GREMLIN Database
T0930_1_670 - T0930 1-670
ID: 99 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 670 (607)
Sequences: 107 (59)
Seq/√Len: 2.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
609_H616_L3.9590.62
368_R377_G3.7260.57
619_N626_R3.6380.55
609_H620_P3.4690.51
616_L619_N3.4260.50
610_W619_N3.3990.49
610_W620_P3.3680.49
615_T620_P3.3540.48
612_L622_L3.3350.48
610_W626_R3.3250.48
620_P626_R3.2730.46
616_L626_R3.2680.46
610_W616_L3.1460.44
616_L620_P3.0430.41
616_L622_L3.0300.41
494_Y559_V2.9200.39
527_D539_D2.8850.38
346_V459_V2.8070.36
188_P196_L2.7770.36
607_R615_T2.7280.35
504_G511_R2.6520.33
612_L626_R2.6520.33
607_R626_R2.6350.33
63_K509_I2.6110.32
504_G539_D2.5900.32
511_R539_D2.5900.32
615_T619_N2.5790.32
42_I47_I2.5780.32
348_A405_Y2.5700.32
61_R73_G2.5370.31
609_H619_N2.5210.31
374_L377_G2.5170.31
619_N622_L2.5060.30
364_M515_T2.4550.29
609_H626_R2.4320.29
607_R612_L2.4180.29
141_C188_P2.4050.28
428_A433_I2.3950.28
607_R616_L2.3870.28
80_F354_L2.3740.28
610_W614_Y2.3550.28
137_P153_G2.3370.27
609_H622_L2.2490.26
615_T626_R2.2480.26
536_E539_D2.2410.26
609_H612_L2.2390.25
193_L196_L2.1920.25
107_S541_G2.1880.25
533_R536_E2.1740.24
429_V617_V2.1710.24
605_R613_L2.1520.24
187_L236_K2.1280.24
607_R610_W2.1180.23
612_L616_L2.0970.23
77_P95_G2.0970.23
271_F494_Y2.0960.23
465_Q485_N2.0950.23
368_R374_L2.0950.23
610_W615_T2.0800.23
153_G171_C2.0700.23
61_R72_T2.0570.23
544_C617_V2.0350.22
155_L416_I2.0290.22
149_G533_R2.0220.22
357_L364_M1.9780.21
72_T487_G1.9620.21
149_G536_E1.9430.21
70_G531_L1.9370.21
622_L626_R1.9270.21
95_G155_L1.9190.20
234_K433_I1.9020.20
149_G463_L1.8970.20
607_R622_L1.8840.20
228_Y326_D1.8720.20
489_L493_S1.8650.20
180_Y423_I1.8450.19
78_V376_R1.8320.19
531_L539_D1.8280.19
95_G416_I1.8200.19
409_F541_G1.8180.19
504_G527_D1.8160.19
511_R527_D1.8160.19
423_I427_F1.7980.19
345_Y359_M1.7860.19
607_R619_N1.7770.18
140_A541_G1.7720.18
609_H615_T1.7680.18
519_N555_Q1.7590.18
229_V559_V1.7580.18
377_G408_A1.7580.18
74_L200_Y1.7280.18
77_P137_P1.7250.18
395_A404_S1.7230.18
525_R539_D1.7130.18
421_F444_L1.7010.17
137_P171_C1.7000.17
129_L166_W1.6970.17
551_I560_M1.6950.17
612_L620_P1.6730.17
612_L615_T1.6710.17
56_A60_R1.6700.17
527_D531_L1.6600.17
273_L562_A1.6380.17
76_S407_A1.6370.17
398_C421_F1.6350.17
494_Y618_N1.6350.17
361_M557_H1.6280.16
77_P558_P1.5900.16
95_G149_G1.5900.16
73_G255_R1.5820.16
500_N504_G1.5790.16
500_N511_R1.5790.16
104_M163_I1.5680.16
614_Y627_K1.5610.16
44_I47_I1.5600.16
464_I474_I1.5590.16
