GREMLIN Database
T0928_1_388 - T0928 1-388
ID: 97 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 388 (325)
Sequences: 2653 (2308)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_G42_K3.3521.00
55_G99_Q2.7501.00
170_A204_L2.6931.00
46_H64_S2.4961.00
225_D288_S2.3601.00
187_E291_L2.3251.00
164_H208_G2.3041.00
51_E96_Q2.2911.00
188_K292_P2.2711.00
324_V371_S2.2551.00
55_G291_L2.1651.00
342_H371_S2.1471.00
51_E225_D2.0941.00
55_G187_E2.0741.00
55_G228_V2.0231.00
167_T313_T2.0041.00
313_T356_G2.0031.00
136_G356_G1.9871.00
206_P256_P1.9821.00
254_Q312_G1.9591.00
342_H375_D1.9591.00
12_A30_A1.9491.00
56_R100_Q1.9471.00
26_G209_K1.9411.00
184_P288_S1.9401.00
26_G136_G1.9341.00
136_G167_T1.9041.00
96_Q288_S1.8941.00
209_K262_L1.8821.00
184_P225_D1.8661.00
195_H212_T1.8401.00
288_S330_F1.8331.00
51_E184_P1.8211.00
316_G351_F1.7251.00
29_I77_L1.6961.00
262_L313_T1.6801.00
99_Q187_E1.6691.00
136_G262_L1.6681.00
189_V293_L1.6621.00
193_K340_E1.6501.00
209_K356_G1.6451.00
252_F308_V1.6121.00
209_K313_T1.6111.00
100_Q188_K1.6101.00
373_A377_R1.6071.00
167_T209_K1.5901.00
310_E355_K1.5761.00
96_Q330_F1.5681.00
251_R307_D1.5621.00
262_L356_G1.5601.00
136_G313_T1.5531.00
100_Q292_P1.5431.00
325_A338_V1.5381.00
26_G356_G1.5281.00
96_Q184_P1.5201.00
26_G313_T1.5191.00
12_A32_G1.5171.00
139_L162_F1.5151.00
96_Q225_D1.5111.00
225_D330_F1.5111.00
158_K174_T1.5071.00
68_E87_D1.5061.00
316_G369_L1.5041.00
187_E228_V1.4991.00
51_E288_S1.4941.00
49_Q52_L1.4911.00
136_G209_K1.4911.00
167_T356_G1.4861.00
85_G89_H1.4791.00
27_L210_L1.4751.00
99_Q291_L1.4611.00
51_E330_F1.4611.00
292_P333_Q1.4261.00
133_Q166_N1.4241.00
175_D179_R1.4231.00
282_L317_L1.4181.00
196_E244_P1.4171.00
348_D372_V1.4141.00
122_A146_A1.4131.00
51_E384_P1.4091.00
27_L314_F1.4061.00
102_G190_L1.4061.00
68_E85_G1.3931.00
99_Q228_V1.3891.00
90_C140_R1.3861.00
228_V291_L1.3851.00
26_G262_L1.3701.00
347_T374_V1.3651.00
66_D193_K1.3611.00
26_G167_T1.3511.00
27_L357_R1.3481.00
265_F308_V1.3411.00
22_D77_L1.3391.00
220_S234_Q1.3361.00
299_G317_L1.3351.00
154_D196_E1.3341.00
200_E215_R1.3301.00
77_L308_V1.3301.00
66_D241_S1.3241.00
127_K143_N1.3221.00
122_A144_L1.3181.00
184_P330_F1.3181.00
123_P154_D1.3161.00
342_H373_A1.3161.00
314_F357_R1.3071.00
243_T279_P1.2931.00
56_R188_K1.2931.00
167_T262_L1.2881.00
168_L210_L1.2711.00
283_T295_T1.2691.00
204_L351_F1.2681.00
27_L137_L1.2601.00
265_F315_L1.2601.00
130_A161_C1.2541.00
203_A251_R1.2521.00
123_P196_E1.2481.00
27_L168_L1.2451.00
162_F204_L1.2441.00
66_D297_S1.2431.00
241_S340_E1.2431.00
195_H216_D1.2431.00
195_H199_I1.2411.00
