KHSE - ECOLI - GREMLIN Contacts

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KHSE - Homoserine kinase

UniProt:	P00547	Sequences: MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPETAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10999
Length:	310 (268)
Sequences:	9551 (7135)
Seq/√Len:	435.8

ECOLI - KHSE GAL1 ISPE
BACSU - KHSE ISPE GAL1
HALSA - KHSE Q9HQI6
SULSO - KHSE PMK MVK Q980I6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
39_E	83_A	3.688	1.00
47_N	83_A	3.488	1.00
119_N	122_R	3.327	1.00
5_Y	33_G	3.141	1.00
59_E	62_E	2.973	1.00
270_C	279_V	2.797	1.00
6_A	102_S	2.671	1.00
35_V	87_E	2.574	1.00
38_V	109_A	2.510	1.00
111_N	117_P	2.485	1.00
107_L	123_L	2.394	1.00
218_Q	221_L	2.377	1.00
257_S	268_A	2.263	1.00
41_A	83_A	2.219	1.00
132_G	157_E	2.206	1.00
49_L	85_T	2.174	1.00
75_E	129_E	1.999	1.00
232_E	246_R	1.965	1.00
175_L	265_T	1.964	1.00
70_E	74_Q	1.947	1.00
236_E	243_R	1.922	1.00
71_R	129_E	1.893	1.00
61_R	64_I	1.881	1.00
185_A	189_A	1.853	1.00
124_L	148_L	1.842	1.00
16_G	20_L	1.820	1.00
61_R	70_E	1.816	1.00
242_F	266_L	1.797	1.00
111_N	116_K	1.746	1.00
37_T	85_T	1.739	1.00
71_R	75_E	1.727	1.00
21_G	153_L	1.722	1.00
111_N	118_L	1.706	1.00
243_R	247_Q	1.690	1.00
174_V	270_C	1.669	1.00
247_Q	251_E	1.661	1.00
226_M	256_A	1.660	1.00
104_V	147_F	1.650	1.00
16_G	19_V	1.641	1.00
172_L	273_P	1.640	1.00
271_D	275_T	1.636	1.00
223_A	256_A	1.633	1.00
183_S	186_E	1.617	1.00
281_D	285_K	1.585	1.00
50_G	53_A	1.557	1.00
36_V	105_A	1.555	1.00
152_Q	155_I	1.549	1.00
275_T	278_R	1.540	1.00
187_A	230_I	1.530	1.00
70_E	73_C	1.529	1.00
173_W	269_L	1.526	1.00
37_T	87_E	1.497	1.00
122_R	125_A	1.485	1.00
172_L	272_K	1.473	1.00
40_A	80_I	1.471	1.00
72_F	116_K	1.466	1.00
273_P	277_Q	1.459	1.00
221_L	224_K	1.446	1.00
65_V	68_C	1.446	1.00
242_F	259_I	1.444	1.00
172_L	276_A	1.444	1.00
71_R	126_L	1.443	1.00
75_E	122_R	1.431	1.00
210_F	222_A	1.423	1.00
280_A	284_G	1.419	1.00
182_V	262_S	1.405	1.00
248_A	252_I	1.391	1.00
5_Y	35_V	1.384	1.00
213_A	221_L	1.359	1.00
66_Y	70_E	1.354	1.00
180_I	241_G	1.351	1.00
17_F	20_L	1.349	1.00
156_E	159_D	1.344	1.00
41_A	44_F	1.343	1.00
272_K	275_T	1.340	1.00
22_A	154_M	1.332	1.00
71_R	74_Q	1.330	1.00
190_I	238_L	1.320	1.00
111_N	123_L	1.316	1.00
190_I	193_A	1.306	1.00
21_G	155_I	1.299	1.00
277_Q	280_A	1.285	1.00
212_H	216_S	1.280	1.00
45_S	83_A	1.276	1.00
16_G	21_G	1.276	1.00
192_P	196_R	1.276	1.00
205_R	209_G	1.274	1.00
248_A	286_N	1.262	1.00
22_A	25_T	1.257	1.00
124_L	147_F	1.248	1.00
84_M	106_A	1.242	1.00
