FRDA - ECOLI - GREMLIN Contacts

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FRDA - Fumarate reductase flavoprotein subunit

UniProt:	P00363	Sequences: MQTFQADLAIVGAGGAGLRAAIAAAQANPNAKIALISKVYPMRSHTVAAEGGSAAVAQDHDSFEYHFHDTVAGGDWLCEQDVVDYFVHHCPTEMTQLELWGCPWSRRPDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLQFPQIQRFDEHFVLDILVDDGHVRGLVAMNMMEGTLVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGLPGSGILMTEGCRGEGGILVNKNGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRKGNTISTPRGDVVYLDLRHLGEKKLHERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEQATERAATAGNGNEAAIEAQAAGVEQRLKDLVNQDGGENWAKIRDEMGLAMEEGCGIYRTPELMQKTIDKLAELQERFKRVRITDTSSVFNTDLLYTIELGHGLNVAECMAHSAMARKESRGAHQRLDEGCTERDDVNFLKHTLAFRDADGTTRLEYSDVKITTLPPAKRVYGGEADAADKAEAANKKEKANG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10330
Length:	602 (520)
Sequences:	5440 (2809)
Seq/√Len:	123.2

ECOLI - FRDA SDHA NADB
BACSU - SDHA NADB
HALSA - Q9HQ66 NADB
SULSO - Q97W79 NADB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_A	171_L	3.900	1.00
268_G	282_Y	3.870	1.00
365_D	369_E	3.852	1.00
158_V	216_M	3.414	1.00
84_D	88_H	3.306	1.00
6_A	34_A	3.265	1.00
261_Y	266_D	3.215	1.00
78_C	83_V	3.131	1.00
257_N	261_Y	3.070	1.00
464_C	520_A	2.984	1.00
86_F	386_L	2.937	1.00
20_A	190_V	2.902	1.00
470_P	527_K	2.871	1.00
463_G	475_K	2.851	1.00
484_Q	517_E	2.839	1.00
257_N	298_E	2.661	1.00
175_N	178_E	2.628	1.00
470_P	474_Q	2.592	1.00
244_M	248_C	2.562	1.00
376_F	410_Q	2.562	1.00
265_Q	283_M	2.538	1.00
153_F	184_I	2.513	1.00
477_I	520_A	2.452	1.00
89_H	406_L	2.430	1.00
11_V	171_L	2.423	1.00
262_R	284_E	2.398	1.00
143_T	146_Q	2.353	1.00
527_K	540_C	2.352	1.00
469_T	536_L	2.349	1.00
218_L	518_C	2.327	1.00
455_E	479_K	2.327	1.00
34_A	153_F	2.308	1.00
32_K	151_Q	2.303	1.00
15_G	400_L	2.292	1.00
481_A	517_E	2.268	1.00
474_Q	524_M	2.261	1.00
362_I	381_C	2.239	1.00
5_Q	185_R	2.222	1.00
20_A	378_V	2.180	1.00
464_C	476_T	2.133	1.00
24_A	411_A	2.132	1.00
65_Y	122_I	2.122	1.00
85_Y	406_L	2.112	1.00
369_E	410_Q	2.109	1.00
15_G	46_T	2.103	1.00
469_T	472_L	2.037	1.00
135_H	138_H	2.034	1.00
214_M	224_L	2.005	1.00
377_A	381_C	2.005	1.00
223_P	371_R	2.004	1.00
160_D	219_S	2.004	1.00
36_I	173_A	1.997	1.00
295_F	313_V	1.991	1.00
191_M	362_I	1.977	1.00
7_D	187_N	1.973	1.00
256_V	318_R	1.950	1.00
322_E	326_H	1.939	1.00
256_V	348_P	1.939	1.00
86_F	403_F	1.930	1.00
480_L	520_A	1.927	1.00
236_G	354_T	1.926	1.00
