ASPG2 - ECOLI - GREMLIN Contacts

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ASPG2 - L-asparaginase 2

UniProt:	P00805	Sequences: MEFFKKTALAALVMGFSGAALALPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10046
Length:	348 (313)
Sequences:	3473 (2485)
Seq/√Len:	140.4

ECOLI - ASPG2 ASPG1
BACSU - ASPG2 ASPG1
HALSA - GATD
SULSO - GATD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
121_L	133_M	4.421	1.00
25_N	69_N	4.105	1.00
251_K	281_T	4.085	1.00
240_Y	264_A	3.742	1.00
117_T	133_M	3.571	1.00
73_E	94_K	3.421	1.00
170_V	182_V	3.313	1.00
125_V	131_V	3.260	1.00
163_S	211_Y	3.087	1.00
340_Q	343_Q	2.949	1.00
251_K	278_T	2.933	1.00
27_T	102_T	2.926	1.00
337_D	340_Q	2.914	1.00
78_I	87_V	2.666	1.00
29_L	75_V	2.656	1.00
177_L	195_S	2.453	1.00
331_A	344_I	2.385	1.00
71_K	102_T	2.366	1.00
260_G	328_L	2.339	1.00
25_N	71_K	2.311	1.00
106_V	158_A	2.284	1.00
254_V	282_A	2.269	1.00
85_D	244_N	2.198	1.00
264_A	321_P	2.187	1.00
99_C	127_C	2.185	1.00
171_V	176_V	2.184	1.00
177_L	182_V	2.172	1.00
280_A	284_K	2.166	1.00
237_G	258_Y	2.154	1.00
95_I	107_I	2.153	1.00
30_A	36_A	2.141	1.00
99_C	105_F	2.090	1.00
292_S	316_S	2.079	1.00
99_C	129_K	2.052	1.00
185_T	194_K	2.021	1.00
176_V	202_G	1.953	1.00
27_T	98_D	1.918	1.00
114_M	170_V	1.885	1.00
92_A	124_T	1.880	1.00
157_T	176_V	1.868	1.00
291_R	313_F	1.866	1.00
153_N	174_D	1.855	1.00
29_L	94_K	1.772	1.00
29_L	73_E	1.769	1.00
247_D	251_K	1.740	1.00
54_V	72_G	1.730	1.00
265_G	291_R	1.729	1.00
290_V	316_S	1.719	1.00
88_W	243_A	1.719	1.00
84_N	87_V	1.713	1.00
290_V	345_F	1.713	1.00
122_D	180_R	1.697	1.00
134_V	172_M	1.651	1.00
76_V	87_V	1.651	1.00
331_A	341_I	1.641	1.00
278_T	281_T	1.639	1.00
338_P	342_Q	1.626	1.00
153_N	171_V	1.620	1.00
338_P	341_I	1.608	1.00
75_V	94_K	1.606	1.00
185_T	192_T	1.564	1.00
88_W	326_V	1.564	1.00
85_D	329_Q	1.554	1.00
233_L	259_D	1.552	1.00
120_F	124_T	1.545	1.00
290_V	328_L	1.536	1.00
83_M	87_V	1.511	1.00
249_P	253_L	1.507	1.00
109_H	117_T	1.493	1.00
247_D	278_T	1.489	1.00
55_E	59_N	1.482	1.00
251_K	255_D	1.471	1.00
281_T	285_T	1.466	1.00
53_G	56_N	1.452	1.00
95_I	131_V	1.451	1.00
235_K	246_S	1.449	1.00
238_I	321_P	1.444	1.00
98_D	101_K	1.442	1.00
94_K	98_D	1.418	1.00
157_T	171_V	1.411	1.00
288_A	341_I	1.411	1.00
152_Y	156_V	1.397	1.00
30_A	54_V	1.392	1.00
89_L	124_T	1.362	1.00
292_S	321_P	1.336	1.00
