T0928_1_388 - CASP12 - GREMLIN Contacts

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T0928_1_388 - T0928 1-388

ID:	97	Sequences: MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLELINGRLSASLLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQQGNKAEKAGSKEQGPRQRKGAAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLPSRRS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	388 (325)
Sequences:	2653 (2308)
Seq/√Len:	128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_G	42_K	3.352	1.00
55_G	99_Q	2.750	1.00
170_A	204_L	2.693	1.00
46_H	64_S	2.496	1.00
225_D	288_S	2.360	1.00
187_E	291_L	2.325	1.00
164_H	208_G	2.304	1.00
51_E	96_Q	2.291	1.00
188_K	292_P	2.271	1.00
324_V	371_S	2.255	1.00
55_G	291_L	2.165	1.00
342_H	371_S	2.147	1.00
51_E	225_D	2.094	1.00
55_G	187_E	2.074	1.00
55_G	228_V	2.023	1.00
167_T	313_T	2.004	1.00
313_T	356_G	2.003	1.00
136_G	356_G	1.987	1.00
206_P	256_P	1.982	1.00
254_Q	312_G	1.959	1.00
342_H	375_D	1.959	1.00
12_A	30_A	1.949	1.00
56_R	100_Q	1.947	1.00
26_G	209_K	1.941	1.00
184_P	288_S	1.940	1.00
26_G	136_G	1.934	1.00
136_G	167_T	1.904	1.00
96_Q	288_S	1.894	1.00
209_K	262_L	1.882	1.00
184_P	225_D	1.866	1.00
195_H	212_T	1.840	1.00
288_S	330_F	1.833	1.00
51_E	184_P	1.821	1.00
316_G	351_F	1.725	1.00
29_I	77_L	1.696	1.00
262_L	313_T	1.680	1.00
99_Q	187_E	1.669	1.00
136_G	262_L	1.668	1.00
189_V	293_L	1.662	1.00
193_K	340_E	1.650	1.00
209_K	356_G	1.645	1.00
252_F	308_V	1.612	1.00
209_K	313_T	1.611	1.00
100_Q	188_K	1.610	1.00
373_A	377_R	1.607	1.00
167_T	209_K	1.590	1.00
310_E	355_K	1.576	1.00
96_Q	330_F	1.568	1.00
251_R	307_D	1.562	1.00
262_L	356_G	1.560	1.00
136_G	313_T	1.553	1.00
100_Q	292_P	1.543	1.00
325_A	338_V	1.538	1.00
26_G	356_G	1.528	1.00
96_Q	184_P	1.520	1.00
26_G	313_T	1.519	1.00
12_A	32_G	1.517	1.00
139_L	162_F	1.515	1.00
96_Q	225_D	1.511	1.00
225_D	330_F	1.511	1.00
158_K	174_T	1.507	1.00
68_E	87_D	1.506	1.00
316_G	369_L	1.504	1.00
187_E	228_V	1.499	1.00
51_E	288_S	1.494	1.00
49_Q	52_L	1.491	1.00
136_G	209_K	1.491	1.00
167_T	356_G	1.486	1.00
85_G	89_H	1.479	1.00
27_L	210_L	1.475	1.00
99_Q	291_L	1.461	1.00
51_E	330_F	1.461	1.00
292_P	333_Q	1.426	1.00
133_Q	166_N	1.424	1.00
175_D	179_R	1.423	1.00
282_L	317_L	1.418	1.00
196_E	244_P	1.417	1.00
348_D	372_V	1.414	1.00
122_A	146_A	1.413	1.00
51_E	384_P	1.409	1.00
27_L	314_F	1.406	1.00
102_G	190_L	1.406	1.00
68_E	85_G	1.393	1.00
99_Q	228_V	1.389	1.00
90_C	140_R	1.386	1.00
