DPO1 - ECOLI - GREMLIN Contacts

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DPO1 - DNA polymerase I

UniProt:	P00582	Sequences: MVQIPQNPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLIMQYKPTHAAVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGLPLLAVSGVEADDVIGTLAREAEKAGRPVLISTGDKDMAQLVTPNITLINTMTNTILGPEEVVNKYGVPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIAGLSFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELELTCEQLEVQQPAAEELLGLFKKYEFKRWTADVEAGKWLQAKGAKPAAKPQETSVADEAPEVTATVISYDNYVTILDEETLKAWIAKLEKAPVFAFDTETDSLDNISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAFDTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQKHKGPLNVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLETVTSEQRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYLPDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQLMENCTRLDVPLLVEVGSGENWDQAH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10746
Length:	928 (885)
Sequences:	2887 (1922)
Seq/√Len:	64.6

ECOLI - DPO1
BACSU - DPO1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
217_E	220_K	6.521	1.00
576_E	593_K	6.034	1.00
808_Q	812_Q	4.617	1.00
161_G	164_E	4.247	1.00
234_A	238_Q	4.058	1.00
539_R	864_D	3.919	1.00
524_N	528_N	3.889	1.00
637_K	642_D	3.751	1.00
818_L	851_T	3.690	1.00
725_T	729_E	3.616	1.00
31_S	283_E	3.586	1.00
549_P	648_I	3.542	1.00
126_E	146_T	3.488	1.00
239_N	242_V	3.307	1.00
569_K	626_V	3.267	1.00
119_G	252_I	3.190	1.00
240_K	244_Y	3.162	1.00
866_W	870_E	3.154	1.00
194_P	239_N	3.104	1.00
558_E	688_R	3.059	1.00
172_P	175_L	3.032	1.00
588_T	592_E	2.977	1.00
785_Q	789_D	2.943	1.00
800_E	804_R	2.943	1.00
700_V	922_E	2.867	1.00
719_R	911_D	2.835	1.00
526_F	531_M	2.832	1.00
224_L	234_A	2.744	1.00
418_G	421_L	2.738	1.00
649_N	652_T	2.692	1.00
406_K	410_E	2.683	1.00
576_E	589_I	2.671	1.00
212_D	247_Y	2.623	1.00
876_M	886_F	2.611	1.00
271_A	274_E	2.590	1.00
163_E	167_N	2.575	1.00
215_Y	240_K	2.573	1.00
196_V	232_M	2.571	1.00
207_G	220_K	2.562	1.00
744_L	753_Q	2.551	1.00
576_E	588_T	2.548	1.00
571_H	577_E	2.541	1.00
901_H	905_E	2.523	1.00
570_A	580_L	2.512	1.00
410_E	433_I	2.509	1.00
215_Y	244_Y	2.508	1.00
163_E	166_V	2.443	1.00
193_V	236_L	2.425	1.00
233_A	237_E	2.425	1.00
190_I	250_A	2.415	1.00
556_S	642_D	2.396	1.00
898_K	902_Q	2.384	1.00
873_R	892_D	2.384	1.00
335_D	338_T	2.381	1.00
22_Y	87_D	2.359	1.00
517_Q	523_L	2.356	1.00
529_I	819_D	2.351	1.00
563_L	634_A	2.346	1.00
546_K	696_P	2.344	1.00
376_E	379_V	2.339	1.00
446_S	456_H	2.318	1.00
97_A	281_K	2.317	1.00
73_L	248_Q	2.317	1.00
162_P	174_E	2.298	1.00
562_R	565_E	2.294	1.00
261_T	264_Q	2.289	1.00
416_K	437_G	2.277	1.00
215_Y	218_P	2.272	1.00
213_T	216_A	2.267	1.00
208_L	221_I	2.229	1.00
359_D	367_N	2.227	1.00
212_D	244_Y	2.216	1.00
8_P	131_P	2.209	1.00
403_E	406_K	2.203	1.00
574_A	623_L	2.201	1.00
332_T	495_G	2.197	1.00
874_V	896_V	2.196	1.00
30_N	283_E	2.178	1.00
210_G	213_T	2.169	1.00
96_H	108_A	2.165	1.00
700_V	890_K	2.137	1.00
276_L	288_T	2.133	1.00
866_W	903_L	2.131	1.00
874_V	892_D	2.108	1.00
213_T	217_E	2.107	1.00
340_K	404_L	2.107	1.00
336_E	400_R	2.104	1.00
698_D	890_K	2.103	1.00
864_D	868_Q	2.092	1.00
730_G	915_L	2.088	1.00
799_L	803_E	2.087	1.00
457_D	460_S	2.084	1.00
573_I	626_V	2.083	1.00
177_I	251_T	2.080	1.00
67_K	72_E	2.068	1.00
419_Q	442_T	2.053	1.00
858_R	907_C	2.039	1.00
100_K	106_L	2.035	1.00
745_P	748_T	2.026	1.00
97_A	100_K	2.024	1.00
123_R	127_K	2.009	1.00
166_V	172_P	2.004	1.00
555_H	559_L	1.996	1.00
699_Y	889_H	1.980	1.00
218_P	237_E	1.963	1.00
440_F	526_F	1.957	1.00
870_E	895_A	1.957	1.00
147_P	162_P	1.948	1.00
571_H	580_L	1.946	1.00
412_E	436_R	1.944	1.00
807_A	811_E	1.941	1.00
581_S	630_Y	1.939	1.00
523_L	527_E	1.938	1.00
804_R	808_Q	1.933	1.00
515_D	518_K	1.933	1.00
122_A	149_I	1.926	1.00
893_V	897_A	1.924	1.00
589_I	593_K	1.901	1.00
886_F	900_I	1.899	1.00
218_P	233_A	1.892	1.00
568_K	577_E	1.876	1.00
886_F	896_V	1.861	1.00
396_I	401_A	1.854	1.00
162_P	166_V	1.850	1.00
179_F	205_L	1.844	1.00
490_A	493_E	1.826	1.00
865_A	869_A	1.824	1.00
