RIR1 - ECOLI - GREMLIN Contacts

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RIR1 - Ribonucleoside-diphosphate reductase 1 subunit alpha

UniProt:	P00452	Sequences: MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10660
Length:	761 (644)
Sequences:	2706 (935)
Seq/√Len:	36.9

ECOLI - RIR1 RIR3
BACSU - RIR1 NRDEB
HALSA - Q9HMU3 Q9HPG8
SULSO - Q97ZH9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
348_L	723_K	7.862	1.00
345_T	376_E	6.688	1.00
560_K	605_S	4.849	1.00
479_E	553_K	4.820	1.00
504_K	508_M	4.601	1.00
483_I	557_E	4.310	1.00
486_V	513_L	4.183	1.00
552_L	606_I	4.062	1.00
313_V	337_V	4.052	1.00
350_G	394_K	3.969	1.00
352_D	394_K	3.912	1.00
553_K	605_S	3.828	1.00
532_S	667_E	3.741	1.00
195_R	480_E	3.715	1.00
352_D	392_R	3.683	1.00
556_N	605_S	3.474	1.00
573_Y	611_L	3.391	1.00
517_V	544_F	3.275	1.00
537_N	684_I	3.250	1.00
538_N	542_K	3.231	1.00
345_T	349_K	3.192	1.00
354_T	388_I	3.105	1.00
479_E	550_Y	3.090	1.00
341_K	422_T	2.998	1.00
680_Q	724_F	2.987	1.00
680_Q	720_T	2.983	1.00
605_S	609_H	2.976	1.00
560_K	609_H	2.956	1.00
263_A	311_L	2.945	1.00
581_D	603_R	2.889	1.00
443_A	692_S	2.881	1.00
239_A	242_S	2.831	1.00
130_Q	194_K	2.827	1.00
354_T	383_E	2.814	1.00
131_M	178_A	2.810	1.00
356_F	361_V	2.803	1.00
354_T	392_R	2.783	1.00
378_L	381_K	2.772	1.00
487_R	561_E	2.748	1.00
134_F	194_K	2.714	1.00
483_I	553_K	2.696	1.00
486_V	616_L	2.677	1.00
381_K	385_D	2.526	1.00
243_A	502_A	2.500	1.00
314_E	391_Q	2.477	1.00
258_A	278_C	2.452	1.00
556_N	609_H	2.437	1.00
604_E	608_T	2.429	1.00
420_C	443_A	2.419	1.00
528_G	665_A	2.380	1.00
501_P	504_K	2.354	1.00
600_E	603_R	2.328	1.00
505_R	509_G	2.321	1.00
355_L	393_V	2.291	0.99
478_L	547_I	2.271	0.99
552_L	611_L	2.262	0.99
556_N	560_K	2.249	0.99
427_D	572_T	2.231	0.99
660_E	664_D	2.226	0.99
350_G	396_V	2.215	0.99
577_I	582_T	2.215	0.99
479_E	549_Y	2.204	0.99
676_D	720_T	2.189	0.99
598_D	601_A	2.183	0.99
541_H	687_K	2.166	0.99
388_I	392_R	2.152	0.99
318_V	401_L	2.117	0.99
282_Y	330_V	2.072	0.99
394_K	397_E	2.031	0.99
568_F	607_K	2.030	0.99
344_Y	416_N	2.011	0.99
204_K	477_E	2.009	0.99
465_S	485_A	2.008	0.99
487_R	554_A	2.002	0.99
580_I	603_R	1.994	0.98
443_A	728_T	1.990	0.98
139_R	201_S	1.985	0.98
102_L	106_V	1.984	0.98
459_I	500_I	1.970	0.98
420_C	728_T	1.954	0.98
205_I	465_S	1.927	0.98
134_F	174_I	1.918	0.98
374_E	377_R	1.914	0.98
231_G	236_S	1.910	0.98
314_E	393_V	1.875	0.98
235_D	242_S	1.868	0.98
341_K	722_Y	1.852	0.98
578_L	606_I	1.847	0.97
143_F	173_Y	1.826	0.97
600_E	604_E	1.804	0.97
279_I	319_L	1.800	0.97
720_T	724_F	1.798	0.97
134_F	198_D	1.787	0.97
528_G	661_H	1.773	0.97
346_R	351_E	1.737	0.96
426_F	565_C	1.734	0.96
264_L	315_S	1.732	0.96
532_S	536_A	1.732	0.96
131_M	174_I	1.695	0.96
342_L	345_T	1.679	0.96
286_Q	332_H	1.667	0.95
230_C	240_T	1.661	0.95
