GREMLIN Database
AK2H - Bifunctional aspartokinase/homoserine dehydrogenase 2
UniProt: P00562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10590
Length: 810 (793)
Sequences: 770 (461)
Seq/√Len: 16.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
714_N717_E7.2181.00
463_L474_L5.6851.00
707_S710_H5.4621.00
373_L377_D5.4501.00
158_R175_L5.2921.00
218_G226_V5.0561.00
154_R202_T4.5921.00
233_A290_T4.5421.00
79_R103_V4.4071.00
158_R196_R4.3631.00
123_A163_A4.3281.00
346_V375_I4.2701.00
197_N201_E4.2331.00
78_L106_L4.1801.00
648_T719_N3.8971.00
337_I376_L3.7471.00
411_F434_A3.7041.00
721_Q725_R3.6881.00
724_Q728_A3.6851.00
139_A142_N3.6561.00
494_L512_A3.6381.00
473_W803_I3.6311.00
546_L803_I3.5171.00
370_D389_Q3.3590.99
17_F21_S3.3000.99
694_R747_K3.2210.99
318_C366_S3.2060.99
171_L175_L3.0760.99
59_N63_L3.0480.99
546_L569_I3.0230.98
222_G279_S3.0170.98
701_A705_G2.9720.98
58_I126_V2.9660.98
153_A190_V2.9440.98
47_V134_A2.9060.98
471_S516_L2.8290.98
552_Q556_D2.8030.97
215_T226_V2.7730.97
96_D100_S2.7170.97
190_V217_I2.7150.97
559_L585_Q2.6740.97
728_A754_A2.6640.97
733_G757_E2.6620.97
161_R197_N2.5980.96
318_C389_Q2.5540.96
723_V727_E2.4910.95
686_Y742_F2.4440.94
35_M45_M2.3980.94
236_Y268_L2.3820.94
597_W602_T2.3700.93
16_K19_G2.3330.93
249_L321_E2.3180.93
80_R84_D2.2920.92
95_A110_A2.2690.92
399_A430_I2.2330.91
20_S24_D2.2310.91
475_E516_L2.1780.90
587_H599_Y2.1760.90
290_T293_Q2.1750.90
624_L776_R2.1720.90
577_A622_T2.1500.89
168_D171_L2.1410.89
20_S23_A2.1390.89
643_G650_L2.1330.89
329_D332_L2.1110.88
773_I783_L2.0930.88
653_Q657_Q2.0750.88
734_L754_A2.0750.88
622_T776_R2.0700.87
694_R749_R2.0670.87
406_L429_G2.0550.87
18_G21_S2.0520.87
52_S81_Y2.0520.87
36_A144_Q2.0400.87
548_V571_A2.0130.86
546_L793_D2.0100.86
241_R681_A1.9800.85
710_H713_E1.9690.85
696_E725_R1.9640.84
226_V276_V1.9620.84
674_M690_P1.9400.84
461_L692_Q1.9340.84
734_L756_R1.9280.83
688_I748_A1.9270.83
494_L497_V1.9210.83
340_I346_V1.9100.83
469_I788_P1.9020.82
169_E216_Q1.8940.82
506_S518_F1.8830.82
106_L552_Q1.8740.82
524_V530_S1.8670.81
50_A85_L1.8580.81
652_D712_F1.8470.81
160_E165_P1.8260.80
773_I785_I1.8210.80
498_V526_Q1.8180.79
169_E212_Y1.8160.79
655_W712_F1.8120.79
340_I375_I1.7690.78
326_A382_P1.7590.77
503_S531_L1.7580.77
174_P178_Q1.7560.77
159_A203_V1.7460.77
474_L681_A1.7240.76
16_K21_S1.7220.76
512_A515_A1.7160.75
516_L520_N1.7120.75
436_L444_L1.7100.75
634_L673_V1.7090.75
409_H416_K1.7040.75
789_G794_V1.7010.75
92_A96_D1.7010.75
53_T78_L1.7010.75
768_D788_P1.6980.74
527_D530_S1.6960.74
401_V406_L1.6940.74
385_L708_I1.6920.74
216_Q436_L1.6880.74