86_D	89_R	1.817	1.00
594_Q	621_Y	1.805	1.00
562_R	629_E	1.803	1.00
539_R	868_Q	1.793	1.00
819_D	908_T	1.792	1.00
429_A	542_R	1.786	1.00
345_K	379_V	1.785	1.00
347_E	411_D	1.782	1.00
342_W	381_A	1.778	1.00
525_V	529_I	1.777	1.00
545_V	877_I	1.770	1.00
702_V	888_V	1.766	1.00
862_A	903_L	1.737	1.00
463_E	469_K	1.729	0.99
769_S	772_G	1.725	0.99
39_M	282_Y	1.720	0.99
473_F	477_A	1.713	0.99
208_L	217_E	1.706	0.99
373_F	383_I	1.705	0.99
131_P	148_N	1.704	0.99
902_Q	906_N	1.701	0.99
896_V	900_I	1.701	0.99
123_R	254_T	1.700	0.99
625_K	629_E	1.696	0.99
552_L	692_A	1.695	0.99
444_L	662_A	1.692	0.99
331_V	338_T	1.679	0.99
659_Y	878_M	1.672	0.99
193_V	243_A	1.669	0.99
833_G	836_R	1.667	0.99
278_L	282_Y	1.662	0.99
84_M	89_R	1.660	0.99
32_A	281_K	1.658	0.99
803_E	806_R	1.658	0.99
203_A	207_G	1.656	0.99
426_G	538_S	1.652	0.99
221_I	236_L	1.643	0.99
922_E	926_Q	1.643	0.99
893_V	920_S	1.639	0.99
568_K	572_E	1.638	0.99
562_R	685_E	1.632	0.99
195_G	235_K	1.628	0.99
486_F	494_A	1.622	0.99
411_D	414_A	1.611	0.99
735_R	746_L	1.607	0.99
866_W	869_A	1.599	0.99
334_L	338_T	1.594	0.99
810_K	836_R	1.594	0.99
564_A	567_E	1.590	0.99
247_Y	251_T	1.590	0.99
862_A	865_A	1.581	0.99
719_R	724_L	1.575	0.99
66_G	110_S	1.571	0.99
19_Y	23_H	1.568	0.99
866_W	902_Q	1.560	0.99
588_T	593_K	1.556	0.99
874_V	889_H	1.556	0.99
48_S	52_Q	1.554	0.99
179_F	198_E	1.547	0.99
362_D	365_S	1.546	0.99
458_M	505_T	1.543	0.99
440_F	445_E	1.540	0.99
565_E	569_K	1.539	0.99
223_G	233_A	1.538	0.99
759_A	776_Q	1.534	0.99
126_E	149_I	1.530	0.99
867_L	896_V	1.522	0.99
73_L	245_L	1.522	0.99
377_P	510_L	1.521	0.99
660_H	672_T	1.518	0.99
235_K	239_N	1.517	0.99
447_Y	663_V	1.516	0.99
601_K	605_G	1.507	0.99
547_I	648_I	1.506	0.99
274_E	277_G	1.500	0.99
183_M	198_E	1.493	0.98
618_A	625_K	1.492	0.98
126_E	148_N	1.491	0.98
120_T	256_V	1.484	0.98
739_A	745_P	1.484	0.98
462_A	470_T	1.482	0.98
119_G	254_T	1.479	0.98
329_N	379_V	1.475	0.98
420_N	423_Y	1.474	0.98
889_H	892_D	1.460	0.98
529_I	858_R	1.460	0.98
354_F	428_L	1.456	0.98
462_A	504_V	1.456	0.98
25_F	37_G	1.453	0.98
248_Q	253_K	1.449	0.98
713_I	848_M	1.448	0.98
752_E	756_S	1.447	0.98
569_K	572_E	1.431	0.98
873_R	891_D	1.431	0.98
602_T	605_G	1.429	0.98
179_F	183_M	1.416	0.98
207_G	222_A	1.415	0.98
34_E	94_P	1.415	0.98
797_G	800_E	1.413	0.98
511_K	515_D	1.411	0.98
118_I	134_I	1.404	0.98
702_V	893_V	1.403	0.98
276_L	280_K	1.403	0.98
474_E	479_K	1.399	0.98
359_D	423_Y	1.397	0.98
828_I	839_A	1.396	0.98
171_V	202_Q	1.394	0.98
476_I	489_I	1.389	0.98
897_A	901_H	1.389	0.98
203_A	223_G	1.387	0.98
872_P	892_D	1.383	0.97
724_L	911_D	1.380	0.97
816_E	822_R	1.370	0.97
333_I	381_A	1.370	0.97
894_D	898_K	1.368	0.97
543_N	875_R	1.367	0.97
212_D	216_A	1.365	0.97
540_I	543_N	1.362	0.97
721_K	725_T	1.361	0.97
360_S	366_A	1.358	0.97
388_D	487_N	1.357	0.97
136_T	141_M	1.356	0.97
164_E	167_N	1.353	0.97
560_T	637_K	1.348	0.97
93_E	97_A	1.348	0.97
551_V	691_Q	1.345	0.97
699_Y	875_R	1.340	0.97
536_V	861_I	1.329	0.97
858_R	862_A	1.327	0.97
98_M	279_F	1.325	0.97
700_V	920_S	1.318	0.97
43_L	98_M	1.317	0.97
724_L	728_A	1.312	0.97
30_N	34_E	1.308	0.96
352_F	408_L	1.306	0.96
702_V	897_A	1.305	0.96
351_V	417_V	1.304	0.96
123_R	146_T	1.303	0.96
370_G	382_Y	1.292	0.96
406_K	433_I	1.290	0.96
696_P	699_Y	1.290	0.96
124_E	128_A	1.287	0.96
235_K	238_Q	1.287	0.96
59_A	265_L	1.286	0.96
741_V	759_A	1.277	0.96
330_Y	503_D	1.276	0.96
888_V	896_V	1.275	0.96
57_H	130_R	1.274	0.96
702_V	900_I	1.270	0.96
67_K	71_D	1.269	0.96
355_D	501_D	1.265	0.96
360_S	423_Y	1.260	0.96
688_R	691_Q	1.256	0.96
39_M	94_P	1.253	0.95
863_V	886_F	1.251	0.95
503_D	507_Q	1.251	0.95
366_A	423_Y	1.249	0.95
569_K	573_I	1.247	0.95
556_S	641_T	1.245	0.95
863_V	903_L	1.241	0.95
691_Q	925_D	1.240	0.95
833_G	837_A	1.235	0.95
72_E	111_G	1.233	0.95
286_R	289_A	1.232	0.95
429_A	539_R	1.230	0.95
721_K	797_G	1.229	0.95
101_A	278_L	1.224	0.95
205_L	210_G	1.223	0.95
509_H	513_W	1.216	0.95
704_A	916_V	1.213	0.95
472_T	475_E	1.211	0.95
357_E	501_D	1.210	0.95
814_Y	822_R	1.210	0.95
867_L	874_V	1.208	0.94