509_G	566_P	1.652	0.95
483_I	554_A	1.650	0.95
393_V	398_L	1.647	0.95
117_N	121_E	1.638	0.95
549_Y	602_L	1.633	0.95
368_F	427_D	1.629	0.95
542_K	596_H	1.626	0.95
548_Q	552_L	1.626	0.95
603_R	607_K	1.620	0.95
314_E	398_L	1.615	0.95
472_I	481_L	1.614	0.94
537_N	681_L	1.611	0.94
360_D	389_R	1.603	0.94
339_I	414_I	1.589	0.94
243_A	459_I	1.578	0.94
739_E	742_Q	1.575	0.94
131_M	190_L	1.567	0.94
282_Y	333_M	1.553	0.93
386_D	389_R	1.551	0.93
367_A	378_L	1.550	0.93
380_T	384_K	1.549	0.93
103_Y	125_E	1.544	0.93
573_Y	578_L	1.539	0.93
86_I	90_R	1.536	0.93
364_L	387_S	1.529	0.93
601_A	605_S	1.521	0.93
417_V	432_P	1.517	0.92
194_K	198_D	1.516	0.92
174_I	178_A	1.503	0.92
238_N	245_V	1.495	0.92
373_E	377_R	1.492	0.92
564_A	568_F	1.488	0.92
209_T	301_A	1.488	0.92
604_E	607_K	1.483	0.92
346_R	354_T	1.481	0.91
530_R	665_A	1.479	0.91
117_N	122_D	1.475	0.91
135_I	197_Y	1.449	0.91
373_E	376_E	1.444	0.90
403_M	714_L	1.441	0.90
523_Y	543_T	1.439	0.90
376_E	380_T	1.436	0.90
536_A	681_L	1.430	0.90
100_P	104_D	1.423	0.90
238_N	288_A	1.417	0.90
241_S	288_A	1.415	0.89
356_F	388_I	1.409	0.89
229_E	257_N	1.406	0.89
366_D	369_F	1.396	0.89
346_R	383_E	1.391	0.89
363_G	382_Y	1.377	0.88
222_F	495_Y	1.372	0.88
127_E	190_L	1.370	0.88
241_S	284_H	1.370	0.88
531_Y	634_G	1.369	0.88
289_V	302_A	1.366	0.88
479_E	483_I	1.360	0.88
556_N	606_I	1.358	0.87
263_A	266_S	1.356	0.87
490_D	612_R	1.343	0.87
314_E	401_L	1.342	0.87
319_L	330_V	1.341	0.87
107_V	111_E	1.340	0.87
683_G	724_F	1.336	0.87
548_Q	617_S	1.329	0.86
313_V	398_L	1.325	0.86
459_I	502_A	1.324	0.86
196_F	488_A	1.318	0.86
525_A	638_P	1.316	0.86
306_Y	310_H	1.309	0.85
181_F	196_F	1.301	0.85
697_T	721_A	1.301	0.85
679_L	697_T	1.291	0.85
203_F	629_S	1.288	0.84
490_D	562_Q	1.281	0.84
364_L	369_F	1.280	0.84
199_A	481_L	1.277	0.84
569_N	574_A	1.270	0.84
122_D	182_S	1.263	0.83
238_N	284_H	1.258	0.83
679_L	724_F	1.253	0.83
88_H	91_K	1.252	0.83
541_H	684_I	1.249	0.83
244_I	256_I	1.244	0.82
197_Y	201_S	1.242	0.82
198_D	202_T	1.234	0.82
532_S	677_G	1.233	0.82
93_A	168_S	1.233	0.82
430_I	567_W	1.227	0.81
190_L	193_V	1.225	0.81
660_E	663_H	1.218	0.81
88_H	92_K	1.214	0.81
551_L	616_L	1.214	0.81
556_N	602_L	1.211	0.81
192_Y	195_R	1.197	0.80
364_L	385_D	1.196	0.80
406_R	718_L	1.195	0.80
101_A	104_D	1.193	0.80
174_I	194_K	1.193	0.80
142_T	203_F	1.180	0.79
548_Q	580_I	1.179	0.79
284_H	287_T	1.177	0.79
342_L	376_E	1.173	0.78
131_M	194_K	1.169	0.78
108_K	112_M	1.166	0.78
225_C	439_C	1.166	0.78
362_P	368_F	1.163	0.78
106_V	110_V	1.161	0.78
524_L	529_K	1.150	0.77
447_K	457_G	1.146	0.77
529_K	539_L	1.144	0.77
678_Y	695_A	1.140	0.76
174_I	197_Y	1.139	0.76
546_A	597_Y	1.131	0.76
172_L	176_V	1.129	0.76
159_N	164_E	1.128	0.76
94_Y	99_P	1.126	0.75
509_G	567_W	1.124	0.75
523_Y	539_L	1.123	0.75
85_A	148_V	1.123	0.75
634_G	698_N	1.121	0.75
