GREMLIN Database
6PGD - 6-phosphogluconate dehydrogenase, decarboxylating
UniProt: P00350 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10411
Length: 468 (463)
Sequences: 1771 (921)
Seq/√Len: 42.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_K406_D4.6641.00
453_Y464_T4.1171.00
85_D114_E3.5531.00
109_I176_D3.4551.00
5_Q65_E3.3661.00
226_E322_R3.3301.00
24_S135_L3.3291.00
212_N248_Y3.1051.00
57_V90_Y3.0981.00
380_E390_A2.9681.00
214_E314_K2.9551.00
204_L321_V2.8991.00
319_E322_R2.8631.00
351_L356_I2.8461.00
211_T214_E2.7951.00
30_S63_S2.7941.00
216_A240_T2.7761.00
202_S206_G2.7141.00
411_A418_V2.7051.00
164_E362_A2.6911.00
43_I53_P2.6651.00
217_Q240_T2.6321.00
340_L351_L2.5751.00
303_L428_Y2.5551.00
352_N355_E2.4891.00
4_Q30_S2.4781.00
153_A157_T2.4501.00
220_T240_T2.4331.00
237_D447_Y2.4261.00
210_L218_T2.4231.00
125_T140_I2.3801.00
7_G60_F2.3761.00
61_V90_Y2.3751.00
215_L239_F2.3691.00
204_L210_L2.3641.00
249_L253_I2.3181.00
123_I152_V2.3011.00
96_I151_L2.2951.00
289_I430_S2.2731.00
66_T92_D2.2551.00
295_Q431_Y2.1841.00
40_E55_Y2.1741.00
408_V412_V2.1741.00
56_T59_E2.1651.00
175_A344_S2.1421.00
245_D252_V2.1320.99
78_A82_A2.1290.99
27_Y158_K2.1220.99
323_R403_A2.1080.99
213_E242_K2.0570.99
409_A413_Q2.0470.99
105_F347_Y2.0390.99
40_E44_A2.0350.99
84_I97_I2.0140.99
212_N251_D2.0010.99
293_K297_V1.9990.99
327_L404_L1.9980.99
58_K62_E1.9950.99
12_A75_K1.9900.99
198_A441_I1.9750.99
238_I443_A1.9570.99
408_V422_S1.9280.99
210_L318_I1.9110.99
69_R151_L1.8690.99
205_K212_N1.8380.98
192_G332_S1.8200.98
313_D316_E1.8080.98
375_T379_A1.7970.98
23_E49_K1.7940.98
171_T355_E1.7930.98
203_L317_F1.7890.98
11_M42_V1.7870.98
88_K118_E1.7820.98
373_K376_D1.7670.98
395_Q399_D1.7480.98
19_A31_I1.7240.98
146_K150_E1.7220.98
328_G421_F1.7200.98
204_L215_L1.7120.98
221_E224_N1.7040.97
193_D329_K1.6940.97
298_A385_A1.6790.97
319_E323_R1.6750.97
422_S426_A1.6690.97
406_D413_Q1.6660.97
80_T103_T1.6620.97
84_I115_L1.6540.97
88_K120_F1.6400.97
410_Y413_Q1.6290.97
247_N252_V1.6260.97
203_L321_V1.6230.97
6_I22_I1.6110.96
405_R429_D1.6070.96
305_G401_Q1.5870.96
167_E358_K1.5740.96
323_R399_D1.5680.96
207_G414_N1.5540.96
31_I42_V1.5530.96
233_D367_R1.5510.95
388_L397_A1.5320.95
218_T318_I1.5260.95
150_E153_A1.5140.95
320_K403_A1.5120.95
36_R40_E1.5030.95
181_Y269_S1.5030.95
270_A285_F1.4930.94
454_K461_V1.4910.94
9_V32_F1.4900.94
70_I97_I1.4860.94