607_R620_P1.5400.15
413_G567_L1.5240.15
275_L462_A1.5210.15
22_K35_A1.5090.15
607_R627_K1.4960.15
139_L525_R1.4930.15
200_Y502_M1.4870.15
536_E560_M1.4840.15
500_N539_D1.4580.14
483_L517_L1.4540.14
276_A487_G1.4450.14
485_N541_G1.4440.14
352_S363_S1.4380.14
290_A300_T1.4370.14
141_C196_L1.4310.14
135_Y140_A1.4300.14
612_L619_N1.4220.14
606_A610_W1.3930.14
439_G564_C1.3830.14
404_S408_A1.3800.14
552_E557_H1.3770.14
496_L549_L1.3760.14
156_L498_L1.3740.14
378_D515_T1.3700.14
367_H370_N1.3640.13
281_V525_R1.3600.13
352_S361_M1.3580.13
331_V433_I1.3490.13
100_K617_V1.3450.13
172_P501_V1.3450.13
485_N549_L1.3420.13
465_Q473_F1.3410.13
235_K559_V1.3380.13
615_T622_L1.3360.13
287_Y563_F1.3340.13
46_A315_L1.3300.13
271_F559_V1.3260.13
401_G499_V1.3260.13
223_S568_L1.3240.13
157_S261_Y1.3150.13
200_Y587_G1.3060.13
405_Y464_I1.3030.13
525_R606_A1.2990.13
304_V315_L1.2920.13
233_L566_L1.2920.13
394_P407_A1.2920.13
376_R387_R1.2890.13
262_I529_S1.2850.13
190_I204_L1.2830.13
100_K601_S1.2830.13
63_K230_K1.2800.13
616_L627_K1.2760.13
412_L519_N1.2750.13
41_H47_I1.2730.13
77_P511_R1.2730.13
77_P504_G1.2730.13
579_Q601_S1.2720.13
291_L614_Y1.2710.13
28_I621_S1.2700.13
153_G504_G1.2690.13
153_G511_R1.2690.13
519_N522_H1.2620.12
190_I548_Y1.2560.12
193_L416_I1.2540.12
188_P558_P1.2520.12
287_Y610_W1.2510.12
141_C558_P1.2510.12
229_V378_D1.2500.12
506_V535_V1.2490.12
141_C153_G1.2440.12
102_V283_F1.2430.12
383_F482_D1.2420.12
156_L160_H1.2420.12
511_R525_R1.2410.12
504_G525_R1.2410.12
284_I535_V1.2330.12
72_T484_N1.2330.12
79_N281_V1.2310.12
610_W627_K1.2290.12
81_L351_L1.2240.12
135_Y540_P1.2200.12
558_P620_P1.2160.12
345_Y370_N1.2150.12
540_P568_L1.2110.12
383_F475_R1.2090.12
197_S200_Y1.2030.12
523_L552_E1.2010.12
156_L367_H1.1960.12
57_I509_I1.1940.12
91_V436_I1.1930.12
104_M271_F1.1920.12
465_Q610_W1.1900.12
171_C196_L1.1880.12
153_G539_D1.1860.12
188_P193_L1.1850.12
350_T551_I1.1830.12
136_Y352_S1.1810.12
133_T352_S1.1800.12
382_V404_S1.1800.12
287_Y494_Y1.1790.12
233_L433_I1.1780.12
257_A548_Y1.1760.12
271_F526_L1.1740.12
203_L348_A1.1660.12
533_R560_M1.1630.12
45_A402_F1.1630.12
80_F407_A1.1610.11
368_R408_A1.1540.11
229_V525_R1.1520.11
378_D525_R1.1520.11
94_Y616_L1.1500.11
270_R346_V1.1500.11
316_L327_R1.1400.11
280_V286_L1.1390.11
233_L413_G1.1340.11
305_R331_V1.1320.11
153_G188_P1.1310.11
129_L220_L1.1220.11
55_L141_C1.1200.11
614_Y619_N1.1190.11
99_C328_Q1.1160.11
504_G619_N1.1140.11
511_R619_N1.1140.11
620_P627_K1.1090.11
87_K403_T1.1090.11
609_H613_L1.1090.11
