GREMLIN Database
AAT - Aspartate aminotransferase
UniProt: P00509 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10096
Length: 396 (394)
Sequences: 2284 (1377)
Seq/√Len: 69.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_A165_S4.2181.00
110_A209_L4.2091.00
360_R364_E3.8441.00
51_K306_I3.5631.00
78_T244_Y3.5531.00
77_C299_S3.4661.00
167_N203_E3.3651.00
171_A205_G3.3531.00
163_I200_L3.2351.00
189_P197_L3.1931.00
304_R308_E3.0661.00
328_T386_A2.9261.00
122_R143_E2.7791.00
158_D161_A2.7781.00
29_I388_L2.7771.00
159_F193_Q2.7681.00
25_R366_G2.7671.00
195_Q230_A2.6961.00
39_E382_P2.6841.00
326_V330_Q2.6261.00
248_F294_V2.5431.00
111_A137_F2.5401.00
210_F231_F2.5221.00
380_M388_L2.5061.00
122_R145_R2.4851.00
54_Q58_E2.4441.00
332_K390_E2.4391.00
359_L363_E2.3671.00
127_N146_E2.3541.00
47_T306_I2.3451.00
191_L226_E2.3361.00
166_L175_V2.3101.00
159_F163_I2.2951.00
163_I196_T2.2381.00
202_V234_M2.1821.00
157_L187_I2.1131.00
108_R112_D2.0961.00
148_A164_N2.0811.00
51_K55_Y2.0481.00
359_L371_A2.0481.00
55_Y300_N2.0441.00
80_E85_K2.0301.00
360_R365_F2.0281.00
55_Y296_T2.0211.00
328_T331_E1.9881.00
360_R395_V1.9821.00
199_Q234_M1.9621.00
196_T199_Q1.9611.00
195_Q226_E1.9201.00
266_E270_R1.9191.00
95_A259_T1.9101.00
49_V293_V1.8961.00
312_T316_Q1.8941.00
88_A92_D1.8911.00
226_E230_A1.8781.00
225_A229_R1.8531.00
232_A238_L1.8521.00
326_V342_I1.8501.00
157_L189_P1.8261.00
199_Q203_E1.7951.00
124_W173_D1.7831.00
353_L392_I1.7821.00
125_V129_S1.7741.00
29_I387_P1.7711.00
219_R345_N1.7491.00
192_E195_Q1.6851.00
230_A234_M1.6841.00
83_F240_V1.6640.99
388_L392_I1.6530.99
51_K54_Q1.6470.99
295_A299_S1.6420.99
171_A204_K1.6300.99
100_T106_A1.6300.99
201_S206_W1.6090.99
323_Q327_N1.6060.99
364_E394_A1.6020.99
209_L241_A1.5910.99
305_A309_Q1.5860.99
108_R282_N1.5790.99
160_D196_T1.5750.99
79_Q97_T1.5740.99
320_R382_P1.5730.99
134_K146_E1.5640.99
114_L174_V1.5630.99
148_A158_D1.5590.99
355_K371_A1.5520.99
365_F394_A1.5500.99
109_V279_I1.5380.99
198_A236_K1.5360.99
27_G387_P1.5350.99
328_T332_K1.5200.99
151_D154_N1.5120.99
19_L362_R1.5110.99
76_R80_E1.5030.99
38_D42_K1.4980.99
207_L239_I1.4960.99
221_L308_E1.4830.99
46_L314_M1.4760.99
125_V134_K1.4580.99
381_T384_N1.4570.99
339_S343_K1.4510.99
69_D276_K1.4450.99
7_A270_R1.4430.98
77_C80_E1.4360.98
324_L385_M1.4200.98
334_A393_V1.4180.98
53_E289_H1.4120.98
327_N331_E1.4080.98
98_A279_I1.4070.98
359_L362_R1.4010.98
390_E394_A1.3950.98
66_L71_I1.3870.98
102_G245_S1.3800.98
