GREMLIN Database
RIR1 - Ribonucleoside-diphosphate reductase 1 subunit alpha
UniProt: P00452 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10660
Length: 761 (644)
Sequences: 2706 (935)
Seq/√Len: 36.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
348_L723_K7.8621.00
345_T376_E6.6881.00
560_K605_S4.8491.00
479_E553_K4.8201.00
504_K508_M4.6011.00
483_I557_E4.3101.00
486_V513_L4.1831.00
552_L606_I4.0621.00
313_V337_V4.0521.00
350_G394_K3.9691.00
352_D394_K3.9121.00
553_K605_S3.8281.00
532_S667_E3.7411.00
195_R480_E3.7151.00
352_D392_R3.6831.00
556_N605_S3.4741.00
573_Y611_L3.3911.00
517_V544_F3.2751.00
537_N684_I3.2501.00
538_N542_K3.2311.00
345_T349_K3.1921.00
354_T388_I3.1051.00
479_E550_Y3.0901.00
341_K422_T2.9981.00
680_Q724_F2.9871.00
680_Q720_T2.9831.00
605_S609_H2.9761.00
560_K609_H2.9561.00
263_A311_L2.9451.00
581_D603_R2.8891.00
443_A692_S2.8811.00
239_A242_S2.8311.00
130_Q194_K2.8271.00
354_T383_E2.8141.00
131_M178_A2.8101.00
356_F361_V2.8031.00
354_T392_R2.7831.00
378_L381_K2.7721.00
487_R561_E2.7481.00
134_F194_K2.7141.00
483_I553_K2.6961.00
486_V616_L2.6771.00
381_K385_D2.5261.00
243_A502_A2.5001.00
314_E391_Q2.4771.00
258_A278_C2.4521.00
556_N609_H2.4371.00
604_E608_T2.4291.00
420_C443_A2.4191.00
528_G665_A2.3801.00
501_P504_K2.3541.00
600_E603_R2.3281.00
505_R509_G2.3211.00
355_L393_V2.2910.99
478_L547_I2.2710.99
552_L611_L2.2620.99
556_N560_K2.2490.99
427_D572_T2.2310.99
660_E664_D2.2260.99
350_G396_V2.2150.99
577_I582_T2.2150.99
479_E549_Y2.2040.99
676_D720_T2.1890.99
598_D601_A2.1830.99
541_H687_K2.1660.99
388_I392_R2.1520.99
318_V401_L2.1170.99
282_Y330_V2.0720.99
394_K397_E2.0310.99
568_F607_K2.0300.99
344_Y416_N2.0110.99
204_K477_E2.0090.99
465_S485_A2.0080.99
487_R554_A2.0020.99
580_I603_R1.9940.98
443_A728_T1.9900.98
139_R201_S1.9850.98
102_L106_V1.9840.98
459_I500_I1.9700.98
420_C728_T1.9540.98
205_I465_S1.9270.98
134_F174_I1.9180.98
374_E377_R1.9140.98
231_G236_S1.9100.98
314_E393_V1.8750.98
235_D242_S1.8680.98
341_K722_Y1.8520.98
578_L606_I1.8470.97
143_F173_Y1.8260.97
600_E604_E1.8040.97
279_I319_L1.8000.97
720_T724_F1.7980.97
134_F198_D1.7870.97
528_G661_H1.7730.97
346_R351_E1.7370.96
426_F565_C1.7340.96
264_L315_S1.7320.96
532_S536_A1.7320.96
131_M174_I1.6950.96
342_L345_T1.6790.96
286_Q332_H1.6670.95
230_C240_T1.6610.95
509_G566_P1.6520.95
483_I554_A1.6500.95
393_V398_L1.6470.95
117_N121_E1.6380.95
549_Y602_L1.6330.95
368_F427_D1.6290.95
542_K596_H1.6260.95
548_Q552_L1.6260.95
603_R607_K1.6200.95
314_E398_L1.6150.95
472_I481_L1.6140.94
537_N681_L1.6110.94
