GREMLIN Database
DCDA - Diaminopimelate decarboxylase
UniProt: P00861 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10549
Length: 420 (366)
Sequences: 8090 (4878)
Seq/√Len: 255.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
230_V275_A3.7611.00
128_D177_V3.7251.00
138_R184_Q3.5601.00
41_A68_Q3.3671.00
81_E111_R3.0721.00
109_L130_L3.0001.00
89_N95_D2.9761.00
37_R68_Q2.9571.00
48_V264_K2.9531.00
110_E133_V2.8931.00
186_V220_Q2.7631.00
106_Q132_Q2.7441.00
24_F402_A2.6721.00
296_V364_V2.6681.00
40_I70_V2.5471.00
136_G184_Q2.4631.00
111_R115_L2.4131.00
289_Q294_H2.3831.00
124_V174_A2.3401.00
298_V337_V2.3331.00
184_Q220_Q2.3321.00
334_E360_A2.3291.00
318_S373_H2.2571.00
281_I369_Y2.2311.00
37_R67_E2.2101.00
106_Q129_Q2.1791.00
84_L115_L2.1761.00
42_A242_E2.1551.00
43_L272_F2.1021.00
138_R186_V2.1011.00
172_P214_E2.0961.00
131_G182_H2.0761.00
294_H333_V2.0051.00
280_L300_A1.9581.00
21_P26_C1.9341.00
109_L119_V1.9211.00
74_S80_I1.9001.00
296_V335_T1.8981.00
72_V83_A1.8981.00
391_L409_Q1.8811.00
28_V281_I1.8641.00
110_E114_E1.8421.00
283_Q369_Y1.8371.00
282_T298_V1.7991.00
135_P182_H1.7931.00
124_V170_D1.7721.00
332_T360_A1.7631.00
72_V88_Y1.7521.00
35_I39_Q1.7481.00
37_R64_L1.7461.00
39_Q276_Q1.7251.00
109_L133_V1.7221.00
84_L90_P1.7061.00
40_I68_Q1.6991.00
333_V363_E1.6981.00
66_R88_Y1.6921.00
77_L81_E1.6721.00
55_A274_V1.6661.00
36_I274_V1.6621.00
113_S137_H1.6581.00
279_V371_V1.6571.00
131_G181_H1.6571.00
40_I65_M1.6501.00
113_S133_V1.6421.00
33_A398_D1.6351.00
37_R41_A1.6271.00
240_D243_H1.5871.00
51_F55_A1.5831.00
334_E358_T1.5661.00
131_G135_P1.5631.00
396_L405_I1.5541.00
206_G210_R1.5511.00
65_M273_L1.5481.00
395_V404_L1.5461.00
167_W170_D1.5371.00
121_A130_L1.5351.00
36_I65_M1.5331.00
281_I371_V1.5201.00
35_I38_R1.5201.00
206_G251_A1.5161.00
37_R398_D1.5101.00
282_T370_L1.5061.00
125_D366_A1.5051.00
202_E250_A1.4961.00
211_Q215_F1.4911.00
178_I185_L1.4891.00
242_E246_G1.4771.00
140_W221_A1.4721.00
81_E85_A1.4681.00
39_Q42_A1.4651.00
24_F28_V1.4551.00
23_E402_A1.4531.00
65_M70_V1.4451.00
34_Q38_R1.4311.00
41_A45_Q1.4251.00
172_P176_D1.4171.00
202_E247_L1.4161.00
280_L375_T1.4061.00
24_F404_L1.4051.00
89_N96_D1.4051.00
212_V215_F1.4051.00
53_Q72_V1.4011.00
77_L108_T1.3971.00
33_A37_R1.3951.00
57_S388_S1.3901.00
287_V296_V1.3761.00
104_I126_M1.3751.00
246_G250_A1.3611.00
207_A210_R1.3601.00
395_V402_A1.3561.00
60_H63_R1.3441.00
293_R358_T1.3431.00
287_V366_A1.3371.00
24_F395_V1.3341.00
230_V374_D1.3341.00
209_V212_V1.3331.00
124_V173_A1.3251.00
385_N391_L1.3181.00
28_V393_P1.3161.00
177_V180_R1.3121.00
90_P97_I1.2961.00
47_D264_K1.2811.00
166_I174_A1.2701.00
48_V96_D1.2681.00
50_R71_K1.2661.00
90_P95_D1.2631.00
112_V119_V1.2591.00
119_V130_L1.2491.00
103_V297_L1.2391.00
220_Q264_K1.2371.00
173_A176_D1.2371.00
287_V294_H1.2321.00
30_V281_I1.2261.00
28_V395_V1.2221.00
393_P408_R1.2211.00
50_R266_E1.2191.00