228_V	291_L	1.385	1.00
26_G	262_L	1.370	1.00
347_T	374_V	1.365	1.00
66_D	193_K	1.361	1.00
26_G	167_T	1.351	1.00
27_L	357_R	1.348	1.00
265_F	308_V	1.341	1.00
22_D	77_L	1.339	1.00
220_S	234_Q	1.336	1.00
299_G	317_L	1.335	1.00
154_D	196_E	1.334	1.00
200_E	215_R	1.330	1.00
77_L	308_V	1.330	1.00
66_D	241_S	1.324	1.00
127_K	143_N	1.322	1.00
122_A	144_L	1.318	1.00
184_P	330_F	1.318	1.00
123_P	154_D	1.316	1.00
342_H	373_A	1.316	1.00
314_F	357_R	1.307	1.00
243_T	279_P	1.293	1.00
56_R	188_K	1.293	1.00
167_T	262_L	1.288	1.00
168_L	210_L	1.271	1.00
283_T	295_T	1.269	1.00
204_L	351_F	1.268	1.00
27_L	137_L	1.260	1.00
265_F	315_L	1.260	1.00
130_A	161_C	1.254	1.00
203_A	251_R	1.252	1.00
123_P	196_E	1.248	1.00
27_L	168_L	1.245	1.00
162_F	204_L	1.244	1.00
66_D	297_S	1.243	1.00
241_S	340_E	1.243	1.00
195_H	216_D	1.243	1.00
195_H	199_I	1.241	1.00
120_G	340_E	1.237	1.00
204_L	308_V	1.236	1.00
263_R	314_F	1.236	1.00
297_S	340_E	1.231	1.00
193_K	241_S	1.229	1.00
137_L	263_R	1.218	0.99
127_K	158_K	1.217	0.99
195_H	214_G	1.203	0.99
95_F	183_V	1.201	0.99
190_L	294_R	1.199	0.99
330_F	384_P	1.198	0.99
154_D	244_P	1.197	0.99
17_Y	33_G	1.195	0.99
185_S	289_N	1.177	0.99
161_C	203_A	1.177	0.99
252_F	351_F	1.167	0.99
20_Q	76_A	1.163	0.99
73_M	200_E	1.160	0.99
69_T	300_H	1.160	0.99
342_H	346_V	1.157	0.99
241_S	297_S	1.151	0.99
210_L	263_R	1.150	0.99
69_T	123_P	1.144	0.99
375_D	379_Q	1.144	0.99
77_L	162_F	1.143	0.99
307_D	350_A	1.139	0.99
319_T	323_S	1.135	0.99
68_E	83_A	1.133	0.99
132_T	162_F	1.128	0.99
73_M	127_K	1.121	0.99
101_Q	189_V	1.121	0.99
120_G	297_S	1.118	0.99
56_R	292_P	1.116	0.99
131_E	204_L	1.116	0.99
63_H	337_Y	1.112	0.99
76_A	130_A	1.110	0.99
95_F	224_K	1.109	0.99
223_Q	226_Q	1.104	0.99
173_G	177_Y	1.104	0.99
216_D	220_S	1.101	0.99
23_P	254_Q	1.097	0.99
137_L	314_F	1.097	0.99
131_E	252_F	1.091	0.99
139_L	169_L	1.088	0.99
204_L	252_F	1.085	0.99
97_A	331_S	1.084	0.99
244_P	300_H	1.083	0.99
127_K	248_Q	1.081	0.99
268_Q	281_Y	1.074	0.99
214_G	218_K	1.071	0.99
162_F	351_F	1.066	0.99
243_T	281_Y	1.066	0.99
210_L	314_F	1.058	0.99
137_L	168_L	1.056	0.99
158_K	200_E	1.049	0.98
188_K	333_Q	1.049	0.98
299_G	321_T	1.045	0.98
179_R	191_E	1.042	0.98
182_K	185_S	1.039	0.98
243_T	247_Y	1.038	0.98
23_P	79_G	1.035	0.98
47_F	77_L	1.035	0.98
30_A	46_H	1.033	0.98
221_V	284_A	1.032	0.98
73_M	86_Q	1.032	0.98
56_R	229_T	1.026	0.98
137_L	357_R	1.016	0.98
69_T	343_G	1.007	0.98
346_V	371_S	1.003	0.98
22_D	25_T	1.002	0.98
