.00
248_L	260_V	0.815	1.00
334_C	338_R	0.813	1.00
368_D	390_R	0.811	1.00
510_T	514_S	0.809	1.00
212_A	215_A	0.809	1.00
201_L	269_V	0.805	1.00
131_L	135_P	0.805	1.00
93_V	146_C	0.804	1.00
29_P	163_L	0.803	1.00
240_D	367_A	0.803	1.00
297_P	311_Q	0.800	1.00
443_R	480_D	0.799	1.00
10_A	13_A	0.798	1.00
194_A	324_P	0.798	1.00
194_A	323_Q	0.797	1.00
364_R	512_L	0.794	1.00
358_L	386_I	0.790	1.00
203_V	229_C	0.790	1.00
300_M	309_A	0.789	1.00
23_P	43_L	0.788	1.00
60_A	416_A	0.786	1.00
483_D	497_H	0.779	1.00
423_V	451_V	0.779	1.00
454_D	523_S	0.778	1.00
11_L	66_V	0.778	1.00
378_H	430_S	0.776	1.00
14_Q	146_C	0.776	1.00
123_K	153_V	0.774	1.00
16_V	142_F	0.773	1.00
329_D	332_Q	0.770	1.00
124_H	140_E	0.769	1.00
203_V	227_A	0.765	1.00
208_G	236_A	0.763	1.00
58_A	92_V	0.760	1.00
52_M	402_T	0.759	1.00
502_D	506_A	0.758	1.00
449_K	515_D	0.758	1.00
192_M	291_I	0.758	1.00
17_N	57_Y	0.756	1.00
124_H	153_V	0.754	1.00
362_S	389_T	0.754	1.00
442_K	517_P	0.751	1.00
442_K	492_G	0.749	1.00
44_C	49_G	0.749	1.00
352_I	501_K	0.748	1.00
483_D	489_S	0.747	1.00
411_V	446_L	0.745	1.00
410_A	448_L	0.745	1.00
127_L	156_D	0.744	1.00
12_R	17_N	0.743	1.00
188_Q	308_V	0.742	1.00
48_Q	77_N	0.742	1.00
337_L	340_E	0.741	1.00
373_T	396_T	0.741	1.00
68_I	95_I	0.739	1.00
58_A	90_I	0.739	1.00
82_L	121_C	0.738	1.00
495_G	521_H	0.737	1.00
22_Y	78_L	0.737	1.00
425_I	451_V	0.737	1.00
83_A	121_C	0.736	1.00
199_P	225_M	0.734	1.00
407_L	450_I	0.734	1.00
373_T	394_F	0.733	1.00
238_E	389_T	0.728	1.00
319_P	322_Q	0.728	1.00
374_D	406_G	0.728	1.00
237_V	244_Y	0.727	1.00
238_E	241_Y	0.726	1.00
180_T	183_H	0.725	1.00
267_I	293_M	0.725	1.00
320_A	324_P	0.725	1.00
19_V	68_I	0.725	1.00
212_A	315_N	0.724	1.00
432_M	482_P	0.723	1.00
365_K	369_C	0.723	1.00
205_G	232_K	0.720	1.00
69_A	96_T	0.719	1.00
143_D	147_S	0.717	1.00
229_C	239_A	0.716	1.00
70_T	110_Q	0.715	1.00
198_K	330_W	0.715	1.00
450_I	493_I	0.711	1.00
32_D	472_R	0.711	1.00
27_I	31_Y	0.708	1.00
20_F	53_A	0.708	1.00
185_E	189_A	0.707	1.00
30_V	162_Q	0.706	1.00
57_Y	63_K	0.706	1.00
421_T	447_P	0.705	1.00
96_T	156_D	0.703	1.00
462_R	466_Q	0.702	1.00
123_K	144_V	0.700	1.00
372_T	395_I	0.700	1.00
101_A	129_Q	0.700	1.00
27_I	68_I	0.698	1.00
207_V	236_A	0.698	1.00
249_G	252_G	0.696	1.00
211_Q	392_E	0.696	1.00