24_A	408_G	1.915	1.00
173_A	184_I	1.869	1.00
464_C	473_M	1.864	1.00
190_V	411_A	1.859	1.00
318_R	348_P	1.841	1.00
459_A	476_T	1.836	1.00
333_C	337_K	1.829	1.00
191_M	381_C	1.809	1.00
34_A	184_I	1.780	1.00
460_M	464_C	1.767	1.00
370_T	377_A	1.764	1.00
455_E	486_R	1.756	1.00
196_A	358_T	1.727	1.00
477_I	517_E	1.727	1.00
248_C	253_G	1.719	1.00
46_T	137_L	1.718	1.00
254_I	262_R	1.715	1.00
75_D	543_R	1.709	1.00
80_Q	84_D	1.699	1.00
175_N	182_V	1.690	1.00
477_I	521_H	1.689	1.00
217_A	362_I	1.676	1.00
93_E	96_Q	1.670	1.00
199_V	519_M	1.661	1.00
219_S	511_H	1.661	1.00
166_G	373_K	1.661	1.00
107_R	111_S	1.660	1.00
297_H	301_K	1.657	1.00
326_H	333_C	1.637	1.00
224_L	227_M	1.636	1.00
67_F	84_D	1.634	1.00
193_T	213_G	1.631	1.00
25_A	147_F	1.627	1.00
167_H	374_G	1.616	1.00
168_V	189_V	1.610	1.00
459_A	479_K	1.605	1.00
74_G	78_C	1.599	1.00
367_N	410_Q	1.599	1.00
56_V	63_F	1.589	1.00
456_M	480_L	1.576	1.00
470_P	535_R	1.572	1.00
82_V	366_Q	1.571	1.00
217_A	222_V	1.567	1.00
447_E	486_R	1.544	1.00
368_C	407_A	1.537	1.00
408_G	412_T	1.533	1.00
223_P	363_E	1.525	1.00
317_L	320_L	1.522	1.00
364_T	382_S	1.516	1.00
463_G	476_T	1.508	1.00
326_H	345_V	1.506	1.00
407_A	411_A	1.494	1.00
8_L	24_A	1.494	1.00
322_E	345_V	1.490	1.00
298_E	303_N	1.481	1.00
38_K	508_E	1.480	1.00
479_K	482_E	1.473	1.00
162_L	183_Q	1.470	1.00
43_R	48_A	1.453	1.00
144_S	152_R	1.450	1.00
484_Q	514_N	1.448	1.00
23_A	409_E	1.447	1.00
63_F	67_F	1.447	1.00
38_K	212_D	1.439	1.00
476_T	520_A	1.437	1.00
186_A	189_V	1.431	1.00
82_V	86_F	1.430	1.00
477_I	524_M	1.429	1.00
167_H	373_K	1.427	1.00
204_T	236_G	1.424	1.00
95_T	99_L	1.424	1.00
63_F	88_H	1.420	1.00
6_A	32_K	1.419	1.00
188_A	414_R	1.415	1.00
67_F	71_V	1.413	1.00
200_Y	464_C	1.407	1.00
38_K	210_T	1.404	1.00
89_H	92_T	1.401	1.00
359_M	532_A	1.391	1.00
98_E	112_V	1.390	1.00
463_G	472_L	1.386	1.00
93_E	405_R	1.383	1.00
161_I	168_V	1.377	1.00
410_Q	414_R	1.377	1.00
53_S	136_M	1.374	1.00
293_Q	534_Q	1.364	1.00
6_A	151_Q	1.362	1.00
517_E	521_H	1.361	1.00
190_V	378_V	1.360	1.00
102_C	136_M	1.359	1.00
46_T	400_L	1.357	1.00
26_Q	147_F	1.355	1.00
470_P	524_M	1.351	1.00
191_M	375_L	1.350	1.00
333_C	345_V	1.349	1.00
245_T	248_C	1.341	1.00
6_A	9_A	1.340	1.00
408_G	411_A	1.336	1.00
11_V	191_M	1.334	1.00
197_G	355_A	1.325	1.00
212_D	511_H	1.321	1.00
153_F	156_H	1.311	1.00
225_R	363_E	1.307	1.00
201_R	458_L	1.306	1.00
6_A	153_F	1.305	1.00
8_L	190_V	1.304	1.00