328_I	331_S	1.001	0.98
168_L	357_R	1.000	0.98
66_D	120_G	0.996	0.98
171_T	181_W	0.992	0.98
217_L	280_C	0.989	0.98
21_V	204_L	0.989	0.98
162_F	308_V	0.985	0.98
21_V	77_L	0.985	0.98
176_G	217_L	0.981	0.98
233_W	337_Y	0.980	0.98
66_D	340_E	0.977	0.98
163_N	204_L	0.977	0.98
168_L	314_F	0.965	0.97
342_H	377_R	0.962	0.97
145_Q	176_G	0.962	0.97
83_A	87_D	0.960	0.97
317_L	327_Y	0.958	0.97
32_G	44_G	0.954	0.97
304_S	347_T	0.953	0.97
101_Q	293_L	0.952	0.97
122_A	142_E	0.950	0.97
78_A	131_E	0.948	0.97
212_T	222_W	0.946	0.97
370_F	378_C	0.941	0.97
229_T	333_Q	0.940	0.97
304_S	320_V	0.940	0.97
76_A	203_A	0.940	0.97
264_L	315_L	0.939	0.97
133_Q	206_P	0.935	0.97
103_N	191_E	0.932	0.97
77_L	351_F	0.930	0.97
138_E	315_L	0.929	0.97
63_H	233_W	0.928	0.97
97_A	226_Q	0.927	0.97
76_A	161_C	0.926	0.97
289_N	331_S	0.925	0.97
357_R	380_L	0.925	0.97
171_T	175_D	0.925	0.97
57_L	335_L	0.924	0.97
211_V	250_C	0.918	0.96
159_V	172_G	0.917	0.96
207_D	210_L	0.910	0.96
98_H	101_Q	0.908	0.96
141_V	144_L	0.903	0.96
244_P	343_G	0.900	0.96
73_M	304_S	0.898	0.96
211_V	252_F	0.890	0.96
316_G	349_V	0.889	0.96
168_L	180_V	0.887	0.96
95_F	287_G	0.885	0.96
97_A	185_S	0.882	0.95
184_P	384_P	0.881	0.95
352_L	370_F	0.878	0.95
169_L	315_L	0.878	0.95
21_V	131_E	0.877	0.95
43_N	88_A	0.874	0.95
56_R	333_Q	0.871	0.95
210_L	357_R	0.869	0.95
321_T	325_A	0.862	0.95
248_Q	347_T	0.861	0.95
68_E	89_H	0.859	0.95
88_A	145_Q	0.859	0.95
91_Q	103_N	0.858	0.95
17_Y	73_M	0.857	0.95
161_C	251_R	0.855	0.95
23_P	133_Q	0.854	0.95
66_D	152_S	0.847	0.94
287_G	329_A	0.845	0.94
183_V	383_L	0.843	0.94
170_A	202_L	0.839	0.94
100_Q	333_Q	0.839	0.94
185_S	331_S	0.838	0.94
315_L	369_L	0.830	0.94
225_D	384_P	0.828	0.94
120_G	241_S	0.828	0.94
309_S	351_F	0.825	0.94
133_Q	164_H	0.823	0.93
21_V	308_V	0.823	0.93
28_L	169_L	0.817	0.93
73_M	158_K	0.817	0.93
328_I	382_L	0.816	0.93
123_P	343_G	0.816	0.93
17_Y	347_T	0.815	0.93
305_C	318_G	0.815	0.93
178_V	212_T	0.814	0.93
122_A	140_R	0.814	0.93
211_V	264_L	0.813	0.93
134_H	137_L	0.810	0.93
194_A	220_S	0.809	0.93
96_Q	384_P	0.807	0.93
168_L	263_R	0.806	0.93
77_L	131_E	0.804	0.93
52_L	226_Q	0.803	0.93
144_L	148_Q	0.802	0.93
68_E	72_T	0.798	0.92
120_G	193_K	0.798	0.92
128_C	141_V	0.797	0.92
87_D	91_Q	0.797	0.92
164_H	206_P	0.796	0.92
153_S	386_R	0.796	0.92
18_A	31_A	0.793	0.92
294_R	336_Y	0.792	0.92
251_R	350_A	0.792	0.92
211_V	219_A	0.791	0.92
254_Q	353_P	0.787	0.92
226_Q	331_S	0.785	0.92
