GREMLIN Database
AROH - Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
UniProt: P00887 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10080
Length: 348 (338)
Sequences: 2156 (1013)
Seq/√Len: 55.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
241_H244_D6.0041.00
81_Q338_E4.8811.00
111_D120_H4.8471.00
44_K49_E4.7621.00
70_E304_L3.9331.00
305_R321_Q3.7121.00
318_T321_Q3.4941.00
328_L336_L3.4821.00
57_I333_T3.3201.00
24_R123_E3.2741.00
306_E329_G3.2711.00
329_G332_D3.1901.00
275_R306_E3.1181.00
41_R87_E2.9901.00
282_E339_K2.9181.00
305_R318_T2.9021.00
127_K131_Q2.7771.00
82_Y338_E2.6951.00
45_I87_E2.6831.00
274_H326_P2.6671.00
76_Q80_N2.6411.00
25_Y130_L2.4561.00
117_R120_H2.4371.00
245_I263_V2.3581.00
68_A128_L2.3511.00
311_I323_I2.3321.00
80_N83_Q2.2331.00
37_D41_R2.2291.00
34_H38_S2.2221.00
283_D286_Q2.1351.00
112_L323_I2.1031.00
55_V337_V2.0781.00
47_N227_Y2.0661.00
249_C294_A2.0471.00
276_R279_E2.0461.00
274_H306_E2.0111.00
128_L132_V1.9991.00
56_I262_V1.9911.00
82_Y337_V1.9891.00
70_E319_Y1.9631.00
79_R87_E1.9311.00
111_D117_R1.9311.00
306_E332_D1.9171.00
265_F281_C1.8821.00
242_A283_D1.8560.99
43_E227_Y1.8460.99
40_R44_K1.8300.99
281_C336_L1.8300.99
72_A132_V1.8030.99
141_T156_I1.7950.99
42_I89_V1.7910.99
331_E334_E1.7600.99
33_T37_D1.7580.99
85_R341_A1.7440.99
66_T73_T1.7260.99
78_L338_E1.7190.99
253_H259_E1.7000.99
158_W229_H1.6830.99
73_T135_L1.6600.99
191_N194_I1.6300.99
281_C298_I1.6000.98
55_V86_L1.5930.98
273_Q276_R1.5830.98
300_A328_L1.5780.98
131_Q134_E1.5720.98
81_Q334_E1.5640.98
55_V298_I1.5550.98
278_L332_D1.5540.98
275_R332_D1.5260.98
74_R304_L1.5130.98
31_V34_H1.5070.98
57_I300_A1.4990.97
199_I228_G1.4740.97
166_T184_F1.4740.97
28_T134_E1.4660.97
340_L344_V1.4650.97
65_L69_M1.4590.97
300_A336_L1.4520.97
285_C340_L1.4410.97
16_V21_L1.4390.97
69_M131_Q1.4310.97
78_L334_E1.4260.97
178_L182_V1.4250.97
42_I54_L1.4090.96
19_A214_N1.3880.96
193_R197_D1.3870.96
212_D218_T1.3770.96
247_A251_T1.3700.96
334_E338_E1.3620.96
31_V133_N1.3610.95
250_D254_E1.3550.95
262_V296_A1.3410.95
260_H296_A1.3140.95
27_V32_A1.3080.94
270_C326_P1.3030.94
187_G191_N1.2960.94
199_I230_I1.2890.94
94_F129_L1.2880.94
246_A250_D1.2860.94
312_V315_Q1.2860.94
20_E23_L1.2830.94
54_L89_V1.2790.94
179_S208_F1.2580.93
159_G197_D1.2470.93
273_Q278_L1.2420.93
16_V119_N1.2350.92
249_C292_S1.2320.92
287_Q292_S1.2240.92
14_S216_Q1.2170.92
263_V295_I1.2020.91
285_C339_K1.1910.91
328_L332_D1.1900.91
263_V284_I1.1870.91
69_M73_T1.1850.91
10_A223_S1.1830.91
6_E9_T1.1800.91
70_E74_R1.1790.91
78_L82_Y1.1780.91
14_S20_E1.1750.90
210_S220_Y1.1670.90
243_D247_A1.1630.90
40_R43_E1.1620.90
311_I314_S1.1610.90
12_I220_Y1.1600.90
