GREMLIN Database
AMPC - Beta-lactamase
UniProt: P00811 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10040
Length: 377 (309)
Sequences: 14263 (11234)
Seq/√Len: 639.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_L192_T3.6971.00
96_R193_R3.4711.00
191_Q196_Q3.3361.00
51_Q349_E3.3101.00
92_D193_R3.1431.00
103_D107_K3.1381.00
89_L189_A3.0721.00
100_K103_D2.8321.00
102_S123_L2.8311.00
78_L241_S2.7461.00
70_V76_F2.7301.00
203_T241_S2.5411.00
189_A193_R2.5061.00
92_D189_A2.4161.00
185_S188_Q2.4101.00
103_D108_Y2.4051.00
58_T72_Q2.3431.00
47_A247_A2.2811.00
176_A180_K2.2331.00
88_V249_W2.2331.00
63_D66_K2.2191.00
178_A189_A2.1821.00
182_S189_A2.1811.00
57_F244_E2.1001.00
84_T249_W2.0741.00
62_A68_Q2.0731.00
74_T216_A2.0701.00
61_Y67_K2.0381.00
92_D96_R2.0021.00
176_A179_V1.9501.00
89_L190_M1.9361.00
250_V342_V1.9241.00
90_G174_F1.8721.00
184_L189_A1.8631.00
250_V351_G1.8441.00
345_I348_K1.8291.00
200_L203_T1.8251.00
80_S83_K1.8051.00
190_M195_F1.7641.00
192_T196_Q1.7451.00
175_G235_E1.7441.00
188_Q192_T1.7391.00
158_W163_Q1.7351.00
104_P107_K1.7281.00
266_Q269_Q1.7031.00
49_I247_A1.7011.00
111_E180_K1.6741.00
184_L188_Q1.6691.00
121_T124_H1.6581.00
94_I101_L1.6101.00
33_T37_E1.6081.00
143_S146_D1.6051.00
90_G99_I1.5981.00
79_G335_T1.5941.00
184_L193_R1.5941.00
45_A243_I1.5801.00
85_F239_V1.5531.00
49_I351_G1.5461.00
47_A243_I1.5441.00
327_S347_E1.5411.00
186_F235_E1.5331.00
202_H214_N1.5151.00
93_A178_A1.5061.00
72_Q244_E1.4951.00
122_L177_L1.4581.00
73_Q244_E1.4541.00
29_H59_W1.4501.00
95_A260_N1.4371.00
124_H161_G1.4361.00
34_P38_Q1.4131.00
29_H33_T1.4121.00
71_T74_T1.4081.00
91_G94_I1.4071.00
130_A133_L1.4071.00
95_A266_Q1.4061.00
93_A182_S1.3971.00
130_A170_S1.3791.00
85_F249_W1.3721.00
50_Y350_L1.3571.00
145_S149_R1.3431.00
195_F200_L1.3411.00
258_D263_T1.3411.00
124_H129_T1.3281.00
58_T70_V1.3261.00
98_E181_P1.3241.00
43_G70_V1.3211.00
186_F190_M1.3071.00
272_Q275_Y1.3021.00
261_E265_Q1.2981.00
61_Y66_K1.2911.00
62_A74_T1.2891.00
90_G126_A1.2881.00
123_L285_L1.2851.00
91_G101_L1.2841.00
56_Y59_W1.2821.00
81_V246_M1.2701.00
260_N263_T1.2691.00
87_G126_A1.2671.00
45_A70_V1.2621.00
83_K166_Y1.2531.00
94_I99_I1.2471.00
70_V74_T1.2441.00
203_T245_D1.2381.00
90_G178_A1.2361.00
85_F190_M1.2211.00
45_A58_T1.2141.00
95_A263_T1.2141.00
93_A98_E1.2111.00
195_F239_V1.2091.00
81_V340_S1.2071.00
81_V342_V1.2061.00
43_G76_F1.1871.00
344_F351_G1.1811.00
218_G338_F1.1811.00
104_P119_G1.1781.00