191_M	217_A	1.303	1.00
196_A	230_V	1.295	1.00
464_C	519_M	1.290	1.00
225_R	383_S	1.286	1.00
245_T	332_I	1.282	1.00
18_L	144_S	1.280	1.00
54_A	394_S	1.279	1.00
458_L	462_E	1.268	1.00
263_Y	267_Y	1.266	1.00
296_W	300_R	1.263	1.00
13_A	37_S	1.261	1.00
474_Q	478_D	1.255	1.00
158_V	171_L	1.247	0.99
156_H	173_A	1.240	0.99
156_H	175_N	1.233	0.99
523_A	533_H	1.233	0.99
410_Q	413_E	1.229	0.99
36_I	171_L	1.225	0.99
22_I	144_S	1.217	0.99
16_A	378_V	1.216	0.99
82_V	386_L	1.216	0.99
35_L	152_R	1.215	0.99
54_A	120_M	1.213	0.99
255_L	351_V	1.212	0.99
63_F	87_V	1.211	0.99
228_E	526_R	1.208	0.99
162_L	172_V	1.206	0.99
158_V	173_A	1.203	0.99
411_A	415_A	1.200	0.99
320_L	324_K	1.197	0.99
144_S	150_I	1.197	0.99
145_L	154_D	1.188	0.99
19_R	23_A	1.184	0.99
89_H	93_E	1.179	0.99
463_G	479_K	1.178	0.99
545_D	548_F	1.177	0.99
376_F	414_R	1.177	0.99
254_I	284_E	1.172	0.99
405_R	409_E	1.171	0.99
262_R	265_Q	1.171	0.99
251_E	328_R	1.170	0.99
219_S	514_N	1.170	0.99
64_E	68_H	1.161	0.99
67_F	87_V	1.155	0.99
66_H	395_N	1.152	0.99
68_H	72_A	1.149	0.99
321_G	324_K	1.145	0.99
90_C	398_A	1.140	0.99
156_H	182_V	1.140	0.99
342_V	347_E	1.137	0.99
470_P	540_C	1.135	0.99
102_C	135_H	1.134	0.99
214_M	515_V	1.132	0.99
64_E	84_D	1.129	0.99
196_A	519_M	1.128	0.99
35_L	144_S	1.126	0.99
9_A	36_I	1.126	0.99
160_D	216_M	1.122	0.99
404_G	408_G	1.120	0.99
487_F	513_L	1.115	0.99
120_M	394_S	1.113	0.99
436_R	510_G	1.108	0.99
474_Q	477_I	1.090	0.99
343_D	346_K	1.089	0.99
85_Y	366_Q	1.088	0.99
323_K	327_E	1.087	0.99
125_T	394_S	1.084	0.99
263_Y	266_D	1.083	0.99
222_V	375_L	1.083	0.99
8_L	411_A	1.083	0.99
475_K	479_K	1.080	0.99
66_H	70_T	1.079	0.99
23_A	408_G	1.075	0.98
20_A	407_A	1.075	0.98
454_D	458_L	1.072	0.98
325_L	333_C	1.069	0.98
364_T	377_A	1.059	0.98
23_A	405_R	1.059	0.98
214_M	358_T	1.059	0.98
20_A	411_A	1.057	0.98
453_R	457_G	1.054	0.98
96_Q	405_R	1.052	0.98
18_L	35_L	1.051	0.98
7_D	32_K	1.051	0.98
85_Y	89_H	1.049	0.98
322_E	346_K	1.044	0.98
116_R	123_E	1.044	0.98
134_F	138_H	1.040	0.98
11_V	158_V	1.040	0.98
85_Y	403_F	1.038	0.98
102_C	139_T	1.036	0.98
83_V	87_V	1.030	0.98
459_A	463_G	1.030	0.98
77_L	530_R	1.026	0.98
143_T	147_F	1.025	0.98
91_P	95_T	1.015	0.98
188_A	376_F	1.015	0.98
67_F	80_Q	1.015	0.98
481_A	521_H	1.013	0.98
164_D	169_R	1.005	0.98
157_F	507_I	1.003	0.98
522_S	552_T	0.999	0.98
131_K	331_F	0.998	0.98
172_V	181_L	0.996	0.98
456_M	509_L	0.995	0.98
112_V	126_W	0.995	0.98
431_A	435_Q	0.988	0.97