120_G340_E1.2371.00
204_L308_V1.2361.00
263_R314_F1.2361.00
297_S340_E1.2311.00
193_K241_S1.2291.00
137_L263_R1.2180.99
127_K158_K1.2170.99
195_H214_G1.2030.99
95_F183_V1.2010.99
190_L294_R1.1990.99
330_F384_P1.1980.99
154_D244_P1.1970.99
17_Y33_G1.1950.99
185_S289_N1.1770.99
161_C203_A1.1770.99
252_F351_F1.1670.99
20_Q76_A1.1630.99
73_M200_E1.1600.99
69_T300_H1.1600.99
342_H346_V1.1570.99
241_S297_S1.1510.99
210_L263_R1.1500.99
69_T123_P1.1440.99
375_D379_Q1.1440.99
77_L162_F1.1430.99
307_D350_A1.1390.99
319_T323_S1.1350.99
68_E83_A1.1330.99
132_T162_F1.1280.99
73_M127_K1.1210.99
101_Q189_V1.1210.99
120_G297_S1.1180.99
56_R292_P1.1160.99
131_E204_L1.1160.99
63_H337_Y1.1120.99
76_A130_A1.1100.99
95_F224_K1.1090.99
223_Q226_Q1.1040.99
173_G177_Y1.1040.99
216_D220_S1.1010.99
23_P254_Q1.0970.99
137_L314_F1.0970.99
131_E252_F1.0910.99
139_L169_L1.0880.99
204_L252_F1.0850.99
97_A331_S1.0840.99
244_P300_H1.0830.99
127_K248_Q1.0810.99
268_Q281_Y1.0740.99
214_G218_K1.0710.99
162_F351_F1.0660.99
243_T281_Y1.0660.99
210_L314_F1.0580.99
137_L168_L1.0560.99
158_K200_E1.0490.98
188_K333_Q1.0490.98
299_G321_T1.0450.98
179_R191_E1.0420.98
182_K185_S1.0390.98
243_T247_Y1.0380.98
23_P79_G1.0350.98
47_F77_L1.0350.98
30_A46_H1.0330.98
221_V284_A1.0320.98
73_M86_Q1.0320.98
56_R229_T1.0260.98
137_L357_R1.0160.98
69_T343_G1.0070.98
346_V371_S1.0030.98
22_D25_T1.0020.98
328_I331_S1.0010.98
168_L357_R1.0000.98
66_D120_G0.9960.98
171_T181_W0.9920.98
217_L280_C0.9890.98
21_V204_L0.9890.98
162_F308_V0.9850.98
21_V77_L0.9850.98
176_G217_L0.9810.98
233_W337_Y0.9800.98
66_D340_E0.9770.98
163_N204_L0.9770.98
168_L314_F0.9650.97
342_H377_R0.9620.97
145_Q176_G0.9620.97
83_A87_D0.9600.97
317_L327_Y0.9580.97
32_G44_G0.9540.97
304_S347_T0.9530.97
101_Q293_L0.9520.97
122_A142_E0.9500.97
78_A131_E0.9480.97
212_T222_W0.9460.97
370_F378_C0.9410.97
229_T333_Q0.9400.97
304_S320_V0.9400.97
76_A203_A0.9400.97
264_L315_L0.9390.97
133_Q206_P0.9350.97
103_N191_E0.9320.97
77_L351_F0.9300.97
138_E315_L0.9290.97
63_H233_W0.9280.97
97_A226_Q0.9270.97
76_A161_C0.9260.97
289_N331_S0.9250.97
357_R380_L0.9250.97
171_T175_D0.9250.97
57_L335_L0.9240.97
211_V250_C0.9180.96
159_V172_G0.9170.96
207_D210_L0.9100.96
98_H101_Q0.9080.96
141_V144_L0.9030.96
244_P343_G0.9000.96
73_M304_S0.8980.96
211_V252_F0.8900.96
316_G349_V0.8890.96
168_L180_V0.8870.96
95_F287_G0.8850.96
97_A185_S0.8820.95
184_P384_P0.8810.95
352_L370_F0.8780.95
169_L315_L0.8780.95
21_V131_E0.8770.95
43_N88_A0.8740.95
56_R333_Q0.8710.95
210_L357_R0.8690.95
321_T325_A0.8620.95
248_Q347_T0.8610.95
68_E89_H0.8590.95
