GREMLIN Database
KHSE - Homoserine kinase
UniProt: P00547 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10999
Length: 310 (268)
Sequences: 9551 (7135)
Seq/√Len: 435.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_E83_A3.6881.00
47_N83_A3.4881.00
119_N122_R3.3271.00
5_Y33_G3.1411.00
59_E62_E2.9731.00
270_C279_V2.7971.00
6_A102_S2.6711.00
35_V87_E2.5741.00
38_V109_A2.5101.00
111_N117_P2.4851.00
107_L123_L2.3941.00
218_Q221_L2.3771.00
257_S268_A2.2631.00
41_A83_A2.2191.00
132_G157_E2.2061.00
49_L85_T2.1741.00
75_E129_E1.9991.00
232_E246_R1.9651.00
175_L265_T1.9641.00
70_E74_Q1.9471.00
236_E243_R1.9221.00
71_R129_E1.8931.00
61_R64_I1.8811.00
185_A189_A1.8531.00
124_L148_L1.8421.00
16_G20_L1.8201.00
61_R70_E1.8161.00
242_F266_L1.7971.00
111_N116_K1.7461.00
37_T85_T1.7391.00
71_R75_E1.7271.00
21_G153_L1.7221.00
111_N118_L1.7061.00
243_R247_Q1.6901.00
174_V270_C1.6691.00
247_Q251_E1.6611.00
226_M256_A1.6601.00
104_V147_F1.6501.00
16_G19_V1.6411.00
172_L273_P1.6401.00
271_D275_T1.6361.00
223_A256_A1.6331.00
183_S186_E1.6171.00
281_D285_K1.5851.00
50_G53_A1.5571.00
36_V105_A1.5551.00
152_Q155_I1.5491.00
275_T278_R1.5401.00
187_A230_I1.5301.00
70_E73_C1.5291.00
173_W269_L1.5261.00
37_T87_E1.4971.00
122_R125_A1.4851.00
172_L272_K1.4731.00
40_A80_I1.4711.00
72_F116_K1.4661.00
273_P277_Q1.4591.00
221_L224_K1.4461.00
65_V68_C1.4461.00
242_F259_I1.4441.00
172_L276_A1.4441.00
71_R126_L1.4431.00
75_E122_R1.4311.00
210_F222_A1.4231.00
280_A284_G1.4191.00
182_V262_S1.4051.00
248_A252_I1.3911.00
5_Y35_V1.3841.00
213_A221_L1.3591.00
66_Y70_E1.3541.00
180_I241_G1.3511.00
17_F20_L1.3491.00
156_E159_D1.3441.00
41_A44_F1.3431.00
272_K275_T1.3401.00
22_A154_M1.3321.00
71_R74_Q1.3301.00
190_I238_L1.3201.00
111_N123_L1.3161.00
190_I193_A1.3061.00
21_G155_I1.2991.00
277_Q280_A1.2851.00
212_H216_S1.2801.00
45_S83_A1.2761.00
16_G21_G1.2761.00
192_P196_R1.2761.00
205_R209_G1.2741.00
248_A286_N1.2621.00
22_A25_T1.2571.00
124_L147_F1.2481.00
84_M106_A1.2421.00
246_R266_L1.2421.00
75_E126_L1.2341.00
246_R257_S1.2311.00
39_E85_T1.2261.00
72_F107_L1.2221.00
23_A26_P1.2171.00
16_G22_A1.2141.00
18_D21_G1.2121.00
241_G244_Q1.2101.00
176_A245_A1.2041.00
41_A81_P1.2031.00
186_E189_A1.2021.00
277_Q281_D1.2021.00
34_D101_C1.2001.00
244_Q248_A1.1911.00
176_A268_A1.1901.00
18_D22_A1.1901.00
220_E271_D1.1781.00
6_A105_A1.1681.00
65_V106_A1.1541.00
174_V279_V1.1491.00
107_L127_M1.1471.00
68_C71_R1.1391.00
220_E224_K1.1391.00
24_V27_V1.1381.00
229_V233_P1.1291.00
16_G25_T1.1271.00
248_A251_E1.1251.00
121_T125_A1.1201.00
177_Y265_T1.1201.00
111_N120_D1.1181.00
35_V89_N1.1171.00
80_I114_C1.1171.00
20_L24_V1.1141.00
249_V268_A1.0971.00
68_C72_F1.0861.00
244_Q247_Q1.0741.00
69_W73_C1.0731.00
57_P62_E1.0691.00
93_G181_K1.0651.00
278_R282_W1.0631.00
65_V86_L1.0631.00
232_E236_E1.0611.00
155_I163_Q1.0571.00