83_F259_T1.3640.98
63_K289_H1.3470.98
23_D368_Y1.3380.98
47_T313_D1.3350.97
93_K265_S1.3320.97
134_K138_N1.3280.97
129_S134_K1.3280.97
264_D267_T1.3140.97
164_N168_E1.3140.97
365_F387_P1.3110.97
82_L212_F1.3010.97
110_A241_A1.2750.97
43_T64_N1.2740.97
191_L230_A1.2670.97
163_I167_N1.2640.97
73_E295_A1.2560.96
195_Q233_A1.2500.96
72_P76_R1.2480.96
179_G212_F1.2420.96
191_L223_E1.2350.96
71_I295_A1.2330.96
262_A268_V1.2290.96
123_V176_L1.2220.96
111_A123_V1.2170.96
17_A30_N1.2140.96
198_A234_M1.2120.96
220_G223_E1.2110.96
124_W145_R1.2060.95
160_D164_N1.1900.95
97_T257_A1.1800.95
351_S373_G1.1730.95
111_A140_A1.1700.95
77_C295_A1.1650.94
97_T259_T1.1620.94
175_V206_W1.1600.94
193_Q196_T1.1590.94
358_V369_A1.1580.94
127_N158_D1.1540.94
330_Q342_I1.1540.94
252_N288_A1.1530.94
89_L95_A1.1400.94
198_A230_A1.1370.94
27_G366_G1.1310.94
59_N296_T1.1290.93
18_D22_A1.1260.93
239_I258_C1.1230.93
44_P310_E1.1150.93
151_D158_D1.1150.93
82_L240_V1.1090.93
230_A233_A1.1080.93
75_G97_T1.1070.93
361_L369_A1.1050.93
279_I283_Y1.0940.92
355_K359_L1.0850.92
18_D276_K1.0830.92
124_W169_A1.0700.92
126_S147_Y1.0690.91
324_L328_T1.0630.91
265_S269_D1.0620.91
324_L382_P1.0590.91
73_E77_C1.0470.91
237_E267_T1.0410.90
17_A33_I1.0260.90
110_A258_C1.0130.89
327_N330_Q1.0120.89
151_D160_D1.0110.89
44_P313_D1.0070.89
314_M317_R1.0010.89
198_A231_F0.9990.88
82_L228_L0.9980.88
100_T258_C0.9970.88
13_I30_N0.9960.88
360_R394_A0.9960.88
47_T51_K0.9960.88
164_N167_N0.9940.88
326_V339_S0.9920.88
367_V388_L0.9900.88
170_Q173_D0.9880.88
260_L271_A0.9860.88
23_D366_G0.9850.88
95_A261_V0.9850.88
354_T357_Q0.9840.88
201_S236_K0.9810.88
239_I260_L0.9800.88
310_E313_D0.9780.87
89_L94_R0.9750.87
294_V298_L0.9740.87
280_R284_S0.9730.87
200_L204_K0.9720.87
325_F389_C0.9660.87
172_G205_G0.9660.87
17_A21_R0.9660.87
114_L123_V0.9600.86
83_F95_A0.9590.86
112_D139_S0.9580.86
328_T389_C0.9540.86
51_K302_A0.9510.86
54_Q57_L0.9500.86
100_T107_L0.9440.85
266_E269_D0.9430.85
112_D140_A0.9410.85
181_C218_A0.9370.85
215_Q225_A0.9360.85
112_D282_N0.9310.85
148_A161_A0.9270.84
100_T278_A0.9270.84
221_L304_R0.9270.84
288_A292_S0.9260.84
199_Q202_V0.9230.84
66_L285_N0.9170.84
385_M389_C0.9130.84
27_G390_E0.9110.83
138_N143_E0.9100.83
386_A390_E0.9000.83
197_L201_S0.8950.82
171_A206_W0.8940.82
201_S231_F0.8920.82
73_E299_S0.8900.82
53_E63_K0.8880.82
167_N196_T0.8870.82
78_T242_S0.8850.82
161_A165_S0.8850.82
63_K253_E0.8840.81
218_A345_N0.8830.81
56_L293_V0.8820.81
79_Q83_F0.8790.81
