GREMLIN Database
AK1H - Bifunctional aspartokinase/homoserine dehydrogenase 1
UniProt: P00561 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10998
Length: 820 (805)
Sequences: 773 (459)
Seq/√Len: 16.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
721_N724_Q7.3951.00
714_D717_A5.4301.00
470_V481_L5.4101.00
371_E375_Q5.0061.00
155_L173_R4.9671.00
215_A223_C4.9021.00
67_A98_F4.7311.00
230_D287_N4.6691.00
155_L193_G4.6341.00
151_V199_L4.4661.00
120_A161_L4.1571.00
344_I373_A4.0661.00
654_S726_D3.9731.00
68_E95_D3.9061.00
335_V374_M3.8441.00
728_L732_R3.6681.00
368_V394_E3.5611.00
500_V518_L3.5571.00
194_N198_E3.5521.00
416_F441_V3.4870.99
136_G139_E3.4440.99
552_V810_L3.3700.99
700_E754_V3.3320.99
6_F10_S3.2450.99
478_G522_Q3.2310.99
219_R276_F3.2150.99
480_L810_L3.2000.99
49_A53_K3.1420.99
150_P187_M3.1390.99
552_V575_V3.1000.99
316_A364_Q2.9920.98
48_V123_I2.9920.98
37_L131_I2.9720.98
558_Q562_D2.9040.98
565_A591_Q2.7930.97
187_M214_L2.7550.97
212_A223_C2.7410.97
482_E522_Q2.6720.97
735_K761_E2.6360.96
107_G110_L2.5880.96
169_E173_R2.5670.96
512_N524_E2.5560.95
740_G764_G2.5190.95
507_K526_A2.5170.95
98_F558_Q2.5020.95
42_K70_I2.4910.95
316_A394_E2.4680.94
730_A734_A2.4620.94
233_Y265_L2.3920.94
24_L35_T2.3910.93
327_G330_G2.3830.93
69_R73_E2.3490.93
88_A92_T2.3430.93
731_A735_K2.3410.93
741_K761_E2.3260.93
158_G194_N2.3050.92
593_R605_Y2.3040.92
603_F608_N2.2730.92
5_K8_G2.2620.91
287_N290_A2.2570.91
404_D437_R2.2480.91
109_S642_Y2.1950.90
157_V163_S2.1740.90
166_D169_E2.1590.89
246_L319_S2.1590.89
9_T13_N2.1560.89
692_R749_I2.1510.89
700_E756_R2.1390.89
504_A532_F2.1040.88
533_N536_R2.0910.88
583_T628_E2.0880.88
717_A720_A2.0880.88
680_A696_L2.0820.87
338_A344_I2.0670.87
630_M783_H2.0330.86
659_L663_M2.0280.86
223_C273_I2.0270.86
9_T12_A2.0170.86
7_G10_S2.0010.85
628_E783_H1.9950.85
411_G436_E1.9850.85
25_E141_R1.9760.85
43_I67_A1.9750.84
741_K763_D1.9690.84
554_C577_P1.9690.84
552_V800_D1.9620.84
780_F790_L1.9600.84
334_R381_E1.9520.84
40_P74_L1.9520.84
160_Y163_S1.9420.83
694_L755_C1.9190.83
702_E732_R1.9120.82
708_E724_Q1.8750.81
649_E656_A1.8470.80
238_R687_A1.8270.79
414_A421_A1.8240.79
156_A200_V1.8210.79
34_A187_M1.8180.79
522_Q526_A1.8120.79
509_L537_L1.8060.79
658_T719_M1.8030.78
533_N560_V1.7950.78
213_V443_V1.7940.78
652_S655_E1.7940.78
481_L687_A1.7710.77
500_V503_V1.7590.77
476_V795_Y1.7490.76
468_V698_D1.7470.76
41_A70_I1.7350.76
167_I213_V1.7350.76
443_V451_G1.7320.76
780_F792_L1.7270.75
566_D740_G1.7230.75
124_C199_L1.7170.75
707_A710_N1.6980.74
5_K10_S1.6830.73
68_E76_T1.6810.73
717_A765_N1.6770.73
796_G801_V1.6590.72
530_E536_R1.6510.72
53_K63_N1.6460.72
371_E392_V1.6460.72