294_H335_T1.2151.00
98_V223_S1.2081.00
71_K96_D1.1831.00
34_Q398_D1.1821.00
106_Q133_V1.1791.00
121_A127_L1.1771.00
121_A139_V1.1761.00
293_R336_V1.1691.00
106_Q110_E1.1641.00
190_M224_A1.1611.00
26_C299_D1.1601.00
40_I44_K1.1591.00
207_A211_Q1.1511.00
124_V128_D1.1511.00
33_A64_L1.1501.00
77_L111_R1.1461.00
63_R67_E1.1441.00
298_V370_L1.1341.00
176_D180_R1.1311.00
337_V370_L1.1301.00
38_R42_A1.1271.00
43_L228_L1.1241.00
113_S130_L1.1241.00
46_F245_Y1.1141.00
190_M208_M1.1111.00
127_L178_I1.1061.00
170_D173_A1.1011.00
199_A203_Q1.1001.00
175_L185_L1.0991.00
347_V350_Q1.0881.00
252_R265_L1.0851.00
205_C208_M1.0821.00
106_Q366_A1.0801.00
21_P369_Y1.0791.00
83_A97_I1.0751.00
35_I276_Q1.0751.00
103_V285_R1.0741.00
282_T300_A1.0711.00
202_E251_A1.0661.00
336_V350_Q1.0651.00
57_S381_S1.0641.00
284_V364_V1.0641.00
224_A267_I1.0551.00
124_V166_I1.0501.00
35_I277_S1.0491.00
36_I277_S1.0481.00
247_L250_A1.0461.00
331_P363_E1.0401.00
118_P264_K1.0381.00
335_T361_L1.0331.00
53_Q62_L1.0331.00
66_R96_D1.0301.00
81_E115_L1.0171.00
31_Y278_G1.0161.00
249_N253_E1.0131.00
25_G28_V1.0111.00
298_V348_F1.0091.00
190_M204_V0.9931.00
211_Q214_E0.9871.00
317_I349_T0.9851.00
129_Q285_R0.9851.00
53_Q83_A0.9841.00
90_P117_I0.9781.00
39_Q272_F0.9781.00
128_D132_Q0.9761.00
276_Q374_D0.9701.00
319_A364_V0.9671.00
250_A254_Q0.9641.00
208_M211_Q0.9621.00
295_F338_A0.9601.00
111_R114_E0.9491.00
221_A266_E0.9441.00
82_R388_S0.9431.00
124_V177_V0.9411.00
222_I265_L0.9301.00
99_F108_T0.9281.00
210_R213_I0.9271.00
64_L68_Q0.9261.00
125_D286_S0.9261.00
251_A254_Q0.9261.00
231_P234_Q0.9211.00
303_N341_L0.9171.00
56_C394_E0.9141.00
336_V347_V0.9131.00
29_W383_S0.9131.00
48_V266_E0.9111.00
198_Y243_H0.9061.00
53_Q57_S0.9061.00
168_Y214_E0.9001.00
50_R98_V0.8981.00
41_A44_K0.8961.00
40_I273_L0.8931.00
202_E243_H0.8911.00
305_L308_P0.8881.00
228_L239_V0.8851.00
57_S62_L0.8821.00
64_L67_E0.8791.00
289_Q333_V0.8761.00
307_R313_S0.8731.00
139_V183_L0.8731.00
140_W187_G0.8691.00
80_I112_V0.8691.00
349_T359_R0.8691.00
129_Q366_A0.8681.00
350_Q358_T0.8681.00
113_S119_V0.8671.00
207_A215_F0.8610.99
287_V335_T0.8600.99
46_F70_V0.8590.99
243_H246_G0.8580.99
77_L107_A0.8570.99
287_V365_K0.8570.99
58_N406_R0.8520.99
224_A248_W0.8470.99
61_I274_V0.8420.99
84_L97_I0.8390.99
59_I85_A0.8380.99
62_L88_Y0.8360.99
279_V373_H0.8350.99
54_K342_C0.8340.99
185_L219_L0.8340.99
307_R382_M0.8320.99
83_A88_Y0.8310.99
322_A365_K0.8290.99
60_H405_I0.8290.99
203_Q206_G0.8260.99
287_V364_V0.8250.99
283_Q299_D0.8220.99
365_K368_D0.8220.99
314_Y359_R0.8150.99
25_G107_A0.8150.99
78_G390_P0.8130.99
205_C209_V0.8130.99
62_L82_R0.8120.99
48_V71_K0.8120.99
210_R214_E0.8100.99
134_S137_H0.8070.99
198_Y247_L0.8050.99
337_V361_L0.8030.99
302_F307_R0.8020.99
22_A283_Q0.8010.99
323_D328_E0.7980.99
282_T372_L0.7970.99
36_I61_I0.7960.99
221_A264_K0.7960.99
131_G136_G0.7940.99
192_I204_V0.7930.99