109_V278_A0.8770.81
47_T310_E0.8760.81
8_A274_Q0.8760.81
52_A55_Y0.8700.80
37_K43_T0.8690.80
142_L176_L0.8640.80
159_F200_L0.8630.80
242_S257_A0.8620.80
66_L288_A0.8620.80
167_N204_K0.8620.80
387_P391_A0.8600.80
260_L275_M0.8590.80
269_D272_F0.8580.80
17_A32_G0.8580.80
35_V43_T0.8570.79
69_D75_G0.8550.79
367_V391_A0.8540.79
215_Q242_S0.8520.79
107_L137_F0.8450.78
114_L142_L0.8450.78
37_K64_N0.8420.78
211_D214_Y0.8410.78
154_N187_I0.8370.78
16_L362_R0.8370.78
150_Y187_I0.8360.78
320_R324_L0.8310.77
78_T257_A0.8300.77
166_L200_L0.8300.77
197_L200_L0.8270.77
306_I309_Q0.8260.77
73_E76_R0.8250.77
120_V174_V0.8250.77
103_G284_S0.8240.77
45_V50_K0.8240.77
135_S281_A0.8240.77
13_I370_V0.8220.77
49_V297_I0.8210.76
134_K144_V0.8170.76
80_E304_R0.8140.76
96_R268_V0.8130.76
48_S311_L0.8100.75
293_V296_T0.8090.75
5_I274_Q0.8090.75
183_N246_K0.8080.75
173_D206_W0.8070.75
56_L296_T0.8060.75
214_Y254_R0.8010.75
325_F385_M0.7980.74
248_F298_L0.7960.74
214_Y246_K0.7910.74
222_E229_R0.7880.73
130_W348_F0.7840.73
330_Q339_S0.7820.73
159_F196_T0.7820.73
305_A308_E0.7800.73
15_G19_L0.7750.72
175_V201_S0.7720.72
80_E299_S0.7630.71
88_A233_A0.7610.71
211_D246_K0.7610.71
356_E359_L0.7590.71
106_A241_A0.7590.71
222_E225_A0.7580.71
242_S338_F0.7580.71
358_V362_R0.7560.70
387_P390_E0.7560.70
177_F201_S0.7550.70
5_I113_F0.7540.70
324_L327_N0.7530.70
34_G254_R0.7530.70
34_G214_Y0.7490.70
137_F144_V0.7460.69
40_T383_D0.7450.69
191_L195_Q0.7440.69
79_Q259_T0.7430.69
262_A271_A0.7420.69
254_R280_R0.7410.69
350_F372_S0.7400.69
100_T109_V0.7380.69
83_F261_V0.7360.68
55_Y59_N0.7320.68
190_T193_Q0.7320.68
377_V380_M0.7280.67
52_A296_T0.7250.67
160_D163_I0.7230.67
246_K374_R0.7210.67
89_L232_A0.7200.67
74_F248_F0.7170.66
103_G106_A0.7160.66
7_A273_S0.7150.66
137_F142_L0.7140.66
246_K254_R0.7140.66
108_R140_A0.7090.65
344_Q350_F0.7080.65
301_D305_A0.7050.65
5_I117_N0.7050.65
150_Y155_H0.7020.65
297_I303_L0.7020.65
116_K139_S0.6990.64
81_L221_L0.6980.64
108_R139_S0.6970.64
318_I321_M0.6960.64
123_V174_V0.6930.64
320_R323_Q0.6900.63
69_D272_F0.6890.63
195_Q234_M0.6860.63
48_S306_I0.6860.63
125_V144_V0.6830.63
9_P273_S0.6830.63
361_L364_E0.6810.62
183_N254_R0.6790.62
181_C345_N0.6760.62
166_L173_D0.6750.62
384_N387_P0.6740.61
7_A269_D0.6730.61
14_L285_N0.6710.61
110_A239_I0.6710.61
222_E308_E0.6700.61
35_V64_N0.6700.61
297_I328_T0.6690.61
149_Y188_D0.6690.61
149_Y162_L0.6660.61
171_A203_E0.6630.60
337_D343_K0.6620.60
119_S174_V0.6620.60
12_P15_G0.6620.60