246_R	266_L	1.242	1.00
75_E	126_L	1.234	1.00
246_R	257_S	1.231	1.00
39_E	85_T	1.226	1.00
72_F	107_L	1.222	1.00
23_A	26_P	1.217	1.00
16_G	22_A	1.214	1.00
18_D	21_G	1.212	1.00
241_G	244_Q	1.210	1.00
176_A	245_A	1.204	1.00
41_A	81_P	1.203	1.00
186_E	189_A	1.202	1.00
277_Q	281_D	1.202	1.00
34_D	101_C	1.200	1.00
244_Q	248_A	1.191	1.00
176_A	268_A	1.190	1.00
18_D	22_A	1.190	1.00
220_E	271_D	1.178	1.00
6_A	105_A	1.168	1.00
65_V	106_A	1.154	1.00
174_V	279_V	1.149	1.00
107_L	127_M	1.147	1.00
68_C	71_R	1.139	1.00
220_E	224_K	1.139	1.00
24_V	27_V	1.138	1.00
229_V	233_P	1.129	1.00
16_G	25_T	1.127	1.00
248_A	251_E	1.125	1.00
121_T	125_A	1.120	1.00
177_Y	265_T	1.120	1.00
111_N	120_D	1.118	1.00
35_V	89_N	1.117	1.00
80_I	114_C	1.117	1.00
20_L	24_V	1.114	1.00
249_V	268_A	1.097	1.00
68_C	72_F	1.086	1.00
244_Q	247_Q	1.074	1.00
69_W	73_C	1.073	1.00
57_P	62_E	1.069	1.00
93_G	181_K	1.065	1.00
278_R	282_W	1.063	1.00
65_V	86_L	1.063	1.00
232_E	236_E	1.061	1.00
155_I	163_Q	1.057	1.00
120_D	148_L	1.054	1.00
20_L	188_R	1.050	1.00
252_I	282_W	1.048	1.00
257_S	266_L	1.045	1.00
47_N	85_T	1.044	1.00
16_G	24_V	1.041	1.00
72_F	114_C	1.030	1.00
22_A	26_P	1.024	1.00
182_V	187_A	1.022	1.00
170_E	272_K	1.020	1.00
193_A	197_R	1.017	1.00
17_F	22_A	1.016	1.00
110_M	114_C	1.015	1.00
182_V	235_R	1.014	1.00
258_G	267_F	1.007	1.00
36_V	106_A	1.004	1.00
211_I	215_Y	1.003	1.00
23_A	27_V	1.001	1.00
106_A	110_M	1.001	1.00
8_A	90_M	0.996	1.00
86_L	102_S	0.993	1.00
38_V	82_V	0.984	1.00
62_E	65_V	0.981	1.00
46_L	66_Y	0.980	1.00
282_W	286_N	0.979	1.00
38_V	84_M	0.977	1.00
82_V	114_C	0.977	1.00
151_M	155_I	0.973	1.00
76_L	116_K	0.971	1.00
19_V	22_A	0.967	1.00
160_I	164_Q	0.965	1.00
108_M	120_D	0.963	1.00
276_A	280_A	0.961	1.00
191_L	195_Y	0.958	1.00
121_T	148_L	0.958	1.00
64_I	67_Q	0.956	1.00
213_A	222_A	0.955	1.00
10_S	22_A	0.955	1.00
175_L	267_F	0.952	1.00
180_I	239_L	0.952	1.00
209_G	225_L	0.950	1.00
227_K	230_I	0.946	1.00
246_R	250_A	0.944	1.00
44_F	81_P	0.935	1.00
212_H	215_Y	0.929	1.00
90_M	96_L	0.923	1.00
10_S	267_F	0.923	1.00
108_M	147_F	0.922	1.00
153_L	211_I	0.919	1.00
236_E	242_F	0.918	1.00
174_V	276_A	0.908	1.00
12_N	15_V	0.906	1.00
17_F	23_A	0.904	1.00
282_W	285_K	0.901	1.00
6_A	146_C	0.899	1.00
255_V	271_D	0.896	1.00
72_F	76_L	0.894	1.00
184_T	187_A	0.890	1.00
25_T	151_M	0.889	1.00
249_V	257_S	0.882	1.00
104_V	127_M	0.876	1.00
68_C	130_L	0.876	1.00
118_L	126_L	0.871	1.00
281_D	284_G	0.868	1.00
9_S	146_C	0.863	1.00
250_A	257_S	0.859	1.00
61_R	66_Y	0.858	1.00