661_R719_M1.6420.71
341_R377_E1.6410.71
51_I119_N1.6370.71
219_R557_S1.6370.71
739_E761_E1.6320.71
311_N340_S1.6210.70
611_A638_G1.6200.70
651_M659_L1.6120.70
633_S766_D1.6000.69
775_E795_Y1.5980.69
679_V757_V1.5960.69
10_S285_T1.5900.69
156_A192_A1.5870.69
50_M105_L1.5820.69
668_P796_G1.5660.68
797_A802_T1.5570.67
227_T282_I1.5570.67
167_I209_Y1.5570.67
580_K672_D1.5540.67
390_L715_V1.5540.67
640_L679_V1.5510.67
559_A562_D1.5470.67
487_Q491_L1.5410.66
222_C281_L1.5330.66
76_T87_L1.5330.66
748_N760_A1.5330.66
382_L756_R1.5320.66
259_Y332_A1.5140.65
123_I385_G1.4960.64
581_A679_V1.4760.63
406_M426_N1.4740.63
639_S643_I1.4730.63
429_A433_G1.4710.63
324_G349_I1.4710.63
88_A99_A1.4700.63
668_P801_V1.4640.62
22_D141_R1.4550.62
567_F574_V1.4550.62
647_L653_F1.4540.62
87_L99_A1.4460.61
554_C576_T1.4380.61
273_I280_C1.4360.61
318_F362_V1.4290.60
64_I392_V1.4260.60
581_A592_L1.4250.60
406_M411_G1.4240.60
349_I353_S1.4220.60
687_A717_A1.4160.60
98_F135_A1.4160.60
338_A373_A1.4130.59
321_S790_L1.4130.59
451_G606_D1.4090.59
710_N713_G1.4040.59
330_G411_G1.4040.59
734_A738_D1.3890.58
582_N605_Y1.3860.58
357_S406_M1.3770.57
374_M390_L1.3750.57
518_L521_W1.3740.57
489_S493_N1.3720.57
590_H693_E1.3680.57
732_R740_G1.3650.57
111_L120_A1.3620.57
481_L503_V1.3550.56
565_A588_Y1.3470.56
87_L102_K1.3460.56
315_M347_V1.3450.56
550_V810_L1.3450.56
432_Q574_V1.3450.56
750_D760_A1.3400.55
327_G336_F1.3400.55
647_L656_A1.3310.55
638_G796_G1.3290.55
131_I150_P1.3260.54
508_A531_P1.3260.54
75_L133_I1.3240.54
61_L106_H1.3220.54
167_I171_T1.3210.54
197_G370_A1.3200.54
52_E119_N1.3180.54
75_L87_L1.3180.54
81_A88_A1.3160.54
611_A785_Y1.3140.54
785_Y801_V1.3130.54
621_N639_S1.3120.54
165_V209_Y1.3110.54
9_T67_A1.3080.53
526_A738_D1.3070.53
324_G411_G1.3040.53
520_N524_E1.3040.53
155_L169_E1.3030.53
166_D195_E1.3030.53
322_G336_F1.3030.53
517_N524_E1.3020.53
310_S459_L1.2970.53
481_L500_V1.2960.53
309_I452_V1.2810.52
322_G349_I1.2800.52
795_Y804_A1.2750.52
35_T62_P1.2740.51
88_A95_D1.2680.51
148_I197_G1.2650.51
57_G311_N1.2640.51
415_K516_L1.2620.51
687_A694_L1.2620.51
520_N631_K1.2610.51
216_A574_V1.2580.51
353_S357_S1.2580.51
658_T662_E1.2570.50
375_Q390_L1.2570.50
124_C128_K1.2560.50
144_N183_H1.2560.50
24_L552_V1.2550.50
565_A569_R1.2550.50
479_A800_D1.2490.50
205_N266_H1.2490.50
654_S725_L1.2460.50
249_M307_K1.2450.50
250_S296_G1.2410.50
330_G336_F1.2410.50
324_G387_L1.2390.49
399_I441_V1.2350.49
330_G355_E1.2320.49
88_A102_K1.2320.49
215_A283_K1.2260.49
415_K497_D1.2260.49
647_L775_E1.2230.48
791_V806_V1.2190.48
24_L344_I1.2180.48
63_N186_L1.2160.48
101_I107_G1.2160.48
573_H596_A1.2150.48
14_A74_L1.2130.48
643_I687_A1.2120.48