267_G271_A1.1781.00
49_I54_P1.1731.00
200_L249_W1.1711.00
251_Q254_L1.1621.00
29_H56_Y1.1581.00
146_D149_R1.1571.00
326_A348_K1.1511.00
88_V253_N1.1501.00
334_A339_G1.1481.00
246_M355_L1.1441.00
57_F72_Q1.1431.00
30_R34_P1.1411.00
167_A170_S1.1401.00
124_H127_T1.1401.00
87_G171_I1.1391.00
158_W165_L1.1321.00
89_L193_R1.1261.00
205_I239_V1.1241.00
47_A54_P1.1201.00
86_T186_F1.1161.00
158_W162_T1.1141.00
119_G159_A1.1111.00
198_L252_S1.1041.00
284_G289_M1.1031.00
254_L344_F1.1011.00
200_L245_D1.0961.00
265_Q268_I1.0921.00
85_F200_L1.0921.00
168_N236_A1.0851.00
80_S166_Y1.0781.00
108_Y181_P1.0721.00
283_Q288_E1.0721.00
343_A352_I1.0711.00
82_S239_V1.0681.00
75_L214_N1.0641.00
243_I355_L1.0611.00
159_A162_T1.0591.00
265_Q270_L1.0471.00
31_T35_L1.0411.00
191_Q195_F1.0381.00
329_V344_F1.0361.00
106_T118_N1.0351.00
195_F203_T1.0291.00
148_L176_A1.0291.00
33_T36_I1.0271.00
36_I59_W1.0261.00
63_D68_Q1.0061.00
250_V344_F1.0001.00
99_I122_L0.9991.00
258_D261_E0.9961.00
50_Y53_K0.9941.00
78_L82_S0.9911.00
61_Y69_P0.9851.00
92_D194_V0.9831.00
99_I181_P0.9831.00
54_P251_Q0.9821.00
45_A76_F0.9801.00
54_P57_F0.9761.00
75_L240_K0.9731.00
77_E240_K0.9681.00
103_D122_L0.9601.00
85_F246_M0.9551.00
332_T341_Y0.9541.00
188_Q191_Q0.9481.00
108_Y177_L0.9471.00
105_T125_L0.9461.00
264_L267_G0.9411.00
164_R283_Q0.9411.00
246_M353_V0.9391.00
46_V354_M0.9381.00
86_T235_E0.9341.00
128_Y170_S0.9331.00
33_T59_W0.9321.00
75_L202_H0.9311.00
251_Q255_K0.9301.00
263_T267_G0.9271.00
105_T177_L0.9231.00
149_R153_N0.9231.00
256_P271_A0.9211.00
63_D217_W0.9201.00
244_E248_R0.9151.00
46_V56_Y0.9151.00
47_A353_V0.9141.00
89_L182_S0.9081.00
200_L241_S0.9071.00
50_Y55_Y0.9061.00
328_W345_I0.9041.00
248_R259_I0.9041.00
226_H230_G0.9001.00
171_I174_F0.8991.00
49_I251_Q0.8991.00
89_L178_A0.8961.00
342_V353_V0.8921.00
30_R33_T0.8921.00
248_R251_Q0.8861.00
87_G286_G0.8851.00
199_K248_R0.8841.00
77_E335_T0.8821.00
202_H245_D0.8821.00
89_L194_V0.8781.00
32_I44_M0.8741.00
252_S257_L0.8731.00
123_L127_T0.8711.00
75_L204_W0.8661.00
126_A174_F0.8651.00
289_M327_S0.8631.00
267_G270_L0.8611.00
144_S176_A0.8511.00
177_L181_P0.8501.00
93_A96_R0.8461.00
64_I219_Y0.8451.00
32_I46_V0.8441.00
109_W180_K0.8431.00
99_I177_L0.8391.00
178_A182_S0.8371.00
114_A117_W0.8271.00
122_L181_P0.8241.00
187_E233_D0.8231.00
186_F205_I0.8221.00
88_V194_V0.8211.00
175_G186_F0.8181.00
86_T175_G0.8161.00
88_V92_D0.8141.00
157_A165_L0.8101.00
247_A351_G0.8091.00