200_A321_V1.4820.94
132_E136_K1.4700.94
204_L208_L1.4590.94
22_I71_L1.4530.94
454_K459_E1.4500.94
16_R45_E1.4360.93
384_I390_A1.4350.93
22_I155_I1.4330.93
24_S136_K1.4260.93
54_Y59_E1.4210.93
114_E117_A1.4190.93
306_P401_Q1.4120.93
380_E391_P1.4050.92
25_R158_K1.4050.92
208_L321_V1.4020.92
30_S54_Y1.4000.92
328_G404_L1.3980.92
221_E315_A1.3960.92
112_N116_S1.3940.92
301_K434_A1.3910.92
221_E322_R1.3890.92
303_L306_P1.3760.92
226_E319_E1.3690.91
264_K272_D1.3570.91
338_S427_Y1.3540.91
216_A239_F1.3380.90
305_G432_R1.3300.90
300_S434_A1.3250.90
22_I29_V1.3250.90
278_S331_V1.3240.90
88_K114_E1.3240.90
11_M31_I1.3220.90
124_G143_G1.3190.90
435_V456_I1.3160.90
98_I152_V1.3150.90
83_A86_S1.3120.90
354_G375_T1.3120.90
225_G322_R1.3110.90
70_I91_L1.3080.89
171_T359_I1.3050.89
409_A412_V1.3020.89
54_Y60_F1.2990.89
207_G416_I1.2980.89
249_L252_V1.2920.89
354_G379_A1.2800.88
344_S353_Y1.2650.88
103_T107_D1.2640.88
116_S145_Q1.2620.88
54_Y63_S1.2470.87
220_T224_N1.2350.86
256_E454_K1.2310.86
113_R117_A1.2280.86
344_S350_D1.2240.86
454_K460_G1.2190.86
327_L400_Y1.2180.86
343_A347_Y1.2160.86
200_A421_F1.2140.86
215_L321_V1.2120.85
12_A33_N1.2050.85
321_V421_F1.1980.85
110_R114_E1.1880.84
317_F410_Y1.1850.84
281_T285_F1.1830.84
242_K248_Y1.1820.84
37_E41_E1.1730.83
4_Q52_V1.1710.83
259_N264_K1.1650.83
73_M159_I1.1590.83
185_V266_T1.1470.82
173_I359_I1.1410.82
185_V339_Q1.1360.81
8_V71_L1.1310.81
104_F268_Q1.1200.81
341_R345_E1.1200.81
36_R55_Y1.1190.80
39_T53_P1.1190.80
164_E167_E1.1150.80
23_E135_L1.1140.80
415_G432_R1.1140.80
342_A345_E1.1130.80
204_L218_T1.1130.80
358_K375_T1.1050.80
20_L135_L1.1020.79
39_T55_Y1.1000.79
33_N39_T1.0970.79
205_K251_D1.0940.79
34_R75_K1.0930.79
417_P433_A1.0850.78
238_I444_Q1.0830.78
203_L411_A1.0790.78
73_M140_I1.0770.78
6_I98_I1.0720.78
244_E464_T1.0710.77
228_S369_Q1.0690.77
394_K398_D1.0680.77
303_L432_R1.0650.77
158_K162_V1.0600.77
139_S360_F1.0540.76
30_S60_F1.0520.76
418_V422_S1.0490.76
173_I356_I1.0450.76
75_K79_G1.0430.76
16_R135_L1.0410.75
121_N145_Q1.0390.75
412_V418_V1.0380.75
221_E225_G1.0340.75
46_N51_L1.0290.75
273_L347_Y1.0260.74
28_T50_K1.0220.74
298_A301_K1.0200.74
71_L98_I1.0160.74
267_S281_T1.0130.73
18_L159_I1.0100.73
79_G82_A1.0090.73
108_T124_G1.0050.73
437_P440_L1.0010.72
401_Q432_R0.9970.72
254_L293_K0.9930.72
35_S38_K0.9900.72
12_A34_R0.9890.72
109_I347_Y0.9870.71
295_Q386_N0.9840.71
8_V29_V0.9840.71