432_M	484_F	0.694	1.00
331_Q	338_R	0.694	1.00
352_I	500_R	0.694	1.00
441_V	446_L	0.692	1.00
192_M	195_K	0.692	1.00
206_G	294_D	0.690	0.99
32_D	36_D	0.690	0.99
370_V	420_D	0.690	0.99
319_P	323_Q	0.687	0.99
210_A	313_D	0.686	0.99
51_A	94_A	0.684	0.99
407_L	426_S	0.683	0.99
90_I	405_F	0.681	0.99
135_P	139_A	0.679	0.99
493_I	516_G	0.678	0.99
457_R	462_R	0.677	0.99
317_L	320_A	0.677	0.99
357_L	451_V	0.677	0.99
341_H	345_Y	0.676	0.99
231_L	383_A	0.676	0.99
17_N	38_G	0.675	0.99
199_P	265_L	0.675	0.99
431_F	484_F	0.675	0.99
76_T	79_I	0.675	0.99
202_Y	268_A	0.675	0.99
341_H	344_R	0.673	0.99
372_T	413_A	0.673	0.99
170_P	174_T	0.673	0.99
101_A	158_P	0.672	0.99
498_I	520_L	0.671	0.99
407_L	437_E	0.670	0.99
373_T	382_A	0.669	0.99
40_E	418_P	0.667	0.99
131_L	166_G	0.666	0.99
201_L	227_A	0.666	0.99
292_H	306_A	0.666	0.99
98_Q	104_I	0.665	0.99
35_Y	472_R	0.661	0.99
86_L	123_K	0.660	0.99
322_Q	326_N	0.660	0.99
424_C	430_S	0.659	0.99
423_V	449_K	0.659	0.99
224_K	242_P	0.655	0.99
137_I	140_E	0.655	0.99
85_A	92_V	0.655	0.99
115_L	119_L	0.654	0.99
131_L	161_I	0.654	0.99
144_V	149_R	0.653	0.99
140_E	143_D	0.652	0.99
77_N	80_T	0.651	0.99
30_V	68_I	0.650	0.99
507_A	518_Y	0.649	0.99
197_Q	264_D	0.649	0.99
482_P	490_A	0.647	0.99
202_Y	230_T	0.647	0.99
45_R	443_R	0.647	0.99
178_E	313_D	0.647	0.99
69_A	75_A	0.645	0.99
325_L	328_Y	0.644	0.99
317_L	321_L	0.644	0.99
181_F	186_V	0.643	0.99
29_P	162_Q	0.638	0.99
18_T	63_K	0.638	0.99
213_V	391_P	0.636	0.99
451_V	504_V	0.635	0.99
222_A	325_L	0.635	0.99
323_Q	326_N	0.635	0.99
128_V	158_P	0.633	0.99
186_V	321_L	0.631	0.99
408_P	437_E	0.631	0.99
300_M	306_A	0.630	0.99
193_L	223_T	0.630	0.99
466_Q	473_Y	0.629	0.99
76_T	112_V	0.629	0.99
447_P	517_P	0.628	0.99
208_G	392_E	0.627	0.99
185_E	310_L	0.626	0.99
3_G	6_W	0.625	0.99
268_A	290_V	0.624	0.99
411_V	440_T	0.624	0.99
235_G	239_A	0.621	0.99
52_M	84_D	0.621	0.99
415_V	444_K	0.621	0.99
27_I	97_G	0.618	0.99
515_D	518_Y	0.618	0.99
483_D	521_H	0.617	0.99
442_K	480_D	0.617	0.99
57_Y	61_T	0.616	0.99
372_T	406_G	0.615	0.99
123_K	149_R	0.614	0.99
56_G	412_G	0.614	0.99
243_Y	331_Q	0.613	0.99
118_S	154_L	0.613	0.99
12_R	39_V	0.612	0.99
395_I	405_F	0.609	0.99
357_L	504_V	0.609	0.99
87_L	400_L	0.609	0.99
186_V	310_L	0.608	0.99
426_S	450_I	0.607	0.99
215_A	219_F	0.607	0.99