612_L627_K1.1080.11
153_G619_N1.1000.11
69_R605_R1.0970.11
405_Y472_L1.0950.11
204_L505_V1.0950.11
345_Y363_S1.0940.11
95_G141_C1.0940.11
471_F599_K1.0910.11
401_G525_R1.0900.11
200_Y232_I1.0890.11
99_C285_A1.0860.11
57_I61_R1.0840.11
274_K407_A1.0830.11
378_D410_L1.0780.11
205_F578_A1.0760.11
112_P272_P1.0700.11
193_L233_L1.0680.11
363_S367_H1.0620.11
54_V320_N1.0610.11
149_G468_A1.0590.11
615_T627_K1.0560.11
396_L459_V1.0550.11
377_G558_P1.0540.11
340_C410_L1.0530.11
123_W454_F1.0520.11
78_V187_L1.0510.11
501_V560_M1.0460.10
137_P563_F1.0450.10
144_L490_F1.0430.10
509_I533_R1.0410.10
113_F622_L1.0410.10
77_P404_S1.0400.10
501_V534_N1.0390.10
428_A437_L1.0370.10
271_F613_L1.0330.10
190_I428_A1.0320.10
43_C275_L1.0310.10
504_G558_P1.0300.10
511_R558_P1.0300.10
278_S370_N1.0290.10
359_M367_H1.0280.10
409_F412_L1.0280.10
417_Q531_L1.0280.10
324_S371_L1.0270.10
421_F529_S1.0260.10
273_L278_S1.0250.10
56_A61_R1.0250.10
35_A53_L1.0210.10
153_G558_P1.0210.10
135_Y377_G1.0200.10
272_P506_V1.0190.10
70_G111_L1.0150.10
125_I463_L1.0130.10
170_D542_Y1.0100.10
172_P272_P1.0020.10
149_G374_L1.0010.10
272_P564_C1.0000.10
149_G155_L1.0000.10
223_S242_S1.0000.10
368_R558_P0.9990.10
35_A231_K0.9990.10
102_V491_L0.9960.10
166_W612_L0.9960.10
232_I382_V0.9950.10
271_F283_F0.9940.10
563_F567_L0.9920.10
143_T354_L0.9890.10
612_L628_H0.9880.10
55_L140_A0.9870.10
232_I472_L0.9860.10
45_A526_L0.9860.10
57_I60_R0.9860.10
293_L542_Y0.9810.10
45_A51_V0.9790.10
77_P539_D0.9790.10
94_Y137_P0.9790.10
180_Y560_M0.9780.10
638_I642_L0.9780.10
80_F163_I0.9770.10
230_K618_N0.9760.10
327_R371_L0.9750.10
151_V166_W0.9700.10
202_L232_I0.9680.10
60_R70_G0.9670.10
78_V387_R0.9670.10
43_C568_L0.9650.10
139_L183_L0.9620.10
374_L382_V0.9610.10
185_G320_N0.9610.10
61_R606_A0.9610.10
345_Y383_F0.9590.10
161_F192_C0.9560.10
193_L567_L0.9560.10
60_R203_L0.9550.10
377_G619_N0.9540.10
326_D517_L0.9530.10
430_F522_H0.9530.10
28_I34_T0.9520.10
281_V378_D0.9510.10
135_Y152_L0.9490.10
483_L607_R0.9490.10
148_V166_W0.9470.10
367_H498_L0.9450.10
104_M563_F0.9450.10
137_P504_G0.9450.10
137_P511_R0.9450.10
283_F446_H0.9440.10
138_L229_V0.9440.10
347_S437_L0.9430.10
494_Y532_N0.9420.10
267_D382_V0.9410.10
148_V164_L0.9400.10
52_M376_R0.9370.10
91_V487_G0.9370.10
352_S367_H0.9340.10
377_G404_S0.9330.10
31_C616_L0.9310.10
392_S397_V0.9310.10
31_C58_L0.9300.10
70_G113_F0.9300.10
338_L409_F0.9290.10
432_I544_C0.9290.10
466_H525_R0.9280.10
61_R71_L0.9270.10
606_A626_R0.9230.09
103_G604_K0.9220.09
57_I230_K0.9210.09