238_L261_V0.6620.60
327_N342_I0.6580.60
130_W246_K0.6580.60
221_L311_L0.6560.59
30_N67_G0.6560.59
224_D229_R0.6560.59
183_N214_Y0.6560.59
316_Q320_R0.6550.59
159_F197_L0.6550.59
60_E288_A0.6540.59
157_L162_L0.6530.59
96_R262_A0.6520.59
3_E6_T0.6520.59
337_D340_F0.6510.59
114_L207_L0.6480.58
302_A306_I0.6470.58
165_S168_E0.6470.58
51_K153_E0.6470.58
318_I347_M0.6460.58
113_F275_M0.6450.58
200_L203_E0.6430.58
35_V376_N0.6420.58
87_S90_I0.6410.58
104_T136_V0.6400.58
287_P290_G0.6400.58
312_T319_Q0.6380.57
166_L201_S0.6370.57
8_A104_T0.6370.57
175_V208_P0.6370.57
138_N277_A0.6370.57
78_T97_T0.6360.57
179_G227_G0.6350.57
301_D304_R0.6330.57
252_N376_N0.6300.56
37_K249_G0.6290.56
214_Y280_R0.6290.56
365_F395_V0.6290.56
29_I384_N0.6280.56
123_V142_L0.6280.56
213_A246_K0.6270.56
309_Q313_D0.6270.56
340_F352_G0.6260.56
118_T174_V0.6260.56
254_R284_S0.6250.56
167_N200_L0.6240.56
283_Y310_E0.6230.56
64_N338_F0.6210.55
166_L206_W0.6160.55
17_A20_F0.6150.55
126_S240_V0.6150.55
56_L300_N0.6140.54
109_V282_N0.6140.54
167_N202_V0.6130.54
43_T249_G0.6130.54
267_T270_R0.6120.54
87_S95_A0.6110.54
34_G130_W0.6110.54
150_Y217_F0.6100.54
132_N280_R0.6070.54
130_W211_D0.6070.54
34_G211_D0.6020.53
202_V236_K0.6010.53
319_Q323_Q0.6010.53
86_G233_A0.6010.53
86_G91_N0.6000.53
223_E315_R0.5990.53
96_R259_T0.5980.53
311_L315_R0.5980.53
145_R165_S0.5970.52
120_V143_E0.5960.52
130_W374_R0.5960.52
68_I279_I0.5960.52
63_K310_E0.5950.52
96_R275_M0.5940.52
160_D193_Q0.5940.52
130_W214_Y0.5930.52
52_A303_L0.5910.52
323_Q342_I0.5910.52
242_S259_T0.5900.52
333_G393_V0.5900.52
308_E312_T0.5880.51
34_G213_A0.5880.51
226_E351_S0.5870.51
102_G242_S0.5870.51
139_S281_A0.5870.51
169_A175_V0.5860.51
122_R173_D0.5860.51
179_G247_N0.5850.51
244_Y259_T0.5850.51
48_S52_A0.5830.51
227_G231_F0.5830.51
13_I17_A0.5800.50
74_F78_T0.5780.50
353_L357_Q0.5780.50
131_P134_K0.5780.50
216_G224_D0.5770.50
130_W213_A0.5770.50
130_W254_R0.5760.50
102_G376_N0.5750.50
2_F118_T0.5750.50
362_R369_A0.5740.50
325_F369_A0.5740.50
312_T315_R0.5730.49
111_A136_V0.5730.49
225_A232_A0.5700.49
330_Q337_D0.5700.49
166_L197_L0.5700.49
278_A282_N0.5690.49
15_G104_T0.5690.49
118_T121_K0.5690.49
302_A305_A0.5690.49
195_Q198_A0.5680.49
8_A273_S0.5660.49
37_K242_S0.5660.49
199_Q301_D0.5660.49
113_F117_N0.5650.49
15_G179_G0.5650.49
6_T327_N0.5650.49
181_C315_R0.5640.48
74_F197_L0.5640.48
155_H336_R0.5640.48
156_T187_I0.5630.48
265_S313_D0.5630.48
214_Y348_F0.5630.48
109_V142_L0.5620.48
