GREMLIN Database
AROF - Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
UniProt: P00888 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10078
Length: 356 (342)
Sequences: 2172 (1011)
Seq/√Len: 54.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_S246_D5.9741.00
83_E341_R4.8731.00
113_H122_A4.7891.00
46_D51_R4.7251.00
72_E306_I3.9221.00
307_H324_V3.6721.00
321_K324_V3.4651.00
331_I339_L3.4131.00
59_C336_T3.3291.00
308_E332_S3.2411.00
26_A125_Q3.2371.00
332_S335_M3.1551.00
277_R308_E3.0971.00
43_S89_Y2.9341.00
87_S348_N2.8841.00
307_H321_K2.8401.00
284_E342_E2.8291.00
129_K133_E2.8001.00
84_V341_R2.6941.00
78_K82_A2.6591.00
276_Y329_A2.6471.00
47_I89_Y2.5871.00
27_F132_L2.4551.00
119_D122_A2.4021.00
247_V265_V2.3511.00
70_A130_L2.3501.00
313_S326_V2.2911.00
82_A85_S2.2621.00
316_P319_E2.2321.00
36_Q40_S2.1681.00
39_D43_S2.1381.00
74_A134_L2.1341.00
285_S288_A2.1231.00
114_M326_V2.0921.00
57_V340_L2.0631.00
49_A229_D2.0611.00
278_R281_A2.0361.00
251_E296_S2.0271.00
276_Y308_E1.9711.00
84_V340_L1.9631.00
72_E322_Y1.9621.00
58_V264_M1.9581.00
81_A89_Y1.8991.00
113_H119_D1.8870.99
267_C283_A1.8830.99
308_E335_M1.8610.99
94_V134_L1.8490.99
244_P285_S1.8340.99
45_S229_D1.8130.99
130_L134_L1.8000.99
283_A339_L1.7960.99
44_I91_V1.7930.99
42_K46_D1.7800.99
334_E337_D1.7610.99
35_A39_D1.7310.99
143_T158_F1.7300.99
68_E75_R1.7000.99
160_W231_H1.6730.99
87_S344_H1.6720.99
255_E261_P1.6590.99
80_L341_R1.6520.99
344_H348_N1.6500.99
302_I331_I1.5880.98
193_S196_T1.5870.98
57_V88_L1.5840.98
283_A300_L1.5700.98
275_D278_R1.5640.98
83_E337_D1.5620.98
75_R137_M1.5510.98
57_V300_L1.5380.98
280_P335_M1.5350.98
6_L9_V1.5280.98
76_R306_I1.5160.98
277_R335_M1.5140.98
133_E136_N1.5070.97
30_S136_N1.4940.97
33_Q36_Q1.4880.97
59_C302_I1.4730.97
201_M230_G1.4610.97
287_V343_I1.4540.97
168_T186_F1.4530.97
302_I339_L1.4310.97
67_P71_L1.4250.96
343_I347_L1.3980.96
80_L337_D1.3860.96
44_I56_L1.3830.96
315_Q318_S1.3780.96
71_L133_E1.3760.96
195_A199_N1.3740.96
33_Q135_V1.3700.96
337_D341_R1.3600.95
180_L184_V1.3590.95
18_M23_L1.3580.95
21_E216_A1.3460.95
249_Q253_E1.3410.95
264_M298_I1.3300.95
189_G193_S1.3180.94
248_A252_K1.2890.94
262_S298_I1.2850.94
201_M232_V1.2800.94
22_Q25_A1.2760.93
214_N220_A1.2760.93
252_K256_Q1.2630.93
96_F131_L1.2580.93
272_S329_A1.2510.93
251_E294_N1.2490.93
56_L91_V1.2490.93
18_M121_E1.2460.93
275_D280_P1.2400.92
161_S199_N1.2400.92
7_N215_Q1.2380.92
313_S317_R1.2330.92
265_V286_V1.2240.92
181_S210_F1.2220.92
29_L34_E1.2150.92
16_V218_Q1.1890.91
265_V297_I1.1840.91
331_I335_M1.1830.91
244_P292_D1.1830.91
240_P246_D1.1750.90
33_Q136_N1.1670.90
8_N11_I1.1640.90
288_A292_D1.1640.90
289_Q294_N1.1640.90
12_T225_Q1.1590.90