254_L455_R0.9800.71
175_A350_D0.9800.71
173_I178_A0.9770.71
70_I89_P0.9770.71
299_A431_Y0.9770.71
305_G428_Y0.9720.70
60_F63_S0.9680.70
202_S437_P0.9630.70
149_Y171_T0.9580.69
72_L97_I0.9540.69
279_L331_V0.9520.69
149_Y153_A0.9520.69
273_L346_E0.9510.69
8_V31_I0.9500.68
248_Y251_D0.9490.68
192_G279_L0.9440.68
216_A220_T0.9420.68
426_A429_D0.9400.68
326_Y396_I0.9380.67
401_Q428_Y0.9340.67
241_K464_T0.9320.67
197_I325_L0.9280.67
433_A436_L0.9280.67
123_I172_Y0.9270.67
271_L284_V0.9270.67
28_T52_V0.9240.66
149_Y172_Y0.9220.66
38_K41_E0.9220.66
16_R23_E0.9200.66
197_I232_I0.9180.66
206_G433_A0.9160.66
109_I113_R0.9150.66
100_G140_I0.9150.66
334_A386_N0.9080.65
112_N145_Q0.9070.65
140_I160_A0.9060.65
23_E50_K0.9010.64
323_R400_Y0.9000.64
250_V440_L0.9000.64
106_Q272_D0.8900.63
125_T156_L0.8900.63
167_E361_R0.8850.63
303_L401_Q0.8840.63
412_V426_A0.8810.63
316_E320_K0.8800.62
372_Q376_D0.8760.62
429_D432_R0.8760.62
146_K350_D0.8720.62
282_E285_F0.8700.62
6_I71_L0.8670.61
108_T122_F0.8650.61
113_R116_S0.8650.61
223_N233_D0.8640.61
241_K249_L0.8610.61
146_K172_Y0.8590.61
36_R39_T0.8580.60
204_L318_I0.8580.60
100_G127_V0.8570.60
235_T444_Q0.8560.60
125_T152_V0.8520.60
398_D428_Y0.8500.60
279_L424_A0.8500.60
196_L420_T0.8490.60
25_R162_V0.8470.59
127_V140_I0.8470.59
202_S205_K0.8440.59
304_S398_D0.8430.59
75_K78_A0.8410.59
417_P436_L0.8400.59
121_N147_E0.8380.59
282_E420_T0.8350.58
143_G178_A0.8330.58
115_L120_F0.8320.58
315_A319_E0.8250.57
8_V11_M0.8250.57
342_A346_E0.8220.57
370_F392_Y0.8200.57
281_T349_W0.8190.57
381_N390_A0.8180.57
19_A22_I0.8160.57
326_Y392_Y0.8130.56
96_I123_I0.8110.56
154_P160_A0.8080.56
139_S359_I0.8070.56
370_F393_F0.8050.56
299_A389_L0.8040.55
412_V425_V0.8030.55
438_A441_I0.8020.55
283_S420_T0.8010.55
177_G349_W0.7990.55
295_Q338_S0.7990.55
7_G10_G0.7980.55
212_N250_V0.7970.55
46_N49_K0.7950.55
203_L418_V0.7950.55
5_Q28_T0.7940.55
79_G83_A0.7900.54
170_V259_N0.7900.54
74_V80_T0.7890.54
245_D248_Y0.7840.54
455_R462_F0.7830.54
140_I346_E0.7820.53
119_G152_V0.7820.53
61_V91_L0.7810.53
140_I170_V0.7800.53
104_F269_S0.7780.53
458_K462_F0.7780.53
71_L100_G0.7770.53
405_R415_G0.7760.53
4_Q28_T0.7750.53
55_Y59_E0.7750.53
210_L314_K0.7740.53
402_Q406_D0.7700.52
303_L398_D0.7700.52
326_Y370_F0.7690.52
140_I152_V0.7690.52
275_E342_A0.7670.52
259_N288_Y0.7630.52
214_E217_Q0.7620.52
19_A30_S0.7600.51
8_V73_M0.7590.51
33_N75_K0.7580.51