360_D389_R1.6030.94
339_I414_I1.5890.94
243_A459_I1.5780.94
739_E742_Q1.5750.94
131_M190_L1.5670.94
282_Y333_M1.5530.93
386_D389_R1.5510.93
367_A378_L1.5500.93
380_T384_K1.5490.93
103_Y125_E1.5440.93
573_Y578_L1.5390.93
86_I90_R1.5360.93
364_L387_S1.5290.93
601_A605_S1.5210.93
417_V432_P1.5170.92
194_K198_D1.5160.92
174_I178_A1.5030.92
238_N245_V1.4950.92
373_E377_R1.4920.92
564_A568_F1.4880.92
209_T301_A1.4880.92
604_E607_K1.4830.92
346_R354_T1.4810.91
530_R665_A1.4790.91
117_N122_D1.4750.91
135_I197_Y1.4490.91
373_E376_E1.4440.90
403_M714_L1.4410.90
523_Y543_T1.4390.90
376_E380_T1.4360.90
536_A681_L1.4300.90
100_P104_D1.4230.90
238_N288_A1.4170.90
241_S288_A1.4150.89
356_F388_I1.4090.89
229_E257_N1.4060.89
366_D369_F1.3960.89
346_R383_E1.3910.89
363_G382_Y1.3770.88
222_F495_Y1.3720.88
127_E190_L1.3700.88
241_S284_H1.3700.88
531_Y634_G1.3690.88
289_V302_A1.3660.88
479_E483_I1.3600.88
556_N606_I1.3580.87
263_A266_S1.3560.87
490_D612_R1.3430.87
314_E401_L1.3420.87
319_L330_V1.3410.87
107_V111_E1.3400.87
683_G724_F1.3360.87
548_Q617_S1.3290.86
313_V398_L1.3250.86
459_I502_A1.3240.86
196_F488_A1.3180.86
525_A638_P1.3160.86
306_Y310_H1.3090.85
181_F196_F1.3010.85
697_T721_A1.3010.85
679_L697_T1.2910.85
203_F629_S1.2880.84
490_D562_Q1.2810.84
364_L369_F1.2800.84
199_A481_L1.2770.84
569_N574_A1.2700.84
122_D182_S1.2630.83
238_N284_H1.2580.83
679_L724_F1.2530.83
88_H91_K1.2520.83
541_H684_I1.2490.83
244_I256_I1.2440.82
197_Y201_S1.2420.82
198_D202_T1.2340.82
532_S677_G1.2330.82
93_A168_S1.2330.82
430_I567_W1.2270.81
190_L193_V1.2250.81
660_E663_H1.2180.81
88_H92_K1.2140.81
551_L616_L1.2140.81
556_N602_L1.2110.81
192_Y195_R1.1970.80
364_L385_D1.1960.80
406_R718_L1.1950.80
101_A104_D1.1930.80
174_I194_K1.1930.80
142_T203_F1.1800.79
548_Q580_I1.1790.79
284_H287_T1.1770.79
342_L376_E1.1730.78
131_M194_K1.1690.78
108_K112_M1.1660.78
225_C439_C1.1660.78
362_P368_F1.1630.78
106_V110_V1.1610.78
524_L529_K1.1500.77
447_K457_G1.1460.77
529_K539_L1.1440.77
678_Y695_A1.1400.76
174_I197_Y1.1390.76
546_A597_Y1.1310.76
172_L176_V1.1290.76
159_N164_E1.1280.76
94_Y99_P1.1260.75
509_G567_W1.1240.75
523_Y539_L1.1230.75
85_A148_V1.1230.75
634_G698_N1.1210.75
475_L546_A1.1190.75
109_M115_Y1.1170.75
305_F336_G1.1170.75
103_Y107_V1.1170.75
263_A357_S1.1150.75
173_Y200_V1.1120.75
552_L573_Y1.1080.74
168_S171_F1.1080.74
546_A598_D1.1050.74
427_D582_T1.1020.74
557_E605_S1.1020.74
103_Y129_K1.1000.74
467_F482_A1.0990.74
519_N522_Y1.0970.74
349_K723_K1.0970.74
321_N329_R1.0910.73
492_L513_L1.0880.73
676_D680_Q1.0850.73
