GREMLIN Database
SODM - Superoxide dismutase [Mn]
UniProt: P00448 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10953
Length: 206 (189)
Sequences: 4172 (2341)
Seq/√Len: 170.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_Q37_N4.0831.00
181_R184_D2.9911.00
100_K104_E2.5871.00
112_N115_A2.5751.00
197_E200_A2.5211.00
22_Q179_Q2.4721.00
135_K140_A2.4311.00
121_A130_A2.3941.00
38_N41_A2.3171.00
21_K25_E2.2811.00
197_E201_R2.2291.00
99_L199_A2.2211.00
167_L186_I2.1811.00
18_H191_N2.1421.00
115_A119_K2.1111.00
101_A104_E1.9631.00
89_L189_F1.9431.00
106_D138_K1.9201.00
118_E187_K1.8931.00
124_R143_S1.8791.00
20_D177_K1.8711.00
87_K197_E1.8701.00
184_D187_K1.8551.00
102_A202_F1.8101.00
112_N116_E1.7981.00
12_Y29_T1.7881.00
102_A105_R1.7811.00
165_M198_A1.7591.00
19_F85_F1.7581.00
121_A167_L1.7551.00
36_V79_H1.7361.00
121_A186_I1.7051.00
52_L60_K1.6461.00
41_A44_E1.6191.00
199_A203_A1.6171.00
119_K123_S1.6091.00
39_A76_A1.5991.00
116_E119_K1.5981.00
4_T7_S1.5921.00
37_N41_A1.5851.00
133_V142_V1.5801.00
13_D21_K1.5591.00
102_A106_D1.5051.00
113_F117_F1.5051.00
98_D203_A1.4771.00
6_P83_S1.4751.00
32_H86_W1.4691.00
53_P56_E1.4301.00
167_L189_F1.4161.00
176_L179_Q1.4151.00
118_E122_A1.4121.00
122_A183_P1.3961.00
88_G198_A1.3911.00
122_A186_I1.3861.00
79_H83_S1.3711.00
134_L202_F1.3611.00
45_S50_A1.3251.00
178_F188_E1.3161.00
22_Q25_E1.2981.00
24_M85_F1.2891.00
98_D101_A1.2881.00
131_W144_T1.2861.00
11_A14_A1.2791.00
118_E186_I1.2571.00
133_V140_A1.2511.00
43_L46_L1.2471.00
94_T111_D1.2351.00
12_Y25_E1.2161.00
87_K201_R1.2061.00
25_E29_T1.2011.00
135_K161_G1.2001.00
5_L28_H1.1971.00
190_W193_V1.1961.00
193_V198_A1.1841.00
38_N75_N1.1831.00
88_G197_E1.1831.00
140_A161_G1.1791.00
39_A72_L1.1781.00
26_I179_Q1.1771.00
94_T100_K1.1671.00
118_E190_W1.1601.00
169_V182_R1.1351.00
196_D199_A1.1341.00
130_A143_S1.1301.00
77_G147_Q1.1231.00
9_P87_K1.1191.00
164_I198_A1.1111.00
124_R130_A1.1081.00
109_S112_N1.1011.00
120_A141_V1.0971.00
110_V113_F1.0971.00
117_F167_L1.0931.00
120_A130_A1.0901.00
174_Y182_R1.0871.00
12_Y28_H1.0791.00
3_Y39_A1.0771.00
83_S87_K1.0701.00
80_A149_S1.0661.00
85_F185_Y1.0450.99
115_A187_K1.0330.99
94_T104_E1.0300.99
34_T38_N1.0280.99
98_D199_A1.0190.99
194_N197_E1.0170.99
80_A84_L1.0060.99
96_Q199_A1.0050.99
31_H175_Y0.9980.99
88_G201_R0.9940.99
73_R148_D0.9920.99
189_F193_V0.9900.99
3_Y43_L0.9880.99
188_E191_N0.9860.99
84_L197_E0.9820.99
119_K122_A0.9760.99
133_V161_G0.9610.99
101_A105_R0.9610.99
111_D114_K0.9610.99
120_A143_S0.9600.99
113_F141_V0.9530.99
165_M193_V0.9510.99
103_I113_F0.9330.99
23_T177_K0.9300.99
46_L49_F0.9300.99
117_F189_F0.9280.99
61_L69_K0.9160.99
46_L50_A0.9130.99
20_D23_T0.9120.99
184_D188_E0.9080.98
142_V161_G0.9010.98
196_D200_A0.8950.98
12_Y21_K0.8950.98
32_H83_S0.8930.98
89_L192_V0.8890.98
36_V40_N0.8720.98
103_I110_V0.8690.98
78_G147_Q0.8660.98
22_Q177_K0.8580.98
85_F167_L0.8530.98
153_G161_G0.8490.98
90_K196_D0.8330.97
54_V80_A0.8270.97
102_A134_L0.8270.97
74_N125_F0.8210.97
29_T33_Q0.8200.97
99_L202_F0.8150.97
116_E120_A0.8070.97
135_K138_K0.8040.97
49_F52_L0.8010.97