200_E	347_T	0.784	0.92
158_K	347_T	0.784	0.92
308_V	351_F	0.782	0.92
131_E	162_F	0.781	0.92
131_E	308_V	0.780	0.92
123_P	244_P	0.779	0.91
73_M	248_Q	0.779	0.91
263_R	357_R	0.774	0.91
266_T	285_W	0.774	0.91
232_H	336_Y	0.770	0.91
212_T	216_D	0.770	0.91
224_K	329_A	0.768	0.91
23_P	206_P	0.768	0.91
263_R	284_A	0.767	0.91
317_L	321_T	0.763	0.91
284_A	326_I	0.762	0.91
13_P	244_P	0.758	0.90
94_R	223_Q	0.753	0.90
200_E	304_S	0.752	0.90
52_L	185_S	0.751	0.90
219_A	266_T	0.749	0.90
300_H	343_G	0.747	0.90
226_Q	289_N	0.746	0.90
161_C	204_L	0.745	0.90
130_A	251_R	0.744	0.90
94_R	97_A	0.744	0.90
69_T	154_D	0.743	0.89
235_E	240_F	0.742	0.89
287_G	383_L	0.739	0.89
24_S	27_L	0.735	0.89
140_R	144_L	0.727	0.88
180_V	204_L	0.726	0.88
142_E	146_A	0.726	0.88
100_Q	229_T	0.722	0.88
286_D	289_N	0.714	0.88
193_K	297_S	0.712	0.87
13_P	123_P	0.709	0.87
162_F	252_F	0.707	0.87
161_C	350_A	0.705	0.87
152_S	241_S	0.703	0.87
310_E	351_F	0.703	0.87
58_S	232_H	0.702	0.87
172_G	202_L	0.700	0.86
221_V	380_L	0.695	0.86
196_E	300_H	0.694	0.86
329_A	332_L	0.693	0.86
137_L	210_L	0.690	0.86
201_D	213_V	0.690	0.86
17_Y	127_K	0.687	0.85
73_M	347_T	0.687	0.85
132_T	135_E	0.685	0.85
265_F	284_A	0.684	0.85
29_I	75_L	0.684	0.85
371_S	375_D	0.683	0.85
280_C	322_G	0.683	0.85
13_P	69_T	0.682	0.85
76_A	307_D	0.682	0.85
30_A	34_G	0.678	0.85
127_K	304_S	0.676	0.85
27_L	263_R	0.675	0.84
102_G	336_Y	0.673	0.84
200_E	248_Q	0.673	0.84
13_P	196_E	0.672	0.84
296_K	299_G	0.672	0.84
191_E	337_Y	0.670	0.84
127_K	347_T	0.670	0.84
131_E	351_F	0.667	0.84
63_H	103_N	0.665	0.84
130_A	350_A	0.665	0.84
194_A	212_T	0.664	0.83
341_A	373_A	0.663	0.83
322_G	376_S	0.663	0.83
229_T	292_P	0.661	0.83
171_T	177_Y	0.657	0.83
293_L	335_L	0.655	0.83
102_G	294_R	0.654	0.83
97_A	289_N	0.651	0.82
303_V	317_L	0.651	0.82
87_D	93_L	0.648	0.82
243_T	268_Q	0.646	0.82
57_L	101_Q	0.643	0.81
23_P	353_P	0.642	0.81
279_P	283_T	0.637	0.81
47_F	92_L	0.637	0.81
176_G	280_C	0.636	0.81
71_A	125_E	0.633	0.80
77_L	204_L	0.631	0.80
248_Q	278_P	0.630	0.80
120_G	152_S	0.629	0.80
49_Q	223_Q	0.628	0.80
50_L	53_I	0.627	0.80
170_A	180_V	0.625	0.80
248_Q	304_S	0.620	0.79
94_R	182_K	0.620	0.79
219_A	324_V	0.619	0.79
299_G	323_S	0.618	0.79
69_T	196_E	0.618	0.79
154_D	300_H	0.615	0.79
173_G	179_R	0.613	0.78
164_H	204_L	0.608	0.78
179_R	188_K	0.607	0.78
170_A	178_V	0.607	0.78
203_A	307_D	0.606	0.78
27_L	47_F	0.604	0.77
165_D	168_L	0.603	0.77
161_C	307_D	0.600	0.77
