GREMLIN Database
T0931_1_178 - T0931 1-178
ID: 98 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 178 (151)
Sequences: 2194 (1573)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_D129_K4.7711.00
114_K146_D3.5381.00
119_S123_D3.3991.00
123_D132_T3.2831.00
20_D118_T2.6831.00
115_Y139_V2.6571.00
124_L132_T2.5821.00
24_A118_T2.3731.00
68_N71_Q2.3381.00
25_I121_I2.2821.00
24_A125_T2.1601.00
115_Y146_D2.1151.00
24_A121_I2.0401.00
111_A150_G2.0351.00
31_A125_T2.0251.00
24_A122_K1.9451.00
25_I113_A1.8911.00
21_K113_A1.8451.00
33_D36_K1.8361.00
86_K165_D1.8241.00
120_E135_K1.7861.00
21_K25_I1.7341.00
123_D135_K1.7211.00
118_T122_K1.7161.00
135_K139_V1.7111.00
69_D72_K1.7061.00
157_P160_I1.7031.00
20_D24_A1.6781.00
120_E123_D1.6751.00
29_L34_A1.6421.00
128_Y136_F1.6381.00
168_D172_A1.5321.00
111_A143_V1.5311.00
72_K77_P1.5241.00
124_L136_F1.4871.00
127_F133_G1.4251.00
134_R138_Q1.4151.00
28_L125_T1.4071.00
30_D35_P1.3551.00
164_R168_D1.3311.00
169_K172_A1.3251.00
17_I21_K1.3191.00
22_K25_I1.3011.00
22_K113_A1.2971.00
24_A27_D1.2861.00
33_D138_Q1.2841.00
90_G93_K1.2831.00
116_Y143_V1.2821.00
36_K39_S1.2531.00
108_Q147_V1.2521.00
115_Y142_Q1.2521.00
116_Y121_I1.2311.00
22_K109_Y1.2160.99
165_D168_D1.2150.99
136_F140_Q1.2120.99
112_Y116_Y1.1980.99
147_V151_L1.1930.99
115_Y143_V1.1820.99
21_K118_T1.1760.99
86_K169_K1.1600.99
26_K101_T1.1590.99
33_D134_R1.1500.99
132_T135_K1.1490.99
155_Y159_A1.1420.99
125_T129_K1.1220.99
22_K26_K1.0800.99
67_L71_Q1.0690.99
70_K74_A1.0600.99
142_Q146_D1.0540.98
89_D93_K1.0350.98
25_I109_Y1.0280.98
21_K24_A1.0230.98
26_K106_Q1.0220.98
158_Q161_K1.0210.98
23_A27_D1.0160.98
89_D92_G1.0100.98
132_T136_F1.0090.98
144_G147_V1.0000.98
18_D118_T0.9860.98
160_I163_T0.9690.97
122_K126_T0.9680.97
120_E139_V0.9540.97
131_P134_R0.9540.97
119_S122_K0.9510.97
153_Q156_M0.9440.97
44_S48_Q0.9440.97
28_L121_I0.9260.97
76_V80_Q0.9240.97
151_L155_Y0.9190.96
151_L159_A0.9170.96
26_K30_D0.9080.96
17_I113_A0.9000.96
18_D21_K0.8620.95
77_P80_Q0.8590.95
78_T86_K0.8560.95
163_T167_A0.8540.95
97_T102_N0.8510.95
145_R149_N0.8480.94
123_D126_T0.8420.94
103_D157_P0.8410.94
69_D73_Q0.8280.94
43_N47_M0.8240.94
157_P161_K0.8210.93
100_F103_D0.8200.93
161_K164_R0.8110.93
73_Q77_P0.8090.93
110_D114_K0.8090.93
21_K121_I0.8050.93
142_Q145_R0.8030.93
37_L137_I0.8020.93
90_G94_V0.8020.93
64_N68_N0.8000.92
26_K109_Y0.7960.92
153_Q157_P0.7960.92
27_D125_T0.7860.92
51_Q55_A0.7850.92
171_V174_V0.7830.92
28_L124_L0.7820.92
90_G165_D0.7810.92
115_Y135_K0.7760.91
160_I164_R0.7710.91