120_D148_L1.0541.00
20_L188_R1.0501.00
252_I282_W1.0481.00
257_S266_L1.0451.00
47_N85_T1.0441.00
16_G24_V1.0411.00
72_F114_C1.0301.00
22_A26_P1.0241.00
182_V187_A1.0221.00
170_E272_K1.0201.00
193_A197_R1.0171.00
17_F22_A1.0161.00
110_M114_C1.0151.00
182_V235_R1.0141.00
258_G267_F1.0071.00
36_V106_A1.0041.00
211_I215_Y1.0031.00
23_A27_V1.0011.00
106_A110_M1.0011.00
8_A90_M0.9961.00
86_L102_S0.9931.00
38_V82_V0.9841.00
62_E65_V0.9811.00
46_L66_Y0.9801.00
282_W286_N0.9791.00
38_V84_M0.9771.00
82_V114_C0.9771.00
151_M155_I0.9731.00
76_L116_K0.9711.00
19_V22_A0.9671.00
160_I164_Q0.9651.00
108_M120_D0.9631.00
276_A280_A0.9611.00
191_L195_Y0.9581.00
121_T148_L0.9581.00
64_I67_Q0.9561.00
213_A222_A0.9551.00
10_S22_A0.9551.00
175_L267_F0.9521.00
180_I239_L0.9521.00
209_G225_L0.9501.00
227_K230_I0.9461.00
246_R250_A0.9441.00
44_F81_P0.9351.00
212_H215_Y0.9291.00
90_M96_L0.9231.00
10_S267_F0.9231.00
108_M147_F0.9221.00
153_L211_I0.9191.00
236_E242_F0.9181.00
174_V276_A0.9081.00
12_N15_V0.9061.00
17_F23_A0.9041.00
282_W285_K0.9011.00
6_A146_C0.8991.00
255_V271_D0.8961.00
72_F76_L0.8941.00
184_T187_A0.8901.00
25_T151_M0.8891.00
249_V257_S0.8821.00
104_V127_M0.8761.00
68_C130_L0.8761.00
118_L126_L0.8711.00
281_D284_G0.8681.00
9_S146_C0.8631.00
250_A257_S0.8591.00
61_R66_Y0.8581.00
34_D88_K0.8561.00
94_S177_Y0.8541.00
24_V154_M0.8501.00
186_E238_L0.8471.00
41_A45_S0.8421.00
43_T81_P0.8391.00
260_S265_T0.8361.00
252_I279_V0.8341.00
174_V280_A0.8331.00
156_E160_I0.8331.00
17_F21_G0.8301.00
178_P245_A0.8301.00
150_G155_I0.8261.00
101_C146_C0.8211.00
240_P244_Q0.8201.00
93_G264_P0.8191.00
111_N119_N0.8141.00
44_F48_N0.8111.00
156_E161_I0.8091.00
16_G23_A0.8041.00
124_L144_A0.8021.00
128_G157_E0.7971.00
223_A226_M0.7961.00
22_A27_V0.7941.00
120_D124_L0.7801.00
249_V254_A0.7801.00
213_A218_Q0.7751.00
38_V113_H0.7741.00
49_L83_A0.7731.00
250_A254_A0.7721.00
18_D24_V0.7721.00
254_A270_C0.7711.00
103_V130_L0.7631.00
67_Q70_E0.7561.00
187_A235_R0.7531.00
108_M123_L0.7511.00
44_F50_G0.7491.00
127_M143_V0.7461.00
203_H206_H0.7441.00
20_L23_A0.7421.00
118_L123_L0.7371.00
34_D90_M0.7331.00
122_R126_L0.7331.00
279_V282_W0.7291.00
49_L87_E0.7281.00
230_I235_R0.7201.00
125_A129_E0.7201.00
145_P149_G0.7171.00
73_C114_C0.7161.00
17_F132_G0.7131.00
124_L127_M0.7121.00
27_V33_G0.7121.00
209_G212_H0.7111.00
82_V110_M0.7101.00
177_Y181_K0.7101.00
33_G90_M0.7101.00
176_A257_S0.7071.00
76_L118_L0.7061.00
213_A225_L0.7041.00
236_E246_R0.7001.00
19_V24_V0.6991.00
5_Y27_V0.6991.00
268_A279_V0.6981.00
226_M258_G0.6971.00
273_P276_A0.6951.00
67_Q71_R0.6941.00
100_A146_C0.6911.00
26_P151_M0.6911.00
36_V84_M0.6901.00
186_E190_I0.6821.00
163_Q215_Y0.6811.00
64_I130_L0.6811.00
9_S145_P0.6801.00
68_C107_L0.6801.00
278_R281_D0.6791.00
21_G24_V0.6751.00
191_L194_Q0.6711.00
123_L147_F0.6691.00
210_F214_C0.6681.00
61_R65_V0.6651.00