34_D	88_K	0.856	1.00
94_S	177_Y	0.854	1.00
24_V	154_M	0.850	1.00
186_E	238_L	0.847	1.00
41_A	45_S	0.842	1.00
43_T	81_P	0.839	1.00
260_S	265_T	0.836	1.00
252_I	279_V	0.834	1.00
174_V	280_A	0.833	1.00
156_E	160_I	0.833	1.00
17_F	21_G	0.830	1.00
178_P	245_A	0.830	1.00
150_G	155_I	0.826	1.00
101_C	146_C	0.821	1.00
240_P	244_Q	0.820	1.00
93_G	264_P	0.819	1.00
111_N	119_N	0.814	1.00
44_F	48_N	0.811	1.00
156_E	161_I	0.809	1.00
16_G	23_A	0.804	1.00
124_L	144_A	0.802	1.00
128_G	157_E	0.797	1.00
223_A	226_M	0.796	1.00
22_A	27_V	0.794	1.00
120_D	124_L	0.780	1.00
249_V	254_A	0.780	1.00
213_A	218_Q	0.775	1.00
38_V	113_H	0.774	1.00
49_L	83_A	0.773	1.00
250_A	254_A	0.772	1.00
18_D	24_V	0.772	1.00
254_A	270_C	0.771	1.00
103_V	130_L	0.763	1.00
67_Q	70_E	0.756	1.00
187_A	235_R	0.753	1.00
108_M	123_L	0.751	1.00
44_F	50_G	0.749	1.00
127_M	143_V	0.746	1.00
203_H	206_H	0.744	1.00
20_L	23_A	0.742	1.00
118_L	123_L	0.737	1.00
34_D	90_M	0.733	1.00
122_R	126_L	0.733	1.00
279_V	282_W	0.729	1.00
49_L	87_E	0.728	1.00
230_I	235_R	0.720	1.00
125_A	129_E	0.720	1.00
145_P	149_G	0.717	1.00
73_C	114_C	0.716	1.00
17_F	132_G	0.713	1.00
124_L	127_M	0.712	1.00
27_V	33_G	0.712	1.00
209_G	212_H	0.711	1.00
82_V	110_M	0.710	1.00
177_Y	181_K	0.710	1.00
33_G	90_M	0.710	1.00
176_A	257_S	0.707	1.00
76_L	118_L	0.706	1.00
213_A	225_L	0.704	1.00
236_E	246_R	0.700	1.00
19_V	24_V	0.699	1.00
5_Y	27_V	0.699	1.00
268_A	279_V	0.698	1.00
226_M	258_G	0.697	1.00
273_P	276_A	0.695	1.00
67_Q	71_R	0.694	1.00
100_A	146_C	0.691	1.00
26_P	151_M	0.691	1.00
36_V	84_M	0.690	1.00
186_E	190_I	0.682	1.00
163_Q	215_Y	0.681	1.00
64_I	130_L	0.681	1.00
9_S	145_P	0.680	1.00
68_C	107_L	0.680	1.00
278_R	281_D	0.679	1.00
21_G	24_V	0.675	1.00
191_L	194_Q	0.671	1.00
123_L	147_F	0.669	1.00
210_F	214_C	0.668	1.00
61_R	65_V	0.665	1.00
73_C	78_K	0.664	1.00
201_I	204_G	0.664	1.00
18_D	23_A	0.663	1.00
16_G	27_V	0.662	1.00
19_V	23_A	0.662	1.00
107_L	126_L	0.662	1.00
109_A	113_H	0.658	1.00
241_G	245_A	0.657	1.00
124_L	128_G	0.657	1.00
209_G	221_L	0.653	0.99
176_A	287_Y	0.652	0.99
112_E	116_K	0.650	0.99
97_G	146_C	0.649	0.99
16_G	26_P	0.647	0.99
54_D	58_S	0.646	0.99
230_I	234_Y	0.646	0.99
13_M	19_V	0.640	0.99
155_I	160_I	0.637	0.99
69_W	84_M	0.631	0.99
245_A	266_L	0.629	0.99
64_I	68_C	0.629	0.99
10_S	173_W	0.628	0.99
69_W	106_A	0.627	0.99
176_A	249_V	0.627	0.99
72_F	126_L	0.626	0.99
223_A	255_V	0.625	0.99
86_L	106_A	0.623	0.99
192_P	195_Y	0.622	0.99
160_I	163_Q	0.620	0.99
61_R	67_Q	0.615	0.99
90_M	101_C	0.615	0.99