475_L	546_A	1.119	0.75
109_M	115_Y	1.117	0.75
305_F	336_G	1.117	0.75
103_Y	107_V	1.117	0.75
263_A	357_S	1.115	0.75
173_Y	200_V	1.112	0.75
552_L	573_Y	1.108	0.74
168_S	171_F	1.108	0.74
546_A	598_D	1.105	0.74
427_D	582_T	1.102	0.74
557_E	605_S	1.102	0.74
103_Y	129_K	1.100	0.74
467_F	482_A	1.099	0.74
519_N	522_Y	1.097	0.74
349_K	723_K	1.097	0.74
321_N	329_R	1.091	0.73
492_L	513_L	1.088	0.73
676_D	680_Q	1.085	0.73
419_H	422_T	1.083	0.73
107_V	125_E	1.081	0.72
106_V	109_M	1.079	0.72
140_D	170_Q	1.077	0.72
520_F	540_T	1.072	0.72
420_C	692_S	1.072	0.72
501_P	505_R	1.068	0.71
357_S	360_D	1.066	0.71
546_A	550_Y	1.066	0.71
697_T	717_D	1.065	0.71
225_C	464_L	1.063	0.71
136_D	170_Q	1.063	0.71
93_A	166_Y	1.059	0.71
564_A	569_N	1.058	0.71
742_Q	745_L	1.058	0.71
377_R	381_K	1.057	0.71
94_Y	101_A	1.055	0.71
554_A	557_E	1.050	0.70
458_E	509_G	1.046	0.70
179_C	220_R	1.045	0.70
190_L	194_K	1.045	0.70
282_Y	319_L	1.043	0.70
159_N	162_T	1.041	0.70
535_S	538_N	1.034	0.69
469_L	517_V	1.034	0.69
552_L	578_L	1.032	0.69
385_D	388_I	1.026	0.68
467_F	547_I	1.026	0.68
308_M	337_V	1.026	0.68
529_K	535_S	1.025	0.68
139_R	198_D	1.025	0.68
225_C	253_G	1.024	0.68
106_V	128_F	1.023	0.68
137_H	171_F	1.021	0.68
537_N	677_G	1.020	0.68
572_T	577_I	1.018	0.68
572_T	582_T	1.018	0.68
416_N	721_A	1.017	0.68
116_D	119_L	1.014	0.67
578_L	611_L	1.013	0.67
686_Q	693_I	1.012	0.67
232_D	262_R	1.011	0.67
553_K	602_L	1.010	0.67
337_V	402_M	1.005	0.67
89_L	156_L	1.003	0.67
242_S	246_K	0.997	0.66
721_A	729_L	0.995	0.66
175_L	216_R	0.994	0.66
118_H	182_S	0.994	0.66
439_C	464_L	0.993	0.66
348_L	719_L	0.986	0.65
129_K	133_T	0.986	0.65
320_K	335_Y	0.986	0.65
170_Q	201_S	0.984	0.65
469_L	547_I	0.984	0.65
526_K	658_D	0.980	0.65
632_T	638_P	0.978	0.65
103_Y	128_F	0.978	0.65
266_S	359_S	0.977	0.65
602_L	605_S	0.976	0.64
678_Y	698_N	0.975	0.64
534_G	538_N	0.975	0.64
178_A	193_V	0.970	0.64
86_I	168_S	0.970	0.64
364_L	368_F	0.969	0.64
473_N	523_Y	0.968	0.64
102_L	115_Y	0.967	0.64
676_D	716_K	0.966	0.64
552_L	556_N	0.964	0.63
90_R	93_A	0.963	0.63
549_Y	598_D	0.963	0.63
556_N	611_L	0.962	0.63
474_N	477_E	0.960	0.63
253_G	298_R	0.956	0.63
367_A	374_E	0.956	0.63
94_Y	100_P	0.954	0.63
553_K	601_A	0.952	0.62
308_M	317_L	0.951	0.62
210_P	298_R	0.951	0.62
174_I	193_V	0.950	0.62
573_Y	603_R	0.949	0.62
92_K	104_D	0.948	0.62
97_F	168_S	0.947	0.62
482_A	550_Y	0.944	0.62
398_L	402_M	0.944	0.62
82_A	86_I	0.943	0.62
105_H	108_K	0.942	0.62
568_F	573_Y	0.940	0.61
460_A	512_T	0.940	0.61
597_Y	601_A	0.939	0.61
517_V	547_I	0.935	0.61
522_Y	631_A	0.932	0.61
570_E	574_A	0.931	0.61
253_G	439_C	0.928	0.60
278_C	306_Y	0.928	0.60
707_G	735_R	0.927	0.60
249_S	292_C	0.927	0.60
682_V	693_I	0.927	0.60
475_L	539_L	0.926	0.60
131_M	134_F	0.926	0.60
225_C	441_E	0.924	0.60
522_Y	632_T	0.924	0.60
540_T	685_M	0.923	0.60
