GREMLIN Database
T0920_323_568 - T0920 323-568
ID: 95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 246 (233)
Sequences: 2553 (1954)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_T120_V4.1031.00
94_H127_F3.9601.00
56_A133_V3.8831.00
60_V132_S3.7551.00
91_I95_E3.2511.00
93_L117_E2.8221.00
155_I217_V2.7871.00
156_F216_A2.6831.00
122_D126_G2.6261.00
103_Q161_D2.6091.00
169_N172_E2.5731.00
152_P223_W2.4281.00
204_G221_L2.3841.00
101_L116_L2.3471.00
121_F127_F2.3361.00
25_V133_V2.2641.00
150_N153_V2.2481.00
163_T176_N2.2371.00
106_K110_G2.2281.00
160_R212_H2.2001.00
121_F125_G2.1391.00
111_F138_D2.1071.00
154_E168_V2.0951.00
97_H121_F2.0861.00
105_I134_L2.0741.00
86_G108_V2.0551.00
156_F218_A2.0481.00
120_V128_I2.0441.00
102_S105_I2.0061.00
149_H153_V1.9871.00
157_V215_H1.9821.00
67_T83_D1.9661.00
68_I84_I1.9551.00
115_D134_L1.9141.00
64_A126_G1.8881.00
230_G234_R1.8711.00
63_D67_T1.8131.00
154_E167_D1.8041.00
83_D86_G1.7881.00
92_R95_E1.7841.00
159_Q163_T1.7481.00
105_I115_D1.7261.00
43_S47_E1.7111.00
100_V117_E1.7091.00
38_R41_R1.7041.00
196_M221_L1.6681.00
148_V223_W1.6481.00
104_A112_V1.6271.00
62_V84_I1.5241.00
154_E218_A1.5161.00
156_F167_D1.4911.00
221_L225_S1.4781.00
99_P118_H1.4761.00
167_D172_E1.4701.00
205_T218_A1.4521.00
102_S115_D1.4491.00
122_D128_I1.4351.00
119_P127_F1.4331.00
107_M134_L1.4221.00
7_L11_A1.3841.00
203_E220_Q1.3841.00
97_H119_P1.3731.00
158_L214_E1.3591.00
90_I130_S1.3541.00
17_I21_M1.3541.00
233_Y236_A1.3461.00
89_Q134_L1.3371.00
58_N134_L1.3281.00
42_A61_T1.3181.00
64_A94_H1.3141.00
46_L61_T1.3141.00
25_V118_H1.3081.00
66_G85_S1.3001.00
62_V89_Q1.2761.00
158_L216_A1.2571.00
196_M204_G1.2491.00
162_G184_D1.2381.00
64_A127_F1.2331.00
22_D99_P1.2311.00
117_E130_S1.2130.99
46_L59_C1.1940.99
83_D87_Q1.1920.99
87_Q90_I1.1860.99
229_H232_N1.1820.99
87_Q91_I1.1750.99
111_F136_Q1.1580.99
62_V90_I1.1490.99
85_S89_Q1.1450.99
138_D142_S1.1450.99
233_Y237_L1.1260.99
102_S117_E1.1240.99
93_L130_S1.1040.99
222_L226_I1.0980.99
169_N201_E1.0950.99
199_Q218_A1.0950.99
59_C131_V1.0920.99
15_N210_D1.0830.99
89_Q108_V1.0800.99
62_V82_E1.0770.99
224_T227_G1.0760.99
151_F223_W1.0720.99
84_I89_Q1.0510.98
169_N173_I1.0500.98
87_Q108_V1.0440.98
21_M24_S1.0330.98
227_G231_T1.0330.98
89_Q105_I1.0320.98
106_K111_F1.0250.98
19_K23_R1.0240.98
45_I48_T1.0200.98
82_E87_Q1.0150.98
115_D132_S1.0130.98
11_A24_S1.0080.98
89_Q130_S1.0080.98
147_K153_V1.0010.98
62_V132_S1.0010.98
6_L9_Q0.9930.98
83_D90_I0.9900.98
86_G91_I0.9830.98