154_M	161_I	0.611	0.99
71_R	130_L	0.611	0.99
31_L	34_D	0.610	0.99
202_A	234_Y	0.608	0.99
68_C	73_C	0.607	0.99
106_A	109_A	0.605	0.99
96_L	175_L	0.604	0.99
20_L	25_T	0.603	0.99
44_F	73_C	0.600	0.99
69_W	110_M	0.600	0.99
64_I	103_V	0.600	0.99
189_A	193_A	0.600	0.99
270_C	276_A	0.598	0.99
107_L	130_L	0.593	0.99
126_L	129_E	0.591	0.99
152_Q	161_I	0.589	0.99
251_E	286_N	0.589	0.99
20_L	26_P	0.589	0.99
248_A	283_L	0.589	0.99
17_F	24_V	0.587	0.99
41_A	48_N	0.586	0.99
120_D	123_L	0.584	0.99
18_D	26_P	0.583	0.99
65_V	71_R	0.583	0.99
7_P	149_G	0.581	0.99
207_L	210_F	0.580	0.99
121_T	124_L	0.579	0.99
55_K	58_S	0.577	0.99
182_V	239_L	0.576	0.99
206_H	209_G	0.576	0.99
46_L	82_V	0.575	0.99
229_V	232_E	0.575	0.99
41_A	47_N	0.574	0.99
62_E	67_Q	0.573	0.99
48_N	63_N	0.568	0.99
46_L	81_P	0.563	0.98
168_F	171_W	0.563	0.98
152_Q	156_E	0.563	0.98
93_G	265_T	0.561	0.98
36_V	86_L	0.558	0.98
182_V	264_P	0.558	0.98
190_I	237_R	0.552	0.98
247_Q	250_A	0.552	0.98
120_D	147_F	0.549	0.98
105_A	109_A	0.549	0.98
114_C	117_P	0.548	0.98
111_N	114_C	0.547	0.98
207_L	211_I	0.547	0.98
193_A	196_R	0.546	0.98
108_M	112_E	0.545	0.98
144_A	148_L	0.544	0.98
205_R	208_A	0.541	0.98
176_A	283_L	0.540	0.98
58_S	61_R	0.538	0.98
67_Q	72_F	0.538	0.98
199_D	229_V	0.538	0.98
190_I	194_Q	0.535	0.98
13_M	22_A	0.535	0.98
76_L	79_Q	0.534	0.98
176_A	266_L	0.534	0.98
18_D	25_T	0.534	0.98
18_D	27_V	0.533	0.98
21_G	27_V	0.533	0.98
63_N	66_Y	0.531	0.98
7_P	33_G	0.530	0.98
238_L	241_G	0.528	0.98
127_M	147_F	0.527	0.98
254_A	268_A	0.527	0.98
244_Q	286_N	0.526	0.98
229_V	250_A	0.523	0.98
249_V	279_V	0.520	0.97
112_E	115_G	0.519	0.97
250_A	256_A	0.517	0.97
177_Y	264_P	0.516	0.97
105_A	108_M	0.515	0.97
151_M	157_E	0.515	0.97
75_E	125_A	0.514	0.97
73_C	76_L	0.514	0.97
93_G	177_Y	0.512	0.97
188_R	191_L	0.510	0.97
66_Y	69_W	0.509	0.97
26_P	145_P	0.507	0.97
279_V	283_L	0.506	0.97
272_K	276_A	0.506	0.97
128_G	132_G	0.505	0.97
128_G	144_A	0.503	0.97
253_G	256_A	0.500	0.97
178_P	264_P	0.500	0.97
145_P	154_M	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rpfA	2	0.9871	100	0.245	Contact Map
4p52A	2	0.9742	100	0.251	Contact Map
1h72C	2	0.9387	100	0.267	Contact Map
3pyfA	1	0.9323	100	0.273	Contact Map
1pieA	1	0.9806	100	0.308	Contact Map
3hulA	4	0.8871	100	0.312	Contact Map
4hacA	2	0.9387	100	0.316	Contact Map
1wuuA	2	0.9742	100	0.316	Contact Map
2cz9A	1	0.9548	100	0.317	Contact Map
2a2cA	1	0.9774	100	0.317	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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