72_E76_R1.1550.90
212_G222_L1.1550.90
66_D69_T1.1540.89
287_V342_E1.1520.89
42_K45_S1.1480.89
80_L84_V1.1450.89
78_K81_A1.1450.89
70_A134_L1.1420.89
109_I127_A1.1390.89
71_L75_R1.1360.89
245_A249_Q1.1340.89
32_Q136_N1.1330.89
179_G224_T1.1270.88
16_V22_Q1.1260.88
135_V141_L1.1220.88
80_L83_E1.1150.88
14_E222_L1.1140.88
76_R333_W1.1140.88
79_A82_A1.1100.88
76_R80_L1.0960.87
44_I159_S1.0860.86
69_T322_Y1.0830.86
11_I222_L1.0770.86
79_A337_D1.0740.86
181_S224_T1.0740.86
78_K139_L1.0740.86
19_T22_Q1.0730.86
30_S33_Q1.0690.86
280_P339_L1.0620.85
71_L137_M1.0520.85
10_H225_Q1.0490.84
291_K342_E1.0410.84
290_I346_D1.0390.84
75_R79_A1.0370.84
148_P222_L1.0310.83
48_I262_S1.0300.83
108_L126_I1.0300.83
195_A253_E1.0200.83
148_P172_T1.0100.82
44_I89_Y1.0060.82
315_Q319_E1.0010.82
24_K215_Q0.9960.81
253_E256_Q0.9860.81
239_A246_D0.9780.80
44_I47_I0.9770.80
152_Q181_S0.9740.80
81_A139_L0.9740.80
84_V344_H0.9710.80
131_L141_L0.9710.80
287_V347_L0.9710.80
209_R223_Q0.9680.79
134_L141_L0.9650.79
248_A296_S0.9550.78
335_M338_A0.9470.78
96_F127_A0.9430.77
96_F109_I0.9430.77
280_P329_A0.9420.77
91_V191_D0.9400.77
287_V346_D0.9350.77
72_E75_R0.9340.77
317_R326_V0.9330.77
68_E72_E0.9300.76
37_I41_R0.9240.76
71_L129_K0.9200.76
29_L33_Q0.9150.75
122_A126_I0.9120.75
247_V289_Q0.9080.75
23_L124_L0.9070.75
50_G262_S0.9060.75
214_N218_Q0.9040.74
48_I56_L0.9020.74
281_A284_E0.8980.74
22_Q218_Q0.8970.74
134_L139_L0.8950.74
56_L298_I0.8880.73
110_N118_F0.8810.73
161_S182_M0.8760.72
23_L125_Q0.8740.72
40_S44_I0.8680.71
287_V290_I0.8680.71
254_M261_P0.8680.71
289_Q297_I0.8660.71
283_A343_I0.8560.70
307_H334_E0.8510.70
29_L157_L0.8490.70
69_T305_N0.8410.69
263_L296_S0.8400.69
12_T223_Q0.8340.68
84_V88_L0.8320.68
22_Q26_A0.8250.67
80_L340_L0.8230.67
343_I346_D0.8230.67
338_A342_E0.8170.67
84_V90_L0.8110.66
43_S46_D0.8110.66
45_S48_I0.8110.66
194_L249_Q0.8080.66
232_V250_C0.8070.66
283_A302_I0.8050.66
267_C300_L0.8040.65
145_A199_N0.8030.65
127_A154_L0.8000.65
189_G196_T0.7980.65
118_F233_I0.7950.65
176_M230_G0.7920.64
300_L340_L0.7890.64
145_A201_M0.7860.64
250_C263_L0.7800.63
194_L265_V0.7760.63
79_A83_E0.7730.62
277_R280_P0.7730.62
288_A291_K0.7710.62
58_V299_G0.7690.62
310_N324_V0.7680.62
244_P288_A0.7650.62
31_L35_A0.7560.61
94_V141_L0.7560.61
151_P181_S0.7560.61
142_A233_I0.7530.60
40_S89_Y0.7530.60
239_A273_N0.7490.60
254_M260_R0.7490.60
110_N120_V0.7480.60
120_V211_V0.7460.60
152_Q210_F0.7450.60
333_W337_D0.7450.60
108_L127_A0.7440.59
50_G298_I0.7430.59
84_V87_S0.7430.59
18_M22_Q0.7420.59
43_S47_I0.7420.59
132_L157_L0.7390.59
198_I261_P0.7390.59
202_R312_S0.7380.59
55_L290_I0.7370.59
202_R257_A0.7310.58
280_P302_I0.7290.58
182_M270_G0.7260.58
96_F147_D0.7240.57