302_G	310_G	0.985	0.97
172_V	183_Q	0.984	0.97
362_I	377_A	0.983	0.97
161_I	171_L	0.982	0.97
453_R	512_G	0.981	0.97
546_V	549_L	0.978	0.97
41_P	141_F	0.976	0.97
527_K	548_F	0.975	0.97
266_D	298_E	0.975	0.97
334_E	338_A	0.974	0.97
467_Y	536_L	0.969	0.97
386_L	403_F	0.968	0.97
369_E	414_R	0.967	0.97
105_S	127_F	0.961	0.97
314_Y	348_P	0.958	0.97
298_E	301_K	0.953	0.97
161_I	189_V	0.949	0.97
97_L	136_M	0.944	0.97
9_A	186_A	0.940	0.96
100_W	143_T	0.939	0.96
378_V	407_A	0.939	0.96
286_G	290_K	0.937	0.96
188_A	415_A	0.936	0.96
65_Y	121_K	0.936	0.96
468_R	523_A	0.934	0.96
103_P	135_H	0.928	0.96
222_V	371_R	0.927	0.96
459_A	483_L	0.922	0.96
325_L	345_V	0.921	0.96
23_A	26_Q	0.918	0.96
248_C	317_L	0.918	0.96
364_T	403_F	0.916	0.96
254_I	319_H	0.915	0.96
227_M	519_M	0.914	0.96
364_T	384_V	0.914	0.96
266_D	301_K	0.910	0.96
412_T	415_A	0.909	0.96
120_M	125_T	0.907	0.96
267_Y	294_A	0.907	0.96
157_F	508_E	0.905	0.96
263_Y	268_G	0.905	0.96
222_V	372_I	0.904	0.96
163_V	168_V	0.903	0.96
211_G	515_V	0.901	0.96
70_T	395_N	0.901	0.96
265_Q	284_E	0.901	0.96
22_I	100_W	0.899	0.95
21_A	150_I	0.899	0.95
317_L	325_L	0.898	0.95
215_G	515_V	0.897	0.95
57_A	126_W	0.896	0.95
19_R	93_E	0.895	0.95
264_L	267_Y	0.894	0.95
47_V	134_F	0.894	0.95
326_H	337_K	0.891	0.95
81_D	366_Q	0.885	0.95
256_V	316_D	0.885	0.95
25_A	33_I	0.883	0.95
201_R	461_E	0.878	0.95
286_G	291_V	0.877	0.95
453_R	509_L	0.877	0.95
265_Q	268_G	0.877	0.95
92_T	95_T	0.875	0.95
479_K	483_L	0.872	0.95
23_A	96_Q	0.871	0.95
86_F	398_A	0.868	0.95
477_I	481_A	0.864	0.94
142_Q	146_Q	0.863	0.94
192_A	378_V	0.862	0.94
53_S	94_M	0.861	0.94
96_Q	100_W	0.861	0.94
456_M	513_L	0.859	0.94
336_A	344_P	0.858	0.94
267_Y	298_E	0.857	0.94
262_R	283_M	0.855	0.94
473_M	520_A	0.854	0.94
480_L	517_E	0.853	0.94
223_P	555_F	0.853	0.94
141_F	152_R	0.852	0.94
22_I	147_F	0.851	0.94
210_T	508_E	0.848	0.94
215_G	219_S	0.848	0.94
267_Y	297_H	0.847	0.94
119_G	359_M	0.846	0.94
115_R	251_E	0.846	0.94
187_N	415_A	0.839	0.93
39_V	208_I	0.837	0.93
25_A	149_Q	0.833	0.93
9_A	34_A	0.832	0.93
8_L	31_A	0.831	0.93
456_M	483_L	0.830	0.93
260_G	268_G	0.829	0.93
335_L	338_A	0.829	0.93
82_V	85_Y	0.828	0.93
258_K	310_G	0.828	0.93
123_E	251_E	0.828	0.93
414_R	418_A	0.826	0.93
67_F	83_V	0.826	0.93
452_I	509_L	0.826	0.93
336_A	342_V	0.825	0.93
230_V	519_M	0.825	0.93
71_V	83_V	0.824	0.93
433_V	436_R	0.821	0.93
263_Y	269_M	0.820	0.93
10_I	33_I	0.820	0.93