177_A222_T1.1580.90
64_D67_A1.1570.90
9_T220_Y1.1530.90
107_I125_A1.1510.90
30_G134_E1.1480.89
133_N139_T1.1470.89
31_V134_E1.1460.89
76_Q79_R1.1400.89
17_T20_E1.1360.89
78_L81_Q1.1350.89
238_P244_D1.1340.89
74_R330_W1.1230.88
77_S80_N1.1160.88
67_A319_Y1.1100.88
74_R78_L1.0990.87
286_Q290_N1.0980.87
76_Q137_V1.0970.87
179_S222_T1.0890.87
42_I157_S1.0860.87
278_L336_L1.0800.86
68_A132_V1.0730.86
106_L124_L1.0730.86
289_R339_K1.0730.86
288_I343_A1.0720.86
77_S334_E1.0620.85
28_T31_V1.0580.85
46_L260_H1.0560.85
242_A290_N1.0520.85
69_M135_L1.0500.85
146_M220_Y1.0490.85
193_R251_T1.0470.85
146_M170_I1.0400.84
82_Y341_A1.0360.84
150_Q179_S1.0320.84
22_A213_K1.0290.84
42_I87_E1.0250.83
27_V31_V1.0240.83
8_R223_S1.0200.83
79_R137_V1.0090.82
73_T77_S1.0070.82
312_V316_P0.9940.81
129_L139_T0.9920.81
207_M221_Q0.9890.81
94_F125_A0.9780.80
251_T254_E0.9680.80
278_L326_P0.9620.79
314_S323_I0.9620.79
94_F107_I0.9550.79
48_G260_H0.9530.78
21_L122_L0.9510.78
120_H124_L0.9510.78
332_D335_R0.9490.78
69_M127_K0.9460.78
89_V189_D0.9360.77
42_I45_I0.9360.77
246_A294_A0.9350.77
237_K268_G0.9340.77
35_V39_R0.9330.77
285_C343_A0.9320.77
108_S116_Y0.9310.77
66_T70_E0.9190.76
279_E282_E0.9180.76
212_D216_Q0.9150.76
70_E73_T0.9060.75
285_C344_V0.9020.75
82_Y86_L0.8930.74
21_L123_E0.8930.74
159_G180_C0.8840.73
38_S42_I0.8800.73
305_R331_E0.8780.73
67_A303_F0.8730.72
46_L54_L0.8710.72
245_I287_Q0.8680.72
20_E216_Q0.8650.71
265_F298_I0.8640.71
54_L296_A0.8570.71
10_A221_Q0.8560.71
82_Y85_R0.8550.71
261_L294_A0.8530.70
77_S81_Q0.8520.70
78_L337_V0.8510.70
340_L343_A0.8480.70
252_L259_E0.8400.69
281_C340_L0.8370.69
312_V317_L0.8350.69
335_R339_K0.8300.68
174_M228_G0.8290.68
287_Q295_I0.8260.68
43_E46_L0.8220.67
29_P33_T0.8190.67
281_C300_A0.8140.67
285_C288_I0.8130.67
41_R44_K0.8120.67
132_V137_V0.8110.66
242_A286_Q0.8090.66
230_I248_A0.8090.66
27_V155_L0.8060.66
248_A261_L0.8050.66
143_F197_D0.8020.66
92_T139_T0.7970.65
187_G194_I0.7960.65
275_R278_L0.7950.65
20_E24_R0.7920.65
56_I297_G0.7900.64
70_E305_R0.7890.64
140_A231_I0.7850.64
116_Y231_I0.7840.64
149_G179_S0.7820.64
82_Y88_I0.7790.63
72_A92_T0.7750.63
143_F199_I0.7740.63
200_R310_K0.7720.63
38_S87_E0.7710.63
125_A152_I0.7670.62
48_G296_A0.7640.62
150_Q208_F0.7630.62
330_W334_E0.7620.62
94_F145_D0.7610.61
200_R255_F0.7600.61
298_I337_V0.7580.61
41_R45_I0.7570.61
192_T247_A0.7500.60
53_L288_I0.7500.60
118_V209_L0.7500.60
107_I179_S0.7480.60
79_R88_I0.7460.60
308_T321_Q0.7440.60
282_E286_Q0.7440.60
192_T263_V0.7430.60
286_Q289_R0.7400.59
252_L258_P0.7340.59
149_G208_F0.7330.59
146_M180_C0.7320.59
130_L155_L0.7250.58
88_I337_V0.7240.58
16_V20_E0.7240.58
106_L125_A0.7240.58