186_F190_K0.9790.98
93_L102_S0.9700.97
116_L135_T0.9610.97
23_R26_A0.9590.97
30_E34_T0.9510.97
48_T52_E0.9470.97
112_V165_I0.9430.97
150_N223_W0.9410.97
139_F142_S0.9380.97
164_T175_K0.9340.97
89_Q132_S0.9320.97
175_K179_A0.9320.97
85_S90_I0.9290.97
90_I105_I0.9280.97
19_K22_D0.9200.96
105_I117_E0.9090.96
104_A159_Q0.9030.96
107_M133_V0.8940.96
199_Q204_G0.8940.96
88_E93_L0.8920.96
96_T119_P0.8840.96
122_D203_E0.8820.95
120_V129_G0.8790.95
30_E203_E0.8730.95
4_P8_T0.8710.95
102_S119_P0.8670.95
141_G166_Y0.8670.95
107_M110_G0.8620.95
149_H223_W0.8600.95
223_W226_I0.8580.95
71_V80_I0.8570.95
6_L24_S0.8520.95
142_S146_R0.8510.95
86_G89_Q0.8500.94
226_I229_H0.8470.94
192_I208_F0.8380.94
91_I94_H0.8350.94
61_T131_V0.8320.94
28_A32_L0.8300.94
26_A29_A0.8290.94
60_V117_E0.8280.94
36_G39_G0.8280.94
60_V113_G0.8260.94
26_A30_E0.8240.94
12_Q16_A0.8210.93
60_V134_L0.8160.93
148_V153_V0.8100.93
222_L229_H0.8070.93
90_I134_L0.8050.93
52_E143_I0.8020.93
229_H233_Y0.8020.93
92_R96_T0.7980.92
47_E72_A0.7950.92
62_V87_Q0.7950.92
59_C133_V0.7930.92
190_K214_E0.7880.92
104_A213_M0.7880.92
185_A190_K0.7870.92
63_D66_G0.7870.92
232_N236_A0.7850.92
22_D116_L0.7820.92
16_A20_D0.7780.91
167_D183_Y0.7760.91
117_E132_S0.7740.91
172_E175_K0.7700.91
60_V84_I0.7680.91
89_Q107_M0.7640.91
56_A174_G0.7630.91
49_L52_E0.7620.91
190_K208_F0.7580.90
208_F214_E0.7550.90
87_Q130_S0.7540.90
63_D69_V0.7520.90
105_I113_G0.7460.90
152_P220_Q0.7390.89
143_I147_K0.7390.89
197_V207_R0.7390.89
203_E222_L0.7380.89
219_K224_T0.7310.89
229_H236_A0.7290.89
57_Y172_E0.7230.88
64_A129_G0.7210.88
106_K112_V0.7200.88
144_I166_Y0.7170.88
120_V131_V0.7170.88
99_P119_P0.7120.87
205_T220_Q0.7120.87
62_V130_S0.7120.87
36_G40_D0.7110.87
88_E91_I0.7020.87
26_A118_H0.7000.86
175_K222_L0.6990.86
214_E217_V0.6960.86
126_G148_V0.6960.86
18_F40_D0.6880.86
88_E105_I0.6870.85
14_L215_H0.6870.85
121_F128_I0.6800.85
166_Y211_R0.6740.84
67_T81_G0.6730.84
128_I132_S0.6720.84
90_I129_G0.6620.83
46_L159_Q0.6610.83
41_R44_A0.6600.83
97_H102_S0.6570.83
43_S80_I0.6560.83
15_N19_K0.6510.82
230_G233_Y0.6490.82
82_E115_D0.6480.82
77_S80_I0.6410.81
82_E89_Q0.6300.80
107_M113_G0.6290.80
156_F235_L0.6290.80
140_F166_Y0.6290.80
175_K202_G0.6290.80
198_S207_R0.6240.80
57_Y107_M0.6240.80
62_V68_I0.6230.79
144_I155_I0.6230.79
186_F214_E0.6210.79
171_E223_W0.6190.79
95_E221_L0.6170.79
158_L164_T0.6150.79
96_T100_V0.6140.78
189_L237_L0.6110.78
135_T194_R0.6090.78
25_V29_A0.6080.78
105_I112_V0.6080.78
216_A232_N0.6080.78