163_V	166_G	0.818	0.93
460_M	516_A	0.815	0.92
227_M	515_V	0.813	0.92
87_V	90_C	0.811	0.92
521_H	525_A	0.807	0.92
53_S	398_A	0.807	0.92
264_L	283_M	0.804	0.92
342_V	349_I	0.803	0.92
164_D	167_H	0.803	0.92
8_L	28_N	0.802	0.92
223_P	553_L	0.801	0.92
216_M	219_S	0.800	0.92
188_A	411_A	0.799	0.92
9_A	189_V	0.797	0.92
106_R	112_V	0.797	0.92
367_N	406_L	0.796	0.92
299_W	312_V	0.795	0.92
264_L	268_G	0.794	0.91
227_M	522_S	0.792	0.91
451_K	455_E	0.792	0.91
467_Y	534_Q	0.788	0.91
300_R	536_L	0.788	0.91
137_L	141_F	0.786	0.91
253_G	317_L	0.786	0.91
428_A	431_A	0.785	0.91
430_A	433_V	0.784	0.91
118_G	282_Y	0.781	0.91
22_I	143_T	0.781	0.91
333_C	344_P	0.781	0.91
71_V	78_C	0.780	0.91
484_Q	513_L	0.776	0.91
103_P	139_T	0.776	0.91
89_H	405_R	0.775	0.90
297_H	467_Y	0.774	0.90
68_H	80_Q	0.773	0.90
408_G	415_A	0.773	0.90
128_A	135_H	0.771	0.90
218_L	556_R	0.771	0.90
411_A	414_R	0.771	0.90
198_R	457_G	0.770	0.90
200_Y	519_M	0.770	0.90
300_R	462_E	0.770	0.90
187_N	419_G	0.762	0.90
263_Y	284_E	0.760	0.90
45_H	209_V	0.759	0.90
27_A	413_E	0.759	0.90
25_A	150_I	0.757	0.89
5_Q	32_K	0.755	0.89
294_A	298_E	0.747	0.89
409_E	413_E	0.742	0.88
163_V	169_R	0.741	0.88
246_E	249_R	0.739	0.88
71_V	80_Q	0.738	0.88
175_N	180_T	0.738	0.88
244_M	349_I	0.736	0.88
257_N	263_Y	0.736	0.88
24_A	28_N	0.735	0.88
55_A	94_M	0.735	0.88
115_R	127_F	0.734	0.88
263_Y	295_F	0.732	0.88
336_A	349_I	0.731	0.88
190_V	407_A	0.730	0.88
79_E	383_S	0.729	0.88
20_A	24_A	0.729	0.88
249_R	252_G	0.728	0.87
63_F	91_P	0.727	0.87
166_G	372_I	0.727	0.87
471_E	475_K	0.726	0.87
226_D	551_H	0.725	0.87
56_V	87_V	0.724	0.87
364_T	368_C	0.724	0.87
481_A	485_E	0.723	0.87
199_V	515_V	0.723	0.87
96_Q	99_L	0.723	0.87
34_A	151_Q	0.723	0.87
39_V	43_R	0.723	0.87
369_E	376_F	0.721	0.87
35_L	41_P	0.721	0.87
41_P	152_R	0.720	0.87
229_F	526_R	0.720	0.87
9_A	184_I	0.720	0.87
24_A	31_A	0.720	0.87
447_E	451_K	0.719	0.87
197_G	203_N	0.718	0.87
434_E	438_K	0.716	0.87
117_F	125_T	0.715	0.87
413_E	417_T	0.714	0.86
224_L	518_C	0.714	0.86
233_H	246_E	0.713	0.86
198_R	512_G	0.708	0.86
103_P	106_R	0.708	0.86
378_V	404_G	0.708	0.86
167_H	414_R	0.707	0.86
187_N	420_N	0.706	0.86
447_E	455_E	0.705	0.86
337_K	345_V	0.705	0.86
15_G	140_L	0.704	0.86
268_G	287_P	0.701	0.85
529_S	534_Q	0.701	0.85
169_R	185_R	0.700	0.85
463_G	520_A	0.698	0.85
482_E	486_R	0.698	0.85
45_H	48_A	0.698	0.85
196_A	214_M	0.696	0.85
449_W	506_T	0.696	0.85
27_A	412_T	0.696	0.85
230_V	358_T	0.695	0.85