196_V259_E0.7210.57
108_S118_V0.7200.57
242_A246_A0.7190.57
112_L154_D0.7170.57
285_C289_R0.7130.57
166_T191_N0.7120.56
32_A36_T0.7110.56
94_F139_T0.7110.56
129_L143_F0.7110.56
273_Q279_E0.7100.56
261_L296_A0.7100.56
150_Q153_A0.7100.56
94_F229_H0.7070.56
274_H329_G0.7060.56
166_T262_V0.7060.56
19_A23_L0.7050.56
278_L300_A0.7050.56
101_V204_A0.7040.56
262_V297_G0.7030.55
85_R342_S0.7020.55
169_Q173_E0.7020.55
180_C268_G0.7000.55
94_F158_W0.6990.55
127_K130_L0.6950.55
65_L124_L0.6910.54
56_I178_L0.6910.54
20_E151_F0.6860.54
281_C285_C0.6860.54
15_L119_N0.6840.53
132_V138_P0.6830.53
143_F174_M0.6820.53
329_G335_R0.6800.53
204_A231_I0.6800.53
34_H136_G0.6740.52
143_F156_I0.6730.52
117_R295_I0.6730.52
100_V200_R0.6730.52
82_Y334_E0.6720.52
140_A226_P0.6710.52
48_G261_L0.6670.52
9_T177_A0.6660.51
67_A321_Q0.6660.51
196_V252_L0.6650.51
253_H293_T0.6630.51
53_L298_I0.6620.51
191_N231_I0.6600.51
170_I174_M0.6560.50
303_F321_Q0.6550.50
312_V318_T0.6540.50
148_T209_L0.6530.50
53_L340_L0.6520.50
196_V255_F0.6480.50
166_T198_A0.6480.50
119_N219_I0.6480.50
246_A249_C0.6450.49
34_H133_N0.6440.49
20_E214_N0.6420.49
114_G170_I0.6420.49
243_D279_E0.6420.49
28_T47_N0.6420.49
38_S138_P0.6420.49
44_K47_N0.6400.49
72_A137_V0.6390.49
16_V23_L0.6390.49
32_A217_M0.6380.48
51_K85_R0.6370.48
249_C261_L0.6360.48
196_V248_A0.6350.48
191_N235_G0.6350.48
230_I261_L0.6340.48
156_I159_G0.6330.48
38_S79_R0.6310.48
141_T180_C0.6290.48
271_Q328_L0.6280.47
341_A344_V0.6270.47
237_K244_D0.6250.47
51_K344_V0.6240.47
243_D290_N0.6220.47
153_A180_C0.6220.47
45_I52_R0.6210.47
30_G34_H0.6200.47
149_G222_T0.6170.46
147_V211_P0.6170.46
48_G292_S0.6160.46
118_V226_P0.6140.46
43_E314_S0.6120.46
246_A288_I0.6120.46
273_Q326_P0.6100.45
303_F326_P0.6100.45
80_N84_S0.6100.45
33_T36_T0.6090.45
289_R343_A0.6080.45
143_F159_G0.6050.45
13_E221_Q0.6040.45
37_D334_E0.6030.45
108_S145_D0.6020.45
111_D124_L0.6010.45
17_T216_Q0.6000.44
42_I46_L0.6000.44
200_R204_A0.6000.44
36_T262_V0.5990.44
243_D286_Q0.5990.44
243_D246_A0.5980.44
159_G182_V0.5980.44
149_G178_L0.5970.44
139_T180_C0.5960.44
16_V123_E0.5950.44
173_E207_M0.5950.44
62_I92_T0.5940.44
13_E261_L0.5900.43
38_S137_V0.5900.43
168_S173_E0.5870.43
42_I181_P0.5870.43
209_L220_Y0.5870.43
67_A318_T0.5860.43
192_T248_A0.5860.43
166_T187_G0.5860.43
212_D219_I0.5850.43
308_T326_P0.5840.43
106_L173_E0.5840.43
281_C328_L0.5840.43
331_E335_R0.5840.43
132_V139_T0.5840.43
207_M238_P0.5820.42
159_G204_A0.5810.42
46_L227_Y0.5800.42
197_D200_R0.5800.42
339_K343_A0.5800.42
6_E12_I0.5800.42
54_L168_S0.5790.42
41_R51_K0.5780.42
7_L32_A0.5770.42
211_P218_T0.5750.42
43_E226_P0.5740.42
249_C253_H0.5730.42
111_D114_G0.5700.41