378_H	453_L	0.606	0.99
496_Q	514_S	0.605	0.99
470_Q	474_S	0.603	0.99
410_A	422_V	0.603	0.99
342_S	345_Y	0.602	0.99
83_A	112_V	0.602	0.99
46_H	77_N	0.597	0.99
105_G	111_E	0.597	0.99
8_V	37_G	0.595	0.98
19_V	39_V	0.595	0.98
220_L	223_T	0.595	0.98
449_K	516_G	0.593	0.98
216_L	220_L	0.593	0.98
500_R	506_A	0.592	0.98
350_D	501_K	0.591	0.98
234_L	388_H	0.589	0.98
331_Q	334_C	0.589	0.98
350_D	500_R	0.589	0.98
109_F	401_G	0.589	0.98
181_F	316_A	0.589	0.98
461_V	465_Q	0.587	0.98
291_I	308_V	0.587	0.98
369_C	420_D	0.586	0.98
462_R	526_E	0.586	0.98
194_A	197_Q	0.585	0.98
368_D	421_T	0.583	0.98
356_L	505_E	0.582	0.98
258_F	261_Q	0.581	0.98
202_Y	271_A	0.581	0.98
508_L	512_L	0.581	0.98
426_S	434_N	0.581	0.98
142_F	146_C	0.581	0.98
93_V	155_V	0.580	0.98
413_A	422_V	0.580	0.98
98_Q	127_L	0.580	0.98
223_T	243_Y	0.580	0.98
329_D	333_H	0.579	0.98
482_P	491_F	0.578	0.98
197_Q	329_D	0.578	0.98
53_A	415_V	0.578	0.98
239_A	387_A	0.576	0.98
407_L	441_V	0.576	0.98
458_L	461_V	0.576	0.98
141_A	155_V	0.574	0.98
431_F	450_I	0.574	0.98
290_V	304_R	0.573	0.98
435_V	490_A	0.572	0.98
482_P	487_L	0.571	0.98
22_Y	458_L	0.570	0.98
432_M	436_Q	0.570	0.98
361_L	451_V	0.570	0.98
314_L	319_P	0.570	0.98
245_L	256_A	0.570	0.98
373_T	406_G	0.569	0.98
202_Y	266_L	0.569	0.98
17_N	61_T	0.568	0.98
200_M	259_A	0.567	0.98
218_E	323_Q	0.567	0.98
95_I	155_V	0.567	0.98
324_P	328_Y	0.564	0.98
345_Y	359_K	0.563	0.98
96_T	114_V	0.562	0.98
55_I	409_A	0.561	0.98
242_P	335_A	0.561	0.98
101_A	130_S	0.561	0.98
365_K	386_I	0.561	0.98
93_V	153_V	0.560	0.98
132_E	167_D	0.559	0.98
370_V	395_I	0.558	0.98
351_A	525_D	0.558	0.98
91_P	145_A	0.558	0.98
439_G	482_P	0.557	0.98
257_N	261_Q	0.556	0.98
442_K	445_Q	0.555	0.98
51_A	82_L	0.555	0.98
178_E	182_P	0.553	0.98
64_T	145_A	0.551	0.98
217_R	220_L	0.551	0.98
101_A	161_I	0.550	0.98
450_I	519_L	0.550	0.98
114_V	154_L	0.550	0.98
339_D	342_S	0.549	0.97
36_D	472_R	0.549	0.97
8_V	34_L	0.549	0.97
57_Y	65_G	0.548	0.97
10_A	135_P	0.548	0.97
95_I	138_M	0.546	0.97
212_A	314_L	0.544	0.97
61_T	412_G	0.543	0.97
232_K	398_S	0.543	0.97
25_G	70_T	0.543	0.97
160_D	164_A	0.541	0.97
78_L	96_T	0.541	0.97
355_P	528_E	0.541	0.97
189_A	321_L	0.539	0.97
126_F	153_V	0.539	0.97
440_T	446_L	0.539	0.97
40_E	415_V	0.539	0.97
354_A	381_W	0.538	0.97