10_I	190_V	0.695	0.85
47_V	138_H	0.695	0.85
530_R	541_T	0.694	0.85
256_V	314_Y	0.694	0.85
204_T	354_T	0.693	0.85
522_S	554_A	0.692	0.85
471_E	474_Q	0.691	0.85
215_G	511_H	0.690	0.85
19_R	96_Q	0.688	0.84
260_G	267_Y	0.687	0.84
53_S	401_V	0.686	0.84
483_L	513_L	0.685	0.84
13_A	35_L	0.685	0.84
41_P	154_D	0.684	0.84
474_Q	521_H	0.683	0.84
213_G	381_C	0.682	0.84
159_L	433_V	0.681	0.84
454_D	457_G	0.680	0.84
289_D	293_Q	0.680	0.84
98_E	106_R	0.680	0.84
432_G	435_Q	0.679	0.84
155_E	177_M	0.678	0.84
156_H	184_I	0.677	0.83
202_Y	461_E	0.676	0.83
482_E	485_E	0.676	0.83
462_E	472_L	0.676	0.83
55_A	126_W	0.675	0.83
248_C	325_L	0.672	0.83
485_E	488_K	0.671	0.83
188_A	374_G	0.671	0.83
117_F	394_S	0.669	0.83
261_Y	298_E	0.669	0.83
530_R	540_C	0.669	0.83
193_T	381_C	0.669	0.83
6_A	184_I	0.668	0.83
518_C	554_A	0.668	0.83
113_N	127_F	0.667	0.83
468_R	533_H	0.665	0.82
168_V	372_I	0.665	0.82
54_A	87_V	0.664	0.82
92_T	405_R	0.664	0.82
160_D	220_H	0.664	0.82
32_K	149_Q	0.663	0.82
10_I	20_A	0.663	0.82
452_I	455_E	0.663	0.82
173_A	182_V	0.663	0.82
288_R	292_S	0.662	0.82
428_A	432_G	0.661	0.82
527_K	547_N	0.660	0.82
380_E	391_R	0.660	0.82
443_Q	446_G	0.659	0.82
325_L	344_P	0.657	0.82
36_I	184_I	0.657	0.82
31_A	412_T	0.657	0.82
141_F	145_L	0.654	0.81
176_M	504_L	0.653	0.81
257_N	266_D	0.651	0.81
258_K	302_G	0.650	0.81
296_W	466_I	0.649	0.81
427_E	431_A	0.649	0.81
159_L	181_L	0.648	0.81
40_Y	154_D	0.645	0.80
218_L	514_N	0.645	0.80
475_K	478_D	0.644	0.80
15_G	401_V	0.644	0.80
187_N	421_G	0.643	0.80
125_T	393_G	0.640	0.80
25_A	412_T	0.638	0.80
225_R	384_V	0.637	0.80
93_E	401_V	0.636	0.79
369_E	373_K	0.636	0.79
296_W	467_Y	0.636	0.79
45_H	206_G	0.635	0.79
58_Q	122_I	0.633	0.79
528_E	541_T	0.632	0.79
160_D	433_V	0.631	0.79
294_A	297_H	0.630	0.79
244_M	332_I	0.629	0.79
480_L	513_L	0.628	0.79
98_E	126_W	0.628	0.79
159_L	174_M	0.628	0.79
215_G	514_N	0.628	0.79
171_L	186_A	0.628	0.79
243_L	246_E	0.627	0.78
233_H	249_R	0.626	0.78
190_V	415_A	0.625	0.78
299_W	352_R	0.625	0.78
7_D	34_A	0.624	0.78
62_S	65_Y	0.623	0.78
378_V	400_L	0.623	0.78
114_V	126_W	0.622	0.78
139_T	143_T	0.622	0.78
426_I	430_A	0.620	0.78
31_A	415_A	0.616	0.77
356_H	392_L	0.616	0.77
310_G	313_V	0.614	0.77
296_W	299_W	0.613	0.77
514_N	517_E	0.613	0.77
103_P	138_H	0.612	0.77
543_R	546_V	0.612	0.77
263_Y	298_E	0.611	0.77
159_L	172_V	0.610	0.77
239_G	340_V	0.610	0.77
357_Y	360_G	0.608	0.76
138_H	142_Q	0.608	0.76