575_A586_I1.6710.73
480_E484_L1.6710.73
401_V421_E1.6700.73
86_I136_L1.6690.73
673_V750_V1.6670.73
158_R171_L1.6490.72
127_G202_T1.6470.72
605_A632_G1.6460.72
646_P649_E1.6410.72
574_L666_D1.6400.72
501_R520_N1.6390.72
645_V653_Q1.6250.71
702_H717_E1.6200.71
123_A160_E1.6020.70
681_A710_H1.6010.70
710_H758_D1.5980.70
560_D733_G1.5940.70
79_R87_S1.5900.69
225_R284_Q1.5860.69
741_R753_E1.5840.69
113_L318_C1.5800.69
548_V570_S1.5720.68
662_P789_G1.5650.68
108_R111_A1.5620.68
576_G599_Y1.5610.68
109_L115_S1.5610.68
323_Q783_L1.5610.68
61_L122_Y1.5590.68
63_L74_V1.5540.68
561_F568_V1.5540.68
633_T637_L1.5510.67
641_F647_F1.5430.67
790_A795_T1.5420.67
96_D107_E1.5360.67
126_V380_G1.5360.67
21_S288_S1.5350.67
313_S342_K1.5250.66
33_G144_Q1.5230.66
627_S759_H1.5170.66
230_S285_L1.5120.65
584_R687_N1.5070.65
373_L387_L1.4990.65
474_L497_V1.4970.65
276_V283_L1.4890.64
474_L494_L1.4810.64
725_R733_G1.4790.64
218_G286_R1.4740.63
326_A351_V1.4740.63
662_P794_V1.4710.63
262_R334_H1.4660.63
727_E731_E1.4630.63
444_L600_N1.4620.63
732_M754_A1.4560.62
351_V355_N1.4540.62
67_D313_S1.4510.62
586_I589_A1.4500.62
312_T452_V1.4460.62
527_D554_L1.4440.62
502_R525_E1.4390.61
96_D103_V1.4350.61
103_V107_E1.4320.61
159_A195_S1.4280.61
102_F107_E1.4270.61
346_V368_V1.4190.60
51_G81_Y1.4190.60
79_R96_D1.4110.60
575_A673_V1.4110.60
743_D753_E1.4080.60
92_A107_E1.4050.59
326_A406_L1.3980.59
96_D110_A1.3930.59
326_A332_L1.3920.59
472_R793_D1.3890.59
156_F179_L1.3870.58
701_A704_E1.3720.58
632_G789_G1.3720.58
168_D198_N1.3700.57
35_M346_V1.3700.57
788_P797_G1.3700.57
778_Y794_V1.3530.56
625_S743_D1.3410.56
222_G551_S1.3370.56
605_A778_Y1.3350.55
394_V434_A1.3330.55
559_L582_K1.3310.55
576_G635_S1.3310.55
311_V445_I1.3300.55
641_F768_D1.3300.55
215_T312_T1.3230.55
359_L401_V1.3200.55
287_C800_Q1.3170.54
615_D633_T1.3160.54
167_V212_Y1.3140.54
324_V338_D1.3080.54
329_D406_L1.3080.54
128_H775_S1.3080.54
673_V740_A1.3040.54
103_V110_A1.3020.54
611_H615_D1.2990.53
329_D338_D1.2980.53
252_L309_R1.2910.53
567_H590_F1.2910.53
127_G131_V1.2890.53
641_F650_L1.2870.53
410_R491_E1.2800.52
637_L681_A1.2770.52
652_D655_W1.2700.52
681_A688_I1.2690.52
553_Q556_D1.2670.51
12_R15_H1.2650.51
520_N524_V1.2630.51
376_L385_L1.2520.51
377_D385_L1.2480.50
463_L473_W1.2450.50
633_T669_S1.2450.50
336_E379_A1.2430.50
169_E173_Y1.2420.50
338_D351_V1.2410.50
191_T788_P1.2380.50
44_M106_L1.2310.49
632_G778_Y1.2290.49
329_D429_G1.2240.49
283_L298_I1.2240.49
75_Q387_L1.2220.49
62_K122_Y1.2200.49
320_I364_Y1.2200.49
20_S51_G1.2170.49
544_V803_I1.2170.49
778_Y789_G1.2140.48
208_N269_H1.2130.48
699_V751_G1.2130.48