60_A	370_V	0.538	0.97
131_L	134_L	0.536	0.97
59_R	88_D	0.536	0.97
235_G	393_N	0.535	0.97
445_Q	516_G	0.534	0.97
496_Q	506_A	0.533	0.97
13_A	168_L	0.533	0.97
45_R	439_G	0.533	0.97
149_R	296_D	0.533	0.97
84_D	88_D	0.532	0.97
289_S	308_V	0.531	0.97
294_D	299_E	0.529	0.97
358_L	362_S	0.528	0.97
144_V	147_S	0.528	0.97
390_R	420_D	0.528	0.97
466_Q	529_N	0.527	0.97
184_A	188_Q	0.527	0.97
224_K	327_Q	0.527	0.97
6_W	168_L	0.526	0.97
50_A	67_C	0.526	0.97
123_K	147_S	0.526	0.97
133_E	137_I	0.526	0.97
24_G	70_T	0.525	0.97
330_W	337_L	0.525	0.97
143_D	146_C	0.525	0.97
10_A	142_F	0.525	0.97
358_L	382_A	0.524	0.97
510_T	518_Y	0.524	0.97
32_D	465_Q	0.524	0.97
426_S	430_S	0.524	0.97
348_P	502_D	0.524	0.97
42_L	440_T	0.523	0.97
483_D	490_A	0.523	0.97
66_V	142_F	0.523	0.97
229_C	236_A	0.522	0.97
58_A	64_T	0.522	0.97
469_F	472_R	0.522	0.97
224_K	331_Q	0.521	0.97
217_R	390_R	0.521	0.97
214_P	221_A	0.521	0.97
437_E	440_T	0.521	0.97
476_T	479_T	0.520	0.97
128_V	155_V	0.520	0.97
324_P	327_Q	0.520	0.97
66_V	95_I	0.519	0.96
462_R	477_T	0.518	0.96
58_A	65_G	0.516	0.96
185_E	308_V	0.516	0.96
86_L	122_T	0.515	0.96
489_S	496_Q	0.515	0.96
229_C	234_L	0.515	0.96
20_F	415_V	0.515	0.96
128_V	157_I	0.513	0.96
299_E	302_K	0.513	0.96
22_Y	44_C	0.511	0.96
498_I	506_A	0.509	0.96
382_A	394_F	0.509	0.96
217_R	243_Y	0.509	0.96
365_K	512_L	0.509	0.96
342_S	387_A	0.508	0.96
454_D	484_F	0.508	0.96
181_F	312_G	0.507	0.96
135_P	138_M	0.507	0.96
449_K	514_S	0.506	0.96
25_G	464_W	0.506	0.96
371_V	394_F	0.506	0.96
26_A	71_S	0.505	0.96
342_S	346_D	0.505	0.96
3_G	164_A	0.504	0.96
438_L	441_V	0.504	0.96
470_Q	473_Y	0.503	0.96
474_S	477_T	0.502	0.96
13_A	172_F	0.502	0.96
178_E	316_A	0.502	0.96
48_Q	434_N	0.502	0.96
70_T	75_A	0.501	0.96
301_N	309_A	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ozhA	4	0.9745	100	0.147	Contact Map
1ybhA	4	0.9909	100	0.154	Contact Map
2panA	3	1	100	0.157	Contact Map
2ihtA	4	0.9726	100	0.159	Contact Map
4rjjA	5	0.9909	100	0.163	Contact Map
1t9bA	2	0.9982	100	0.164	Contact Map
2uz1A	4	0.9726	100	0.165	Contact Map
2pgnA	4	0.9781	100	0.171	Contact Map
2x7jA	4	0.9964	100	0.174	Contact Map
3eyaA	5	0.9398	100	0.175	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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