73_M230_Y0.7560.51
34_R38_K0.7560.51
340_L356_I0.7550.51
415_G429_D0.7530.51
259_N268_Q0.7520.51
224_N247_N0.7510.50
270_A277_L0.7490.50
116_S147_E0.7470.50
357_A374_I0.7460.50
355_E358_K0.7450.50
337_F441_I0.7430.50
19_A51_L0.7420.50
150_E172_Y0.7400.49
65_E69_R0.7390.49
340_L360_F0.7390.49
74_V79_G0.7380.49
150_E154_P0.7380.49
41_E44_A0.7370.49
273_L342_A0.7340.49
331_V404_L0.7320.49
207_G410_Y0.7300.48
218_T239_F0.7290.48
148_A152_V0.7250.48
226_E323_R0.7250.48
4_Q63_S0.7230.48
176_D347_Y0.7230.48
176_D348_N0.7210.48
82_A86_S0.7180.47
20_L24_S0.7170.47
33_N38_K0.7140.47
297_V434_A0.7120.47
282_E423_A0.7110.47
23_E51_L0.7100.47
368_A427_Y0.7100.47
93_K147_E0.7090.47
217_Q221_E0.7080.46
71_L156_L0.7080.46
273_L343_A0.7080.46
376_D392_Y0.7070.46
249_L456_I0.7070.46
109_I349_W0.7060.46
337_F349_W0.7030.46
331_V368_A0.7020.46
302_V394_K0.7010.46
292_L295_Q0.6990.46
39_T46_N0.6990.46
235_T440_L0.6980.45
212_N247_N0.6960.45
121_N151_L0.6960.45
20_L46_N0.6950.45
405_R426_A0.6930.45
458_K461_V0.6930.45
51_L135_L0.6930.45
115_L424_A0.6920.45
322_R400_Y0.6910.45
269_S272_D0.6900.45
337_F353_Y0.6900.45
35_S42_V0.6900.45
31_I35_S0.6890.45
205_K378_Y0.6890.45
56_T60_F0.6880.45
33_N73_M0.6880.45
314_K318_I0.6850.44
428_Y432_R0.6840.44
285_F349_W0.6830.44
208_L317_F0.6830.44
233_D236_K0.6820.44
329_K370_F0.6820.44
298_A389_L0.6810.44
72_L83_A0.6800.44
294_D297_V0.6800.44
256_E441_I0.6760.43
226_E400_Y0.6760.43
93_K118_E0.6720.43
62_E65_E0.6710.43
70_I90_Y0.6710.43
177_G193_D0.6700.43
85_D88_K0.6700.43
385_A395_Q0.6700.43
230_Y234_I0.6680.43
202_S433_A0.6670.43
193_D197_I0.6670.43
196_L325_L0.6640.42
201_Y205_K0.6630.42
16_R42_V0.6630.42
375_T397_A0.6630.42
82_A85_D0.6630.42
38_K74_V0.6610.42
58_K89_P0.6610.42
316_E406_D0.6590.42
373_K396_I0.6580.42
354_G370_F0.6570.42
24_S49_K0.6560.42
25_R136_K0.6540.41
243_D248_Y0.6530.41
44_A47_P0.6530.41
299_A432_R0.6530.41
154_P158_K0.6520.41
194_M444_Q0.6510.41
120_F145_Q0.6500.41
320_K323_R0.6500.41
377_A390_A0.6490.41
266_T277_L0.6480.41
322_R403_A0.6450.41
210_L214_E0.6450.41
70_I92_D0.6420.40
269_S339_Q0.6420.40
142_P171_T0.6420.40
327_L397_A0.6410.40
374_I377_A0.6400.40
108_T176_D0.6400.40
45_E135_L0.6390.40
125_T170_V0.6380.40
337_F392_Y0.6360.40
221_E226_E0.6360.40
142_P173_I0.6360.40
21_N191_Y0.6350.40
12_A17_N0.6350.40
268_Q278_S0.6340.40
373_K392_Y0.6340.40
258_A268_Q0.6320.39
444_Q447_Y0.6320.39