367_V387_P0.5610.48
332_K335_N0.5610.48
339_S342_I0.5600.48
111_A125_V0.5600.48
43_T62_T0.5590.48
212_F242_S0.5590.48
120_V269_D0.5570.48
74_F257_A0.5560.47
67_G235_H0.5560.47
43_T63_K0.5560.47
39_E383_D0.5560.47
82_L242_S0.5550.47
34_G246_K0.5520.47
223_E245_S0.5510.47
121_K172_G0.5480.46
26_P366_G0.5470.46
85_K233_A0.5460.46
213_A348_F0.5460.46
104_T209_L0.5460.46
46_L217_F0.5460.46
131_P281_A0.5450.46
151_D302_A0.5440.46
169_A206_W0.5430.46
25_R387_P0.5420.46
53_E57_L0.5410.46
332_K393_V0.5400.46
15_G370_V0.5390.45
224_D307_W0.5390.45
181_C219_R0.5390.45
20_F32_G0.5380.45
170_Q206_W0.5380.45
211_D374_R0.5370.45
109_V271_A0.5370.45
147_Y177_F0.5370.45
112_D278_A0.5370.45
292_S295_A0.5370.45
227_G230_A0.5370.45
249_G376_N0.5350.45
198_A202_V0.5350.45
32_G370_V0.5340.45
123_V137_F0.5330.45
43_T46_L0.5330.45
183_N213_A0.5330.45
198_A201_S0.5330.45
107_L283_Y0.5320.45
34_G280_R0.5310.44
130_W183_N0.5300.44
231_F235_H0.5290.44
15_G68_I0.5290.44
11_D15_G0.5280.44
96_R272_F0.5270.44
183_N211_D0.5270.44
211_D254_R0.5270.44
110_A114_L0.5260.44
196_T200_L0.5250.44
131_P372_S0.5250.44
214_Y374_R0.5250.44
83_F97_T0.5240.44
178_H245_S0.5230.43
315_R338_F0.5230.43
123_V297_I0.5220.43
98_A209_L0.5220.43
190_T196_T0.5220.43
14_L126_S0.5210.43
306_I327_N0.5210.43
89_L92_D0.5190.43
309_Q312_T0.5170.43
34_G183_N0.5170.43
177_F197_L0.5170.43
380_M385_M0.5160.43
52_A57_L0.5160.43
7_A10_A0.5160.43
115_A121_K0.5150.43
19_L359_L0.5150.43
82_L89_L0.5150.43
114_L120_V0.5140.42
111_A209_L0.5140.42
53_E293_V0.5140.42
165_S169_A0.5140.42
135_S277_A0.5140.42
126_S150_Y0.5120.42
348_F374_R0.5110.42
309_Q316_Q0.5090.42
23_D307_W0.5080.42
29_I380_M0.5080.42
102_G338_F0.5080.42
247_N379_G0.5070.42
365_F391_A0.5070.42
324_L386_A0.5060.41
43_T181_C0.5050.41
209_L239_I0.5050.41
318_I377_V0.5050.41
213_A374_R0.5040.41
113_F274_Q0.5030.41
195_Q199_Q0.5030.41
377_V395_V0.5020.41
51_K59_N0.5020.41
198_A227_G0.5010.41
115_A120_V0.5010.41
160_D167_N0.5000.41
21_R62_T0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mebA 2 1 100 0.559 Contact Map
1yaaA 2 1 100 0.561 Contact Map
3k7yA 2 0.9924 100 0.589 Contact Map
1ajsA 2 1 100 0.59 Contact Map
4wd2A 2 0.9924 100 0.591 Contact Map
4w5kA 2 0.952 100 0.591 Contact Map
2q7wA 2 0.9495 100 0.597 Contact Map
4rkcA 2 1 100 0.597 Contact Map
2ay1A 2 0.9924 100 0.601 Contact Map
3fslA 2 1 100 0.602 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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