243_I247_A0.8091.00
109_W177_L0.8041.00
202_H242_T0.8031.00
178_A186_F0.8021.00
42_P64_I0.8001.00
102_S121_T0.7981.00
85_F195_F0.7951.00
268_I271_A0.7911.00
63_D67_K0.7891.00
140_E146_D0.7871.00
326_A345_I0.7871.00
114_A159_A0.7841.00
73_Q202_H0.7831.00
200_L248_R0.7781.00
44_M354_M0.7751.00
124_H160_P0.7751.00
179_V185_S0.7721.00
179_V182_S0.7711.00
254_L351_G0.7661.00
172_G236_A0.7651.00
92_D95_A0.7641.00
46_V59_W0.7611.00
44_M356_A0.7601.00
242_T245_D0.7591.00
226_H229_P0.7571.00
129_T161_G0.7561.00
288_E331_K0.7551.00
283_Q287_W0.7531.00
95_A269_Q0.7521.00
329_V346_P0.7511.00
57_F243_I0.7461.00
128_Y171_I0.7421.00
146_D150_F0.7391.00
75_L242_T0.7381.00
198_L248_R0.7371.00
105_T109_W0.7341.00
263_T270_L0.7331.00
36_I44_M0.7331.00
78_L246_M0.7331.00
62_A71_T0.7291.00
68_Q74_T0.7271.00
94_I100_K0.7271.00
48_V352_I0.7271.00
122_L174_F0.7251.00
253_N274_R0.7211.00
187_E191_Q0.7201.00
208_P211_E0.7171.00
100_K122_L0.7151.00
258_D267_G0.7141.00
34_P37_E0.7111.00
253_N287_W0.7111.00
78_L340_S0.7091.00
26_D30_R0.7091.00
84_T250_V0.7071.00
111_E149_R0.7051.00
108_Y122_L0.7041.00
182_S185_S0.7031.00
250_V353_V0.7011.00
47_A351_G0.6991.00
26_D29_H0.6981.00
81_V84_T0.6951.00
61_Y68_Q0.6921.00
100_K108_Y0.6911.00
261_E267_G0.6891.00
120_I130_A0.6881.00
145_S176_A0.6841.00
278_T281_M0.6831.00
89_L92_D0.6811.00
272_Q277_Q0.6791.00
142_K146_D0.6791.00
263_T266_Q0.6781.00
32_I36_I0.6781.00
84_T342_V0.6751.00
27_I30_R0.6731.00
61_Y64_I0.6721.00
194_V197_P0.6711.00
125_L130_A0.6671.00
225_V228_S0.6661.00
93_A181_P0.6661.00
271_A275_Y0.6651.00
35_L41_I0.6651.00
261_E264_L0.6631.00
116_Q159_A0.6631.00
144_S179_V0.6621.00
76_F355_L0.6601.00
42_P358_K0.6571.00
254_L349_E0.6571.00
92_D264_L0.6561.00
287_W344_F0.6561.00
24_I27_I0.6551.00
50_Y349_E0.6541.00
247_A353_V0.6521.00
271_A274_R0.6521.00
265_Q269_Q0.6501.00
171_I286_G0.6501.00
100_K123_L0.6491.00
326_A347_E0.6491.00
182_S193_R0.6481.00
61_Y65_A0.6461.00
270_L273_S0.6451.00
224_A227_V0.6451.00
109_W176_A0.6431.00
189_A192_T0.6431.00
190_M203_T0.6411.00
101_L285_L0.6401.00
328_W343_A0.6391.00
83_K168_N0.6381.00
201_N245_D0.6381.00
47_A57_F0.6351.00
98_E182_S0.6341.00
79_G338_F0.6331.00
264_L268_I0.6311.00
136_Q169_S0.6291.00
282_Y289_M0.6291.00
78_L203_T0.6271.00
91_G95_A0.6241.00
52_G251_Q0.6241.00
190_M194_V0.6181.00
106_T113_T0.6151.00
104_P121_T0.6141.00
247_A251_Q0.6131.00
330_H343_A0.6131.00
203_T242_T0.6121.00
211_E214_N0.6121.00
31_T34_P0.6121.00