619_L	625_K	1.206	0.94
735_R	751_S	1.205	0.94
545_V	878_M	1.199	0.94
873_R	889_H	1.198	0.94
202_Q	206_Q	1.195	0.94
905_E	915_L	1.194	0.94
10_I	135_S	1.194	0.94
807_A	810_K	1.184	0.94
336_E	340_K	1.183	0.94
458_M	504_V	1.182	0.94
654_R	696_P	1.176	0.94
771_F	781_R	1.173	0.94
142_A	151_L	1.172	0.94
356_T	368_L	1.171	0.93
756_S	783_E	1.171	0.93
737_T	761_N	1.170	0.93
234_A	237_E	1.167	0.93
872_P	895_A	1.166	0.93
367_N	431_Y	1.164	0.93
551_V	554_N	1.164	0.93
112_V	257_E	1.162	0.93
513_W	517_Q	1.157	0.93
819_D	858_R	1.157	0.93
458_M	470_T	1.152	0.93
215_Y	243_A	1.152	0.93
190_I	246_S	1.152	0.93
874_V	900_I	1.151	0.93
493_E	496_R	1.149	0.93
253_K	256_V	1.146	0.93
485_T	488_Q	1.142	0.93
408_L	414_A	1.141	0.93
240_K	243_A	1.141	0.93
68_T	71_D	1.140	0.93
740_E	794_R	1.138	0.92
132_V	149_I	1.137	0.92
14_G	60_V	1.133	0.92
35_P	90_A	1.131	0.92
215_Y	236_L	1.131	0.92
7_N	56_T	1.131	0.92
194_P	242_V	1.130	0.92
411_D	416_K	1.128	0.92
770_A	785_Q	1.127	0.92
444_L	534_V	1.125	0.92
901_H	918_V	1.123	0.92
622_P	625_K	1.121	0.92
18_L	95_L	1.121	0.92
103_G	271_A	1.120	0.92
550_K	554_N	1.120	0.92
780_P	783_E	1.119	0.92
704_A	918_V	1.117	0.92
141_M	252_I	1.116	0.92
700_V	893_V	1.114	0.92
109_V	117_V	1.114	0.92
897_A	920_S	1.109	0.91
531_M	534_V	1.107	0.91
539_R	543_N	1.106	0.91
208_L	220_K	1.105	0.91
855_I	914_L	1.105	0.91
339_L	343_I	1.104	0.91
182_L	200_T	1.104	0.91
568_K	571_H	1.103	0.91
97_A	274_E	1.100	0.91
584_K	588_T	1.098	0.91
892_D	896_V	1.093	0.91
125_A	132_V	1.093	0.91
786_K	790_L	1.091	0.91
181_A	250_A	1.090	0.91
61_V	117_V	1.087	0.91
210_G	216_A	1.087	0.91
561_L	565_E	1.085	0.91
445_E	526_F	1.085	0.91
923_N	926_Q	1.083	0.90
566_L	571_H	1.083	0.90
80_H	83_P	1.082	0.90
701_I	885_V	1.081	0.90
899_Q	903_L	1.079	0.90
430_N	651_K	1.073	0.90
145_V	151_L	1.072	0.90
273_E	277_G	1.070	0.90
810_K	840_E	1.068	0.90
740_E	787_Y	1.065	0.90
34_E	90_A	1.064	0.90
580_L	627_I	1.064	0.90
26_P	41_G	1.062	0.90
415_L	439_A	1.062	0.90
204_L	232_M	1.055	0.89
355_D	424_D	1.055	0.89
170_G	206_Q	1.049	0.89
894_D	897_A	1.048	0.89
355_D	361_L	1.047	0.89
731_K	736_A	1.047	0.89
279_F	287_W	1.045	0.89
107_L	265_L	1.044	0.89
64_A	67_K	1.043	0.89
827_D	839_A	1.043	0.89
237_E	240_K	1.040	0.89
621_Y	624_P	1.035	0.88
331_V	379_V	1.035	0.88
218_P	240_K	1.035	0.88
360_S	427_I	1.028	0.88
802_M	844_I	1.028	0.88
581_S	634_A	1.028	0.88
35_P	87_D	1.026	0.88
221_I	224_L	1.026	0.88
126_E	132_V	1.026	0.88
410_E	436_R	1.024	0.88
7_N	130_R	1.024	0.88
772_G	776_Q	1.024	0.88
866_W	899_Q	1.022	0.88
474_E	483_Q	1.022	0.88
340_K	344_A	1.021	0.88
21_A	45_M	1.020	0.88
384_P	387_H	1.018	0.88
618_A	624_P	1.017	0.88
425_R	538_S	1.015	0.87
399_E	403_E	1.014	0.87
354_F	409_L	1.014	0.87
419_Q	458_M	1.014	0.87
781_R	785_Q	1.013	0.87
870_E	903_L	1.008	0.87
64_A	110_S	1.008	0.87
175_L	210_G	1.007	0.87
731_K	746_L	1.003	0.87
739_A	744_L	1.002	0.87
805_T	808_Q	1.002	0.87
855_I	908_T	1.001	0.87
501_D	505_T	1.001	0.87
214_L	218_P	1.000	0.87
484_L	489_I	0.999	0.87
330_Y	499_A	0.997	0.86
23_H	82_P	0.996	0.86
26_P	37_G	0.995	0.86
66_G	71_D	0.995	0.86
385_V	401_A	0.995	0.86
23_H	27_P	0.995	0.86
546_K	694_I	0.995	0.86
827_D	835_R	0.994	0.86
418_G	424_D	0.991	0.86
400_R	403_E	0.990	0.86
16_S	154_T	0.987	0.86
40_Y	44_N	0.985	0.86
825_L	839_A	0.985	0.86
610_S	613_V	0.985	0.86
567_E	577_E	0.984	0.86
217_E	221_I	0.983	0.86
183_M	205_L	0.982	0.86
417_V	509_H	0.978	0.85
40_Y	286_R	0.978	0.85
64_A	117_V	0.975	0.85
470_T	504_V	0.975	0.85
179_F	202_Q	0.975	0.85
218_P	236_L	0.974	0.85
342_W	346_L	0.971	0.85
420_N	443_M	0.970	0.85
112_V	253_K	0.970	0.85
560_T	564_A	0.970	0.85
346_L	373_F	0.967	0.85
513_W	527_E	0.967	0.85
208_L	218_P	0.967	0.85
179_F	196_V	0.965	0.85
697_E	890_K	0.963	0.84
112_V	256_V	0.961	0.84
589_I	623_L	0.959	0.84
838_A	842_A	0.957	0.84
279_F	284_F	0.957	0.84
774_A	781_R	0.956	0.84
51_M	290_D	0.954	0.84
341_A	345_K	0.954	0.84
12_V	17_Y	0.953	0.84
906_N	909_R	0.952	0.84
280_K	288_T	0.951	0.84
98_M	278_L	0.950	0.84
43_L	279_F	0.950	0.84
263_E	266_E	0.947	0.83
468_H	507_Q	0.946	0.83
