GREMLIN Database
LSPA - Lipoprotein signal peptidase
UniProt: P00804 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10548
Length: 164 (142)
Sequences: 4394 (3260)
Seq/√Len: 273.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_V143_A3.8141.00
26_S124_M3.7091.00
19_V106_G2.7251.00
20_L113_F2.7211.00
52_R120_F2.5911.00
126_D133_H2.5441.00
31_L122_V2.5121.00
46_L125_I2.2081.00
29_L33_N2.1781.00
30_I34_F2.1021.00
34_F40_V2.0681.00
58_F135_A2.0191.00
26_S139_L1.9771.00
24_L113_F1.9641.00
142_T146_V1.9351.00
31_L52_R1.8961.00
47_N126_D1.7681.00
145_C149_A1.7491.00
16_V105_I1.7411.00
100_A150_L1.7181.00
41_P44_P1.7071.00
51_A136_T1.7041.00
139_L142_T1.6651.00
47_N128_Y1.6421.00
54_Y62_A1.5981.00
25_G29_L1.5711.00
39_T47_N1.5341.00
104_I147_G1.5261.00
83_L105_I1.5211.00
80_S105_I1.5121.00
134_F145_C1.5101.00
85_V89_R1.4771.00
139_L143_A1.4671.00
54_Y120_F1.4421.00
28_Y32_Q1.4231.00
102_A106_G1.3911.00
16_V102_A1.3621.00
30_I50_Y1.3611.00
34_F50_Y1.3491.00
22_I139_L1.3401.00
81_V85_V1.3211.00
30_I48_L1.3111.00
39_T49_H1.2941.00
49_H136_T1.2731.00
118_H122_V1.2311.00
41_P47_N1.2291.00
142_T145_C1.2141.00
76_A112_L1.1851.00
21_I25_G1.1781.00
82_I86_M1.1641.00
96_L150_L1.1641.00
49_H126_D1.1481.00
100_A147_G1.1461.00
46_L127_F1.1321.00
42_L48_L1.1231.00
77_I81_V1.1011.00
106_G143_A1.1011.00
100_A154_E1.1001.00
26_S125_I1.0991.00
20_L109_L1.0931.00
78_G82_I1.0881.00
96_L100_A1.0811.00
80_S108_A1.0791.00
48_L125_I1.0671.00
54_Y59_S1.0661.00
95_K99_I1.0641.00
100_A151_I1.0591.00
15_L19_V1.0431.00
35_A50_Y1.0401.00
146_V150_L1.0381.00
126_D129_V1.0361.00
125_I142_T1.0351.00
148_A152_V1.0341.00
39_T126_D1.0231.00
153_L157_L0.9991.00
59_S62_A0.9731.00
12_W87_M0.9691.00
42_L46_L0.9581.00
69_R73_A0.9571.00
74_G78_G0.9521.00
35_A38_D0.9501.00
50_Y122_V0.9451.00
56_A72_F0.9431.00
82_I85_V0.9251.00
113_F117_W0.9191.00
73_A112_L0.9151.00
34_F38_D0.9111.00
87_M101_Y0.9091.00
19_V102_A0.9041.00
96_L154_E0.9011.00
50_Y120_F0.8931.00
68_Q71_F0.8931.00
61_L72_F0.8821.00
76_A80_S0.8781.00
126_D136_T0.8771.00
149_A153_L0.8751.00
94_Q97_N0.8701.00
124_M139_L0.8671.00
103_L143_A0.8661.00
84_A88_Y0.8641.00
15_L102_A0.8601.00
61_L68_Q0.8541.00
23_D27_K0.8491.00
19_V103_L0.8401.00
73_A116_L0.8391.00
83_L101_Y0.8290.99
85_V88_Y0.8260.99
16_V106_G0.8260.99
26_S30_I0.8230.99
26_S29_L0.8190.99
127_F137_F0.8130.99
87_M98_N0.8040.99
30_I36_L0.8010.99