284_E288_A0.7210.57
283_A287_V0.7210.57
72_E307_H0.7180.57
102_T202_R0.7160.57
131_L145_A0.7140.56
151_P210_F0.7120.56
96_F141_L0.7120.56
96_F231_H0.7110.56
17_L121_E0.7100.56
114_M156_D0.7090.56
263_L298_I0.7070.56
152_Q155_G0.7060.55
168_T193_S0.7050.55
119_D297_I0.7030.55
171_Q175_E0.7020.55
287_V291_K0.7020.55
81_A90_L0.7010.55
34_E38_A0.7010.55
276_Y332_S0.7000.55
109_I181_S0.6990.55
134_L137_M0.6970.55
244_P248_A0.6970.55
96_F160_W0.6950.54
21_E25_A0.6950.54
145_A176_M0.6940.54
103_V206_Q0.6920.54
264_M299_G0.6910.54
275_D281_A0.6890.54
148_P182_M0.6880.54
168_T264_M0.6880.54
90_L340_L0.6850.53
129_K132_L0.6840.53
332_S338_A0.6820.53
55_L300_L0.6810.53
84_V337_D0.6790.53
6_L34_E0.6780.52
74_A94_V0.6770.52
67_P126_I0.6740.52
198_I254_M0.6730.52
251_E263_L0.6730.52
150_S211_V0.6710.52
50_G263_L0.6700.52
198_I250_C0.6680.51
18_M25_A0.6660.51
193_S233_I0.6660.51
121_E221_L0.6610.51
344_H347_L0.6600.51
158_F161_S0.6590.50
50_G294_N0.6590.50
40_S140_P0.6570.50
206_Q233_I0.6570.50
74_A139_L0.6560.50
11_I179_G0.6560.50
22_Q153_Y0.6490.49
261_P348_N0.6480.49
142_A228_P0.6470.49
116_G172_T0.6440.49
172_T176_M0.6440.49
145_A158_F0.6410.49
58_V180_L0.6390.48
36_Q138_G0.6390.48
69_T324_V0.6380.48
345_Q348_N0.6370.48
245_A281_A0.6360.48
44_I48_I0.6330.48
44_I183_P0.6330.48
273_N331_I0.6330.48
53_P347_L0.6320.48
168_T200_A0.6300.47
291_K346_D0.6300.47
143_T182_M0.6280.47
113_H126_I0.6280.47
170_S175_E0.6270.47
305_N324_V0.6260.47
198_I257_A0.6240.47
248_A251_E0.6220.46
194_L250_C0.6170.46
55_L343_I0.6170.46
30_S49_A0.6170.46
145_A161_S0.6170.46
342_E346_D0.6150.46
7_N156_D0.6120.45
175_E209_R0.6110.45
248_A290_I0.6110.45
87_S345_Q0.6100.45
245_A248_A0.6100.45
40_S81_A0.6090.45
283_A331_I0.6090.45
22_Q216_A0.6080.45
18_M125_Q0.6070.45
275_D329_A0.6050.45
255_E295_R0.6050.45
15_Q263_L0.6040.45
149_N213_I0.6040.45
40_S139_L0.6040.45
47_I54_R0.6020.44
341_R345_Q0.5980.44
305_N329_A0.5970.44
155_G182_M0.5960.44
96_F145_A0.5960.44
110_N147_D0.5960.44
211_V222_L0.5950.44
46_D49_A0.5940.44
38_A264_M0.5940.44
19_T218_Q0.5930.43
34_E219_V0.5930.43
15_Q223_Q0.5930.43
183_P250_C0.5930.43
141_L182_M0.5910.43
151_P224_T0.5900.43
39_D337_D0.5900.43
193_S237_G0.5900.43
232_V263_L0.5890.43
161_S184_V0.5890.43
251_E255_E0.5880.43
32_Q36_Q0.5860.43
161_S206_Q0.5840.42
76_R334_E0.5830.42
237_G270_G0.5820.42
108_L175_E0.5810.42
45_S228_P0.5800.42
215_Q233_I0.5790.42
310_N329_A0.5780.42
27_F129_K0.5780.42
151_P180_L0.5770.42
46_D277_R0.5770.42
199_N202_R0.5760.42
189_G233_I0.5760.42
168_T189_G0.5750.42
313_S319_E0.5730.41
222_L316_P0.5720.41
48_I229_D0.5710.41
267_C302_I0.5710.41
53_P87_S0.5710.41
120_V228_P0.5710.41
247_V286_V0.5690.41
69_T321_K0.5680.41