187_T	293_S	1.334	1.00
94_K	97_T	1.327	1.00
250_A	282_A	1.318	1.00
88_W	120_F	1.294	1.00
167_G	178_D	1.289	1.00
239_V	250_A	1.283	1.00
166_R	216_A	1.281	1.00
306_V	310_K	1.265	1.00
235_K	248_L	1.264	1.00
186_N	297_T	1.262	1.00
73_E	98_D	1.255	1.00
92_A	96_N	1.252	1.00
280_A	311_Y	1.246	1.00
175_T	191_A	1.239	1.00
235_K	259_D	1.237	1.00
149_F	153_N	1.196	1.00
145_A	148_P	1.193	1.00
101_K	129_K	1.190	1.00
40_D	48_T	1.187	1.00
271_L	279_L	1.166	0.99
250_A	278_T	1.164	0.99
261_I	282_A	1.161	0.99
204_I	209_I	1.161	0.99
240_Y	321_P	1.157	0.99
78_I	83_M	1.153	0.99
93_K	97_T	1.152	0.99
331_A	335_T	1.150	0.99
82_D	273_K	1.147	0.99
288_A	314_V	1.143	0.99
87_V	90_T	1.138	0.99
30_A	74_Q	1.133	0.99
235_K	258_Y	1.116	0.99
157_T	163_S	1.113	0.99
91_L	107_I	1.109	0.99
52_V	140_S	1.109	0.99
263_S	279_L	1.107	0.99
47_Y	50_G	1.106	0.99
181_D	213_R	1.101	0.99
85_D	88_W	1.098	0.99
252_A	256_A	1.096	0.99
106_V	155_V	1.086	0.99
237_G	253_L	1.086	0.99
253_L	258_Y	1.079	0.99
111_T	135_G	1.072	0.99
93_K	229_K	1.072	0.99
254_V	287_T	1.070	0.99
37_G	47_Y	1.063	0.99
283_A	289_V	1.060	0.99
234_P	333_T	1.060	0.99
106_V	159_A	1.051	0.99
250_A	275_V	1.047	0.99
114_M	135_G	1.039	0.99
95_I	105_F	1.031	0.99
25_N	103_D	1.028	0.99
247_D	281_T	1.023	0.99
26_I	103_D	1.020	0.99
236_V	332_L	1.019	0.99
160_D	163_S	1.016	0.99
43_T	47_Y	1.012	0.99
163_S	166_R	1.007	0.99
241_N	272_Y	1.003	0.98
107_I	133_M	1.002	0.98
335_T	344_I	0.999	0.98
203_Y	212_Q	0.987	0.98
135_G	172_M	0.985	0.98
248_L	252_A	0.981	0.98
24_P	161_K	0.979	0.98
183_T	321_P	0.978	0.98
166_R	211_Y	0.977	0.98
169_L	201_L	0.971	0.98
132_V	169_L	0.966	0.98
283_A	312_G	0.965	0.98
279_L	313_F	0.962	0.98
177_L	200_P	0.962	0.98
105_F	129_K	0.962	0.98
336_K	340_Q	0.960	0.98
86_N	90_T	0.960	0.98
166_R	214_T	0.957	0.98
35_I	147_G	0.955	0.98
116_E	294_R	0.946	0.98
29_L	107_I	0.936	0.98
81_Q	270_N	0.935	0.98
138_R	190_V	0.931	0.98
171_V	204_I	0.931	0.98
294_R	322_Q	0.925	0.97
71_K	98_D	0.922	0.97
76_V	91_L	0.921	0.97
115_E	322_Q	0.918	0.97
113_T	266_V	0.913	0.97
325_R	329_Q	0.913	0.97
48_T	139_P	0.912	0.97
112_D	267_G	0.907	0.97
176_V	209_I	0.902	0.97
68_A	159_A	0.901	0.97
250_A	279_L	0.898	0.97
64_L	155_V	0.897	0.97
127_C	131_V	0.895	0.97
27_T	73_E	0.892	0.97
239_V	253_L	0.892	0.97
96_N	227_V	0.891	0.97
69_N	103_D	0.890	0.97
307_D	310_K	0.890	0.97