575_V810_L1.2110.48
284_N807_F1.2090.48
617_E621_N1.2080.48
776_N797_A1.2040.47
327_G411_G1.2040.47
26_S510_L1.2030.47
399_I740_G1.1970.47
469_F502_G1.1910.47
234_T467_E1.1900.47
364_Q394_E1.1850.46
668_P681_R1.1820.46
638_G785_Y1.1790.46
125_R782_S1.1790.46
9_T41_A1.1740.46
120_A157_V1.1710.45
631_K750_D1.1680.45
778_L808_A1.1680.45
172_R177_S1.1660.45
785_Y796_G1.1650.45
324_G330_G1.1640.45
426_N436_E1.1640.45
308_G354_S1.1630.45
355_E378_F1.1630.45
107_G460_F1.1620.45
111_L791_V1.1590.45
123_I318_F1.1590.45
733_V737_R1.1580.45
582_N641_S1.1570.45
618_N784_Y1.1570.45
28_A184_M1.1550.45
262_A279_P1.1500.44
442_V604_L1.1500.44
22_D552_V1.1460.44
76_T91_K1.1450.44
653_F704_V1.1400.44
49_A512_N1.1390.44
550_V714_D1.1380.44
470_V480_L1.1370.44
166_D180_P1.1320.43
639_S675_S1.1320.43
157_V161_L1.1300.43
30_Q300_D1.1300.43
592_L595_A1.1270.43
406_M432_Q1.1250.43
398_I699_I1.1250.43
236_D554_C1.1240.43
188_A795_Y1.1230.43
450_T453_R1.1190.42
336_F349_I1.1170.42
520_N523_E1.1140.42
639_S705_L1.1120.42
135_A145_V1.1120.42
454_V476_V1.1100.42
68_E81_A1.1080.42
325_M330_G1.1080.42
718_F802_T1.1070.42
660_A674_L1.1060.42
476_V672_D1.1040.42
205_N268_R1.1040.42
54_T606_D1.1020.42
215_A476_V1.1020.42
776_N785_Y1.1010.41
223_C270_I1.0970.41
240_V790_L1.0960.41
327_G436_E1.0960.41
412_I557_S1.0950.41
348_L440_S1.0930.41
406_M439_I1.0930.41
655_E740_G1.0910.41
705_L758_K1.0850.41
4_L224_E1.0840.41
785_Y797_A1.0820.40
324_G327_G1.0810.40
172_R727_D1.0790.40
131_I188_A1.0780.40
512_N515_G1.0780.40
679_V747_G1.0750.40
679_V746_V1.0740.40
330_G436_E1.0730.40
718_F801_V1.0730.40
785_Y798_G1.0710.40
281_L294_L1.0700.40
208_D228_D1.0690.40
168_A372_R1.0670.40
322_G327_G1.0660.39
247_K574_V1.0640.39
188_A709_F1.0630.39
332_A358_I1.0610.39
477_G757_V1.0610.39
100_Q103_H1.0600.39
483_Q807_F1.0590.39
12_A264_V1.0580.39
285_T476_V1.0550.39
635_I641_S1.0530.39
611_A796_G1.0530.39
212_A310_S1.0510.39
73_E77_G1.0500.39
21_A134_M1.0500.39
62_P66_D1.0500.39
763_D769_F1.0500.39
153_K178_R1.0470.38
727_D739_E1.0460.38
327_G355_E1.0460.38
658_T661_R1.0440.38
336_F378_F1.0430.38
426_N439_I1.0420.38
73_E765_N1.0390.38
797_A801_V1.0390.38
334_R377_E1.0340.38
668_P718_F1.0330.38
666_T775_E1.0320.38
123_I347_V1.0310.38
399_I625_A1.0310.38
18_L655_E1.0300.38
336_F353_S1.0290.37
119_N123_I1.0290.37
622_L801_V1.0280.37
148_I185_V1.0270.37
693_E735_K1.0250.37
56_S700_E1.0250.37
426_N430_I1.0230.37
670_P796_G1.0210.37
278_I616_I1.0190.37
93_F132_A1.0180.37
120_A156_A1.0180.37
246_L317_M1.0150.37
37_L41_A1.0130.37
120_A160_Y1.0120.37
266_H634_G1.0110.36
349_I398_I1.0110.36
350_T431_A1.0080.36
280_C295_I1.0070.36
662_E735_K1.0060.36
509_L533_N1.0050.36