518_F522_E1.2120.48
641_F723_V1.2120.48
324_V351_V1.2100.48
447_G469_I1.2000.48
138_S148_A1.1980.47
317_V349_L1.1980.47
64_S600_N1.1970.47
174_P720_E1.1900.47
320_I387_L1.1880.47
435_V598_L1.1850.47
237_S460_G1.1840.47
329_D347_R1.1780.46
769_N790_A1.1740.46
126_V320_I1.1710.46
569_I803_I1.1690.46
59_N506_S1.1630.45
343_R379_A1.1590.45
351_V357_R1.1590.45
134_A153_A1.1520.45
462_V496_G1.1520.45
612_T777_W1.1490.45
219_A568_V1.1490.45
648_T718_L1.1490.45
288_S469_I1.1450.44
337_I341_L1.1440.44
13_Q212_Y1.1430.44
239_D548_V1.1430.44
407_H551_S1.1420.44
559_L563_S1.1330.44
284_Q297_R1.1270.43
784_V799_I1.1260.43
352_G424_W1.1250.43
605_A789_G1.1240.43
778_Y790_A1.1210.43
583_Y683_E1.1180.43
109_L112_L1.1170.43
469_I666_D1.1170.43
136_L474_L1.1160.43
503_S527_D1.1150.43
605_A662_P1.1100.42
123_A126_V1.1080.42
324_V329_D1.1070.42
778_Y791_G1.1070.42
122_Y126_V1.1060.42
55_N123_A1.1060.42
652_D656_Q1.1050.42
662_P675_R1.1040.42
476_L800_Q1.1020.42
544_V758_D1.1020.42
253_R299_E1.1000.42
265_A282_D1.0990.42
769_N778_Y1.0980.42
756_R762_A1.0930.41
726_L730_R1.0910.41
511_D518_F1.0910.41
470_G750_V1.0870.41
790_A794_V1.0850.41
309_R376_L1.0840.41
514_R518_F1.0840.41
366_S390_G1.0830.41
208_N271_R1.0810.41
601_A798_A1.0790.41
629_I635_S1.0790.41
250_P568_V1.0790.41
660_T768_D1.0780.41
338_D406_L1.0780.41
332_L357_R1.0750.40
249_L319_L1.0740.40
131_V494_L1.0730.40
496_G696_E1.0720.40
561_F566_F1.0720.40
37_E504_L1.0710.40
401_V432_L1.0710.40
33_G546_L1.0690.40
211_D231_D1.0680.40
226_V273_L1.0650.40
34_I623_I1.0640.40
191_T469_I1.0630.40
649_E656_Q1.0610.40
443_S446_Q1.0590.39
771_F801_S1.0590.39
616_L794_V1.0570.39
463_L475_E1.0550.39
662_P711_F1.0520.39
393_L693_V1.0500.39
606_G794_V1.0490.39
332_L406_L1.0460.39
688_I693_V1.0460.39
73_Q77_T1.0450.39
45_M73_Q1.0440.39
720_E732_M1.0420.39
648_T700_P1.0400.38
482_S486_A1.0400.38
327_S429_G1.0400.38
32_A137_M1.0390.38
101_A135_R1.0390.38
647_F698_L1.0380.38
109_L759_H1.0380.38
15_H227_T1.0360.38
218_G469_I1.0350.38
665_R708_I1.0350.38
171_L174_P1.0310.38
632_G662_P1.0290.38
664_P789_G1.0290.38
338_D355_N1.0280.38
355_N359_L1.0260.38
497_V697_S1.0260.38
570_S799_I1.0240.38
134_A191_T1.0230.37
243_V783_L1.0190.37
366_S389_Q1.0170.37
25_V85_L1.0140.37
74_V189_V1.0130.37
336_E433_V1.0130.37
633_T699_V1.0090.37
395_A445_I1.0060.37
32_A249_L1.0060.37
619_S777_W1.0050.36
673_V739_V1.0050.36
506_S516_L1.0040.36
647_F768_D1.0030.36
649_E733_G1.0020.36
241_R636_W1.0020.36
281_I610_N0.9990.36
691_D701_A0.9990.36
23_A267_V0.9990.36
151_L200_G0.9980.36
33_G420_V0.9970.36
548_V799_I0.9960.36
35_M140_V0.9940.36
