GREMLIN Database
CYNS - Cyanate hydratase
UniProt: P00816 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10175
Length: 156 (142)
Sequences: 645 (325)
Seq/√Len: 27.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_A53_L3.0961.00
32_I64_K2.7061.00
55_A59_R2.6920.99
97_F144_I2.6050.99
62_G72_I2.6010.99
108_L130_V2.5750.99
40_E115_K2.4960.99
50_Q82_G2.4890.99
89_P98_Y2.3670.99
30_A34_D2.3250.98
31_E34_D2.2820.98
133_V147_D2.2780.98
45_A51_Q2.2060.98
38_L57_A2.1630.98
25_K66_D2.1330.97
17_A71_S1.9990.96
68_D71_S1.9320.95
97_F108_L1.8890.95
14_L71_S1.8840.94
112_V142_A1.8390.94
36_T43_V1.8100.93
100_M146_L1.7520.92
115_K132_K1.7510.92
44_T107_T1.7130.91
60_L63_A1.5980.88
110_A144_I1.5940.88
44_T111_L1.5930.88
38_L42_F1.5790.87
16_D20_L1.5690.87
42_F53_L1.5650.87
38_L43_V1.5530.86
100_M130_V1.5510.86
48_L110_A1.5380.86
18_I47_L1.4560.82
108_L113_H1.4440.82
24_K66_D1.4190.81
137_E140_E1.4170.81
23_A77_M1.3980.80
47_L61_V1.3960.80
28_S31_E1.3670.78
133_V143_V1.3620.78
17_A68_D1.3450.77
125_N141_R1.3390.77
125_N137_E1.3260.76
32_I65_L1.3230.76
86_D90_T1.3180.76
81_R93_T1.2960.74
50_Q84_I1.2620.72
55_A76_Q1.2470.71
91_D113_H1.2450.71
38_L53_L1.2010.68
90_T102_Q1.1960.68
50_Q102_Q1.1750.67
121_I142_A1.1750.67
29_F48_L1.1740.67
35_G43_V1.1580.66
100_M144_I1.1530.65
130_V144_I1.1480.65
110_A113_H1.1450.65
93_T125_N1.1350.64
97_F101_L1.1330.64
29_F47_L1.1160.63
97_F100_M1.0960.61
62_G71_S1.0960.61
100_M126_F1.0930.61
85_D88_I1.0760.60
90_T98_Y1.0740.60
22_K152_P1.0720.59
63_A66_D1.0710.59
17_A66_D1.0690.59
47_L65_L1.0680.59
36_T42_F1.0620.59
52_A81_R1.0590.58
56_D60_L1.0390.57
27_L64_K1.0340.57
59_R63_A1.0250.56
134_A140_E1.0160.55
30_A115_K1.0050.54
82_G102_Q1.0040.54
45_A81_R0.9860.53
11_R78_I0.9830.53
123_A126_F0.9790.52
26_D69_E0.9750.52
84_I107_T0.9730.52
30_A40_E0.9710.52
17_A21_S0.9670.52
54_P57_A0.9630.51
136_P140_E0.9390.49
116_F142_A0.9340.49
87_R98_Y0.9120.47
52_A93_T0.8930.46
143_V147_D0.8850.45
31_E70_D0.8740.45
32_I35_G0.8600.43
69_E73_L0.8550.43
94_M101_L0.8480.43
27_L31_E0.8360.42
126_F146_L0.8330.41
33_A43_V0.8310.41
44_T48_L0.8270.41
55_A66_D0.8260.41
108_L146_L0.8250.41
62_G76_Q0.8240.41
132_K140_E0.8050.39
42_F103_V0.8040.39
42_F142_A0.8010.39
19_L22_K0.7990.39
109_K113_H0.7950.39
112_V121_I0.7870.38
150_Y153_T0.7870.38
113_H153_T0.7830.38
107_T128_L0.7830.38
33_A39_A0.7740.37
15_A19_L0.7690.37