24_L137_V1.0040.36
503_V703_P1.0030.36
336_F355_E1.0000.36
611_A668_P0.9960.36
625_A784_Y0.9950.36
409_L418_A0.9950.36
612_G801_V0.9950.36
550_V765_N0.9940.36
382_L745_Y0.9930.36
120_A163_S0.9920.35
81_A99_A0.9910.35
188_A476_V0.9910.35
653_F775_E0.9890.35
667_E670_P0.9890.35
120_A123_I0.9860.35
21_A246_L0.9860.35
671_R715_V0.9850.35
693_E697_A0.9770.35
49_A164_T0.9770.35
23_I362_V0.9760.35
603_F636_L0.9750.35
317_M321_S0.9750.35
282_I546_L0.9730.34
336_F411_G0.9730.34
632_F780_F0.9680.34
654_S706_P0.9670.34
318_F392_V0.9660.34
169_E172_R0.9630.34
387_L651_M0.9620.34
156_A459_L0.9590.34
232_V683_L0.9580.34
541_V567_F0.9580.34
502_G702_E0.9570.34
363_P366_D0.9560.34
351_Q355_E0.9530.33
567_F572_F0.9530.33
681_R801_V0.9530.33
349_I355_E0.9500.33
483_Q784_Y0.9490.33
280_C629_L0.9480.33
332_A349_I0.9470.33
108_I480_L0.9460.33
327_G378_F0.9460.33
643_I730_A0.9450.33
50_M67_A0.9450.33
638_G668_P0.9440.33
64_I536_R0.9400.33
128_K500_V0.9380.33
77_G739_E0.9350.32
29_R61_L0.9340.32
59_D516_L0.9340.32
615_V777_A0.9320.32
454_V780_F0.9310.32
732_R735_K0.9310.32
322_G411_G0.9300.32
647_L730_A0.9290.32
634_G641_S0.9280.32
115_P749_I0.9270.32
483_Q521_W0.9230.32
270_I795_Y0.9230.32
45_N318_F0.9220.32
609_V613_L0.9220.32
620_Q624_N0.9210.32
694_L699_I0.9210.32
248_S298_S0.9180.32
680_A701_I0.9140.31
221_D503_V0.9140.31
238_R642_Y0.9140.31
611_A797_A0.9130.31
195_E338_A0.9120.31
9_T43_I0.9120.31
330_G353_S0.9100.31
258_S518_L0.9090.31
103_H106_H0.9090.31
13_N178_R0.9070.31
605_Y695_E0.9070.31
512_N531_P0.9070.31
749_I755_C0.9070.31
423_A625_A0.9060.31
336_F354_S0.9060.31
382_L583_T0.9040.31
485_K519_E0.9000.31
344_I366_D0.8990.31
129_M234_T0.8960.31
24_L138_L0.8930.30
554_C806_V0.8920.30
56_S738_D0.8910.30
225_I269_T0.8890.30
608_N762_V0.8890.30
493_N526_A0.8860.30
377_E390_L0.8850.30
406_M436_E0.8850.30
171_T314_N0.8840.30
681_R797_A0.8830.30
554_C639_S0.8810.30
443_V728_L0.8810.30
314_N512_N0.8770.30
392_V738_D0.8770.30
135_A526_A0.8750.29
379_Y401_V0.8730.29
322_G353_S0.8730.29
133_I481_L0.8720.29
57_G740_G0.8700.29
323_P335_V0.8690.29
523_E662_E0.8680.29
438_S645_G0.8670.29
334_R440_S0.8670.29
466_I500_V0.8670.29
638_G801_V0.8660.29
267_P406_M0.8650.29
312_L768_L0.8650.29
210_S233_Y0.8640.29
306_V656_A0.8630.29
125_R164_T0.8600.29
81_A87_L0.8590.29
25_E77_G0.8590.29
374_M573_H0.8590.29
717_A740_G0.8580.29
683_L747_G0.8570.29
330_G349_I0.8560.29
302_D375_Q0.8540.28
617_E639_S0.8540.28
36_V228_D0.8540.28
535_G563_Q0.8540.28
101_I249_M0.8530.28
128_K763_D0.8530.28
233_Y424_N0.8520.28
267_P439_I0.8510.28
706_P801_V0.8480.28
539_R543_E0.8460.28
523_E529_K0.8450.28
654_S723_S0.8430.28
653_F657_T0.8410.28
223_C476_V0.8400.28