110_V114_K0.7990.97
97_G101_A0.7920.96
90_K194_N0.7910.96
52_L56_E0.7900.96
6_P32_H0.7880.96
99_L198_A0.7860.96
10_Y89_L0.7810.96
30_K181_R0.7800.96
34_T37_N0.7770.96
13_D16_E0.7700.96
95_L110_V0.7680.96
124_R145_A0.7620.95
99_L103_I0.7560.95
22_Q26_I0.7530.95
79_H86_W0.7470.95
95_L100_K0.7450.95
94_T114_K0.7360.95
32_H79_H0.7270.94
134_L162_F0.7260.94
106_D139_L0.7250.94
58_I61_L0.7230.94
130_A167_L0.7180.94
44_E50_A0.7150.94
12_Y24_M0.7110.94
48_E52_L0.7080.93
5_L32_H0.6980.93
56_E60_K0.6960.93
82_H168_D0.6950.93
134_L164_I0.6940.93
70_T73_R0.6910.93
111_D115_A0.6880.92
107_F116_E0.6840.92
30_K180_N0.6840.92
16_E21_K0.6810.92
105_R138_K0.6790.92
100_K110_V0.6770.92
34_T122_A0.6740.92
114_K118_E0.6730.92
19_F185_Y0.6700.91
18_H188_E0.6670.91
96_Q196_D0.6660.91
3_Y57_L0.6640.91
80_A151_L0.6630.91
131_W166_G0.6610.91
127_S146_N0.6610.91
7_S11_A0.6600.91
81_N131_W0.6550.90
84_L201_R0.6530.90
114_K191_N0.6490.90
41_A45_S0.6480.90
30_K33_Q0.6430.90
97_G100_K0.6390.89
38_N71_V0.6370.89
27_H82_H0.6310.89
46_L68_K0.6270.88
104_E109_S0.6270.88
114_K190_W0.6270.88
149_S152_M0.6240.88
19_F24_M0.6190.88
36_V83_S0.6160.88
35_Y78_G0.6150.87
114_K187_K0.6150.87
5_L33_Q0.6100.87
134_L137_D0.6090.87
19_F89_L0.6080.87
128_G169_V0.6050.87
33_Q36_V0.6030.86
195_W198_A0.6020.86
24_M185_Y0.5990.86
43_L57_L0.5990.86
178_F184_D0.5960.86
96_Q100_K0.5960.86
93_T97_G0.5910.85
97_G110_V0.5900.85
148_D153_G0.5890.85
18_H189_F0.5880.85
107_F139_L0.5870.85
200_A203_A0.5790.84
39_A54_V0.5790.84
132_L139_L0.5770.84
27_H168_D0.5770.84
166_G185_Y0.5760.84
142_V152_M0.5750.84
77_G81_N0.5740.84
73_R147_Q0.5700.83
124_R141_V0.5690.83
18_H192_V0.5680.83
73_R78_G0.5650.83
93_T96_Q0.5650.83
183_P187_K0.5650.83
123_S143_S0.5620.82
50_A55_E0.5610.82
130_A169_V0.5570.82
98_D202_F0.5560.82
168_D172_H0.5540.81
45_S48_E0.5490.81
144_T153_G0.5470.81
54_V61_L0.5470.81
153_G160_S0.5450.80
116_E141_V0.5440.80
82_H172_H0.5440.80
131_W150_P0.5410.80
26_I176_L0.5400.80
90_K93_T0.5380.80
7_S29_T0.5370.79
120_A124_R0.5370.79
26_I29_T0.5330.79
147_Q166_G0.5320.79
5_L36_V0.5320.79
69_K153_G0.5310.79
97_G199_A0.5300.79
31_H180_N0.5230.78
42_A72_L0.5230.78
110_V190_W0.5200.77
49_F69_K0.5160.77
79_H85_F0.5140.76
121_A169_V0.5120.76
55_E59_T0.5110.76
106_D140_A0.5100.76
26_I181_R0.5090.76
20_D26_I0.5090.76
92_G97_G0.5080.76
96_Q110_V0.5070.75
27_H172_H0.5070.75
175_Y180_N0.5070.75
177_K192_V0.5060.75
152_M161_G0.5050.75
39_A43_L0.5040.75
22_Q176_L0.5030.75
9_P194_N0.5030.75
61_L68_K0.5020.75
88_G164_I0.5020.75
73_R152_M0.5010.75
61_L152_M0.5010.75
50_A54_V0.5000.74
56_E59_T0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rcvA 2 0.9612 100 0.006 Contact Map
1gv3A 2 0.966 100 0.008 Contact Map
3kkyA 2 0.9854 100 0.011 Contact Map
3tjtA 2 0.966 100 0.012 Contact Map
1mngA 3 0.9417 100 0.012 Contact Map
1xreA 2 0.966 100 0.019 Contact Map
1ix9A 2 0.9951 100 0.02 Contact Map
2cw2A 2 0.932 100 0.028 Contact Map
4f6eA 4 0.8883 100 0.034 Contact Map
3tqjA 2 0.9175 100 0.034 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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