545_Y552_E0.9210.09
74_L570_S0.9200.09
426_L449_G0.9200.09
262_I417_Q0.9180.09
132_P156_L0.9160.09
294_I364_M0.9150.09
539_D558_P0.9140.09
345_Y367_H0.9130.09
45_A67_N0.9130.09
100_K542_Y0.9110.09
529_S533_R0.9100.09
377_G545_Y0.9100.09
545_Y557_H0.9080.09
72_T183_L0.9040.09
502_M515_T0.9030.09
366_L375_Y0.9030.09
610_W622_L0.9000.09
370_N555_Q0.9000.09
205_F341_V0.9000.09
79_N101_L0.8970.09
454_F501_V0.8950.09
35_A259_K0.8930.09
526_L534_N0.8920.09
228_Y327_R0.8920.09
431_L531_L0.8920.09
191_A629_F0.8910.09
131_Y614_Y0.8890.09
619_N627_K0.8880.09
75_L544_C0.8870.09
408_A536_E0.8860.09
350_T470_R0.8850.09
539_D619_N0.8790.09
197_S204_L0.8770.09
197_S288_Q0.8770.09
160_H519_N0.8760.09
630_Q638_I0.8750.09
368_R473_F0.8720.09
190_I595_K0.8720.09
396_L404_S0.8700.09
435_P564_C0.8700.09
204_L542_Y0.8680.09
370_N377_G0.8670.09
541_G567_L0.8670.09
175_P297_V0.8660.09
39_L568_L0.8660.09
193_L204_L0.8660.09
526_L536_E0.8650.09
406_Q500_N0.8620.09
278_S421_F0.8620.09
133_T136_Y0.8610.09
129_L566_L0.8600.09
200_Y521_V0.8570.09
593_Q613_L0.8570.09
282_A484_N0.8570.09
227_D316_L0.8560.09
270_R312_I0.8550.09
92_A360_L0.8520.09
374_L391_P0.8460.09
177_I351_L0.8460.09
205_F372_K0.8450.09
60_R505_V0.8450.09
405_Y488_S0.8440.09
528_I548_Y0.8430.09
408_A435_P0.8400.09
105_V382_V0.8400.09
286_L295_S0.8390.09
278_S494_Y0.8380.09
137_P141_C0.8350.09
453_P531_L0.8340.09
610_W613_L0.8340.09
473_F485_N0.8320.09
94_Y419_L0.8310.09
432_I437_L0.8290.09
111_L432_I0.8280.09
354_L372_K0.8280.09
67_N228_Y0.8260.09
57_I603_A0.8250.09
501_V541_G0.8250.09
28_I33_P0.8240.09
169_V423_I0.8230.09
229_V232_I0.8230.09
415_A488_S0.8230.09
475_R482_D0.8220.09
404_S536_E0.8220.09
298_L314_F0.8210.09
636_S643_S0.8190.09
80_F275_L0.8090.09
306_R392_S0.8090.09
419_L469_S0.8080.09
235_K551_I0.8070.09
459_V470_R0.8060.09
196_L567_L0.8060.09
75_L139_L0.8050.09
30_P35_A0.8050.09
433_I445_F0.8050.09
408_A542_Y0.8040.09
137_P539_D0.8040.09
598_N636_S0.8030.09
191_A474_I0.8030.09
423_I625_S0.8030.09
105_V121_E0.8020.09
558_P619_N0.8010.09
378_D552_E0.8000.09
346_V502_M0.8000.09
522_H530_L0.7990.09
130_Y160_H0.7970.09
558_P615_T0.7970.09
149_G192_C0.7960.09
412_L555_Q0.7960.09
162_G372_K0.7950.09
78_V357_L0.7940.09
81_L545_Y0.7940.09
181_Y217_S0.7920.09
240_K568_L0.7920.09
284_I508_G0.7900.09
368_R619_N0.7900.09
204_L560_M0.7900.09
151_V280_V0.7880.08
87_K361_M0.7860.08
453_P557_H0.7860.08
302_H305_R0.7850.08
495_I519_N0.7840.08
138_L200_Y0.7840.08
56_A524_G0.7830.08
136_Y610_W0.7830.08
505_V509_I0.7830.08