261_I	281_F	0.922	0.60
380_T	383_E	0.915	0.59
136_D	139_R	0.912	0.59
243_A	500_I	0.909	0.59
582_T	687_K	0.907	0.59
235_D	246_K	0.905	0.59
699_Y	713_Q	0.901	0.58
419_H	423_H	0.900	0.58
252_A	300_G	0.898	0.58
259_G	365_Y	0.897	0.58
509_G	570_E	0.896	0.58
443_A	726_V	0.891	0.57
429_A	570_E	0.890	0.57
191_Q	195_R	0.890	0.57
679_L	683_G	0.890	0.57
298_R	439_C	0.889	0.57
102_L	109_M	0.887	0.57
151_L	156_L	0.886	0.57
550_Y	553_K	0.885	0.57
342_L	380_T	0.885	0.57
477_E	480_E	0.884	0.57
569_N	608_T	0.883	0.57
118_H	122_D	0.883	0.57
258_A	285_F	0.882	0.57
308_M	340_N	0.881	0.56
485_A	515_I	0.877	0.56
341_K	345_T	0.876	0.56
307_P	417_V	0.869	0.55
267_P	359_S	0.868	0.55
649_D	737_G	0.868	0.55
699_Y	717_D	0.868	0.55
313_V	355_L	0.868	0.55
479_E	557_E	0.868	0.55
346_R	395_A	0.867	0.55
253_G	464_L	0.867	0.55
253_G	441_E	0.866	0.55
152_E	156_L	0.865	0.55
257_N	435_Q	0.863	0.55
541_H	688_F	0.862	0.55
458_E	510_R	0.861	0.55
494_D	612_R	0.861	0.55
276_T	320_K	0.859	0.55
441_E	464_L	0.857	0.54
281_F	291_S	0.856	0.54
344_Y	347_L	0.854	0.54
557_E	609_H	0.854	0.54
491_A	562_Q	0.854	0.54
210_P	439_C	0.853	0.54
448_P	457_G	0.853	0.54
210_P	225_C	0.852	0.54
209_T	224_S	0.852	0.54
102_L	114_K	0.849	0.54
210_P	224_S	0.842	0.53
170_Q	197_Y	0.841	0.53
191_Q	600_E	0.840	0.53
492_L	496_Q	0.839	0.53
568_F	580_I	0.837	0.53
351_E	394_K	0.837	0.53
283_K	287_T	0.837	0.53
235_D	239_A	0.836	0.53
102_L	110_V	0.831	0.52
180_L	211_I	0.830	0.52
225_C	298_R	0.830	0.52
79_Y	82_A	0.829	0.52
442_I	618_A	0.829	0.52
431_A	445_P	0.828	0.52
483_I	487_R	0.827	0.52
125_E	534_G	0.826	0.52
257_N	434_R	0.823	0.51
623_E	696_N	0.823	0.51
682_V	695_A	0.823	0.51
109_M	114_K	0.822	0.51
89_L	93_A	0.822	0.51
364_L	382_Y	0.821	0.51
367_A	381_K	0.821	0.51
483_I	605_S	0.819	0.51
129_K	136_D	0.819	0.51
685_M	693_I	0.818	0.51
557_E	560_K	0.816	0.51
317_L	413_Y	0.816	0.51
549_Y	553_K	0.815	0.51
510_R	614_S	0.814	0.51
473_N	527_H	0.814	0.51
377_R	384_K	0.812	0.50
173_Y	206_S	0.812	0.50
347_L	396_V	0.811	0.50
556_N	568_F	0.811	0.50
192_Y	561_E	0.810	0.50
308_M	347_L	0.809	0.50
118_H	121_E	0.808	0.50
572_T	575_K	0.803	0.50
330_V	333_M	0.803	0.50
622_S	626_S	0.802	0.50
368_F	422_T	0.798	0.49
276_T	293_S	0.797	0.49
471_A	526_K	0.797	0.49
427_D	575_K	0.796	0.49
601_A	604_E	0.796	0.49
659_Y	662_L	0.796	0.49
239_A	502_A	0.795	0.49
243_A	501_P	0.795	0.49
492_L	515_I	0.795	0.49
339_I	558_L	0.794	0.49
553_K	556_N	0.794	0.49
466_A	620_M	0.793	0.49
523_Y	527_H	0.793	0.49
679_L	726_V	0.792	0.49
132_D	174_I	0.792	0.49
309_W	375_F	0.790	0.48
396_V	400_S	0.790	0.48
537_N	680_Q	0.789	0.48
363_G	366_D	0.788	0.48
105_H	109_M	0.787	0.48
233_S	236_S	0.787	0.48
278_C	282_Y	0.786	0.48
111_E	604_E	0.786	0.48
542_K	594_P	0.785	0.48
560_K	608_T	0.784	0.48
446_T	460_A	0.783	0.48
669_L	698_N	0.783	0.48
158_Q	165_I	0.782	0.48