419_H422_T1.0830.73
107_V125_E1.0810.72
106_V109_M1.0790.72
140_D170_Q1.0770.72
520_F540_T1.0720.72
420_C692_S1.0720.72
501_P505_R1.0680.71
357_S360_D1.0660.71
546_A550_Y1.0660.71
697_T717_D1.0650.71
225_C464_L1.0630.71
136_D170_Q1.0630.71
93_A166_Y1.0590.71
564_A569_N1.0580.71
742_Q745_L1.0580.71
377_R381_K1.0570.71
94_Y101_A1.0550.71
554_A557_E1.0500.70
458_E509_G1.0460.70
179_C220_R1.0450.70
190_L194_K1.0450.70
282_Y319_L1.0430.70
159_N162_T1.0410.70
535_S538_N1.0340.69
469_L517_V1.0340.69
552_L578_L1.0320.69
385_D388_I1.0260.68
467_F547_I1.0260.68
308_M337_V1.0260.68
529_K535_S1.0250.68
139_R198_D1.0250.68
225_C253_G1.0240.68
106_V128_F1.0230.68
137_H171_F1.0210.68
537_N677_G1.0200.68
572_T577_I1.0180.68
572_T582_T1.0180.68
416_N721_A1.0170.68
116_D119_L1.0140.67
578_L611_L1.0130.67
686_Q693_I1.0120.67
232_D262_R1.0110.67
553_K602_L1.0100.67
337_V402_M1.0050.67
89_L156_L1.0030.67
242_S246_K0.9970.66
721_A729_L0.9950.66
175_L216_R0.9940.66
118_H182_S0.9940.66
439_C464_L0.9930.66
348_L719_L0.9860.65
129_K133_T0.9860.65
320_K335_Y0.9860.65
170_Q201_S0.9840.65
469_L547_I0.9840.65
526_K658_D0.9800.65
632_T638_P0.9780.65
103_Y128_F0.9780.65
266_S359_S0.9770.65
602_L605_S0.9760.64
678_Y698_N0.9750.64
534_G538_N0.9750.64
178_A193_V0.9700.64
86_I168_S0.9700.64
364_L368_F0.9690.64
473_N523_Y0.9680.64
102_L115_Y0.9670.64
676_D716_K0.9660.64
552_L556_N0.9640.63
90_R93_A0.9630.63
549_Y598_D0.9630.63
556_N611_L0.9620.63
474_N477_E0.9600.63
253_G298_R0.9560.63
367_A374_E0.9560.63
94_Y100_P0.9540.63
553_K601_A0.9520.62
308_M317_L0.9510.62
210_P298_R0.9510.62
174_I193_V0.9500.62
573_Y603_R0.9490.62
92_K104_D0.9480.62
97_F168_S0.9470.62
482_A550_Y0.9440.62
398_L402_M0.9440.62
82_A86_I0.9430.62
105_H108_K0.9420.62
568_F573_Y0.9400.61
460_A512_T0.9400.61
597_Y601_A0.9390.61
517_V547_I0.9350.61
522_Y631_A0.9320.61
570_E574_A0.9310.61
253_G439_C0.9280.60
278_C306_Y0.9280.60
707_G735_R0.9270.60
249_S292_C0.9270.60
682_V693_I0.9270.60
475_L539_L0.9260.60
131_M134_F0.9260.60
225_C441_E0.9240.60
522_Y632_T0.9240.60
540_T685_M0.9230.60
261_I281_F0.9220.60
380_T383_E0.9150.59
136_D139_R0.9120.59
243_A500_I0.9090.59
582_T687_K0.9070.59
235_D246_K0.9050.59
699_Y713_Q0.9010.58
419_H423_H0.9000.58
252_A300_G0.8980.58
259_G365_Y0.8970.58
509_G570_E0.8960.58
443_A726_V0.8910.57
429_A570_E0.8900.57
191_Q195_R0.8900.57
679_L683_G0.8900.57
298_R439_C0.8890.57
102_L109_M0.8870.57
151_L156_L0.8860.57
550_Y553_K0.8850.57
342_L380_T0.8850.57
477_E480_E0.8840.57
569_N608_T0.8830.57
118_H122_D0.8830.57
258_A285_F0.8820.57