290_I293_G0.5670.41
56_L170_S0.5660.41
42_K318_S0.5660.41
43_S53_P0.5660.41
64_I94_V0.5650.40
263_L294_N0.5650.40
35_A38_A0.5620.40
68_E322_Y0.5620.40
245_A288_A0.5610.40
23_L200_A0.5600.40
169_E190_T0.5580.40
11_I151_P0.5560.40
244_P278_R0.5560.40
202_R206_Q0.5560.40
198_I202_R0.5550.39
56_L264_M0.5550.39
284_E346_D0.5540.39
110_N150_S0.5510.39
43_S276_Y0.5490.39
82_A86_D0.5490.39
115_D320_M0.5490.39
169_E186_F0.5470.39
145_A182_M0.5460.39
156_D264_M0.5460.39
205_A230_G0.5450.38
20_P210_F0.5430.38
287_V339_L0.5430.38
162_A169_E0.5430.38
339_L342_E0.5410.38
209_R240_P0.5410.38
11_I94_V0.5410.38
36_Q135_V0.5400.38
147_D175_E0.5400.38
141_L159_S0.5390.38
65_H305_N0.5390.38
25_A216_A0.5390.38
291_K347_L0.5380.38
196_T199_N0.5380.38
148_P216_A0.5380.38
132_L135_V0.5370.38
252_K255_E0.5370.38
18_M246_D0.5360.38
109_I151_P0.5350.37
172_T212_G0.5350.37
251_E290_I0.5350.37
293_G297_I0.5330.37
9_V34_E0.5320.37
334_E338_A0.5320.37
245_A292_D0.5310.37
267_C324_V0.5300.37
295_R345_Q0.5300.37
74_A141_L0.5300.37
79_A341_R0.5290.37
31_L34_E0.5290.37
10_H229_D0.5290.37
64_I70_A0.5270.37
48_I211_V0.5260.37
106_K110_N0.5260.37
272_S279_Q0.5250.36
36_Q48_I0.5250.36
131_L160_W0.5250.36
143_T148_P0.5250.36
78_K203_A0.5240.36
276_Y280_P0.5230.36
89_Y336_T0.5230.36
175_E212_G0.5230.36
196_T237_G0.5220.36
294_N297_I0.5220.36
64_I209_R0.5220.36
172_T213_I0.5210.36
45_S317_R0.5200.36
273_N281_A0.5200.36
6_L29_L0.5190.36
8_N14_E0.5190.36
292_D295_R0.5180.36
283_A335_M0.5180.36
170_S180_L0.5180.36
108_L168_T0.5160.36
130_L208_H0.5160.36
42_K51_R0.5160.36
160_W186_F0.5150.35
127_A151_P0.5140.35
16_V21_E0.5140.35
130_L141_L0.5130.35
14_E124_L0.5120.35
111_D167_T0.5120.35
246_D285_S0.5120.35
147_D214_N0.5110.35
7_N148_P0.5110.35
131_L147_D0.5100.35
90_L158_F0.5100.35
142_A158_F0.5090.35
267_C321_K0.5090.35
313_S316_P0.5080.35
267_C286_V0.5080.35
113_H116_G0.5080.35
8_N181_S0.5070.35
42_K288_A0.5070.35
42_K90_L0.5070.35
45_S49_A0.5070.35
170_S217_G0.5060.35
58_V108_L0.5030.34
158_F182_M0.5030.34
18_M200_A0.5030.34
278_R284_E0.5020.34
78_K137_M0.5020.34
118_F208_H0.5020.34
214_N221_L0.5010.34
172_T222_L0.5010.34
76_R307_H0.5010.34
97_E105_W0.5010.34
7_N11_I0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1of8A 2 0.9635 100 0.205 Contact Map
1n8fA 2 0.9635 100 0.217 Contact Map
4umaA 3 0.9382 100 0.247 Contact Map
3tqkA 2 0.9551 100 0.25 Contact Map
2nwrA 4 0.6854 100 0.684 Contact Map
4lu0A 4 0.6994 100 0.685 Contact Map
1o60A 4 0.7247 100 0.704 Contact Map
1vs1A 4 0.7163 100 0.716 Contact Map
3fs2A 4 0.7051 100 0.716 Contact Map
2qkfA 4 0.6966 100 0.719 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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