92_K	164_E	0.782	0.48
423_H	583_Y	0.781	0.48
675_N	678_Y	0.780	0.48
447_K	458_E	0.780	0.48
117_N	218_P	0.779	0.48
234_L	292_C	0.777	0.47
600_E	607_K	0.775	0.47
672_M	675_N	0.773	0.47
344_Y	722_Y	0.772	0.47
525_A	665_A	0.771	0.47
716_K	720_T	0.771	0.47
125_E	129_K	0.770	0.47
553_K	557_E	0.770	0.47
355_L	398_L	0.769	0.47
98_E	168_S	0.769	0.47
78_Q	144_S	0.768	0.47
102_L	107_V	0.768	0.47
158_Q	634_G	0.766	0.46
679_L	717_D	0.766	0.46
302_A	632_T	0.766	0.46
82_A	501_P	0.766	0.46
214_G	289_V	0.766	0.46
557_E	608_T	0.763	0.46
350_G	608_T	0.763	0.46
129_K	504_K	0.762	0.46
549_Y	601_A	0.760	0.46
319_L	335_Y	0.760	0.46
253_G	621_P	0.758	0.46
628_I	635_I	0.757	0.46
560_K	564_A	0.757	0.46
102_L	125_E	0.757	0.46
133_T	136_D	0.754	0.45
531_Y	678_Y	0.754	0.45
549_Y	599_W	0.752	0.45
583_Y	686_Q	0.752	0.45
425_P	445_P	0.752	0.45
149_K	153_G	0.750	0.45
543_T	547_I	0.748	0.45
129_K	132_D	0.748	0.45
198_D	477_E	0.748	0.45
673_P	717_D	0.747	0.45
716_K	719_L	0.746	0.45
596_H	600_E	0.745	0.45
115_Y	118_H	0.745	0.45
478_L	543_T	0.745	0.45
213_S	297_V	0.744	0.44
140_D	197_Y	0.742	0.44
532_S	681_L	0.741	0.44
619_L	689_I	0.739	0.44
552_L	690_D	0.739	0.44
442_I	691_Q	0.739	0.44
94_Y	98_E	0.738	0.44
90_R	94_Y	0.736	0.44
626_S	634_G	0.734	0.44
255_G	398_L	0.734	0.44
402_M	414_I	0.733	0.44
306_Y	316_L	0.731	0.43
424_S	433_V	0.731	0.43
130_Q	134_F	0.729	0.43
620_M	718_L	0.729	0.43
692_S	728_T	0.729	0.43
203_F	471_A	0.727	0.43
512_T	614_S	0.727	0.43
82_A	85_A	0.725	0.43
76_D	80_L	0.725	0.43
365_Y	369_F	0.725	0.43
519_N	632_T	0.721	0.42
69_L	72_R	0.720	0.42
569_N	607_K	0.720	0.42
720_T	723_K	0.719	0.42
603_R	611_L	0.719	0.42
424_S	445_P	0.719	0.42
482_A	543_T	0.719	0.42
684_I	687_K	0.717	0.42
95_G	133_T	0.717	0.42
473_N	526_K	0.717	0.42
564_A	611_L	0.716	0.42
81_A	84_L	0.716	0.42
162_T	167_E	0.715	0.42
225_C	731_Y	0.715	0.42
504_K	603_R	0.714	0.42
349_K	384_K	0.708	0.41
103_Y	110_V	0.708	0.41
181_F	193_V	0.708	0.41
505_R	566_P	0.708	0.41
362_P	382_Y	0.708	0.41
425_P	615_T	0.708	0.41
305_F	440_L	0.706	0.41
478_L	482_A	0.705	0.41
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246_K	249_S	0.702	0.41
320_K	442_I	0.701	0.41
207_L	488_A	0.701	0.41
130_Q	190_L	0.701	0.41
679_L	699_Y	0.700	0.41
266_S	357_S	0.700	0.41
136_D	198_D	0.699	0.41
675_N	717_D	0.698	0.41
568_F	611_L	0.698	0.41
248_V	293_S	0.697	0.40
476_D	479_E	0.696	0.40
377_R	604_E	0.695	0.40
107_V	113_G	0.693	0.40
399_F	719_L	0.693	0.40
144_S	299_G	0.692	0.40
180_L	495_Y	0.690	0.40
284_H	288_A	0.689	0.40
251_R	275_H	0.689	0.40
378_L	382_Y	0.689	0.40
498_Y	512_T	0.689	0.40
421_N	433_V	0.688	0.40
173_Y	201_S	0.688	0.40
414_I	718_L	0.688	0.40
548_Q	633_N	0.687	0.40
672_M	677_G	0.686	0.39
496_Q	687_K	0.686	0.39
518_I	622_S	0.686	0.39
107_V	110_V	0.685	0.39
276_T	295_G	0.685	0.39
641_Y	668_L	0.685	0.39