88_A145_Q0.8590.95
91_Q103_N0.8580.95
17_Y73_M0.8570.95
161_C251_R0.8550.95
23_P133_Q0.8540.95
66_D152_S0.8470.94
287_G329_A0.8450.94
183_V383_L0.8430.94
170_A202_L0.8390.94
100_Q333_Q0.8390.94
185_S331_S0.8380.94
315_L369_L0.8300.94
225_D384_P0.8280.94
120_G241_S0.8280.94
309_S351_F0.8250.94
133_Q164_H0.8230.93
21_V308_V0.8230.93
28_L169_L0.8170.93
73_M158_K0.8170.93
328_I382_L0.8160.93
123_P343_G0.8160.93
17_Y347_T0.8150.93
305_C318_G0.8150.93
178_V212_T0.8140.93
122_A140_R0.8140.93
211_V264_L0.8130.93
134_H137_L0.8100.93
194_A220_S0.8090.93
96_Q384_P0.8070.93
168_L263_R0.8060.93
77_L131_E0.8040.93
52_L226_Q0.8030.93
144_L148_Q0.8020.93
68_E72_T0.7980.92
120_G193_K0.7980.92
128_C141_V0.7970.92
87_D91_Q0.7970.92
164_H206_P0.7960.92
153_S386_R0.7960.92
18_A31_A0.7930.92
294_R336_Y0.7920.92
251_R350_A0.7920.92
211_V219_A0.7910.92
254_Q353_P0.7870.92
226_Q331_S0.7850.92
200_E347_T0.7840.92
158_K347_T0.7840.92
308_V351_F0.7820.92
131_E162_F0.7810.92
131_E308_V0.7800.92
123_P244_P0.7790.91
73_M248_Q0.7790.91
263_R357_R0.7740.91
266_T285_W0.7740.91
232_H336_Y0.7700.91
212_T216_D0.7700.91
224_K329_A0.7680.91
23_P206_P0.7680.91
263_R284_A0.7670.91
317_L321_T0.7630.91
284_A326_I0.7620.91
13_P244_P0.7580.90
94_R223_Q0.7530.90
200_E304_S0.7520.90
52_L185_S0.7510.90
219_A266_T0.7490.90
300_H343_G0.7470.90
226_Q289_N0.7460.90
161_C204_L0.7450.90
130_A251_R0.7440.90
94_R97_A0.7440.90
69_T154_D0.7430.89
235_E240_F0.7420.89
287_G383_L0.7390.89
24_S27_L0.7350.89
140_R144_L0.7270.88
180_V204_L0.7260.88
142_E146_A0.7260.88
100_Q229_T0.7220.88
286_D289_N0.7140.88
193_K297_S0.7120.87
13_P123_P0.7090.87
162_F252_F0.7070.87
161_C350_A0.7050.87
152_S241_S0.7030.87
310_E351_F0.7030.87
58_S232_H0.7020.87
172_G202_L0.7000.86
221_V380_L0.6950.86
196_E300_H0.6940.86
329_A332_L0.6930.86
137_L210_L0.6900.86
201_D213_V0.6900.86
17_Y127_K0.6870.85
73_M347_T0.6870.85
132_T135_E0.6850.85
265_F284_A0.6840.85
29_I75_L0.6840.85
371_S375_D0.6830.85
280_C322_G0.6830.85
13_P69_T0.6820.85
76_A307_D0.6820.85
30_A34_G0.6780.85
127_K304_S0.6760.85
27_L263_R0.6750.84
102_G336_Y0.6730.84
200_E248_Q0.6730.84
13_P196_E0.6720.84
296_K299_G0.6720.84
191_E337_Y0.6700.84
127_K347_T0.6700.84
131_E351_F0.6670.84
63_H103_N0.6650.84
130_A350_A0.6650.84
194_A212_T0.6640.83
341_A373_A0.6630.83
322_G376_S0.6630.83
229_T292_P0.6610.83
171_T177_Y0.6570.83
293_L335_L0.6550.83
102_G294_R0.6540.83
97_A289_N0.6510.82
303_V317_L0.6510.82
87_D93_L0.6480.82
243_T268_Q0.6460.82
57_L101_Q0.6430.81
23_P353_P0.6420.81
279_P283_T0.6370.81
47_F92_L0.6370.81
176_G280_C0.6360.81
71_A125_E0.6330.80