195_H	220_S	0.600	0.77
11_R	30_A	0.598	0.77
235_E	242_S	0.595	0.76
163_N	170_A	0.590	0.76
350_A	370_F	0.589	0.76
164_H	254_Q	0.585	0.75
189_V	232_H	0.584	0.75
288_S	384_P	0.581	0.75
206_P	353_P	0.579	0.74
69_T	244_P	0.576	0.74
255_V	263_R	0.574	0.74
299_G	319_T	0.573	0.74
183_V	224_K	0.573	0.74
224_K	287_G	0.571	0.73
125_E	345_V	0.569	0.73
20_Q	31_A	0.569	0.73
286_D	328_I	0.568	0.73
122_A	126_K	0.568	0.73
302_V	345_V	0.566	0.73
243_T	266_T	0.566	0.73
130_A	203_A	0.565	0.73
149_T	284_A	0.564	0.72
77_L	252_F	0.562	0.72
194_A	216_D	0.562	0.72
131_E	138_E	0.562	0.72
91_Q	283_T	0.560	0.72
53_I	290_F	0.560	0.72
23_P	310_E	0.560	0.72
220_S	283_T	0.557	0.71
255_V	262_L	0.557	0.71
172_G	175_D	0.557	0.71
195_H	218_K	0.556	0.71
145_Q	217_L	0.555	0.71
139_L	147_V	0.554	0.71
180_V	326_I	0.554	0.71
130_A	307_D	0.554	0.71
133_Q	310_E	0.554	0.71
217_L	322_G	0.553	0.71
344_I	374_V	0.553	0.71
46_H	56_R	0.552	0.71
139_L	316_G	0.548	0.70
21_V	351_F	0.548	0.70
154_D	343_G	0.547	0.70
268_Q	279_P	0.545	0.70
158_K	304_S	0.544	0.70
354_E	357_R	0.542	0.69
43_N	376_S	0.542	0.69
370_F	380_L	0.541	0.69
64_S	118_R	0.541	0.69
125_E	198_E	0.538	0.69
17_Y	158_K	0.538	0.69
267_V	372_V	0.537	0.69
182_K	223_Q	0.535	0.68
201_D	249_A	0.534	0.68
147_V	171_T	0.532	0.68
29_I	81_I	0.530	0.68
311_S	314_F	0.529	0.68
190_L	336_Y	0.529	0.68
357_R	370_F	0.528	0.67
317_L	323_S	0.528	0.67
185_S	226_Q	0.525	0.67
243_T	283_T	0.523	0.67
88_A	217_L	0.522	0.67
12_A	44_G	0.522	0.67
164_H	353_P	0.520	0.66
52_L	331_S	0.518	0.66
53_I	227_L	0.517	0.66
157_Q	171_T	0.515	0.66
313_T	330_F	0.515	0.66
153_S	171_T	0.514	0.65
49_Q	94_R	0.511	0.65
188_K	229_T	0.509	0.65
169_L	183_V	0.509	0.65
88_A	176_G	0.508	0.64
135_E	208_G	0.507	0.64
84_A	141_V	0.506	0.64
52_L	289_N	0.505	0.64
23_P	77_L	0.505	0.64
188_K	191_E	0.504	0.64
185_S	385_S	0.503	0.64
32_G	46_H	0.502	0.64
371_S	377_R	0.501	0.63
20_Q	203_A	0.500	0.63
307_D	349_V	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3sfz_A	1	0.8737	100	0.359	Contact Map
4wju_A	1	0.8299	100	0.389	Contact Map
4wjs_A	1	0.8325	100	0.404	Contact Map
5dfz_B	1	0.8402	100	0.408	Contact Map
4ci8_A	1	0.8711	100	0.412	Contact Map
4nsx_A	1	0.8351	100	0.412	Contact Map
5cvo_A	1	0.8376	100	0.419	Contact Map
1vyh_C	1	0.7526	100	0.419	Contact Map
5cvl_A	1	0.8454	100	0.42	Contact Map
5ams_A	1	0.8454	100	0.424	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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