334_H351_V0.9930.36
626_I773_I0.9930.36
191_T703_C0.9920.36
700_P703_C0.9920.36
350_A433_V0.9910.36
710_H733_G0.9900.36
611_H633_T0.9890.36
126_V349_L0.9880.36
131_V756_R0.9850.35
118_N742_F0.9840.35
106_L145_G0.9840.35
60_W78_L0.9810.35
528_E613_V0.9800.35
101_A510_L0.9800.35
447_G773_I0.9800.35
87_S91_P0.9790.35
254_L282_D0.9790.35
476_L777_W0.9770.35
394_V619_S0.9730.35
725_R728_A0.9720.35
316_D506_S0.9720.35
411_F422_F0.9720.35
548_V633_T0.9720.35
401_V425_Q0.9720.35
599_Y689_E0.9710.35
92_A155_E0.9710.35
334_H360_L0.9690.35
148_A189_V0.9680.34
353_V356_D0.9670.34
273_L788_P0.9650.34
20_S53_T0.9650.34
155_E196_R0.9640.34
628_G635_S0.9610.34
123_A159_A0.9610.34
332_L338_D0.9600.34
12_R227_T0.9600.34
20_S78_L0.9590.34
458_R541_D0.9590.34
365_T368_V0.9550.34
261_A512_A0.9540.34
84_D88_G0.9510.34
88_G189_V0.9510.34
329_D357_R0.9500.34
675_R794_V0.9480.33
310_I356_D0.9480.33
324_V406_L0.9480.33
385_L784_V0.9470.33
635_S666_D0.9460.33
12_R542_D0.9460.33
379_A385_L0.9440.33
324_V355_N0.9440.33
473_W665_R0.9430.33
330_F637_L0.9420.33
529_E557_Q0.9420.33
677_L740_A0.9400.33
506_S509_G0.9390.33
147_P186_K0.9380.33
478_A513_S0.9370.33
353_V406_L0.9330.33
320_I376_L0.9310.33
467_G662_P0.9300.33
700_P794_V0.9280.32
235_V677_L0.9280.32
374_K501_R0.9220.32
263_L324_V0.9210.32
47_V51_G0.9200.32
308_A650_L0.9190.32
105_D132_W0.9190.32
226_V469_I0.9180.32
283_L623_I0.9180.32
228_I272_T0.9180.32
97_S139_A0.9160.32
605_A790_A0.9120.32
39_S187_R0.9090.31
106_L138_S0.9070.31
661_E664_P0.9060.31
632_G794_V0.9040.31
76_Q588_D0.9030.31
138_S142_N0.9000.31
35_M141_L0.8980.31
579_D689_E0.8970.31
425_Q568_V0.8960.31
476_L639_L0.8940.31
35_M546_L0.8910.31
125_V656_Q0.8910.31
67_D379_A0.8880.30
654_A668_L0.8880.30
172_S394_V0.8880.30
357_R406_L0.8870.30
59_N106_L0.8850.30
24_D479_R0.8830.30
463_L494_L0.8820.30
85_L88_G0.8800.30
614_R618_D0.8800.30
280_E300_R0.8780.30
46_V231_D0.8770.30
151_L188_L0.8770.30
178_Q579_D0.8760.30
474_L634_L0.8750.30
535_M561_F0.8750.30
269_H628_G0.8730.30
635_S788_P0.8690.29
326_A329_D0.8660.29
79_R92_A0.8660.29
157_L235_V0.8650.29
475_E478_A0.8650.29
696_E749_R0.8650.29
401_V429_G0.8630.29
353_V357_R0.8630.29
270_A401_V0.8570.29
678_V738_Y0.8560.29
22_L55_N0.8560.29
52_S133_S0.8560.29
319_L323_Q0.8520.29
239_D615_D0.8500.29
198_N340_I0.8490.28
431_S639_L0.8470.28
499_D601_A0.8470.28
418_Q619_S0.8470.28
544_V707_S0.8470.28
270_A432_L0.8430.28
23_A218_G0.8430.28
173_Y316_D0.8420.28
675_R790_A0.8400.28
495_A633_T0.8400.28
88_G155_E0.8390.28
356_D426_S0.8390.28
637_L657_Q0.8380.28
476_L515_A0.8380.28
628_G698_L0.8380.28
87_S99_I0.8370.28