145_C152_V0.7960.99
128_Y133_H0.7930.99
128_Y132_W0.7930.99
44_P47_N0.7920.99
12_W102_A0.7850.99
97_N154_E0.7840.99
20_L24_L0.7800.99
12_W98_N0.7800.99
16_V109_L0.7790.99
103_L147_G0.7720.99
80_S112_L0.7710.99
58_F134_F0.7650.99
104_I151_I0.7650.99
56_A60_F0.7640.99
97_N101_Y0.7610.99
94_Q154_E0.7570.99
154_E158_P0.7550.99
154_E157_L0.7520.99
79_I108_A0.7470.99
76_A115_R0.7400.99
90_S94_Q0.7370.99
24_L117_W0.7320.99
110_G113_F0.7310.99
24_L28_Y0.7250.99
19_V139_L0.7220.99
15_L99_I0.7180.99
51_A59_S0.7180.99
129_V133_H0.7150.98
73_A119_G0.7140.98
137_F142_T0.7100.98
47_N133_H0.7100.98
41_P128_Y0.7090.98
52_R122_V0.7030.98
14_W18_V0.7020.98
125_I139_L0.6750.98
59_S135_A0.6710.98
30_I33_N0.6680.98
87_M102_A0.6670.98
104_I144_I0.6670.98
57_A135_A0.6530.97
16_V20_L0.6510.97
149_A152_V0.6510.97
73_A76_A0.6490.97
112_L116_L0.6470.97
76_A108_A0.6470.97
98_N102_A0.6450.97
62_A68_Q0.6420.97
104_I108_A0.6400.97
63_D68_Q0.6350.97
146_V149_A0.6340.97
20_L106_G0.6310.97
84_A105_I0.6280.97
22_I26_S0.6270.97
31_L120_F0.6260.97
125_I135_A0.6250.97
129_V132_W0.6220.96
93_T158_P0.6200.96
152_V155_G0.6150.96
22_I25_G0.6060.96
30_I124_M0.6050.96
13_L88_Y0.6020.96
108_A144_I0.6000.96
132_W135_A0.5970.95
128_Y136_T0.5970.95
24_L118_H0.5940.95
29_L34_F0.5880.95
31_L50_Y0.5840.95
70_W74_G0.5820.95
125_I136_T0.5820.95
11_R14_W0.5800.95
80_S109_L0.5770.95
25_G28_Y0.5770.95
77_I112_L0.5740.94
13_L17_V0.5710.94
33_N36_L0.5700.94
17_V21_I0.5630.94
31_L118_H0.5540.93
78_G81_V0.5430.93
36_L52_R0.5420.93
45_S128_Y0.5420.93
69_R119_G0.5410.93
97_N158_P0.5380.92
11_R90_S0.5380.92
44_P128_Y0.5370.92
36_L39_T0.5340.92
30_I39_T0.5310.92
148_A155_G0.5240.91
155_G158_P0.5230.91
109_L113_F0.5180.91
68_Q72_F0.5180.91
24_L114_D0.5140.91
133_H136_T0.5140.91
19_V142_T0.5120.90
103_L150_L0.5100.90
71_F74_G0.5070.90
103_L146_V0.5070.90
134_F137_F0.5070.90
56_A69_R0.5030.90
70_W73_A0.5020.89
129_V134_F0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlbA 1 0.9329 19 0.937 Contact Map
4x5mA 2 0.5488 14.3 0.94 Contact Map
4qncA 2 0.5 10.4 0.944 Contact Map
4tkrA 2 0.939 9.5 0.945 Contact Map
4rfsS 1 0.9146 8.4 0.946 Contact Map
2cfqA 1 0.9024 6.4 0.949 Contact Map
2qi9A 2 0.9817 6.3 0.949 Contact Map
4ev6A 3 0.4207 6.2 0.949 Contact Map
4i0uA 4 0.4085 4.9 0.952 Contact Map
4huqS 1 0.8963 4.5 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0059 seconds.