25_F	41_G	0.946	0.83
716_H	911_D	0.946	0.83
426_G	542_R	0.945	0.83
473_F	476_I	0.945	0.83
203_A	232_M	0.944	0.83
136_T	250_A	0.944	0.83
546_K	695_A	0.943	0.83
186_S	198_E	0.942	0.83
425_R	435_L	0.942	0.83
445_E	509_H	0.941	0.83
336_E	404_L	0.940	0.83
338_T	341_A	0.939	0.83
543_N	864_D	0.938	0.83
218_P	223_G	0.937	0.83
774_A	780_P	0.937	0.83
421_L	534_V	0.934	0.83
224_L	235_K	0.933	0.83
47_R	279_F	0.932	0.82
521_G	816_E	0.931	0.82
559_L	641_T	0.930	0.82
10_I	133_L	0.928	0.82
786_K	789_D	0.927	0.82
341_A	344_A	0.926	0.82
98_M	282_Y	0.925	0.82
549_P	553_H	0.924	0.82
39_M	95_L	0.924	0.82
899_Q	902_Q	0.924	0.82
101_A	274_E	0.922	0.82
736_A	740_E	0.921	0.82
176_I	179_F	0.918	0.82
442_T	505_T	0.918	0.82
198_E	202_Q	0.915	0.81
827_D	830_S	0.913	0.81
811_E	829_K	0.913	0.81
109_V	257_E	0.912	0.81
514_P	518_K	0.912	0.81
816_E	820_G	0.912	0.81
386_A	398_R	0.910	0.81
812_Q	815_V	0.910	0.81
150_T	159_I	0.909	0.81
19_Y	84_M	0.905	0.81
86_D	90_A	0.905	0.81
423_Y	427_I	0.902	0.80
750_T	753_Q	0.901	0.80
43_L	95_L	0.899	0.80
790_L	793_E	0.895	0.80
657_T	671_S	0.892	0.80
125_A	129_G	0.890	0.79
477_A	483_Q	0.890	0.79
560_T	642_D	0.890	0.79
469_K	475_E	0.888	0.79
764_L	768_M	0.888	0.79
383_I	401_A	0.887	0.79
618_A	622_P	0.887	0.79
221_I	233_A	0.884	0.79
756_S	759_A	0.884	0.79
888_V	893_V	0.881	0.79
420_N	424_D	0.881	0.79
890_K	922_E	0.881	0.79
713_I	717_L	0.879	0.79
513_W	523_L	0.879	0.79
570_A	626_V	0.878	0.79
716_H	910_L	0.877	0.78
856_I	876_M	0.876	0.78
351_V	415_L	0.876	0.78
802_M	806_R	0.876	0.78
450_N	464_R	0.875	0.78
578_F	589_I	0.875	0.78
145_V	165_V	0.874	0.78
23_H	26_P	0.874	0.78
751_S	755_R	0.874	0.78
551_V	692_A	0.873	0.78
175_L	209_G	0.873	0.78
497_Y	501_D	0.871	0.78
442_T	501_D	0.868	0.78
351_V	509_H	0.867	0.78
430_N	542_R	0.866	0.78
805_T	815_V	0.865	0.78
367_N	398_R	0.865	0.78
371_L	383_I	0.864	0.77
139_K	180_L	0.863	0.77
365_S	650_P	0.862	0.77
374_A	380_A	0.861	0.77
515_D	520_K	0.861	0.77
356_T	424_D	0.861	0.77
277_G	281_K	0.861	0.77
124_E	127_K	0.860	0.77
919_G	927_A	0.857	0.77
696_P	887_E	0.857	0.77
789_D	793_E	0.856	0.77
343_I	408_L	0.853	0.77
223_G	234_A	0.851	0.76
699_Y	887_E	0.849	0.76
770_A	781_R	0.849	0.76
175_L	205_L	0.848	0.76
64_A	108_A	0.848	0.76
337_E	340_K	0.846	0.76
557_E	561_L	0.846	0.76
332_T	491_L	0.846	0.76
214_L	217_E	0.845	0.76
285_K	289_A	0.845	0.76
733_I	761_N	0.845	0.76
566_L	626_V	0.845	0.76
363_N	426_G	0.844	0.76
400_R	404_L	0.843	0.76
34_E	281_K	0.839	0.75
356_T	505_T	0.838	0.75
160_L	164_E	0.838	0.75
424_D	501_D	0.834	0.75
204_L	237_E	0.834	0.75
251_T	254_T	0.833	0.75
204_L	233_A	0.833	0.75
67_K	111_G	0.832	0.75
209_G	213_T	0.832	0.75
84_M	92_I	0.831	0.75
616_E	775_R	0.830	0.75
196_V	239_N	0.830	0.75
353_A	372_S	0.829	0.74
717_L	818_L	0.829	0.74
863_V	876_M	0.828	0.74
204_L	240_K	0.828	0.74
125_A	130_R	0.828	0.74
570_A	623_L	0.826	0.74
808_Q	816_E	0.826	0.74
421_L	438_I	0.825	0.74
196_V	204_L	0.825	0.74
867_L	899_Q	0.825	0.74
759_A	763_G	0.824	0.74
473_F	486_F	0.823	0.74
546_K	697_E	0.822	0.74
44_N	290_D	0.820	0.74
122_A	132_V	0.819	0.74
22_Y	26_P	0.817	0.73
222_A	232_M	0.817	0.73
367_N	430_N	0.816	0.73
752_E	755_R	0.815	0.73
331_V	342_W	0.815	0.73
551_V	555_H	0.813	0.73
571_H	578_F	0.813	0.73
397_S	400_R	0.812	0.73
331_V	341_A	0.811	0.73
171_V	176_I	0.810	0.73
29_T	37_G	0.809	0.73
874_V	886_F	0.809	0.73
702_V	896_V	0.809	0.73
612_E	775_R	0.807	0.72
176_I	205_L	0.804	0.72
214_L	221_I	0.804	0.72
221_I	232_M	0.804	0.72
836_R	840_E	0.802	0.72
567_E	571_H	0.802	0.72
193_V	235_K	0.802	0.72
556_S	637_K	0.800	0.72
812_Q	816_E	0.798	0.72
355_D	497_Y	0.797	0.72
648_I	652_T	0.797	0.72
49_L	135_S	0.795	0.71
131_P	150_T	0.795	0.71
354_F	373_F	0.793	0.71
277_G	280_K	0.792	0.71
107_L	117_V	0.790	0.71
100_K	274_E	0.790	0.71
9_L	132_V	0.789	0.71
483_Q	487_N	0.788	0.71
343_I	404_L	0.786	0.70
43_L	47_R	0.783	0.70
258_L	261_T	0.782	0.70
139_K	153_N	0.781	0.70
122_A	254_T	0.781	0.70
204_L	243_A	0.780	0.70
411_D	437_G	0.780	0.70
608_S	613_V	0.779	0.70
455_R	460_S	0.778	0.70
22_Y	37_G	0.778	0.70
694_I	923_N	0.777	0.70