129_K134_R0.7700.91
128_Y133_G0.7680.91
116_Y140_Q0.7680.91
118_T125_T0.7650.91
161_K165_D0.7610.91
158_Q162_A0.7590.90
165_D169_K0.7500.90
143_V146_D0.7420.89
53_V67_L0.7260.88
137_I148_V0.7250.88
88_V91_A0.7200.88
78_T169_K0.7140.88
166_Q170_E0.7120.87
65_K68_N0.7060.87
77_P81_K0.7040.87
99_Q103_D0.7020.87
32_I140_Q0.6990.86
24_A113_A0.6920.86
27_D30_D0.6920.86
23_A26_K0.6870.85
68_N74_A0.6840.85
26_K29_L0.6830.85
160_I165_D0.6800.85
68_N72_K0.6770.85
32_I35_P0.6740.84
149_N153_Q0.6730.84
164_R167_A0.6710.84
76_V79_L0.6620.83
27_D122_K0.6610.83
17_I22_K0.6610.83
155_Y158_Q0.6600.83
87_L91_A0.6580.83
139_V142_Q0.6570.83
28_L118_T0.6510.82
128_Y140_Q0.6510.82
111_A147_V0.6450.82
50_K77_P0.6420.81
78_T81_K0.6420.81
45_A49_S0.6290.80
100_F104_A0.6240.80
140_Q147_V0.6240.80
118_T121_I0.6230.79
44_S152_M0.6180.79
159_A163_T0.6140.78
12_A15_A0.6120.78
150_G153_Q0.6080.78
32_I37_L0.6070.78
88_V92_G0.6070.78
30_D131_P0.6070.78
101_T110_D0.6060.78
64_N67_L0.6060.78
70_K73_Q0.6050.77
68_N73_Q0.6040.77
49_S53_V0.6000.77
104_A134_R0.5870.75
73_Q78_T0.5860.75
101_T105_M0.5820.75
28_L140_Q0.5740.74
39_S101_T0.5730.74
63_E66_T0.5720.73
35_P101_T0.5720.73
91_A94_V0.5690.73
74_A173_A0.5680.73
13_A153_Q0.5670.73
160_I169_K0.5670.73
157_P165_D0.5660.73
52_L153_Q0.5610.72
29_L111_A0.5600.72
133_G137_I0.5560.71
116_Y128_Y0.5550.71
156_M160_I0.5540.71
130_S137_I0.5530.71
154_K157_P0.5510.71
110_D150_G0.5470.70
119_S132_T0.5460.70
116_Y139_V0.5440.70
124_L128_Y0.5430.70
92_G96_G0.5410.69
74_A166_Q0.5370.69
67_L171_V0.5370.69
96_G120_E0.5350.68
116_Y124_L0.5350.68
116_Y120_E0.5330.68
142_Q164_R0.5310.68
41_I140_Q0.5310.68
87_L95_F0.5290.68
167_A171_V0.5280.67
116_Y132_T0.5280.67
27_D31_A0.5260.67
98_Q101_T0.5260.67
122_K166_Q0.5220.67
95_F115_Y0.5210.66
46_E92_G0.5200.66
79_L91_A0.5170.66
123_D136_F0.5160.66
107_A153_Q0.5150.66
97_T100_F0.5140.65
103_D154_K0.5120.65
86_K89_D0.5100.65
111_A115_Y0.5090.65
34_A37_L0.5060.64
53_V91_A0.5020.64
41_I151_L0.5020.64
16_P19_A0.5010.63
149_N152_M0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oao_A 1 0.7865 99.9 0.362 Contact Map
2vml_B 1 0.4101 8.2 0.932 Contact Map
3l0f_B 1 0.4101 8.2 0.932 Contact Map
1xg0_C 1 0.3933 7.7 0.933 Contact Map
1gdj_A 1 0.5393 7.1 0.934 Contact Map
2vml_A 1 0.4101 6.4 0.936 Contact Map
3o18_A 1 0.4101 6.4 0.936 Contact Map
3v57_A 1 0.4101 6.3 0.936 Contact Map
2j96_A 1 0.4101 6 0.936 Contact Map
4x86_A 1 0.2865 5.6 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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