93_L96_T0.6070.78
61_T226_I0.6060.78
196_M201_E0.6060.78
87_Q93_L0.6050.77
93_L98_Q0.6040.77
11_A15_N0.6030.77
104_A134_L0.6010.77
27_A31_Q0.6000.77
8_T19_K0.5980.77
91_I96_T0.5980.77
62_V85_S0.5950.76
182_I185_A0.5950.76
17_I155_I0.5930.76
214_E218_A0.5910.76
92_R99_P0.5910.76
8_T34_T0.5880.75
24_S27_A0.5870.75
180_D200_A0.5860.75
14_L213_M0.5850.75
167_D173_I0.5850.75
20_D39_G0.5840.75
10_T17_I0.5830.75
93_L108_V0.5830.75
89_Q115_D0.5830.75
207_R218_A0.5800.74
5_M34_T0.5800.74
111_F137_P0.5790.74
107_M111_F0.5770.74
16_A54_Q0.5760.74
231_T235_L0.5750.74
68_I227_G0.5750.74
200_A207_R0.5740.74
227_G234_R0.5740.74
10_T27_A0.5730.74
194_R204_G0.5730.74
14_L219_K0.5720.73
26_A203_E0.5710.73
59_C214_E0.5700.73
108_V165_I0.5700.73
104_A211_R0.5690.73
92_R225_S0.5680.73
166_Y195_K0.5660.73
101_L131_V0.5660.73
107_M114_I0.5660.73
102_S114_I0.5650.73
17_I166_Y0.5630.72
173_I197_V0.5620.72
157_V166_Y0.5620.72
22_D157_V0.5600.72
11_A29_A0.5600.72
104_A165_I0.5580.72
213_M220_Q0.5580.72
26_A38_R0.5500.71
209_Q216_A0.5490.70
119_P131_V0.5480.70
12_Q31_Q0.5470.70
158_L228_L0.5460.70
13_E19_K0.5430.70
18_F116_L0.5430.70
56_A118_H0.5370.69
32_L41_R0.5370.69
22_D93_L0.5370.69
7_L49_L0.5350.68
232_N235_L0.5350.68
50_F131_V0.5350.68
183_Y200_A0.5330.68
87_Q117_E0.5320.68
210_D237_L0.5320.68
142_S153_V0.5320.68
61_T129_G0.5320.68
176_N179_A0.5310.68
5_M8_T0.5300.68
159_Q165_I0.5290.68
102_S155_I0.5270.67
135_T152_P0.5260.67
93_L119_P0.5250.67
12_Q23_R0.5240.67
206_Y224_T0.5230.67
5_M10_T0.5230.67
58_N166_Y0.5220.67
24_S33_S0.5210.66
116_L194_R0.5210.66
99_P102_S0.5200.66
90_I115_D0.5200.66
8_T11_A0.5190.66
165_I213_M0.5190.66
49_L53_N0.5160.66
187_P190_K0.5140.65
128_I171_E0.5130.65
69_V168_V0.5120.65
146_R170_A0.5110.65
81_G107_M0.5090.65
84_I90_I0.5070.64
11_A209_Q0.5060.64
5_M12_Q0.5050.64
10_T147_K0.5050.64
182_I186_F0.5050.64
135_T215_H0.5040.64
44_A80_I0.5040.64
56_A112_V0.5030.64
234_R237_L0.5020.64
169_N228_L0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c8c_A 1 0.9146 99.9 0.309 Contact Map
3lic_A 1 0.8943 99.9 0.319 Contact Map
3lif_A 1 0.9106 99.9 0.355 Contact Map
4wy9_A 1 0.9228 99.9 0.371 Contact Map
4xmr_A 1 0.878 99.9 0.382 Contact Map
3lib_A 1 0.935 99.9 0.385 Contact Map
3lid_A 1 0.9472 99.9 0.392 Contact Map
3li9_A 1 0.9024 99.9 0.395 Contact Map
4jgp_A 1 0.7927 99.8 0.408 Contact Map
3e4o_A 1 0.8659 99.7 0.483 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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