320_L	325_L	0.608	0.76
222_V	370_T	0.608	0.76
197_G	205_N	0.608	0.76
260_G	263_Y	0.608	0.76
262_R	267_Y	0.606	0.76
53_S	56_V	0.605	0.76
196_A	199_V	0.605	0.76
317_L	321_G	0.600	0.75
548_F	551_H	0.600	0.75
453_R	508_E	0.598	0.75
210_T	511_H	0.597	0.75
56_V	66_H	0.597	0.75
54_A	66_H	0.596	0.75
374_G	414_R	0.595	0.75
455_E	458_L	0.595	0.75
455_E	482_E	0.595	0.75
450_A	505_Y	0.595	0.75
353_P	356_H	0.595	0.75
218_L	224_L	0.594	0.75
65_Y	68_H	0.593	0.75
52_G	249_R	0.593	0.75
235_T	249_R	0.593	0.75
54_A	125_T	0.593	0.75
102_C	401_V	0.592	0.74
63_F	84_D	0.592	0.74
313_V	351_V	0.592	0.74
27_A	409_E	0.591	0.74
476_T	479_K	0.589	0.74
183_Q	430_A	0.589	0.74
171_L	189_V	0.588	0.74
44_S	137_L	0.588	0.74
343_D	347_E	0.588	0.74
295_F	351_V	0.588	0.74
472_L	476_T	0.587	0.74
135_H	139_T	0.586	0.74
19_R	100_W	0.586	0.74
246_E	250_G	0.585	0.74
77_L	229_F	0.584	0.73
325_L	329_L	0.584	0.73
48_A	206_G	0.583	0.73
7_D	31_A	0.583	0.73
258_K	303_N	0.582	0.73
162_L	185_R	0.581	0.73
161_I	227_M	0.581	0.73
71_V	76_W	0.580	0.73
508_E	512_G	0.579	0.73
41_P	44_S	0.579	0.73
473_M	523_A	0.579	0.73
356_H	359_M	0.578	0.73
197_G	230_V	0.577	0.73
321_G	345_V	0.577	0.73
199_V	516_A	0.576	0.72
444_D	491_R	0.576	0.72
402_V	406_L	0.576	0.72
136_M	401_V	0.575	0.72
161_I	191_M	0.573	0.72
228_E	522_S	0.573	0.72
82_V	384_V	0.572	0.72
435_Q	438_K	0.571	0.72
322_E	343_D	0.571	0.72
452_I	513_L	0.571	0.72
202_Y	352_R	0.570	0.72
462_E	475_K	0.569	0.72
107_R	113_N	0.569	0.72
543_R	549_L	0.568	0.71
162_L	169_R	0.566	0.71
382_S	403_F	0.566	0.71
258_K	312_V	0.566	0.71
459_A	480_L	0.565	0.71
354_T	357_Y	0.563	0.71
10_I	28_N	0.563	0.71
169_R	373_K	0.562	0.71
248_C	332_I	0.562	0.71
434_E	437_L	0.561	0.70
77_L	228_E	0.561	0.70
242_I	332_I	0.561	0.70
421_G	424_A	0.560	0.70
403_F	406_L	0.559	0.70
324_K	327_E	0.559	0.70
117_F	120_M	0.559	0.70
87_V	403_F	0.559	0.70
548_F	552_T	0.557	0.70
117_F	393_G	0.556	0.70
243_L	249_R	0.556	0.70
296_W	352_R	0.556	0.70
89_H	402_V	0.556	0.70
452_I	490_V	0.556	0.70
38_K	512_G	0.554	0.70
260_G	269_M	0.553	0.69
56_V	67_F	0.552	0.69
84_D	87_V	0.552	0.69
446_G	491_R	0.551	0.69
264_L	286_G	0.551	0.69
53_S	104_W	0.551	0.69
67_F	88_H	0.551	0.69
259_N	303_N	0.549	0.69
442_N	482_E	0.548	0.69
197_G	358_T	0.548	0.69
302_G	312_V	0.548	0.69
521_H	524_M	0.548	0.69
52_G	233_H	0.546	0.68
335_L	340_V	0.546	0.68
26_Q	99_L	0.545	0.68
59_D	111_S	0.545	0.68
289_D	292_S	0.544	0.68
115_R	328_R	0.543	0.68