20_L24_K0.7660.37
131_K145_T0.7660.37
84_I88_I0.7650.37
72_I76_Q0.7550.36
38_L61_V0.7400.35
125_N147_D0.7380.35
35_G63_A0.7300.34
65_L74_L0.7190.33
108_L128_L0.7180.33
80_L113_H0.7150.33
75_L107_T0.7140.33
29_F67_L0.7110.33
128_L141_R0.7110.33
108_L133_V0.7070.33
103_V153_T0.7050.32
134_A144_I0.7050.32
19_L110_A0.7040.32
12_L16_D0.6960.32
80_L128_L0.6900.32
73_L76_Q0.6900.32
41_A111_L0.6840.31
84_I106_T0.6800.31
18_I44_T0.6770.31
14_L49_G0.6770.31
11_R85_D0.6710.30
46_A61_V0.6710.30
26_D66_D0.6700.30
42_F150_Y0.6640.30
103_V141_R0.6470.29
22_K135_D0.6430.29
52_A58_A0.6400.28
108_L141_R0.6340.28
94_M110_A0.6330.28
36_T54_P0.6240.27
125_N140_E0.6230.27
47_L81_R0.6210.27
47_L72_I0.6210.27
31_E69_E0.6200.27
39_A125_N0.6200.27
45_A104_Y0.6170.27
11_R15_A0.6140.27
29_F39_A0.6140.27
53_L57_A0.6130.27
51_Q125_N0.6110.27
100_M123_A0.6070.26
91_D103_V0.6060.26
47_L50_Q0.6030.26
141_R147_D0.6020.26
14_L74_L0.5990.26
58_A76_Q0.5970.26
31_E61_V0.5960.26
81_R88_I0.5950.26
121_I153_T0.5940.26
35_G64_K0.5910.25
56_D59_R0.5850.25
66_D69_E0.5850.25
37_G44_T0.5800.25
78_I113_H0.5770.25
46_A52_A0.5740.24
18_I29_F0.5720.24
84_I102_Q0.5710.24
36_T57_A0.5710.24
94_M107_T0.5680.24
36_T137_E0.5680.24
140_E153_T0.5630.24
38_L54_P0.5620.24
44_T106_T0.5580.24
49_G65_L0.5530.23
38_L137_E0.5510.23
64_K88_I0.5500.23
81_R147_D0.5470.23
75_L91_D0.5440.23
19_L32_I0.5430.23
13_D44_T0.5390.23
121_I140_E0.5390.23
41_A84_I0.5390.23
126_F133_V0.5390.23
45_A50_Q0.5380.22
82_G90_T0.5360.22
16_D70_D0.5350.22
32_I61_V0.5340.22
26_D74_L0.5330.22
20_L25_K0.5330.22
52_A77_M0.5320.22
136_P150_Y0.5310.22
57_A82_G0.5270.22
23_A78_I0.5240.22
16_D21_S0.5200.22
54_P82_G0.5200.22
82_G86_D0.5190.22
53_L107_T0.5180.21
29_F50_Q0.5130.21
21_S71_S0.5120.21
18_I32_I0.5110.21
29_F110_A0.5110.21
132_K142_A0.5100.21
40_E86_D0.5010.21
58_A123_A0.5010.21
35_G60_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dw9A 6 1 100 0.163 Contact Map
4y42A 6 0.9936 100 0.318 Contact Map
2kpjA 1 0.6026 97.4 0.892 Contact Map
3f6wA 2 0.5256 97.3 0.893 Contact Map
1y7yA 2 0.4423 97.3 0.894 Contact Map
1adrA 1 0.4872 97.2 0.895 Contact Map
4ghjA 2 0.4744 97.2 0.896 Contact Map
4mcxA 2 0.5962 97.1 0.897 Contact Map
3ivpA 2 0.75 97.1 0.897 Contact Map
2r1jL 2 0.4231 97.1 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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