308_M340_N0.8810.56
485_A515_I0.8770.56
341_K345_T0.8760.56
307_P417_V0.8690.55
267_P359_S0.8680.55
649_D737_G0.8680.55
699_Y717_D0.8680.55
313_V355_L0.8680.55
479_E557_E0.8680.55
346_R395_A0.8670.55
253_G464_L0.8670.55
253_G441_E0.8660.55
152_E156_L0.8650.55
257_N435_Q0.8630.55
541_H688_F0.8620.55
458_E510_R0.8610.55
494_D612_R0.8610.55
276_T320_K0.8590.55
441_E464_L0.8570.54
281_F291_S0.8560.54
344_Y347_L0.8540.54
557_E609_H0.8540.54
491_A562_Q0.8540.54
210_P439_C0.8530.54
448_P457_G0.8530.54
210_P225_C0.8520.54
209_T224_S0.8520.54
102_L114_K0.8490.54
210_P224_S0.8420.53
170_Q197_Y0.8410.53
191_Q600_E0.8400.53
492_L496_Q0.8390.53
568_F580_I0.8370.53
351_E394_K0.8370.53
283_K287_T0.8370.53
235_D239_A0.8360.53
102_L110_V0.8310.52
180_L211_I0.8300.52
225_C298_R0.8300.52
79_Y82_A0.8290.52
442_I618_A0.8290.52
431_A445_P0.8280.52
483_I487_R0.8270.52
125_E534_G0.8260.52
257_N434_R0.8230.51
623_E696_N0.8230.51
682_V695_A0.8230.51
109_M114_K0.8220.51
89_L93_A0.8220.51
364_L382_Y0.8210.51
367_A381_K0.8210.51
483_I605_S0.8190.51
129_K136_D0.8190.51
685_M693_I0.8180.51
557_E560_K0.8160.51
317_L413_Y0.8160.51
549_Y553_K0.8150.51
510_R614_S0.8140.51
473_N527_H0.8140.51
377_R384_K0.8120.50
173_Y206_S0.8120.50
347_L396_V0.8110.50
556_N568_F0.8110.50
192_Y561_E0.8100.50
308_M347_L0.8090.50
118_H121_E0.8080.50
572_T575_K0.8030.50
330_V333_M0.8030.50
622_S626_S0.8020.50
368_F422_T0.7980.49
276_T293_S0.7970.49
471_A526_K0.7970.49
427_D575_K0.7960.49
601_A604_E0.7960.49
659_Y662_L0.7960.49
239_A502_A0.7950.49
243_A501_P0.7950.49
492_L515_I0.7950.49
339_I558_L0.7940.49
553_K556_N0.7940.49
466_A620_M0.7930.49
523_Y527_H0.7930.49
679_L726_V0.7920.49
132_D174_I0.7920.49
309_W375_F0.7900.48
396_V400_S0.7900.48
537_N680_Q0.7890.48
363_G366_D0.7880.48
105_H109_M0.7870.48
233_S236_S0.7870.48
278_C282_Y0.7860.48
111_E604_E0.7860.48
542_K594_P0.7850.48
560_K608_T0.7840.48
446_T460_A0.7830.48
669_L698_N0.7830.48
158_Q165_I0.7820.48
92_K164_E0.7820.48
423_H583_Y0.7810.48
675_N678_Y0.7800.48
447_K458_E0.7800.48
117_N218_P0.7790.48
234_L292_C0.7770.47
600_E607_K0.7750.47
672_M675_N0.7730.47
344_Y722_Y0.7720.47
525_A665_A0.7710.47
716_K720_T0.7710.47
125_E129_K0.7700.47
553_K557_E0.7700.47
355_L398_L0.7690.47
98_E168_S0.7690.47
78_Q144_S0.7680.47
102_L107_V0.7680.47
158_Q634_G0.7660.46
679_L717_D0.7660.46
302_A632_T0.7660.46
82_A501_P0.7660.46
214_G289_V0.7660.46
557_E608_T0.7630.46
350_G608_T0.7630.46
129_K504_K0.7620.46
549_Y601_A0.7600.46
319_L335_Y0.7600.46
253_G621_P0.7580.46
628_I635_I0.7570.46