468_N	629_S	0.682	0.39
88_H	107_V	0.681	0.39
320_K	411_R	0.681	0.39
244_I	465_S	0.680	0.39
494_D	562_Q	0.679	0.39
183_N	193_V	0.678	0.39
294_Q	300_G	0.676	0.39
547_I	617_S	0.676	0.39
237_I	262_R	0.676	0.39
606_I	611_L	0.675	0.39
87_F	92_K	0.673	0.38
344_Y	719_L	0.672	0.38
253_G	437_N	0.672	0.38
90_R	100_P	0.671	0.38
464_L	514_G	0.671	0.38
88_H	95_G	0.669	0.38
636_E	696_N	0.669	0.38
638_P	672_M	0.668	0.38
74_A	89_L	0.666	0.38
363_G	367_A	0.665	0.38
621_P	694_S	0.663	0.38
290_K	293_S	0.661	0.37
415_Q	420_C	0.661	0.37
241_S	285_F	0.660	0.37
227_L	435_Q	0.659	0.37
565_C	571_T	0.658	0.37
78_Q	81_A	0.658	0.37
483_I	550_Y	0.657	0.37
127_E	130_Q	0.654	0.37
111_E	117_N	0.653	0.37
225_C	621_P	0.653	0.37
211_I	492_L	0.652	0.37
177_A	215_V	0.652	0.37
195_R	484_L	0.650	0.37
416_N	718_L	0.650	0.37
298_R	464_L	0.649	0.36
234_L	245_V	0.648	0.36
541_H	586_D	0.648	0.36
114_K	123_Y	0.648	0.36
128_F	132_D	0.647	0.36
138_D	202_T	0.646	0.36
349_K	422_T	0.644	0.36
79_Y	88_H	0.644	0.36
534_G	689_I	0.644	0.36
122_D	133_T	0.643	0.36
604_E	661_H	0.643	0.36
341_K	419_H	0.643	0.36
444_L	690_D	0.643	0.36
333_M	670_W	0.642	0.36
581_D	598_D	0.642	0.36
214_G	251_R	0.641	0.36
257_N	446_T	0.641	0.36
740_D	745_L	0.640	0.36
104_D	111_E	0.639	0.36
136_D	476_D	0.639	0.36
268_I	273_A	0.638	0.36
268_I	312_E	0.638	0.36
221_Q	496_Q	0.637	0.35
76_D	79_Y	0.636	0.35
87_F	90_R	0.636	0.35
625_S	718_L	0.635	0.35
88_H	94_Y	0.634	0.35
102_L	105_H	0.632	0.35
439_C	462_C	0.632	0.35
95_G	136_D	0.630	0.35
89_L	199_A	0.629	0.35
499_P	640_G	0.629	0.35
622_S	625_S	0.629	0.35
218_P	269_R	0.628	0.35
475_L	542_K	0.628	0.35
278_C	310_H	0.627	0.35
479_E	597_Y	0.627	0.35
336_G	413_Y	0.627	0.35
135_I	174_I	0.627	0.35
90_R	168_S	0.626	0.35
251_R	270_G	0.625	0.34
85_A	389_R	0.624	0.34
249_S	466_A	0.624	0.34
87_F	95_G	0.624	0.34
115_Y	123_Y	0.623	0.34
97_F	100_P	0.623	0.34
155_Y	439_C	0.623	0.34
145_Y	734_T	0.622	0.34
119_L	216_R	0.621	0.34
346_R	380_T	0.621	0.34
308_M	398_L	0.620	0.34
177_A	270_G	0.618	0.34
367_A	382_Y	0.617	0.34
192_Y	196_F	0.616	0.34
178_A	194_K	0.616	0.34
294_Q	298_R	0.616	0.34
611_L	616_L	0.614	0.34
204_K	481_L	0.614	0.34
487_R	562_Q	0.614	0.34
121_E	125_E	0.613	0.34
102_L	118_H	0.613	0.34
384_K	604_E	0.613	0.34
265_G	269_R	0.612	0.33
91_K	95_G	0.612	0.33
301_A	468_N	0.612	0.33
341_K	344_Y	0.612	0.33
345_T	348_L	0.611	0.33
510_R	567_W	0.611	0.33
100_P	105_H	0.610	0.33
78_Q	95_G	0.609	0.33
470_G	526_K	0.608	0.33
144_S	446_T	0.607	0.33
559_A	610_G	0.606	0.33
463_T	493_L	0.605	0.33
394_K	609_H	0.605	0.33
98_E	108_K	0.604	0.33
81_A	88_H	0.604	0.33
210_P	253_G	0.604	0.33
136_D	141_M	0.604	0.33
601_A	609_H	0.603	0.33
108_K	387_S	0.602	0.33
111_E	384_K	0.602	0.33
535_S	688_F	0.601	0.33
87_F	93_A	0.600	0.33
255_G	519_N	0.600	0.33
238_N	404_Q	0.599	0.32
95_G	98_E	0.599	0.32