112_N176_D0.6310.39
391_P394_K0.6310.39
197_I329_K0.6310.39
397_A404_L0.6300.39
302_V391_P0.6290.39
103_T259_N0.6290.39
80_T339_Q0.6260.39
91_L97_I0.6240.39
202_S207_G0.6240.39
109_I112_N0.6230.39
100_G156_L0.6220.38
331_V334_A0.6200.38
133_G191_Y0.6200.38
156_L170_V0.6200.38
74_V83_A0.6200.38
58_K90_Y0.6200.38
75_K127_V0.6200.38
418_V426_A0.6200.38
49_K135_L0.6190.38
329_K349_W0.6190.38
8_V19_A0.6190.38
127_V444_Q0.6190.38
193_D349_W0.6190.38
149_Y157_T0.6180.38
310_P313_D0.6180.38
343_A441_I0.6170.38
293_K434_A0.6170.38
447_Y467_L0.6160.38
73_M135_L0.6160.38
103_T122_F0.6160.38
306_P432_R0.6150.38
142_P170_V0.6140.38
230_Y447_Y0.6130.38
197_I227_L0.6130.38
133_G141_M0.6120.38
61_V87_L0.6110.37
160_A167_E0.6110.37
16_R24_S0.6110.37
288_Y291_S0.6100.37
254_L457_D0.6100.37
73_M286_A0.6090.37
299_A405_R0.6090.37
9_V57_V0.6090.37
57_V86_S0.6080.37
27_Y155_I0.6070.37
45_E49_K0.6070.37
437_P441_I0.6060.37
220_T236_K0.6060.37
115_L122_F0.6060.37
275_E338_S0.6050.37
327_L428_Y0.6050.37
403_A406_D0.6040.37
135_L269_S0.6040.37
277_L331_V0.6040.37
42_V51_L0.6030.37
282_E430_S0.6030.37
121_N152_V0.6010.37
89_P93_K0.6000.37
337_F357_A0.5990.36
232_I235_T0.5990.36
350_D353_Y0.5970.36
410_Y414_N0.5960.36
323_R327_L0.5950.36
160_A170_V0.5940.36
175_A356_I0.5940.36
25_R85_D0.5910.36
295_Q322_R0.5910.36
258_A444_Q0.5910.36
317_F407_V0.5900.36
88_K115_L0.5900.36
22_I98_I0.5900.36
32_F57_V0.5890.36
31_I54_Y0.5880.35
155_I158_K0.5880.35
171_T178_A0.5880.35
153_A171_T0.5860.35
457_D462_F0.5860.35
114_E118_E0.5860.35
139_S324_A0.5850.35
59_E62_E0.5850.35
377_A393_F0.5830.35
157_T171_T0.5820.35
108_T115_L0.5810.35
333_Y393_F0.5800.35
452_T464_T0.5790.35
116_S420_T0.5770.35
196_L279_L0.5770.35
278_S368_A0.5770.35
396_I399_D0.5770.35
69_R155_I0.5760.34
17_N38_K0.5760.34
243_D457_D0.5750.34
20_L192_G0.5740.34
18_L71_L0.5740.34
181_Y343_A0.5730.34
212_N239_F0.5730.34
373_K390_A0.5720.34
409_A417_P0.5720.34
11_M33_N0.5720.34
264_K293_K0.5710.34
12_A79_G0.5710.34
279_L420_T0.5710.34
213_E248_Y0.5700.34
200_A203_L0.5700.34
64_L70_I0.5690.34
31_I167_E0.5680.34
344_S355_E0.5680.34
268_Q272_D0.5660.34
282_E286_A0.5660.34
226_E326_Y0.5650.33
208_L318_I0.5630.33
209_N435_V0.5630.33
205_K215_L0.5630.33
319_E403_A0.5620.33
24_S45_E0.5600.33
224_N383_Q0.5600.33
442_Q445_R0.5590.33
271_L281_T0.5590.33
46_N135_L0.5590.33
23_E48_G0.5570.33
81_D111_R0.5570.33
312_G414_N0.5560.33