560_K564_A0.7570.46
102_L125_E0.7570.46
133_T136_D0.7540.45
531_Y678_Y0.7540.45
549_Y599_W0.7520.45
583_Y686_Q0.7520.45
425_P445_P0.7520.45
149_K153_G0.7500.45
543_T547_I0.7480.45
129_K132_D0.7480.45
198_D477_E0.7480.45
673_P717_D0.7470.45
716_K719_L0.7460.45
596_H600_E0.7450.45
115_Y118_H0.7450.45
478_L543_T0.7450.45
213_S297_V0.7440.44
140_D197_Y0.7420.44
532_S681_L0.7410.44
619_L689_I0.7390.44
552_L690_D0.7390.44
442_I691_Q0.7390.44
94_Y98_E0.7380.44
90_R94_Y0.7360.44
626_S634_G0.7340.44
255_G398_L0.7340.44
402_M414_I0.7330.44
306_Y316_L0.7310.43
424_S433_V0.7310.43
130_Q134_F0.7290.43
620_M718_L0.7290.43
692_S728_T0.7290.43
203_F471_A0.7270.43
512_T614_S0.7270.43
82_A85_A0.7250.43
76_D80_L0.7250.43
365_Y369_F0.7250.43
519_N632_T0.7210.42
69_L72_R0.7200.42
569_N607_K0.7200.42
720_T723_K0.7190.42
603_R611_L0.7190.42
424_S445_P0.7190.42
482_A543_T0.7190.42
684_I687_K0.7170.42
95_G133_T0.7170.42
473_N526_K0.7170.42
564_A611_L0.7160.42
81_A84_L0.7160.42
162_T167_E0.7150.42
225_C731_Y0.7150.42
504_K603_R0.7140.42
349_K384_K0.7080.41
103_Y110_V0.7080.41
181_F193_V0.7080.41
505_R566_P0.7080.41
362_P382_Y0.7080.41
425_P615_T0.7080.41
305_F440_L0.7060.41
478_L482_A0.7050.41
473_N477_E0.7040.41
246_K249_S0.7020.41
320_K442_I0.7010.41
207_L488_A0.7010.41
130_Q190_L0.7010.41
679_L699_Y0.7000.41
266_S357_S0.7000.41
136_D198_D0.6990.41
675_N717_D0.6980.41
568_F611_L0.6980.41
248_V293_S0.6970.40
476_D479_E0.6960.40
377_R604_E0.6950.40
107_V113_G0.6930.40
399_F719_L0.6930.40
144_S299_G0.6920.40
180_L495_Y0.6900.40
284_H288_A0.6890.40
251_R275_H0.6890.40
378_L382_Y0.6890.40
498_Y512_T0.6890.40
421_N433_V0.6880.40
173_Y201_S0.6880.40
414_I718_L0.6880.40
548_Q633_N0.6870.40
672_M677_G0.6860.39
496_Q687_K0.6860.39
518_I622_S0.6860.39
107_V110_V0.6850.39
276_T295_G0.6850.39
641_Y668_L0.6850.39
468_N629_S0.6820.39
88_H107_V0.6810.39
320_K411_R0.6810.39
244_I465_S0.6800.39
494_D562_Q0.6790.39
183_N193_V0.6780.39
294_Q300_G0.6760.39
547_I617_S0.6760.39
237_I262_R0.6760.39
606_I611_L0.6750.39
87_F92_K0.6730.38
344_Y719_L0.6720.38
253_G437_N0.6720.38
90_R100_P0.6710.38
464_L514_G0.6710.38
88_H95_G0.6690.38
636_E696_N0.6690.38
638_P672_M0.6680.38
74_A89_L0.6660.38
363_G367_A0.6650.38
621_P694_S0.6630.38
290_K293_S0.6610.37
415_Q420_C0.6610.37
241_S285_F0.6600.37
227_L435_Q0.6590.37
565_C571_T0.6580.37
78_Q81_A0.6580.37
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127_E130_Q0.6540.37
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177_A215_V0.6520.37
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416_N718_L0.6500.37