96_Q	99_P	0.599	0.32
222_F	487_R	0.598	0.32
227_L	512_T	0.597	0.32
601_A	661_H	0.597	0.32
439_C	694_S	0.596	0.32
140_D	201_S	0.596	0.32
95_G	138_D	0.595	0.32
107_V	129_K	0.595	0.32
98_E	107_V	0.595	0.32
102_L	175_L	0.594	0.32
369_F	382_Y	0.594	0.32
101_A	129_K	0.594	0.32
83_R	86_I	0.593	0.32
301_A	737_G	0.592	0.32
336_G	411_R	0.592	0.32
226_V	463_T	0.591	0.32
557_E	601_A	0.591	0.32
307_P	338_Q	0.591	0.32
199_A	204_K	0.590	0.32
567_W	570_E	0.590	0.32
122_D	191_Q	0.590	0.32
605_S	608_T	0.589	0.32
180_L	492_L	0.589	0.32
144_S	657_P	0.589	0.32
116_D	569_N	0.588	0.32
162_T	384_K	0.587	0.32
255_G	630_N	0.587	0.32
433_V	436_S	0.587	0.32
290_K	332_H	0.587	0.32
486_V	551_L	0.587	0.32
69_L	90_R	0.586	0.31
124_T	127_E	0.586	0.31
158_Q	264_L	0.585	0.31
69_L	88_H	0.583	0.31
197_Y	545_E	0.583	0.31
604_E	609_H	0.583	0.31
102_L	112_M	0.582	0.31
373_E	422_T	0.582	0.31
707_G	736_D	0.582	0.31
381_K	601_A	0.581	0.31
214_G	249_S	0.581	0.31
310_H	358_P	0.580	0.31
347_L	395_A	0.580	0.31
100_P	107_V	0.580	0.31
476_D	597_Y	0.580	0.31
151_L	628_I	0.580	0.31
110_V	117_N	0.579	0.31
256_I	302_A	0.579	0.31
170_Q	174_I	0.578	0.31
461_L	507_A	0.578	0.31
394_K	601_A	0.578	0.31
130_Q	191_Q	0.577	0.31
99_P	139_R	0.576	0.31
505_R	604_E	0.576	0.31
345_T	352_D	0.575	0.31
532_S	664_D	0.575	0.31
301_A	440_L	0.574	0.31
117_N	569_N	0.573	0.30
258_A	304_L	0.573	0.30
231_G	261_I	0.573	0.30
538_N	601_A	0.572	0.30
298_R	441_E	0.570	0.30
90_R	98_E	0.570	0.30
345_T	351_E	0.570	0.30
102_L	108_K	0.569	0.30
393_V	422_T	0.569	0.30
247_Y	254_I	0.569	0.30
210_P	464_L	0.566	0.30
215_V	515_I	0.565	0.30
133_T	560_K	0.564	0.30
267_P	360_D	0.563	0.30
189_R	509_G	0.563	0.30
438_L	731_Y	0.562	0.30
210_P	410_G	0.562	0.30
222_F	496_Q	0.562	0.30
346_R	375_F	0.562	0.30
225_C	462_C	0.561	0.30
287_T	327_G	0.561	0.30
480_E	484_L	0.561	0.30
225_C	437_N	0.561	0.30
544_F	624_T	0.560	0.30
112_M	116_D	0.560	0.30
305_F	436_S	0.560	0.30
560_K	568_F	0.560	0.30
270_G	289_V	0.559	0.29
136_D	162_T	0.558	0.29
531_Y	675_N	0.558	0.29
479_E	605_S	0.558	0.29
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164_E	476_D	0.557	0.29
168_S	242_S	0.557	0.29
191_Q	397_E	0.557	0.29
490_D	613_N	0.556	0.29
253_G	301_A	0.556	0.29
494_D	558_L	0.555	0.29
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247_Y	625_S	0.555	0.29
322_N	696_N	0.555	0.29
157_V	301_A	0.555	0.29
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87_F	94_Y	0.553	0.29
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209_T	580_I	0.552	0.29
644_I	651_I	0.551	0.29
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153_G	482_A	0.546	0.29
293_S	323_R	0.545	0.28
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191_Q	601_A	0.543	0.28
163_G	167_E	0.543	0.28
119_L	179_C	0.543	0.28
719_L	723_K	0.543	0.28
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511_R	613_N	0.539	0.28