119_Y	123_L	0.888	0.97
114_M	133_M	0.888	0.97
163_S	169_L	0.881	0.97
245_A	275_V	0.880	0.97
54_V	57_L	0.875	0.96
241_N	275_V	0.870	0.96
48_T	51_K	0.869	0.96
68_A	155_V	0.865	0.96
26_I	159_A	0.864	0.96
89_L	93_K	0.863	0.96
38_G	56_N	0.862	0.96
241_N	263_S	0.860	0.96
122_D	179_G	0.860	0.96
283_A	311_Y	0.848	0.96
49_V	53_G	0.846	0.96
111_T	184_K	0.843	0.96
279_L	283_A	0.843	0.96
28_I	151_L	0.841	0.95
160_D	211_Y	0.841	0.95
186_N	189_D	0.838	0.95
181_D	323_K	0.833	0.95
95_I	99_C	0.833	0.95
115_E	294_R	0.832	0.95
144_S	149_F	0.831	0.95
340_Q	344_I	0.829	0.95
157_T	204_I	0.829	0.95
67_I	152_Y	0.828	0.95
149_F	190_V	0.825	0.95
328_L	341_I	0.821	0.95
37_G	50_G	0.806	0.94
187_T	295_V	0.804	0.94
28_I	108_T	0.803	0.94
173_N	191_A	0.798	0.94
188_T	268_N	0.794	0.94
85_D	243_A	0.794	0.94
39_G	43_T	0.790	0.94
187_T	299_A	0.788	0.94
302_Q	305_E	0.787	0.94
157_T	209_I	0.786	0.94
62_P	67_I	0.786	0.94
63_Q	148_P	0.786	0.94
175_T	200_P	0.786	0.94
212_Q	317_G	0.782	0.93
308_D	313_F	0.782	0.93
271_L	275_V	0.781	0.93
236_V	262_V	0.779	0.93
169_L	176_V	0.778	0.93
102_T	129_K	0.770	0.93
181_D	318_T	0.768	0.93
119_Y	326_V	0.766	0.93
209_I	212_Q	0.765	0.93
38_G	51_K	0.764	0.93
50_G	53_G	0.762	0.92
183_T	320_N	0.761	0.92
283_A	286_G	0.758	0.92
132_V	158_A	0.755	0.92
292_S	324_A	0.754	0.92
122_D	178_D	0.752	0.92
254_V	257_G	0.752	0.92
126_K	226_D	0.748	0.92
31_T	109_H	0.748	0.92
67_I	159_A	0.746	0.92
102_T	105_F	0.744	0.92
104_G	130_P	0.739	0.91
24_P	103_D	0.739	0.91
175_T	194_K	0.738	0.91
202_G	211_Y	0.737	0.91
169_L	211_Y	0.737	0.91
303_D	307_D	0.736	0.91
36_A	108_T	0.735	0.91
277_D	280_A	0.735	0.91
37_G	49_V	0.734	0.91
241_N	266_V	0.733	0.91
255_D	281_T	0.732	0.91
184_K	267_G	0.731	0.91
324_A	345_F	0.730	0.91
112_D	270_N	0.729	0.91
119_Y	180_R	0.728	0.91
123_L	327_L	0.725	0.90
132_V	157_T	0.722	0.90
259_D	287_T	0.722	0.90
320_N	323_K	0.720	0.90
62_P	152_Y	0.719	0.90
167_G	201_L	0.717	0.90
241_N	271_L	0.717	0.90
319_L	327_L	0.716	0.90
245_A	272_Y	0.715	0.90
62_P	68_A	0.715	0.90
40_D	43_T	0.714	0.90
95_I	125_V	0.713	0.90
35_I	136_A	0.712	0.90
28_I	155_V	0.711	0.90
186_N	298_G	0.710	0.90
118_A	170_V	0.710	0.90
266_V	272_Y	0.707	0.89
185_T	296_P	0.707	0.89
146_D	184_K	0.706	0.89
96_N	229_K	0.706	0.89
260_G	324_A	0.706	0.89
126_K	228_S	0.704	0.89
50_G	57_L	0.702	0.89