284_V296_V0.7930.99
118_P138_R0.7920.99
45_Q242_E0.7910.99
34_Q399_N0.7860.99
316_H373_H0.7860.99
298_V301_G0.7850.99
335_T364_V0.7840.99
60_H403_R0.7840.99
332_T363_E0.7830.99
200_H203_Q0.7820.99
343_E386_Y0.7760.99
42_A45_Q0.7740.99
202_E206_G0.7720.99
43_L269_P0.7720.99
199_A202_E0.7670.99
380_A392_L0.7620.99
119_V137_H0.7610.99
42_A241_T0.7600.99
191_H269_P0.7580.99
56_C61_I0.7550.99
30_V279_V0.7540.99
135_P181_H0.7530.99
312_G315_H0.7530.99
318_S323_D0.7520.99
154_K312_G0.7490.99
88_Y96_D0.7480.99
134_S182_H0.7450.99
341_L389_R0.7420.99
44_K70_V0.7390.98
87_G90_P0.7370.98
305_L375_T0.7370.98
188_I222_I0.7330.98
208_M215_F0.7330.98
212_V219_L0.7320.98
241_T245_Y0.7310.98
332_T362_P0.7250.98
179_Q217_Q0.7240.98
97_I100_T0.7240.98
339_G346_D0.7220.98
330_A363_E0.7210.98
33_A396_L0.7200.98
163_K387_N0.7170.98
209_V213_I0.7170.98
136_G182_H0.7160.98
398_D401_Q0.7160.98
319_A322_A0.7160.98
383_S392_L0.7150.98
307_R311_Y0.7110.98
28_V402_A0.7100.98
98_V120_N0.7060.98
116_Q138_R0.7030.98
52_A55_A0.7030.98
301_G340_P0.6980.98
123_S286_S0.6970.98
129_Q132_Q0.6970.98
99_F112_V0.6950.98
63_R66_R0.6930.98
153_Q156_N0.6930.98
323_D329_H0.6920.98
380_A394_E0.6910.98
27_P299_D0.6900.98
138_R220_Q0.6890.98
51_F56_C0.6880.98
331_P362_P0.6870.98
309_A345_G0.6870.98
129_Q286_S0.6850.97
222_I252_R0.6830.97
348_F372_L0.6830.97
318_S321_A0.6820.97
126_M129_Q0.6800.97
62_L72_V0.6800.97
39_Q277_S0.6770.97
61_I405_I0.6760.97
207_A212_V0.6760.97
310_M314_Y0.6750.97
206_G254_Q0.6730.97
105_D285_R0.6690.97
49_V70_V0.6650.97
36_I64_L0.6650.97
59_I82_R0.6640.97
308_P312_G0.6630.97
131_G183_L0.6620.97
59_I63_R0.6620.97
243_H247_L0.6610.97
306_M379_G0.6610.97
343_E387_N0.6600.97
311_Y343_E0.6590.97
176_D179_Q0.6590.97
102_D122_G0.6580.97
224_A265_L0.6570.97
205_C212_V0.6560.97
173_A177_V0.6540.97
124_V171_L0.6540.97
184_Q218_D0.6530.97
127_L174_A0.6510.97
283_Q367_G0.6490.97
120_N140_W0.6480.97
84_L111_R0.6470.96
63_R86_A0.6470.96
90_P116_Q0.6470.96
172_P211_Q0.6460.96
49_V267_I0.6460.96
105_D108_T0.6450.96
199_A243_H0.6440.96
26_C283_Q0.6420.96
380_A391_L0.6410.96
404_L408_R0.6390.96
40_I49_V0.6390.96
127_L139_V0.6380.96
206_G209_V0.6380.96
141_L174_A0.6350.96
38_R45_Q0.6330.96
247_L251_A0.6310.96
300_A303_N0.6300.96
107_A110_E0.6300.96
185_L217_Q0.6290.96
176_D215_F0.6280.96
166_I171_L0.6260.96
178_I183_L0.6240.96
36_I40_I0.6240.96
62_L86_A0.6230.96
64_L396_L0.6230.96
131_G134_S0.6220.96
31_Y394_E0.6220.96
311_Y315_H0.6210.96
43_L273_L0.6210.96
303_N307_R0.6160.95
302_F309_A0.6160.95
65_M72_V0.6150.95
177_V181_H0.6150.95
302_F305_L0.6150.95
172_P215_F0.6110.95
233_Q236_E0.6110.95
197_D200_H0.6100.95
66_R86_A0.6100.95
336_V358_T0.6090.95
239_V243_H0.6090.95
308_P311_Y0.6090.95
302_F313_S0.6080.95
169_T291_G0.6080.95
302_F310_M0.6060.95
319_A362_P0.6030.95
307_R310_M0.6020.95
301_G304_D0.6010.95
280_L379_G0.6010.95
99_F116_Q0.6010.95