600_K	610_S	0.776	0.69
142_A	160_L	0.775	0.69
196_V	200_T	0.775	0.69
484_L	488_Q	0.775	0.69
423_Y	501_D	0.772	0.69
11_L	132_V	0.771	0.69
203_A	233_A	0.771	0.69
736_A	739_A	0.771	0.69
564_A	568_K	0.770	0.69
410_E	434_E	0.768	0.69
260_L	265_L	0.766	0.68
178_D	247_Y	0.766	0.68
740_E	790_L	0.763	0.68
540_I	877_I	0.762	0.68
362_D	649_N	0.762	0.68
345_K	375_I	0.761	0.68
760_I	768_M	0.760	0.68
270_P	275_L	0.760	0.68
424_D	497_Y	0.759	0.68
275_L	279_F	0.758	0.68
691_Q	926_Q	0.758	0.68
357_E	505_T	0.755	0.67
373_F	381_A	0.755	0.67
211_L	244_Y	0.754	0.67
354_F	371_L	0.754	0.67
877_I	887_E	0.754	0.67
276_L	292_E	0.754	0.67
204_L	218_P	0.753	0.67
875_R	887_E	0.753	0.67
451_S	665_A	0.752	0.67
540_I	876_M	0.752	0.67
204_L	223_G	0.752	0.67
200_T	203_A	0.752	0.67
630_Y	634_A	0.751	0.67
819_D	851_T	0.751	0.67
800_E	803_E	0.751	0.67
153_N	180_L	0.749	0.67
723_L	798_V	0.748	0.67
867_L	889_H	0.748	0.67
210_G	247_Y	0.748	0.67
211_L	215_Y	0.748	0.67
468_H	504_V	0.748	0.67
355_D	358_T	0.748	0.67
613_V	617_L	0.747	0.67
458_M	508_L	0.746	0.66
195_G	204_L	0.746	0.66
339_L	342_W	0.746	0.66
647_M	673_D	0.744	0.66
356_T	501_D	0.744	0.66
619_L	624_P	0.743	0.66
749_V	753_Q	0.743	0.66
739_A	746_L	0.742	0.66
151_L	160_L	0.742	0.66
529_I	861_I	0.742	0.66
374_A	506_L	0.742	0.66
855_I	907_C	0.742	0.66
468_H	471_I	0.741	0.66
562_R	633_L	0.740	0.66
243_A	246_S	0.739	0.66
355_D	505_T	0.739	0.66
892_D	895_A	0.739	0.66
171_V	205_L	0.738	0.66
744_L	749_V	0.737	0.65
344_A	348_K	0.735	0.65
763_G	768_M	0.735	0.65
525_V	851_T	0.734	0.65
360_S	365_S	0.734	0.65
204_L	214_L	0.734	0.65
223_G	237_E	0.733	0.65
550_K	553_H	0.732	0.65
587_Q	606_A	0.732	0.65
27_P	37_G	0.731	0.65
339_L	405_L	0.730	0.65
38_A	95_L	0.729	0.65
26_P	45_M	0.729	0.65
370_G	384_P	0.729	0.65
659_Y	885_V	0.728	0.65
776_Q	787_Y	0.726	0.64
359_D	369_V	0.724	0.64
429_A	434_E	0.723	0.64
194_P	238_Q	0.723	0.64
419_Q	443_M	0.723	0.64
548_D	694_I	0.723	0.64
573_I	622_P	0.722	0.64
804_R	807_A	0.721	0.64
50_I	58_A	0.721	0.64
578_F	623_L	0.721	0.64
425_R	429_A	0.720	0.64
346_L	352_F	0.720	0.64
218_P	222_A	0.719	0.64
16_S	673_D	0.718	0.63
477_A	484_L	0.718	0.63
555_H	641_T	0.717	0.63
152_I	159_I	0.717	0.63
154_T	157_N	0.717	0.63
897_A	918_V	0.717	0.63
128_A	263_E	0.716	0.63
574_A	578_F	0.715	0.63
358_T	427_I	0.715	0.63
162_P	172_P	0.714	0.63
67_K	73_L	0.714	0.63
45_M	154_T	0.714	0.63
783_E	786_K	0.714	0.63
133_L	159_I	0.713	0.63
358_T	501_D	0.713	0.63
325_I	328_D	0.713	0.63
50_I	267_V	0.713	0.63
473_F	501_D	0.713	0.63
105_P	264_Q	0.712	0.63
347_E	414_A	0.712	0.63
695_A	699_Y	0.711	0.63
54_K	267_V	0.711	0.63
169_Y	176_I	0.711	0.63
768_M	776_Q	0.710	0.63
19_Y	71_D	0.710	0.63
331_V	381_A	0.709	0.62
218_P	244_Y	0.708	0.62
242_V	245_L	0.708	0.62
149_I	254_T	0.708	0.62
7_N	57_H	0.708	0.62
365_S	651_K	0.707	0.62
28_L	71_D	0.707	0.62
208_L	233_A	0.707	0.62
420_N	501_D	0.706	0.62
132_V	148_N	0.706	0.62
702_V	918_V	0.705	0.62
181_A	246_S	0.705	0.62
714_M	765_I	0.705	0.62
401_A	404_L	0.705	0.62
473_F	497_Y	0.705	0.62
484_L	487_N	0.704	0.62
473_F	485_T	0.704	0.62
32_A	283_E	0.703	0.62
862_A	907_C	0.703	0.62
591_F	599_L	0.703	0.62
330_Y	380_A	0.703	0.62
74_F	191_P	0.702	0.62
83_P	86_D	0.702	0.62
461_L	465_W	0.701	0.62
435_L	438_I	0.701	0.62
106_L	117_V	0.700	0.62
545_V	701_I	0.699	0.61
207_G	217_E	0.699	0.61
65_K	89_R	0.698	0.61
361_L	423_Y	0.698	0.61
449_L	520_K	0.697	0.61
74_F	245_L	0.697	0.61
888_V	900_I	0.696	0.61
34_E	39_M	0.696	0.61
158_T	164_E	0.696	0.61
346_L	414_A	0.694	0.61
94_P	282_Y	0.694	0.61
191_P	246_S	0.693	0.61
553_H	557_E	0.691	0.61
874_V	893_V	0.690	0.60
172_P	209_G	0.689	0.60
172_P	210_G	0.688	0.60
183_M	250_A	0.688	0.60
558_E	562_R	0.687	0.60
657_T	669_L	0.687	0.60
203_A	215_Y	0.686	0.60
19_Y	86_D	0.685	0.60
599_L	610_S	0.685	0.60
46_L	95_L	0.685	0.60
350_P	414_A	0.685	0.60
39_M	98_M	0.684	0.60
344_A	347_E	0.684	0.60
410_E	437_G	0.682	0.59
619_L	622_P	0.682	0.59
753_Q	756_S	0.681	0.59
448_I	522_P	0.681	0.59
440_F	513_W	0.679	0.59
47_R	287_W	0.679	0.59
377_P	507_Q	0.679	0.59
458_M	501_D	0.678	0.59