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234_L245_V0.6480.36
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128_F132_D0.6470.36
138_D202_T0.6460.36
349_K422_T0.6440.36
79_Y88_H0.6440.36
534_G689_I0.6440.36
122_D133_T0.6430.36
604_E661_H0.6430.36
341_K419_H0.6430.36
444_L690_D0.6430.36
333_M670_W0.6420.36
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214_G251_R0.6410.36
257_N446_T0.6410.36
740_D745_L0.6400.36
104_D111_E0.6390.36
136_D476_D0.6390.36
268_I273_A0.6380.36
268_I312_E0.6380.36
221_Q496_Q0.6370.35
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625_S718_L0.6350.35
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102_L105_H0.6320.35
439_C462_C0.6320.35
95_G136_D0.6300.35
89_L199_A0.6290.35
499_P640_G0.6290.35
622_S625_S0.6290.35
218_P269_R0.6280.35
475_L542_K0.6280.35
278_C310_H0.6270.35
479_E597_Y0.6270.35
336_G413_Y0.6270.35
135_I174_I0.6270.35
90_R168_S0.6260.35
251_R270_G0.6250.34
85_A389_R0.6240.34
249_S466_A0.6240.34
87_F95_G0.6240.34
115_Y123_Y0.6230.34
97_F100_P0.6230.34
155_Y439_C0.6230.34
145_Y734_T0.6220.34
119_L216_R0.6210.34
346_R380_T0.6210.34
308_M398_L0.6200.34
177_A270_G0.6180.34
367_A382_Y0.6170.34
192_Y196_F0.6160.34
178_A194_K0.6160.34
294_Q298_R0.6160.34
611_L616_L0.6140.34
204_K481_L0.6140.34
487_R562_Q0.6140.34
121_E125_E0.6130.34
102_L118_H0.6130.34
384_K604_E0.6130.34
265_G269_R0.6120.33
91_K95_G0.6120.33
301_A468_N0.6120.33
341_K344_Y0.6120.33
345_T348_L0.6110.33
510_R567_W0.6110.33
100_P105_H0.6100.33
78_Q95_G0.6090.33
470_G526_K0.6080.33
144_S446_T0.6070.33
559_A610_G0.6060.33
463_T493_L0.6050.33
394_K609_H0.6050.33
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81_A88_H0.6040.33
210_P253_G0.6040.33
136_D141_M0.6040.33
601_A609_H0.6030.33
108_K387_S0.6020.33
111_E384_K0.6020.33
535_S688_F0.6010.33
87_F93_A0.6000.33
255_G519_N0.6000.33
238_N404_Q0.5990.32
95_G98_E0.5990.32
96_Q99_P0.5990.32
222_F487_R0.5980.32
227_L512_T0.5970.32
601_A661_H0.5970.32
439_C694_S0.5960.32
140_D201_S0.5960.32
95_G138_D0.5950.32
107_V129_K0.5950.32
98_E107_V0.5950.32
102_L175_L0.5940.32
369_F382_Y0.5940.32
101_A129_K0.5940.32
83_R86_I0.5930.32
301_A737_G0.5920.32
336_G411_R0.5920.32
226_V463_T0.5910.32
557_E601_A0.5910.32
307_P338_Q0.5910.32
199_A204_K0.5900.32
567_W570_E0.5900.32
122_D191_Q0.5900.32
605_S608_T0.5890.32
180_L492_L0.5890.32
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162_T384_K0.5870.32
255_G630_N0.5870.32
433_V436_S0.5870.32
290_K332_H0.5870.32
486_V551_L0.5870.32
69_L90_R0.5860.31