21_P25_G0.6010.95
76_S389_R0.6010.95
222_I251_A0.6000.95
43_L267_I0.5990.95
201_L244_Y0.5990.95
159_G162_S0.5980.95
31_Y58_N0.5980.95
385_N409_Q0.5970.95
29_W392_L0.5940.94
80_I97_I0.5910.94
44_K49_V0.5890.94
402_A406_R0.5890.94
208_M212_V0.5880.94
107_A111_R0.5880.94
168_Y171_L0.5880.94
106_Q283_Q0.5880.94
141_L166_I0.5870.94
101_A104_I0.5860.94
205_C215_F0.5810.94
251_A255_I0.5810.94
342_C387_N0.5810.94
153_Q159_G0.5800.94
329_H332_T0.5790.94
110_E132_Q0.5790.94
155_T195_G0.5780.94
400_G403_R0.5770.93
130_L137_H0.5770.93
246_G249_N0.5760.93
38_R41_A0.5750.93
212_V222_I0.5720.93
289_Q363_E0.5720.93
131_G177_V0.5720.93
26_C369_Y0.5710.93
233_Q316_H0.5700.93
173_A180_R0.5690.93
344_S387_N0.5690.93
300_A304_D0.5690.93
149_H203_Q0.5690.93
307_R312_G0.5680.93
229_S271_R0.5670.93
140_W189_H0.5670.93
46_F267_I0.5650.93
308_P313_S0.5650.93
74_S83_A0.5650.93
39_Q273_L0.5640.93
121_A141_L0.5640.93
186_V221_A0.5600.92
77_L99_F0.5600.92
287_V363_E0.5600.92
103_V301_G0.5600.92
191_H387_N0.5580.92
306_M310_M0.5570.92
393_P404_L0.5570.92
311_Y382_M0.5560.92
203_Q207_A0.5560.92
49_V273_L0.5550.92
107_A283_Q0.5550.92
73_D100_T0.5540.92
100_T223_S0.5500.92
164_H344_S0.5500.92
54_K164_H0.5500.92
42_A272_F0.5490.92
28_V408_R0.5450.91
39_Q241_T0.5450.91
317_I337_V0.5450.91
286_S297_L0.5400.91
100_T120_N0.5400.91
143_V211_Q0.5380.91
206_G255_I0.5380.91
397_F400_G0.5380.91
288_K295_F0.5380.91
105_D283_Q0.5370.91
143_V208_M0.5360.91
148_G151_H0.5360.91
188_I208_M0.5350.91
61_I64_L0.5330.91
139_V185_L0.5320.90
54_K191_H0.5320.90
88_Y95_D0.5300.90
108_T389_R0.5300.90
163_K343_E0.5280.90
66_R72_V0.5280.90
141_L178_I0.5270.90
306_M313_S0.5270.90
218_D261_H0.5260.90
308_P315_H0.5250.90
42_A240_D0.5250.90
25_G393_P0.5240.90
54_K73_D0.5240.90
299_D303_N0.5220.90
343_E382_M0.5210.90
58_N396_L0.5210.90
196_V201_L0.5210.90
286_S366_A0.5200.89
308_P382_M0.5190.89
143_V168_Y0.5190.89
318_S322_A0.5190.89
300_A305_L0.5170.89
310_M313_S0.5160.89
72_V87_G0.5140.89
29_W375_T0.5130.89
341_L386_Y0.5110.89
206_G215_F0.5100.89
239_V247_L0.5080.88
108_T340_P0.5080.88
191_H194_S0.5070.88
51_F62_L0.5070.88
231_P238_A0.5070.88
323_D365_K0.5060.88
305_L315_H0.5060.88
160_E292_S0.5050.88
33_A68_Q0.5040.88
169_T172_P0.5030.88
234_Q316_H0.5030.88
78_G81_E0.5010.88
61_I396_L0.5010.88
58_N394_E0.5010.88
34_Q37_R0.5010.88
306_M309_A0.5000.88
168_Y172_P0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1knwA 2 0.981 100 0.211 Contact Map
1twiA 4 0.9571 100 0.258 Contact Map
3vabA 2 0.9405 100 0.264 Contact Map
2qghA 2 0.8976 100 0.267 Contact Map
2o0tA 2 0.9619 100 0.267 Contact Map
2j66A 2 0.8905 100 0.275 Contact Map
3n2bA 2 0.9357 100 0.282 Contact Map
3n29A 2 0.8381 100 0.301 Contact Map
3nzpA 2 0.9286 100 0.313 Contact Map
2p3eA 2 0.9095 100 0.32 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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