355_D	423_Y	0.678	0.59
810_K	829_K	0.678	0.59
136_T	142_A	0.678	0.59
358_T	424_D	0.677	0.59
218_P	221_I	0.677	0.59
733_I	737_T	0.677	0.59
380_A	499_A	0.676	0.59
602_T	606_A	0.674	0.59
357_E	361_L	0.674	0.59
171_V	179_F	0.673	0.58
119_G	250_A	0.671	0.58
272_A	276_L	0.671	0.58
658_S	672_T	0.671	0.58
634_A	637_K	0.670	0.58
89_R	92_I	0.670	0.58
921_G	926_Q	0.670	0.58
57_H	266_E	0.669	0.58
170_G	202_Q	0.669	0.58
185_D	250_A	0.669	0.58
366_A	370_G	0.668	0.58
211_L	240_K	0.667	0.58
699_Y	877_I	0.667	0.58
58_A	267_V	0.667	0.58
596_I	617_L	0.667	0.58
124_E	261_T	0.666	0.58
27_P	41_G	0.665	0.58
286_R	290_D	0.665	0.58
10_I	58_A	0.665	0.58
409_L	419_Q	0.664	0.57
465_W	515_D	0.664	0.57
84_M	88_L	0.664	0.57
235_K	242_V	0.663	0.57
204_L	215_Y	0.662	0.57
12_V	60_V	0.662	0.57
153_N	156_T	0.661	0.57
181_A	243_A	0.661	0.57
181_A	244_Y	0.661	0.57
10_I	16_S	0.661	0.57
372_S	380_A	0.661	0.57
699_Y	873_R	0.661	0.57
92_I	96_H	0.660	0.57
444_L	448_I	0.660	0.57
208_L	222_A	0.659	0.57
133_L	150_T	0.659	0.57
659_Y	880_V	0.659	0.57
142_A	153_N	0.659	0.57
333_I	383_I	0.658	0.57
280_K	292_E	0.658	0.57
514_P	517_Q	0.657	0.57
208_L	214_L	0.655	0.56
595_G	598_P	0.655	0.56
717_L	801_Y	0.655	0.56
444_L	526_F	0.653	0.56
771_F	787_Y	0.653	0.56
183_M	200_T	0.653	0.56
142_A	145_V	0.652	0.56
383_I	387_H	0.651	0.56
47_R	290_D	0.651	0.56
357_E	369_V	0.651	0.56
117_V	121_L	0.650	0.56
350_P	411_D	0.649	0.56
353_A	357_E	0.649	0.56
123_R	126_E	0.645	0.55
626_V	629_E	0.645	0.55
554_N	558_E	0.645	0.55
725_T	728_A	0.644	0.55
480_G	484_L	0.644	0.55
894_D	920_S	0.644	0.55
66_G	72_E	0.644	0.55
696_P	875_R	0.643	0.55
459_D	470_T	0.643	0.55
129_G	132_V	0.642	0.55
160_L	168_K	0.642	0.55
890_K	893_V	0.642	0.55
58_A	104_L	0.641	0.55
193_V	218_P	0.641	0.55
717_L	848_M	0.640	0.55
713_I	907_C	0.640	0.55
837_A	840_E	0.638	0.54
363_N	366_A	0.637	0.54
736_A	761_N	0.637	0.54
222_A	235_K	0.637	0.54
536_V	864_D	0.637	0.54
196_V	235_K	0.636	0.54
177_I	252_I	0.635	0.54
357_E	424_D	0.635	0.54
17_Y	155_M	0.635	0.54
357_E	372_S	0.635	0.54
378_G	507_Q	0.634	0.54
47_R	102_M	0.634	0.54
8_P	133_L	0.634	0.54
657_T	877_I	0.633	0.54
470_T	501_D	0.633	0.54
10_I	49_L	0.632	0.54
333_I	339_L	0.632	0.54
176_I	180_L	0.631	0.54
699_Y	890_K	0.631	0.54
370_G	498_A	0.631	0.54
771_F	775_R	0.630	0.54
357_E	497_Y	0.630	0.54
416_K	435_L	0.629	0.53
208_L	213_T	0.629	0.53
355_D	498_A	0.629	0.53
194_P	235_K	0.629	0.53
687_R	925_D	0.628	0.53
760_I	787_Y	0.628	0.53
634_A	638_S	0.628	0.53
769_S	837_A	0.627	0.53
358_T	423_Y	0.627	0.53
105_P	444_L	0.627	0.53
171_V	175_L	0.626	0.53
361_L	501_D	0.626	0.53
353_A	506_L	0.626	0.53
714_M	919_G	0.625	0.53
905_E	916_V	0.625	0.53
723_L	733_I	0.625	0.53
279_F	291_V	0.625	0.53
215_Y	237_E	0.624	0.53
644_L	655_V	0.624	0.53
872_P	896_V	0.624	0.53
88_L	91_Q	0.623	0.53
103_G	268_Q	0.623	0.53
551_V	694_I	0.623	0.53
419_Q	424_D	0.622	0.53
365_S	649_N	0.621	0.53
556_S	560_T	0.621	0.53
218_P	234_A	0.621	0.53
575_G	593_K	0.620	0.52
425_R	535_P	0.618	0.52
717_L	802_M	0.618	0.52
17_Y	153_N	0.618	0.52
87_D	90_A	0.618	0.52
368_L	385_V	0.617	0.52
177_I	247_Y	0.617	0.52
659_Y	672_T	0.617	0.52
224_L	233_A	0.617	0.52
695_A	701_I	0.617	0.52
702_V	920_S	0.616	0.52
566_L	629_E	0.615	0.52
9_L	265_L	0.614	0.52
483_Q	486_F	0.612	0.51
569_K	622_P	0.612	0.51
30_N	282_Y	0.612	0.51
792_F	799_L	0.612	0.51
423_Y	505_T	0.611	0.51
477_A	486_F	0.611	0.51
94_P	97_A	0.610	0.51
378_G	503_D	0.610	0.51
153_N	158_T	0.610	0.51
454_G	464_R	0.610	0.51
203_A	224_L	0.609	0.51
808_Q	811_E	0.608	0.51
358_T	442_T	0.608	0.51
358_T	366_A	0.606	0.51
375_I	379_V	0.606	0.51
142_A	176_I	0.606	0.51
166_V	174_E	0.605	0.51
239_N	243_A	0.605	0.51
805_T	812_Q	0.605	0.51
685_E	688_R	0.604	0.51
648_I	653_G	0.604	0.51
893_V	918_V	0.603	0.50
417_V	439_A	0.603	0.50
372_S	498_A	0.602	0.50
557_E	560_T	0.602	0.50
563_L	633_L	0.602	0.50
183_M	232_M	0.601	0.50
484_L	493_E	0.601	0.50
728_A	911_D	0.601	0.50
136_T	153_N	0.600	0.50
339_L	404_L	0.599	0.50
867_L	892_D	0.598	0.50
16_S	137_G	0.598	0.50
474_E	478_G	0.598	0.50