124_T127_E0.5860.31
158_Q264_L0.5850.31
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197_Y545_E0.5830.31
604_E609_H0.5830.31
102_L112_M0.5820.31
373_E422_T0.5820.31
707_G736_D0.5820.31
381_K601_A0.5810.31
214_G249_S0.5810.31
310_H358_P0.5800.31
347_L395_A0.5800.31
100_P107_V0.5800.31
476_D597_Y0.5800.31
151_L628_I0.5800.31
110_V117_N0.5790.31
256_I302_A0.5790.31
170_Q174_I0.5780.31
461_L507_A0.5780.31
394_K601_A0.5780.31
130_Q191_Q0.5770.31
99_P139_R0.5760.31
505_R604_E0.5760.31
345_T352_D0.5750.31
532_S664_D0.5750.31
301_A440_L0.5740.31
117_N569_N0.5730.30
258_A304_L0.5730.30
231_G261_I0.5730.30
538_N601_A0.5720.30
298_R441_E0.5700.30
90_R98_E0.5700.30
345_T351_E0.5700.30
102_L108_K0.5690.30
393_V422_T0.5690.30
247_Y254_I0.5690.30
210_P464_L0.5660.30
215_V515_I0.5650.30
133_T560_K0.5640.30
267_P360_D0.5630.30
189_R509_G0.5630.30
438_L731_Y0.5620.30
210_P410_G0.5620.30
222_F496_Q0.5620.30
346_R375_F0.5620.30
225_C462_C0.5610.30
287_T327_G0.5610.30
480_E484_L0.5610.30
225_C437_N0.5610.30
544_F624_T0.5600.30
112_M116_D0.5600.30
305_F436_S0.5600.30
560_K568_F0.5600.30
270_G289_V0.5590.29
136_D162_T0.5580.29
531_Y675_N0.5580.29
479_E605_S0.5580.29
423_H582_T0.5570.29
164_E476_D0.5570.29
168_S242_S0.5570.29
191_Q397_E0.5570.29
490_D613_N0.5560.29
253_G301_A0.5560.29
494_D558_L0.5550.29
518_I631_A0.5550.29
236_S240_T0.5550.29
247_Y625_S0.5550.29
322_N696_N0.5550.29
157_V301_A0.5550.29
89_L152_E0.5530.29
354_T357_S0.5530.29
361_V369_F0.5530.29
87_F94_Y0.5530.29
739_E745_L0.5520.29
126_E189_R0.5520.29
209_T580_I0.5520.29
644_I651_I0.5510.29
76_D231_G0.5510.29
208_P334_D0.5510.29
349_K352_D0.5500.29
245_V288_A0.5490.29
641_Y663_H0.5490.29
223_S496_Q0.5490.29
79_Y144_S0.5490.29
601_A608_T0.5470.29
153_G482_A0.5460.29
293_S323_R0.5450.28
130_Q560_K0.5450.28
226_V252_A0.5440.28
191_Q601_A0.5430.28
163_G167_E0.5430.28
119_L179_C0.5430.28
719_L723_K0.5430.28
98_E132_D0.5430.28
102_L132_D0.5430.28
179_C215_V0.5420.28
464_L621_P0.5420.28
106_V115_Y0.5420.28
493_L511_R0.5420.28
494_D498_Y0.5410.28
363_G378_L0.5400.28
351_E608_T0.5400.28
202_T477_E0.5400.28
530_R667_E0.5400.28
191_Q724_F0.5400.28
347_L719_L0.5400.28
182_S495_Y0.5390.28
215_V535_S0.5390.28
511_R613_N0.5390.28
534_G680_Q0.5390.28
334_D411_R0.5380.28
438_L730_Y0.5380.28
278_C301_A0.5370.28
721_A726_V0.5370.28
105_H166_Y0.5370.28
174_I201_S0.5370.28
439_C514_G0.5370.28
141_M475_L0.5360.28
299_G383_E0.5350.28
164_E167_E0.5350.28
79_Y448_P0.5350.28
123_Y127_E0.5350.28
68_D78_Q0.5350.28
248_V251_R0.5350.28
626_S633_N0.5350.28
204_K471_A0.5350.28