322_E	325_L	0.543	0.68
261_Y	265_Q	0.543	0.68
185_R	421_G	0.542	0.68
23_A	27_A	0.542	0.68
356_H	360_G	0.542	0.68
20_A	404_G	0.542	0.68
22_I	150_I	0.541	0.68
542_E	547_N	0.540	0.68
36_I	153_F	0.540	0.68
287_P	290_K	0.539	0.67
431_A	434_E	0.539	0.67
460_M	463_G	0.539	0.67
257_N	262_R	0.539	0.67
255_L	264_L	0.538	0.67
19_R	404_G	0.538	0.67
527_K	535_R	0.538	0.67
262_R	268_G	0.537	0.67
100_W	139_T	0.537	0.67
174_M	179_G	0.537	0.67
26_Q	96_Q	0.536	0.67
376_F	411_A	0.536	0.67
478_D	481_A	0.536	0.67
486_R	489_R	0.535	0.67
212_D	508_E	0.535	0.67
235_T	246_E	0.535	0.67
430_A	434_E	0.534	0.67
437_L	440_L	0.533	0.67
429_Q	432_G	0.533	0.67
244_M	351_V	0.532	0.66
481_A	484_Q	0.531	0.66
268_G	290_K	0.531	0.66
95_T	98_E	0.530	0.66
24_A	412_T	0.530	0.66
435_Q	439_D	0.529	0.66
169_R	189_V	0.529	0.66
70_T	83_V	0.529	0.66
366_Q	403_F	0.529	0.66
50_E	329_L	0.527	0.66
409_E	412_T	0.527	0.66
282_Y	290_K	0.525	0.65
23_A	404_G	0.525	0.65
258_K	314_Y	0.524	0.65
352_R	461_E	0.524	0.65
414_R	417_T	0.523	0.65
26_Q	143_T	0.523	0.65
37_S	154_D	0.523	0.65
68_H	71_V	0.522	0.65
254_I	283_M	0.521	0.65
285_L	288_R	0.521	0.65
242_I	335_L	0.521	0.65
525_A	552_T	0.520	0.65
157_F	511_H	0.520	0.65
290_K	293_Q	0.520	0.65
131_K	135_H	0.520	0.65
443_Q	495_T	0.518	0.64
213_G	220_H	0.517	0.64
547_N	550_K	0.516	0.64
453_R	456_M	0.516	0.64
424_A	428_A	0.516	0.64
404_G	411_A	0.514	0.64
58_Q	65_Y	0.514	0.64
492_I	506_T	0.514	0.64
244_M	335_L	0.513	0.64
114_V	394_S	0.512	0.64
51_G	246_E	0.511	0.63
189_V	216_M	0.510	0.63
83_V	86_F	0.509	0.63
462_E	479_K	0.509	0.63
60_H	122_I	0.508	0.63
204_T	355_A	0.508	0.63
52_G	235_T	0.508	0.63
337_K	343_D	0.506	0.63
228_E	528_E	0.506	0.63
525_A	550_K	0.505	0.62
163_V	372_I	0.505	0.62
73_G	287_P	0.505	0.62
472_L	475_K	0.505	0.62
105_S	205_N	0.504	0.62
43_R	47_V	0.503	0.62
268_G	286_G	0.503	0.62
288_R	293_Q	0.502	0.62
128_A	139_T	0.501	0.62
298_E	302_G	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1kf6A	1	0.9585	100	0.271	Contact Map
2bs2A	2	0.9734	100	0.272	Contact Map
2h88A	2	0.9352	100	0.288	Contact Map
2wdqA	1	0.9319	100	0.304	Contact Map
1chuA	2	0.7724	100	0.393	Contact Map
3gyxA	2	0.907	100	0.398	Contact Map
2e5vA	1	0.7807	100	0.423	Contact Map
1jnrA	2	0.8887	100	0.429	Contact Map
4c3xA	4	0.6229	100	0.622	Contact Map
1y0pA	1	0.6645	100	0.673	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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