298_L324_S0.7830.08
291_L318_G0.7800.08
354_L625_S0.7790.08
39_L43_C0.7780.08
57_I512_V0.7780.08
408_A545_Y0.7780.08
135_Y368_R0.7770.08
229_V364_M0.7760.08
151_V335_V0.7750.08
57_I643_S0.7750.08
98_F127_A0.7740.08
376_R601_S0.7740.08
199_Q207_G0.7740.08
73_G436_I0.7730.08
29_P37_E0.7690.08
111_L467_V0.7690.08
132_P519_N0.7670.08
291_L351_L0.7660.08
80_F238_P0.7650.08
426_L496_L0.7650.08
169_V190_I0.7650.08
251_F525_R0.7640.08
95_G192_C0.7620.08
39_L195_F0.7590.08
43_C556_S0.7590.08
550_K557_H0.7580.08
140_A473_F0.7570.08
467_V593_Q0.7570.08
396_L606_A0.7570.08
229_V515_T0.7550.08
609_H623_V0.7550.08
489_L554_S0.7550.08
495_I498_L0.7540.08
86_H149_G0.7540.08
165_V266_E0.7540.08
418_T487_G0.7530.08
90_A367_H0.7520.08
71_L601_S0.7510.08
474_I482_D0.7510.08
137_P619_N0.7500.08
44_I105_V0.7490.08
307_G316_L0.7460.08
66_D350_T0.7450.08
412_L541_G0.7450.08
521_V530_L0.7440.08
139_L557_H0.7440.08
165_V282_A0.7440.08
135_Y564_C0.7400.08
278_S351_L0.7400.08
128_L412_L0.7390.08
54_V483_L0.7390.08
170_D469_S0.7390.08
262_I531_L0.7360.08
135_Y373_G0.7360.08
369_S528_I0.7330.08
245_T248_P0.7310.08
336_Y432_I0.7300.08
182_A502_M0.7300.08
300_T457_T0.7290.08
551_I579_Q0.7280.08
279_V459_V0.7270.08
269_F469_S0.7260.08
75_L424_C0.7260.08
104_M515_T0.7250.08
417_Q493_S0.7250.08
170_D560_M0.7240.08
368_R620_P0.7220.08
89_L348_A0.7210.08
190_I560_M0.7210.08
169_V429_V0.7180.08
157_S165_V0.7160.08
489_L557_H0.7140.08
78_V551_I0.7120.08
609_H627_K0.7120.08
78_V418_T0.7110.08
27_V32_D0.7110.08
525_R536_E0.7110.08
147_K520_I0.7070.08
162_G596_K0.7060.08
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536_E548_Y0.6130.07
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383_F386_H0.6040.07
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263_Y486_R0.6020.07
141_C615_T0.6010.07
407_A525_R0.6010.07
464_I472_L0.6000.07
335_V340_C0.5990.07
614_Y626_R0.5990.07
139_L203_L0.5980.07
70_G189_Q0.5980.07
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228_Y455_W0.5960.07
555_Q567_L0.5950.07
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294_I378_D0.5940.07
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394_P474_I0.5850.07
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272_P530_L0.5790.07
151_V220_L0.5790.07
87_K525_R0.5790.07
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473_F558_P0.5760.07
302_H517_L0.5760.07
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236_K419_L0.5750.07
549_L563_F0.5750.07
158_W201_P0.5730.07
100_K206_K0.5720.07
171_C539_D0.5710.07