321_P	324_A	0.701	0.89
248_L	256_A	0.700	0.89
262_V	290_V	0.697	0.89
277_D	281_T	0.696	0.89
98_D	105_F	0.694	0.88
98_D	102_T	0.694	0.88
27_T	71_K	0.693	0.88
123_L	330_L	0.691	0.88
243_A	322_Q	0.688	0.88
335_T	340_Q	0.683	0.88
134_V	154_A	0.681	0.88
339_Q	343_Q	0.681	0.88
74_Q	77_N	0.680	0.87
92_A	120_F	0.679	0.87
79_G	82_D	0.678	0.87
335_T	338_P	0.678	0.87
254_V	278_T	0.675	0.87
281_T	284_K	0.674	0.87
270_N	305_E	0.674	0.87
181_D	327_L	0.673	0.87
96_N	126_K	0.672	0.87
161_K	166_R	0.672	0.87
81_Q	266_V	0.672	0.87
115_E	182_V	0.671	0.87
90_T	94_K	0.669	0.87
212_Q	215_P	0.669	0.87
302_Q	308_D	0.668	0.87
239_V	249_P	0.668	0.87
166_R	169_L	0.667	0.86
26_I	155_V	0.667	0.86
247_D	250_A	0.666	0.86
107_I	121_L	0.664	0.86
205_H	268_N	0.664	0.86
118_A	182_V	0.662	0.86
85_D	89_L	0.662	0.86
82_D	304_A	0.662	0.86
260_G	288_A	0.659	0.86
268_N	301_T	0.658	0.86
282_A	287_T	0.658	0.86
29_L	98_D	0.657	0.86
337_D	344_I	0.656	0.86
133_M	179_G	0.656	0.86
31_T	91_L	0.655	0.85
140_S	147_G	0.654	0.85
278_T	282_A	0.654	0.85
241_N	245_A	0.653	0.85
178_D	181_D	0.653	0.85
178_D	201_L	0.652	0.85
135_G	184_K	0.652	0.85
288_A	338_P	0.649	0.85
237_G	246_S	0.648	0.85
140_S	145_A	0.647	0.85
88_W	117_T	0.646	0.85
112_D	302_Q	0.645	0.85
139_P	142_S	0.644	0.85
99_C	125_V	0.638	0.84
24_P	68_A	0.635	0.84
323_K	327_L	0.635	0.84
245_A	250_A	0.634	0.84
308_D	311_Y	0.632	0.83
67_I	155_V	0.631	0.83
37_G	48_T	0.629	0.83
268_N	291_R	0.629	0.83
247_D	274_S	0.628	0.83
172_M	177_L	0.628	0.83
76_V	90_T	0.627	0.83
88_W	121_L	0.627	0.83
183_T	296_P	0.626	0.83
154_A	171_V	0.626	0.83
254_V	261_I	0.625	0.83
39_G	141_T	0.623	0.83
270_N	304_A	0.620	0.82
259_D	336_K	0.620	0.82
156_V	207_G	0.618	0.82
137_M	192_T	0.618	0.82
116_E	325_R	0.617	0.82
258_Y	287_T	0.614	0.82
330_L	334_Q	0.614	0.82
228_S	334_Q	0.613	0.82
175_T	203_Y	0.613	0.82
123_L	323_K	0.612	0.81
196_V	297_T	0.611	0.81
50_G	56_N	0.610	0.81
239_V	245_A	0.610	0.81
123_L	180_R	0.609	0.81
36_A	54_V	0.608	0.81
314_V	342_Q	0.606	0.81
35_I	108_T	0.605	0.81
191_A	194_K	0.602	0.80
67_I	70_V	0.596	0.80
267_G	270_N	0.596	0.80
29_L	95_I	0.596	0.80
265_G	271_L	0.595	0.80
71_K	103_D	0.593	0.79
234_P	259_D	0.591	0.79
82_D	303_D	0.591	0.79
89_L	229_K	0.590	0.79
316_S	324_A	0.590	0.79
37_G	81_Q	0.589	0.79
163_S	167_G	0.588	0.79
92_A	227_V	0.588	0.79
70_V	106_V	0.586	0.79