73_C78_K0.6641.00
201_I204_G0.6641.00
18_D23_A0.6631.00
16_G27_V0.6621.00
19_V23_A0.6621.00
107_L126_L0.6621.00
109_A113_H0.6581.00
241_G245_A0.6571.00
124_L128_G0.6571.00
209_G221_L0.6530.99
176_A287_Y0.6520.99
112_E116_K0.6500.99
97_G146_C0.6490.99
16_G26_P0.6470.99
54_D58_S0.6460.99
230_I234_Y0.6460.99
13_M19_V0.6400.99
155_I160_I0.6370.99
69_W84_M0.6310.99
245_A266_L0.6290.99
64_I68_C0.6290.99
10_S173_W0.6280.99
69_W106_A0.6270.99
176_A249_V0.6270.99
72_F126_L0.6260.99
223_A255_V0.6250.99
86_L106_A0.6230.99
192_P195_Y0.6220.99
160_I163_Q0.6200.99
61_R67_Q0.6150.99
90_M101_C0.6150.99
154_M161_I0.6110.99
71_R130_L0.6110.99
31_L34_D0.6100.99
202_A234_Y0.6080.99
68_C73_C0.6070.99
106_A109_A0.6050.99
96_L175_L0.6040.99
20_L25_T0.6030.99
44_F73_C0.6000.99
69_W110_M0.6000.99
64_I103_V0.6000.99
189_A193_A0.6000.99
270_C276_A0.5980.99
107_L130_L0.5930.99
126_L129_E0.5910.99
152_Q161_I0.5890.99
251_E286_N0.5890.99
20_L26_P0.5890.99
248_A283_L0.5890.99
17_F24_V0.5870.99
41_A48_N0.5860.99
120_D123_L0.5840.99
18_D26_P0.5830.99
65_V71_R0.5830.99
7_P149_G0.5810.99
207_L210_F0.5800.99
121_T124_L0.5790.99
55_K58_S0.5770.99
182_V239_L0.5760.99
206_H209_G0.5760.99
46_L82_V0.5750.99
229_V232_E0.5750.99
41_A47_N0.5740.99
62_E67_Q0.5730.99
48_N63_N0.5680.99
46_L81_P0.5630.98
168_F171_W0.5630.98
152_Q156_E0.5630.98
93_G265_T0.5610.98
36_V86_L0.5580.98
182_V264_P0.5580.98
190_I237_R0.5520.98
247_Q250_A0.5520.98
120_D147_F0.5490.98
105_A109_A0.5490.98
114_C117_P0.5480.98
111_N114_C0.5470.98
207_L211_I0.5470.98
193_A196_R0.5460.98
108_M112_E0.5450.98
144_A148_L0.5440.98
205_R208_A0.5410.98
176_A283_L0.5400.98
58_S61_R0.5380.98
67_Q72_F0.5380.98
199_D229_V0.5380.98
190_I194_Q0.5350.98
13_M22_A0.5350.98
76_L79_Q0.5340.98
176_A266_L0.5340.98
18_D25_T0.5340.98
18_D27_V0.5330.98
21_G27_V0.5330.98
63_N66_Y0.5310.98
7_P33_G0.5300.98
238_L241_G0.5280.98
127_M147_F0.5270.98
254_A268_A0.5270.98
244_Q286_N0.5260.98
229_V250_A0.5230.98
249_V279_V0.5200.97
112_E115_G0.5190.97
250_A256_A0.5170.97
177_Y264_P0.5160.97
105_A108_M0.5150.97
151_M157_E0.5150.97
75_E125_A0.5140.97
73_C76_L0.5140.97
93_G177_Y0.5120.97
188_R191_L0.5100.97
66_Y69_W0.5090.97
26_P145_P0.5070.97
279_V283_L0.5060.97
272_K276_A0.5060.97
128_G132_G0.5050.97
128_G144_A0.5030.97
253_G256_A0.5000.97
178_P264_P0.5000.97
145_P154_M0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rpfA 2 0.9871 100 0.245 Contact Map
4p52A 2 0.9742 100 0.251 Contact Map
1h72C 2 0.9387 100 0.267 Contact Map
3pyfA 1 0.9323 100 0.273 Contact Map
1pieA 1 0.9806 100 0.308 Contact Map
3hulA 4 0.8871 100 0.312 Contact Map
4hacA 2 0.9387 100 0.316 Contact Map
1wuuA 2 0.9742 100 0.316 Contact Map
2cz9A 1 0.9548 100 0.317 Contact Map
2a2cA 1 0.9774 100 0.317 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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