741_A745_L0.5340.28
377_R538_N0.5340.28
635_I685_M0.5340.28
154_K624_T0.5320.28
221_Q322_N0.5310.27
191_Q194_K0.5310.27
298_R621_P0.5290.27
691_Q728_T0.5280.27
146_A247_Y0.5280.27
380_T508_M0.5280.27
101_A105_H0.5270.27
253_G694_S0.5270.27
102_L116_D0.5270.27
100_P122_D0.5270.27
440_L514_G0.5260.27
71_S92_K0.5250.27
101_A132_D0.5250.27
76_D89_L0.5250.27
134_F190_L0.5250.27
560_K607_K0.5240.27
301_A650_G0.5230.27
473_N539_L0.5230.27
361_V382_Y0.5230.27
563_G612_R0.5230.27
191_Q608_T0.5230.27
111_E397_E0.5230.27
344_Y417_V0.5220.27
89_L136_D0.5220.27
708_K713_Q0.5210.27
155_Y253_G0.5210.27
288_A293_S0.5210.27
115_Y119_L0.5210.27
176_V212_M0.5200.27
437_N621_P0.5200.27
407_A644_I0.5200.27
136_D202_T0.5190.27
426_F445_P0.5190.27
349_K393_V0.5190.27
155_Y225_C0.5180.27
99_P168_S0.5180.27
274_F349_K0.5180.27
164_E168_S0.5180.27
467_F481_L0.5180.27
435_Q446_T0.5170.26
85_A538_N0.5170.26
117_N133_T0.5170.26
439_C621_P0.5160.26
105_H171_F0.5160.26
416_N419_H0.5160.26
375_F379_Y0.5150.26
225_C694_S0.5150.26
315_S391_Q0.5150.26
103_Y381_K0.5150.26
156_L165_I0.5140.26
339_I342_L0.5140.26
221_Q324_G0.5130.26
362_P369_F0.5130.26
580_I633_N0.5130.26
482_A689_I0.5120.26
205_I485_A0.5120.26
350_G395_A0.5120.26
381_K384_K0.5110.26
441_E462_C0.5110.26
281_F625_S0.5110.26
558_L613_N0.5110.26
208_P248_V0.5100.26
596_H603_R0.5100.26
129_K569_N0.5100.26
441_E621_P0.5090.26
87_F99_P0.5090.26
673_P676_D0.5080.26
84_L183_N0.5080.26
286_Q327_G0.5080.26
402_M406_R0.5080.26
96_Q129_K0.5080.26
524_L539_L0.5080.26
397_E586_D0.5070.26
525_A657_P0.5070.26
134_F193_V0.5070.26
308_M313_V0.5070.26
257_N365_Y0.5060.26
211_I215_V0.5060.26
617_S687_K0.5060.26
142_T202_T0.5060.26
95_G99_P0.5060.26
180_L488_A0.5050.26
94_Y104_D0.5050.26
75_P82_A0.5050.26
86_I95_G0.5040.26
111_E129_K0.5030.26
139_R202_T0.5030.26
350_G533_D0.5030.26
476_D480_E0.5030.26
266_S351_E0.5030.26
88_H108_K0.5020.25
130_Q384_K0.5020.25
308_M339_I0.5010.25
94_Y168_S0.5010.25
317_L337_V0.5010.25
86_I94_Y0.5010.25
214_G466_A0.5000.25
520_F524_L0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xapA 4 0.9553 100 0.099 Contact Map
3hncA 2 0.9106 100 0.138 Contact Map
3k8tA 2 0.7832 100 0.142 Contact Map
2wghA 2 0.8068 100 0.218 Contact Map
1peqA 2 0.8397 100 0.227 Contact Map
3o0qA 2 0.707 100 0.314 Contact Map
1l1lA 1 0.6649 100 0.49 Contact Map
4u3eA 2 0.7162 99.7 0.931 Contact Map
1h7bA 2 0.5795 68.8 0.984 Contact Map
2ebuA 1 0.1314 17.5 0.989 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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