406_L425_Q0.8370.28
494_L515_A0.8370.28
552_Q579_D0.8360.28
656_Q728_A0.8340.28
16_K49_A0.8330.28
548_V648_T0.8330.28
603_V607_L0.8320.28
92_A103_V0.8320.28
224_S758_D0.8310.28
236_Y419_P0.8310.28
228_I231_D0.8310.28
151_L179_L0.8310.28
602_T755_V0.8290.28
324_V429_G0.8290.28
252_L797_G0.8280.27
85_L367_E0.8270.27
636_W733_G0.8270.27
677_L742_F0.8250.27
648_T716_D0.8230.27
309_R428_D0.8230.27
421_E429_G0.8220.27
337_I531_L0.8190.27
158_R613_V0.8180.27
174_P371_S0.8170.27
268_L738_Y0.8170.27
26_K30_R0.8160.27
332_L353_V0.8160.27
273_L286_R0.8160.27
384_E461_L0.8160.27
327_S332_L0.8160.27
649_E694_R0.8150.27
754_A772_A0.8130.27
132_W237_S0.8100.27
687_N691_D0.8090.27
674_M695_V0.8090.27
59_N497_V0.8070.27
405_P633_T0.8060.26
21_S133_S0.8060.26
317_V689_E0.8050.26
687_N728_A0.8040.26
394_V448_L0.8030.26
213_S347_R0.8030.26
213_S236_Y0.8030.26
597_W630_F0.7980.26
464_F554_L0.7980.26
44_M316_D0.7980.26
329_D355_N0.7970.26
66_T694_R0.7960.26
650_L788_P0.7950.26
337_I349_L0.7930.26
326_A338_D0.7920.26
338_D357_R0.7920.26
102_F803_I0.7920.26
641_F719_N0.7920.26
35_M506_S0.7910.26
425_Q429_G0.7910.26
55_N629_I0.7910.26
51_G260_L0.7910.26
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430_I788_P0.5120.15
102_F735_V0.5120.15
647_F726_L0.5120.15
530_S533_L0.5120.15
768_D789_G0.5110.15
46_V49_A0.5110.15
373_L556_D0.5110.15
150_W191_T0.5110.15
673_V789_G0.5110.15
729_A773_I0.5110.15
675_R791_G0.5090.15
553_Q691_D0.5090.15
167_V241_R0.5090.15
40_Q687_N0.5090.15
211_D229_W0.5080.15
469_I535_M0.5080.15
45_M731_E0.5080.15
105_D784_V0.5080.15
270_A476_L0.5080.15
326_A428_D0.5070.15
97_S694_R0.5060.15
771_F788_P0.5060.15
354_H760_P0.5060.15
470_G480_E0.5060.15
469_I577_A0.5060.15
332_L356_D0.5050.15
265_A398_G0.5050.15
332_L347_R0.5050.15
128_H497_V0.5050.15
167_V299_E0.5050.15
97_S556_D0.5040.15
105_D340_I0.5040.15
366_S369_A0.5040.15
17_F49_A0.5030.15
203_V287_C0.5030.15
97_S374_K0.5020.15
573_K675_R0.5020.15
695_V738_Y0.5010.15
766_P777_W0.5010.15
226_V788_P0.5010.15
191_T384_E0.5010.15
131_V313_S0.5010.15
635_S698_L0.5000.15
298_I372_A0.5000.15
481_Q485_S0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j0wA 2 0.537 100 0.674 Contact Map
3c1mA 3 0.5457 100 0.683 Contact Map
2cdqA 2 0.5469 100 0.684 Contact Map
3tviA 2 0.5235 100 0.697 Contact Map
3ab4A 7 0.463 100 0.718 Contact Map
3l76A 2 0.4827 100 0.726 Contact Map
1ebfA 2 0.4284 100 0.746 Contact Map
3do5A 2 0.3877 100 0.792 Contact Map
3ingA 2 0.3778 100 0.804 Contact Map
4xb1A 2 0.3753 100 0.804 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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