77_L204_L0.6310.80
248_Q278_P0.6300.80
120_G152_S0.6290.80
49_Q223_Q0.6280.80
50_L53_I0.6270.80
170_A180_V0.6250.80
248_Q304_S0.6200.79
94_R182_K0.6200.79
219_A324_V0.6190.79
299_G323_S0.6180.79
69_T196_E0.6180.79
154_D300_H0.6150.79
173_G179_R0.6130.78
164_H204_L0.6080.78
179_R188_K0.6070.78
170_A178_V0.6070.78
203_A307_D0.6060.78
27_L47_F0.6040.77
165_D168_L0.6030.77
161_C307_D0.6000.77
195_H220_S0.6000.77
11_R30_A0.5980.77
235_E242_S0.5950.76
163_N170_A0.5900.76
350_A370_F0.5890.76
164_H254_Q0.5850.75
189_V232_H0.5840.75
288_S384_P0.5810.75
206_P353_P0.5790.74
69_T244_P0.5760.74
255_V263_R0.5740.74
299_G319_T0.5730.74
183_V224_K0.5730.74
224_K287_G0.5710.73
125_E345_V0.5690.73
20_Q31_A0.5690.73
286_D328_I0.5680.73
122_A126_K0.5680.73
302_V345_V0.5660.73
243_T266_T0.5660.73
130_A203_A0.5650.73
149_T284_A0.5640.72
77_L252_F0.5620.72
194_A216_D0.5620.72
131_E138_E0.5620.72
91_Q283_T0.5600.72
53_I290_F0.5600.72
23_P310_E0.5600.72
220_S283_T0.5570.71
255_V262_L0.5570.71
172_G175_D0.5570.71
195_H218_K0.5560.71
145_Q217_L0.5550.71
139_L147_V0.5540.71
180_V326_I0.5540.71
130_A307_D0.5540.71
133_Q310_E0.5540.71
217_L322_G0.5530.71
344_I374_V0.5530.71
46_H56_R0.5520.71
139_L316_G0.5480.70
21_V351_F0.5480.70
154_D343_G0.5470.70
268_Q279_P0.5450.70
158_K304_S0.5440.70
354_E357_R0.5420.69
43_N376_S0.5420.69
370_F380_L0.5410.69
64_S118_R0.5410.69
125_E198_E0.5380.69
17_Y158_K0.5380.69
267_V372_V0.5370.69
182_K223_Q0.5350.68
201_D249_A0.5340.68
147_V171_T0.5320.68
29_I81_I0.5300.68
311_S314_F0.5290.68
190_L336_Y0.5290.68
357_R370_F0.5280.67
317_L323_S0.5280.67
185_S226_Q0.5250.67
243_T283_T0.5230.67
88_A217_L0.5220.67
12_A44_G0.5220.67
164_H353_P0.5200.66
52_L331_S0.5180.66
53_I227_L0.5170.66
157_Q171_T0.5150.66
313_T330_F0.5150.66
153_S171_T0.5140.65
49_Q94_R0.5110.65
188_K229_T0.5090.65
169_L183_V0.5090.65
88_A176_G0.5080.64
135_E208_G0.5070.64
84_A141_V0.5060.64
52_L289_N0.5050.64
23_P77_L0.5050.64
188_K191_E0.5040.64
185_S385_S0.5030.64
32_G46_H0.5020.64
371_S377_R0.5010.63
20_Q203_A0.5000.63
307_D349_V0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sfz_A 1 0.8737 100 0.359 Contact Map
4wju_A 1 0.8299 100 0.389 Contact Map
4wjs_A 1 0.8325 100 0.404 Contact Map
5dfz_B 1 0.8402 100 0.408 Contact Map
4ci8_A 1 0.8711 100 0.412 Contact Map
4nsx_A 1 0.8351 100 0.412 Contact Map
5cvo_A 1 0.8376 100 0.419 Contact Map
1vyh_C 1 0.7526 100 0.419 Contact Map
5cvl_A 1 0.8454 100 0.42 Contact Map
5ams_A 1 0.8454 100 0.424 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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