277_L281_T0.5560.33
430_S436_L0.5550.33
31_I51_L0.5550.33
94_G119_G0.5550.33
146_K175_A0.5530.32
271_L285_F0.5530.32
175_A348_N0.5520.32
297_V300_S0.5520.32
206_G416_I0.5510.32
236_K256_E0.5450.32
293_K431_Y0.5450.32
405_R432_R0.5440.32
333_Y371_L0.5440.32
78_A416_I0.5440.32
17_N35_S0.5430.32
267_S271_L0.5430.32
241_K244_E0.5430.32
277_L339_Q0.5430.32
386_N431_Y0.5410.31
37_E40_E0.5410.31
202_S417_P0.5410.31
38_K53_P0.5410.31
381_N384_I0.5400.31
193_D333_Y0.5400.31
120_F147_E0.5390.31
374_I393_F0.5370.31
12_A35_S0.5370.31
297_V301_K0.5360.31
249_L465_E0.5360.31
304_S307_Q0.5360.31
21_N445_R0.5350.31
302_V389_L0.5350.31
39_T56_T0.5340.31
243_D252_V0.5340.31
27_Y154_P0.5330.31
27_Y162_V0.5310.31
170_V349_W0.5310.31
20_L51_L0.5300.31
79_G267_S0.5290.31
166_G239_F0.5280.30
208_L247_N0.5270.30
116_S120_F0.5260.30
105_F269_S0.5260.30
51_L112_N0.5260.30
189_I336_G0.5250.30
326_Y393_F0.5240.30
192_G353_Y0.5240.30
157_T359_I0.5230.30
201_Y439_N0.5230.30
131_E450_A0.5220.30
24_S427_Y0.5220.30
162_V362_A0.5210.30
135_L427_Y0.5210.30
72_L103_T0.5200.30
31_I53_P0.5200.30
198_A353_Y0.5190.30
453_Y462_F0.5190.30
93_K224_N0.5190.30
230_Y357_A0.5180.30
72_L148_A0.5180.30
54_Y277_L0.5170.30
61_V68_R0.5170.30
276_P289_I0.5150.29
60_F421_F0.5150.29
286_A430_S0.5140.29
191_Y263_G0.5140.29
224_N341_R0.5140.29
79_G103_T0.5140.29
208_L313_D0.5130.29
420_T424_A0.5130.29
269_S275_E0.5120.29
19_A71_L0.5120.29
23_E427_Y0.5100.29
214_E315_A0.5100.29
65_E92_D0.5080.29
57_V87_L0.5080.29
203_L214_E0.5080.29
213_E224_N0.5080.29
115_L118_E0.5070.29
308_A414_N0.5050.29
274_G288_Y0.5050.29
12_A69_R0.5050.29
191_Y445_R0.5040.29
170_V430_S0.5040.29
306_P391_P0.5040.29
184_M452_T0.5030.28
181_Y339_Q0.5030.28
31_I43_I0.5030.28
31_I60_F0.5030.28
264_K443_A0.5030.28
208_L211_T0.5030.28
374_I387_L0.5030.28
155_I160_A0.5030.28
337_F370_F0.5010.28
87_L204_L0.5000.28
243_D455_R0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zydA 2 0.9957 100 0.342 Contact Map
2p4qA 2 0.9915 100 0.352 Contact Map
1pgjA 2 0.9872 100 0.356 Contact Map
4gwgA 2 0.9915 100 0.36 Contact Map
2iz1A 2 0.9979 100 0.363 Contact Map
4e21A 4 0.641 100 0.781 Contact Map
3dojA 3 0.609 100 0.849 Contact Map
3pefA 5 0.6047 100 0.852 Contact Map
3pduA 4 0.6047 100 0.853 Contact Map
3ckyA 4 0.6218 100 0.853 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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