184_F357_L0.5710.07
147_K612_L0.5690.07
527_D536_E0.5690.07
585_E596_K0.5680.07
274_K412_L0.5670.07
184_F231_K0.5660.07
188_P541_G0.5650.07
344_C371_L0.5650.07
232_I416_I0.5640.07
368_R371_L0.5640.07
181_Y461_A0.5630.07
197_S564_C0.5630.07
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530_L545_Y0.5540.07
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72_T78_V0.5520.07
70_G180_Y0.5510.07
354_L368_R0.5500.07
101_L499_V0.5490.07
135_Y370_N0.5490.07
295_S419_L0.5490.07
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380_L611_Q0.5380.07
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533_R605_R0.5320.07
403_T408_A0.5310.07
488_S515_T0.5310.07
437_L442_L0.5300.07
247_K250_L0.5300.07
272_P284_I0.5290.07
50_V57_I0.5290.07
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233_L262_I0.5280.07
278_S548_Y0.5280.07
399_W552_E0.5280.07
381_N490_F0.5280.07
318_G351_L0.5260.07
548_Y569_Q0.5260.07
130_Y526_L0.5260.07
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628_H638_I0.5260.07
120_K275_L0.5250.07
217_S297_V0.5250.07
122_F567_L0.5240.07
39_L151_V0.5240.07
217_S220_L0.5240.07
422_F566_L0.5230.07
397_V483_L0.5230.07
180_Y218_E0.5220.07
43_C48_S0.5210.07
401_G418_T0.5210.07
250_L271_F0.5200.07
262_I422_F0.5200.07
171_C563_F0.5200.07
204_L220_L0.5190.07
61_R500_N0.5180.07
80_F305_R0.5170.07
284_I390_R0.5170.07
60_R159_T0.5170.07
204_L517_L0.5170.07
347_S370_N0.5160.07
131_Y345_Y0.5150.07
197_S545_Y0.5140.07
274_K555_Q0.5140.07
339_W367_H0.5130.07
22_K30_P0.5120.07
242_S278_S0.5110.07
416_I512_V0.5110.07
269_F405_Y0.5090.07
93_V519_N0.5080.07
44_I121_E0.5080.07
336_Y518_F0.5080.07
235_K635_E0.5080.07
406_Q412_L0.5070.07
114_T240_K0.5060.07
95_G559_V0.5050.07
434_I535_V0.5040.07
142_G266_E0.5020.07
189_Q476_K0.5020.07
284_I287_Y0.5020.07
330_V333_I0.5020.07
383_F495_I0.5020.07
139_L508_G0.5020.07
99_C120_K0.5020.07
79_N544_C0.5020.07
197_S506_V0.5020.07
104_M614_Y0.5010.07
350_T407_A0.5000.07
192_C494_Y0.5000.07
415_A461_A0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qho_A 1 0.0239 23.7 0.988 Contact Map
4s0v_A 1 0.4418 19.7 0.988 Contact Map
4m5d_A 1 0 11.1 0.989 Contact Map
3pbl_A 1 0.4299 10.6 0.99 Contact Map
4ib4_A 1 0.4418 10.2 0.99 Contact Map
3ol0_A 1 0.0612 10.1 0.99 Contact Map
5dhg_A 1 0.3672 9.6 0.99 Contact Map
1cqt_I 1 0.0328 8.1 0.99 Contact Map
4grv_A 1 0.4537 5.2 0.991 Contact Map
2kj1_A 1 0.0194 5.2 0.991 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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