154_D262_V0.5690.41
213_K231_I0.5690.41
285_C336_L0.5690.41
338_E342_S0.5690.41
237_K271_Q0.5670.41
265_F318_T0.5670.41
194_I197_D0.5660.41
106_L166_T0.5650.41
94_F143_F0.5650.41
187_G231_I0.5640.41
203_R228_G0.5640.41
44_K275_R0.5640.41
265_F300_A0.5630.41
76_Q135_L0.5630.41
196_V200_R0.5630.41
16_V244_D0.5610.40
66_T319_Y0.5610.40
282_E343_A0.5600.40
289_R344_V0.5600.40
132_V135_L0.5600.40
194_I235_G0.5600.40
167_E188_T0.5600.40
242_A276_R0.5590.40
181_P248_A0.5590.40
18_P208_F0.5570.40
139_T157_S0.5570.40
249_C288_I0.5540.40
9_T149_G0.5530.39
250_D253_H0.5530.39
170_I211_P0.5520.39
74_R331_E0.5520.39
167_E184_F0.5520.39
271_Q279_E0.5510.39
25_Y127_K0.5510.39
274_H278_L0.5510.39
54_L262_V0.5500.39
288_I291_G0.5490.39
160_A167_E0.5490.39
235_G268_G0.5470.39
77_S338_E0.5470.39
292_S295_I0.5460.39
143_F180_C0.5460.39
108_S148_T0.5460.39
76_Q201_A0.5460.39
173_E210_S0.5450.39
8_R227_Y0.5440.39
145_D173_E0.5440.39
72_A139_T0.5430.38
107_I149_G0.5430.38
21_L198_A0.5400.38
146_M214_N0.5390.38
336_L339_K0.5390.38
270_C277_Q0.5390.38
170_I210_S0.5380.38
145_D212_D0.5370.38
265_F321_Q0.5370.38
261_L292_S0.5370.38
109_D165_T0.5360.38
63_H303_F0.5360.38
141_T146_M0.5350.38
129_L158_W0.5340.38
72_A90_M0.5340.38
287_Q291_G0.5330.37
281_C332_D0.5310.37
113_N317_L0.5300.37
9_T92_T0.5300.37
129_L145_D0.5290.37
92_T132_V0.5290.37
41_R274_H0.5280.37
62_I207_M0.5280.37
34_H46_L0.5280.37
62_I68_A0.5270.37
293_T342_S0.5270.37
43_E47_N0.5260.37
276_R282_E0.5240.37
16_V198_A0.5230.36
16_V216_Q0.5230.36
12_I122_L0.5210.36
56_I106_L0.5210.36
125_A149_G0.5210.36
6_E213_K0.5210.36
40_R315_Q0.5190.36
23_L214_N0.5170.36
128_L206_H0.5170.36
104_K108_S0.5170.36
310_K314_S0.5160.36
6_E211_P0.5160.36
265_F284_I0.5160.36
210_S213_K0.5160.36
112_L311_I0.5150.36
46_L209_L0.5140.36
212_D217_M0.5140.36
37_D192_T0.5120.35
16_V27_V0.5100.35
107_I150_Q0.5100.35
40_R49_E0.5090.35
311_I316_P0.5090.35
158_W184_F0.5090.35
104_K173_E0.5080.35
194_I220_Y0.5080.35
132_V136_G0.5070.35
119_N344_V0.5060.35
305_R326_P0.5050.35
140_A156_I0.5040.35
28_T133_N0.5040.35
73_T131_Q0.5040.35
156_I180_C0.5020.34
147_V222_T0.5010.34
35_V227_Y0.5000.34
74_R305_R0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1of8A 2 0.9713 100 0.194 Contact Map
1n8fA 2 0.9828 100 0.202 Contact Map
4umaA 3 0.954 100 0.23 Contact Map
3tqkA 2 0.9741 100 0.237 Contact Map
2nwrA 4 0.6897 100 0.679 Contact Map
4lu0A 4 0.7098 100 0.68 Contact Map
1o60A 4 0.7241 100 0.702 Contact Map
1vs1A 4 0.7356 100 0.709 Contact Map
3fs2A 4 0.7098 100 0.713 Contact Map
2qkfA 4 0.6983 100 0.716 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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