78_L81_V0.6101.00
291_D327_S0.6091.00
234_A237_Y0.6071.00
256_P267_G0.6071.00
32_I59_W0.6071.00
105_T112_L0.6021.00
79_G237_Y0.6011.00
211_E215_Y0.6001.00
267_G273_S0.6001.00
144_S148_L0.5991.00
330_H334_A0.5971.00
149_R152_Q0.5961.00
331_K334_A0.5951.00
54_P247_A0.5911.00
48_V350_L0.5841.00
150_F153_N0.5841.00
36_I39_Q0.5831.00
120_I133_L0.5821.00
204_W208_P0.5811.00
144_S147_L0.5781.00
123_L277_Q0.5771.00
78_L355_L0.5771.00
268_I272_Q0.5771.00
241_S246_M0.5771.00
126_A171_I0.5761.00
225_V230_G0.5751.00
205_I234_A0.5741.00
80_S168_N0.5711.00
94_I103_D0.5701.00
217_W224_A0.5691.00
130_A167_A0.5691.00
71_T214_N0.5691.00
120_I124_H0.5671.00
112_L120_I0.5661.00
283_Q286_G0.5641.00
128_Y331_K0.5641.00
190_M205_I0.5631.00
274_R329_V0.5631.00
84_T287_W0.5621.00
106_T119_G0.5601.00
243_I353_V0.5601.00
265_Q273_S0.5561.00
164_R288_E0.5561.00
45_A49_I0.5541.00
111_E176_A0.5521.00
35_L38_Q0.5491.00
43_G357_N0.5481.00
190_M239_V0.5481.00
113_T117_W0.5471.00
245_D248_R0.5461.00
340_S355_L0.5451.00
252_S264_L0.5441.00
78_L85_F0.5431.00
82_S238_G0.5411.00
212_E215_Y0.5391.00
127_T285_L0.5380.99
84_T87_G0.5360.99
259_I267_G0.5350.99
270_L274_R0.5340.99
94_I266_Q0.5340.99
248_R252_S0.5290.99
127_T271_A0.5280.99
289_M292_W0.5280.99
216_A219_Y0.5260.99
91_G263_T0.5260.99
58_T71_T0.5260.99
148_L152_Q0.5230.99
268_I273_S0.5220.99
45_A57_F0.5200.99
225_V229_P0.5200.99
247_A250_V0.5180.99
120_I160_P0.5180.99
105_T108_Y0.5170.99
133_L173_L0.5160.99
83_K331_K0.5160.99
339_G358_K0.5150.99
204_W240_K0.5150.99
281_M288_E0.5140.99
258_D262_K0.5120.99
177_L180_K0.5110.99
68_Q71_T0.5100.99
234_A238_G0.5100.99
41_I356_A0.5090.99
116_Q120_I0.5060.99
259_I263_T0.5050.99
75_L211_E0.5050.99
93_A189_A0.5040.99
55_Y350_L0.5030.99
227_V230_G0.5030.99
85_F203_T0.5020.99
330_H341_Y0.5020.99
90_G122_L0.5020.99
257_L263_T0.5010.99
205_I238_G0.5010.99
100_K107_K0.5010.99
127_T277_Q0.5000.99
142_K150_F0.5000.99
105_T173_L0.5000.99
123_L266_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ffyA 1 0.9496 100 0.201 Contact Map
4netA 1 0.9443 100 0.213 Contact Map
3wrzA 1 0.9443 100 0.217 Contact Map
2qz6A 1 0.9204 100 0.22 Contact Map
4wz4A 1 0.9496 100 0.225 Contact Map
3w8kA 1 0.9151 100 0.228 Contact Map
2qmiA 5 0.8541 100 0.248 Contact Map
1ei5A 2 0.8329 100 0.252 Contact Map
3rjuA 1 0.8647 100 0.252 Contact Map
4p6bA 5 0.8515 100 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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