219_H	223_T	0.585	0.78
260_G	332_L	0.584	0.78
263_S	271_L	0.584	0.78
273_K	277_D	0.583	0.78
202_G	209_I	0.583	0.78
87_V	91_L	0.581	0.78
119_Y	327_L	0.581	0.78
283_A	313_F	0.580	0.78
300_T	315_A	0.579	0.78
260_G	292_S	0.578	0.78
92_A	125_V	0.576	0.77
27_T	95_I	0.573	0.77
137_M	267_G	0.573	0.77
176_V	211_Y	0.572	0.77
276_F	280_A	0.572	0.77
80_S	109_H	0.572	0.77
253_L	257_G	0.570	0.77
254_V	285_T	0.568	0.76
307_D	311_Y	0.568	0.76
316_S	345_F	0.561	0.76
188_T	299_A	0.559	0.75
90_T	97_T	0.558	0.75
79_G	179_G	0.558	0.75
91_L	94_K	0.557	0.75
31_T	34_T	0.555	0.75
282_A	288_A	0.553	0.74
114_M	154_A	0.553	0.74
214_T	226_D	0.552	0.74
100_D	103_D	0.552	0.74
75_V	244_N	0.549	0.74
223_T	226_D	0.548	0.74
169_L	202_G	0.547	0.74
137_M	172_M	0.547	0.74
93_K	227_V	0.547	0.74
30_A	37_G	0.547	0.74
137_M	184_K	0.546	0.74
249_P	252_A	0.546	0.74
119_Y	179_G	0.545	0.73
61_V	155_V	0.544	0.73
126_K	223_T	0.542	0.73
237_G	245_A	0.542	0.73
55_E	71_K	0.541	0.73
217_R	222_D	0.541	0.73
249_P	258_Y	0.538	0.72
197_N	318_T	0.538	0.72
250_A	261_I	0.535	0.72
99_C	102_T	0.534	0.72
252_A	255_D	0.534	0.72
79_G	114_M	0.532	0.72
111_T	177_L	0.532	0.72
32_G	35_I	0.530	0.71
93_K	234_P	0.530	0.71
64_L	68_A	0.525	0.71
108_T	151_L	0.525	0.71
83_M	117_T	0.525	0.71
78_I	84_N	0.525	0.71
226_D	229_K	0.524	0.71
183_T	322_Q	0.524	0.71
62_P	65_K	0.524	0.71
276_F	311_Y	0.523	0.70
39_G	142_S	0.522	0.70
242_Y	329_Q	0.522	0.70
240_Y	322_Q	0.522	0.70
106_V	134_V	0.522	0.70
314_V	345_F	0.521	0.70
118_A	133_M	0.521	0.70
26_I	70_V	0.519	0.70
238_I	325_R	0.519	0.70
156_V	160_D	0.514	0.69
282_A	289_V	0.514	0.69
67_I	156_V	0.514	0.69
172_M	192_T	0.510	0.68
52_V	62_P	0.509	0.68
88_W	109_H	0.509	0.68
108_T	147_G	0.508	0.68
341_I	345_F	0.508	0.68
323_K	326_V	0.505	0.68
143_M	174_D	0.503	0.67
337_D	343_Q	0.502	0.67
258_Y	261_I	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wsaA	4	0.9138	100	0.078	Contact Map
2wltA	4	0.9253	100	0.08	Contact Map
1nnsA	4	0.931	100	0.08	Contact Map
3nxkA	4	0.9339	100	0.082	Contact Map
4pgaA	4	0.9368	100	0.086	Contact Map
1agxA	4	0.9282	100	0.088	Contact Map
1o7jA	4	0.9253	100	0.091	Contact Map
2d6fA	2	0.9626	100	0.099	Contact Map
1zq1A	2	0.9799	100	0.1	Contact Map
1wlsA	2	0.8966	100	0.105	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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