136_T	252_I	0.598	0.50
623_L	626_V	0.598	0.50
215_Y	233_A	0.597	0.50
366_A	427_I	0.597	0.50
164_E	168_K	0.597	0.50
145_V	162_P	0.596	0.50
124_E	259_E	0.596	0.50
618_A	621_Y	0.596	0.50
171_V	206_Q	0.596	0.50
166_V	206_Q	0.596	0.50
125_A	128_A	0.595	0.49
553_H	645_P	0.595	0.49
145_V	164_E	0.595	0.49
181_A	211_L	0.595	0.49
419_Q	501_D	0.594	0.49
26_P	29_T	0.594	0.49
61_V	107_L	0.594	0.49
374_A	502_A	0.594	0.49
380_A	384_P	0.594	0.49
183_M	196_V	0.593	0.49
370_G	502_A	0.593	0.49
398_R	431_Y	0.593	0.49
759_A	787_Y	0.592	0.49
563_L	581_S	0.592	0.49
109_V	112_V	0.592	0.49
193_V	239_N	0.592	0.49
641_T	689_I	0.591	0.49
241_E	244_Y	0.591	0.49
716_H	914_L	0.591	0.49
461_L	508_L	0.591	0.49
244_Y	248_Q	0.590	0.49
216_A	240_K	0.590	0.49
639_T	643_K	0.589	0.49
527_E	531_M	0.589	0.49
660_H	663_V	0.588	0.49
858_R	908_T	0.588	0.49
19_Y	24_A	0.588	0.49
621_Y	625_K	0.588	0.49
603_P	606_A	0.587	0.49
533_L	536_V	0.587	0.49
695_A	885_V	0.587	0.49
375_I	381_A	0.587	0.49
380_A	502_A	0.586	0.48
601_K	606_A	0.586	0.48
233_A	240_K	0.586	0.48
756_S	776_Q	0.584	0.48
179_F	768_M	0.584	0.48
768_M	838_A	0.584	0.48
896_V	899_Q	0.584	0.48
150_T	162_P	0.584	0.48
867_L	886_F	0.584	0.48
358_T	369_V	0.584	0.48
177_I	254_T	0.583	0.48
823_L	848_M	0.582	0.48
40_Y	287_W	0.582	0.48
30_N	796_P	0.582	0.48
665_A	718_S	0.581	0.48
681_V	917_E	0.581	0.48
15_S	18_L	0.580	0.48
145_V	153_N	0.580	0.48
558_E	684_E	0.579	0.48
142_A	180_L	0.579	0.48
648_I	655_V	0.579	0.48
18_L	88_L	0.579	0.48
119_G	251_T	0.579	0.48
358_T	497_Y	0.579	0.48
741_V	756_S	0.579	0.48
358_T	361_L	0.578	0.47
362_D	366_A	0.578	0.47
180_L	252_I	0.578	0.47
613_V	795_Y	0.578	0.47
8_P	53_Y	0.576	0.47
713_I	855_I	0.575	0.47
71_D	80_H	0.574	0.47
208_L	223_G	0.574	0.47
559_L	563_L	0.574	0.47
204_L	221_I	0.573	0.47
22_Y	27_P	0.573	0.47
790_L	794_R	0.573	0.47
10_I	22_Y	0.572	0.47
834_A	838_A	0.572	0.47
382_Y	387_H	0.572	0.47
87_D	830_S	0.572	0.47
537_L	661_Q	0.571	0.47
109_V	256_V	0.571	0.47
425_R	534_V	0.571	0.47
434_E	539_R	0.570	0.47
34_E	282_Y	0.570	0.47
599_L	616_E	0.570	0.47
46_L	104_L	0.570	0.47
782_K	789_D	0.570	0.47
459_D	472_T	0.569	0.46
799_L	806_R	0.569	0.46
856_I	884_L	0.569	0.46
289_A	293_A	0.568	0.46
440_F	512_M	0.568	0.46
827_D	834_A	0.568	0.46
74_F	250_A	0.567	0.46
880_V	927_A	0.567	0.46
25_F	916_V	0.567	0.46
380_A	503_D	0.566	0.46
15_S	139_K	0.566	0.46
419_Q	423_Y	0.566	0.46
510_L	514_P	0.565	0.46
863_V	900_I	0.565	0.46
121_L	261_T	0.565	0.46
28_L	33_G	0.564	0.46
414_A	417_V	0.563	0.46
497_Y	505_T	0.563	0.46
721_K	728_A	0.563	0.46
347_E	350_P	0.562	0.46
102_M	275_L	0.562	0.46
203_A	218_P	0.561	0.46
14_G	18_L	0.561	0.46
31_S	40_Y	0.560	0.45
171_V	198_E	0.560	0.45
714_M	798_V	0.560	0.45
723_L	917_E	0.560	0.45
898_K	901_H	0.560	0.45
355_D	372_S	0.559	0.45
7_N	266_E	0.559	0.45
440_F	509_H	0.559	0.45
803_E	807_A	0.558	0.45
691_Q	923_N	0.558	0.45
29_T	40_Y	0.558	0.45
342_W	375_I	0.558	0.45
810_K	833_G	0.558	0.45
665_A	823_L	0.558	0.45
356_T	442_T	0.556	0.45
654_R	887_E	0.556	0.45
567_E	581_S	0.556	0.45
99_V	102_M	0.555	0.45
533_L	538_S	0.555	0.45
165_V	168_K	0.554	0.45
764_L	838_A	0.554	0.45
830_S	836_R	0.554	0.45
597_K	621_Y	0.554	0.45
901_H	915_L	0.554	0.45
243_A	250_A	0.554	0.45
629_E	633_L	0.553	0.45
127_K	146_T	0.553	0.45
596_I	621_Y	0.553	0.45
204_L	224_L	0.552	0.44
402_L	406_K	0.552	0.44
697_E	922_E	0.552	0.44
355_D	359_D	0.551	0.44
218_P	290_D	0.551	0.44
58_A	101_A	0.551	0.44
40_Y	284_F	0.550	0.44
150_T	161_G	0.550	0.44
447_Y	664_T	0.550	0.44
103_G	270_P	0.550	0.44
475_E	478_G	0.549	0.44
556_S	645_P	0.549	0.44
29_T	35_P	0.549	0.44
466_L	504_V	0.549	0.44
498_A	502_A	0.549	0.44
122_A	126_E	0.549	0.44
443_M	458_M	0.548	0.44
118_I	141_M	0.547	0.44
357_E	443_M	0.547	0.44
643_K	646_L	0.547	0.44
664_T	670_S	0.546	0.44
374_A	499_A	0.546	0.44
856_I	886_F	0.546	0.44
459_D	500_E	0.546	0.44
842_A	846_A	0.545	0.44
818_L	910_L	0.545	0.44
260_L	264_Q	0.545	0.44
664_T	672_T	0.545	0.44
755_R	763_G	0.544	0.44
334_L	381_A	0.544	0.44
30_N	35_P	0.544	0.44
176_I	250_A	0.544	0.44
506_L	510_L	0.543	0.43