483_Q645_G0.8400.28
251_Y279_P0.8400.28
324_G336_F0.8390.28
13_N486_R0.8390.28
230_D554_C0.8380.28
389_P468_V0.8370.28
501_C639_S0.8370.28
480_L671_R0.8350.28
260_F322_G0.8300.27
92_T96_Q0.8300.27
249_M804_A0.8290.27
474_G668_P0.8290.27
26_S184_M0.8280.27
145_V186_L0.8280.27
539_R665_Y0.8280.27
684_L745_Y0.8270.27
118_I550_V0.8270.27
335_V339_M0.8270.27
325_M436_E0.8270.27
58_Q172_R0.8250.27
607_T805_G0.8240.27
634_G704_V0.8240.27
681_R718_F0.8220.27
471_I551_I0.8200.27
85_F145_V0.8190.27
527_Q629_L0.8190.27
585_S695_E0.8170.27
364_Q395_R0.8170.27
225_I228_D0.8160.27
681_R802_T0.8160.27
135_A139_E0.8140.27
152_E193_G0.8140.27
298_S699_I0.8130.27
17_F23_I0.8130.27
484_L623_L0.8120.27
647_L726_D0.8110.26
34_A377_E0.8100.26
389_P765_N0.8100.26
668_P678_D0.8090.26
706_P709_F0.8090.26
52_E56_S0.8090.26
400_S452_V0.8070.26
98_F142_G0.8060.26
45_N120_A0.8060.26
655_E662_E0.8060.26
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467_E625_A0.5150.15
205_N571_G0.5140.15
295_I430_I0.5140.15
236_D654_S0.5140.15
566_D734_A0.5130.15
645_G777_A0.5130.15
94_V133_I0.5130.15
140_A397_A0.5130.15
8_G36_V0.5120.15
188_A234_T0.5120.15
76_T88_A0.5120.15
369_R559_A0.5120.15
210_S788_L0.5120.15
443_V732_R0.5120.15
258_S548_N0.5110.15
735_K739_E0.5110.15
234_T401_V0.5110.15
343_R373_A0.5110.15
294_L782_S0.5110.15
554_C775_E0.5110.15
615_V625_A0.5110.15
731_A740_G0.5110.15
131_I148_I0.5110.15
520_N527_Q0.5100.15
399_I702_E0.5100.15
477_G581_A0.5100.15
30_Q73_E0.5100.15
667_E797_A0.5100.15
76_T95_D0.5100.15
270_I280_C0.5090.15
573_H625_A0.5090.15
516_L524_E0.5080.15
372_R526_A0.5080.15
49_A368_V0.5070.15
180_P219_R0.5070.15
788_L795_Y0.5070.15
160_Y296_G0.5060.15
669_D718_F0.5060.15
113_Q684_L0.5060.15
221_D716_A0.5060.15
246_L484_L0.5060.15
289_Q558_Q0.5060.15
376_E765_N0.5050.15
476_V580_K0.5050.15
266_H551_I0.5050.15
76_T119_N0.5040.15
195_E665_Y0.5040.15
3_V289_Q0.5040.15
327_G332_A0.5030.15
715_V736_A0.5030.15
702_E734_A0.5030.15
107_G515_G0.5020.15
79_A511_T0.5010.15
558_Q569_R0.5010.15
192_A533_N0.5010.15
13_N241_P0.5000.15
349_I432_Q0.5000.15
639_S709_F0.5000.15
116_D512_N0.5000.15
413_S699_I0.5000.15
222_C546_L0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c1mA 3 0.5598 100 0.668 Contact Map
2j0wA 2 0.5378 100 0.673 Contact Map
2cdqA 2 0.55 100 0.677 Contact Map
3tviA 2 0.522 100 0.695 Contact Map
3ab4A 7 0.4622 100 0.715 Contact Map
3l76A 2 0.6476 100 0.725 Contact Map
1ebfA 2 0.4244 100 0.749 Contact Map
3do5A 2 0.3829 100 0.795 Contact Map
4xb1A 2 0.3744 100 0.806 Contact Map
3ingA 2 0.3732 100 0.807 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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