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105_H	166_Y	0.537	0.28
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141_M	475_L	0.536	0.28
299_G	383_E	0.535	0.28
164_E	167_E	0.535	0.28
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123_Y	127_E	0.535	0.28
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635_I	685_M	0.534	0.28
154_K	624_T	0.532	0.28
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191_Q	194_K	0.531	0.27
298_R	621_P	0.529	0.27
691_Q	728_T	0.528	0.27
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440_L	514_G	0.526	0.27
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563_G	612_R	0.523	0.27
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437_N	621_P	0.520	0.27
407_A	644_I	0.520	0.27
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99_P	168_S	0.518	0.27
274_F	349_K	0.518	0.27
164_E	168_S	0.518	0.27
467_F	481_L	0.518	0.27
435_Q	446_T	0.517	0.26
85_A	538_N	0.517	0.26
117_N	133_T	0.517	0.26
439_C	621_P	0.516	0.26
105_H	171_F	0.516	0.26
416_N	419_H	0.516	0.26
375_F	379_Y	0.515	0.26
225_C	694_S	0.515	0.26
315_S	391_Q	0.515	0.26
103_Y	381_K	0.515	0.26
156_L	165_I	0.514	0.26
339_I	342_L	0.514	0.26
221_Q	324_G	0.513	0.26
362_P	369_F	0.513	0.26
580_I	633_N	0.513	0.26
482_A	689_I	0.512	0.26
205_I	485_A	0.512	0.26
350_G	395_A	0.512	0.26
381_K	384_K	0.511	0.26
441_E	462_C	0.511	0.26
281_F	625_S	0.511	0.26
558_L	613_N	0.511	0.26
208_P	248_V	0.510	0.26
596_H	603_R	0.510	0.26
129_K	569_N	0.510	0.26
441_E	621_P	0.509	0.26
87_F	99_P	0.509	0.26
673_P	676_D	0.508	0.26
84_L	183_N	0.508	0.26
286_Q	327_G	0.508	0.26
402_M	406_R	0.508	0.26
96_Q	129_K	0.508	0.26
524_L	539_L	0.508	0.26
397_E	586_D	0.507	0.26
525_A	657_P	0.507	0.26
134_F	193_V	0.507	0.26
308_M	313_V	0.507	0.26
257_N	365_Y	0.506	0.26
211_I	215_V	0.506	0.26
617_S	687_K	0.506	0.26
142_T	202_T	0.506	0.26
95_G	99_P	0.506	0.26
180_L	488_A	0.505	0.26
94_Y	104_D	0.505	0.26
75_P	82_A	0.505	0.26
86_I	95_G	0.504	0.26
111_E	129_K	0.503	0.26
139_R	202_T	0.503	0.26
350_G	533_D	0.503	0.26
476_D	480_E	0.503	0.26
266_S	351_E	0.503	0.26
88_H	108_K	0.502	0.25
130_Q	384_K	0.502	0.25
308_M	339_I	0.501	0.25
94_Y	168_S	0.501	0.25
317_L	337_V	0.501	0.25
86_I	94_Y	0.501	0.25
214_G	466_A	0.500	0.25
520_F	524_L	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2xapA	4	0.9553	100	0.099	Contact Map
3hncA	2	0.9106	100	0.138	Contact Map
3k8tA	2	0.7832	100	0.142	Contact Map
2wghA	2	0.8068	100	0.218	Contact Map
1peqA	2	0.8397	100	0.227	Contact Map
3o0qA	2	0.707	100	0.314	Contact Map
1l1lA	1	0.6649	100	0.49	Contact Map
4u3eA	2	0.7162	99.7	0.931	Contact Map
1h7bA	2	0.5795	68.8	0.984	Contact Map
2ebuA	1	0.1314	17.5	0.989	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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