825_L	842_A	0.542	0.43
386_A	487_N	0.542	0.43
326_S	329_N	0.542	0.43
361_L	424_D	0.541	0.43
457_D	501_D	0.541	0.43
142_A	165_V	0.541	0.43
450_N	665_A	0.541	0.43
269_Q	371_L	0.541	0.43
335_D	339_L	0.541	0.43
452_V	664_T	0.540	0.43
421_L	655_V	0.540	0.43
755_R	769_S	0.539	0.43
48_S	51_M	0.539	0.43
419_Q	505_T	0.539	0.43
788_M	842_A	0.539	0.43
12_V	58_A	0.539	0.43
665_A	846_A	0.539	0.43
445_E	513_W	0.539	0.43
149_I	241_E	0.538	0.43
416_K	438_I	0.538	0.43
119_G	180_L	0.538	0.43
219_E	233_A	0.538	0.43
470_T	473_F	0.537	0.43
215_Y	223_G	0.536	0.43
660_H	670_S	0.536	0.43
107_L	430_N	0.536	0.43
403_E	407_P	0.536	0.43
57_H	263_E	0.535	0.43
756_S	787_Y	0.535	0.43
14_G	137_G	0.535	0.43
809_A	828_I	0.535	0.43
566_L	570_A	0.534	0.42
411_D	436_R	0.534	0.42
476_I	486_F	0.534	0.42
511_K	514_P	0.534	0.42
402_L	405_L	0.534	0.42
222_A	233_A	0.534	0.42
180_L	250_A	0.534	0.42
25_F	44_N	0.534	0.42
357_E	457_D	0.534	0.42
769_S	776_Q	0.534	0.42
893_V	896_V	0.533	0.42
419_Q	457_D	0.533	0.42
26_P	30_N	0.533	0.42
584_K	851_T	0.532	0.42
814_Y	824_Y	0.532	0.42
615_E	621_Y	0.532	0.42
450_N	454_G	0.532	0.42
480_G	483_Q	0.532	0.42
525_V	805_T	0.531	0.42
357_E	423_Y	0.531	0.42
535_P	539_R	0.531	0.42
94_P	281_K	0.531	0.42
473_F	483_Q	0.529	0.42
200_T	232_M	0.529	0.42
69_F	768_M	0.528	0.42
177_I	180_L	0.527	0.42
11_L	59_A	0.527	0.42
599_L	602_T	0.526	0.42
364_I	649_N	0.526	0.42
120_T	257_E	0.525	0.41
738_A	761_N	0.525	0.41
447_Y	854_D	0.525	0.41
683_N	716_H	0.525	0.41
196_V	243_A	0.525	0.41
9_L	927_A	0.524	0.41
417_V	886_F	0.524	0.41
461_L	512_M	0.524	0.41
684_E	752_E	0.523	0.41
817_T	850_G	0.522	0.41
681_V	925_D	0.522	0.41
491_L	495_G	0.522	0.41
80_H	245_L	0.521	0.41
236_L	243_A	0.521	0.41
681_V	689_I	0.521	0.41
775_R	780_P	0.521	0.41
57_H	182_L	0.521	0.41
23_H	85_P	0.521	0.41
870_E	899_Q	0.521	0.41
357_E	473_F	0.520	0.41
462_A	468_H	0.520	0.41
516_L	906_N	0.519	0.41
44_N	111_G	0.519	0.41
683_N	752_E	0.519	0.41
146_T	149_I	0.519	0.41
11_L	755_R	0.519	0.41
223_G	240_K	0.519	0.41
83_P	89_R	0.519	0.41
420_N	497_Y	0.519	0.41
511_K	865_A	0.519	0.41
15_S	153_N	0.518	0.41
765_I	768_M	0.518	0.41
432_G	512_M	0.518	0.41
9_L	130_R	0.517	0.41
17_Y	141_M	0.517	0.41
606_A	855_I	0.517	0.41
611_E	615_E	0.517	0.41
900_I	905_E	0.515	0.40
19_Y	83_P	0.515	0.40
558_E	565_E	0.515	0.40
158_T	168_K	0.515	0.40
573_I	623_L	0.515	0.40
11_L	121_L	0.515	0.40
154_T	740_E	0.515	0.40
866_W	895_A	0.514	0.40
445_E	512_M	0.514	0.40
211_L	236_L	0.513	0.40
730_G	735_R	0.513	0.40
118_I	144_L	0.513	0.40
19_Y	82_P	0.513	0.40
479_K	687_R	0.513	0.40
256_V	587_Q	0.513	0.40
724_L	923_N	0.513	0.40
478_G	481_K	0.512	0.40
232_M	235_K	0.512	0.40
554_N	557_E	0.511	0.40
44_N	846_A	0.511	0.40
355_D	420_N	0.511	0.40
8_P	130_R	0.510	0.40
367_N	651_K	0.510	0.40
216_A	244_Y	0.510	0.40
410_E	416_K	0.510	0.40
736_A	774_A	0.509	0.40
346_L	350_P	0.509	0.40
459_D	501_D	0.508	0.39
61_V	823_L	0.508	0.39
11_L	796_P	0.508	0.39
177_I	250_A	0.508	0.39
471_I	501_D	0.508	0.39
287_W	290_D	0.508	0.39
765_I	838_A	0.507	0.39
471_I	496_R	0.507	0.39
163_E	174_E	0.507	0.39
497_Y	500_E	0.506	0.39
679_I	693_F	0.506	0.39
102_M	247_Y	0.505	0.39
334_L	491_L	0.505	0.39
215_Y	239_N	0.505	0.39
127_K	149_I	0.504	0.39
382_Y	494_A	0.504	0.39
420_N	427_I	0.503	0.39
445_E	531_M	0.503	0.39
72_E	75_E	0.503	0.39
183_M	186_S	0.503	0.39
402_L	431_Y	0.502	0.39
339_L	384_P	0.502	0.39
433_I	436_R	0.501	0.39
266_E	528_N	0.501	0.39
224_L	232_M	0.500	0.39
80_H	136_T	0.500	0.39
22_Y	35_P	0.500	0.39
331_V	335_D	0.500	0.39
420_N	457_D	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1bgxT	1	0.8836	100	0.274	Contact Map
2kfnA	1	0.6476	100	0.474	Contact Map
4x0qA	1	0.625	100	0.483	Contact Map
4yfuA	1	0.6239	100	0.505	Contact Map
4xvkA	1	0.6379	100	0.506	Contact Map
4bwjA	1	0.5765	100	0.515	Contact Map
1x9mA	1	0.5884	100	0.557	Contact Map
3ikmA	1	0.7166	100	0.757	Contact Map
3h7iA	1	0.292	100	0.788	Contact Map
1exnA	1	0.2759	100	0.789	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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