GREMLIN Database
T0920_2_322 - T0920 2-322
ID: 94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 321 (315)
Sequences: 3833 (2272)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_A246_R5.6041.00
146_E156_A3.8821.00
2_V36_E3.7771.00
241_S245_D3.4851.00
267_R270_E3.1991.00
49_A73_A3.1811.00
267_R271_Q3.0351.00
31_S266_S3.0151.00
21_Q25_E3.0101.00
237_H241_S2.9691.00
157_Q172_T2.8831.00
238_P242_A2.8241.00
40_K55_D2.7831.00
4_G56_L2.7361.00
266_S270_E2.6411.00
85_D103_H2.6171.00
30_E242_A2.6121.00
43_G48_T2.6111.00
278_A281_E2.4351.00
25_E29_A2.4001.00
275_T278_A2.2951.00
127_R177_D2.2821.00
6_I53_F2.1991.00
129_A155_A2.1851.00
22_R243_F2.1621.00
128_I180_A2.1421.00
64_A265_L2.1301.00
65_A81_A2.1081.00
287_T296_T2.0911.00
44_A70_S2.0801.00
30_E263_T2.0771.00
244_T250_E2.0551.00
28_L262_C1.9681.00
121_Y227_V1.9021.00
126_E179_E1.8951.00
238_P241_S1.8881.00
289_T294_K1.8581.00
40_K52_A1.8121.00
235_Q289_T1.8101.00
272_G282_W1.7671.00
85_D277_K1.7661.00
242_A245_D1.7491.00
96_L112_Q1.7481.00
35_F266_S1.7341.00
127_R152_Q1.7291.00
162_Q188_E1.7201.00
132_A158_E1.7171.00
24_V262_C1.7031.00
21_Q39_F1.6991.00
68_S74_S1.6921.00
284_A301_G1.6871.00
28_L37_I1.6741.00
146_E150_P1.6711.00
89_V265_L1.6711.00
30_E259_Y1.6631.00
129_A157_Q1.6571.00
262_C266_S1.6411.00
143_R147_D1.6401.00
127_R154_V1.5901.00
64_A279_L1.5861.00
31_S263_T1.5831.00
40_K60_Q1.5381.00
68_S77_I1.5211.00
265_L269_L1.5051.00
277_K281_E1.5041.00
234_N238_P1.4971.00
55_D60_Q1.4971.00
2_V62_N1.4901.00
25_E246_R1.4741.00
147_D151_K1.4741.00
24_V37_I1.4671.00
57_V80_L1.4661.00
129_A176_R1.4591.00
53_F65_A1.4501.00
131_L192_I1.4391.00
6_I77_I1.4151.00
287_T294_K1.3931.00
6_I52_A1.3921.00
159_Y185_S1.3881.00
122_L206_V1.3861.00
20_Q258_A1.3731.00
163_Q169_Q1.3731.00
170_L195_Q1.3721.00
274_Q278_A1.3661.00
6_I42_G1.3391.00
22_R247_Y1.3291.00
128_I149_F1.3281.00
232_S237_H1.3201.00
40_K56_L1.3121.00
269_L279_L1.3071.00
185_S192_I1.3011.00
263_T266_S1.2891.00
22_R25_E1.2891.00
74_S93_S1.2851.00
195_Q198_Q1.2801.00
38_V60_Q1.2761.00
241_S244_T1.2731.00
53_F81_A1.2701.00
215_E218_A1.2601.00
27_A259_Y1.2551.00
105_I283_Y1.2461.00
99_T106_R1.2451.00
270_E273_R1.2281.00
181_L205_L1.2220.99
281_E284_A1.2190.99
25_E37_I1.2190.99
2_V38_V1.2100.99
45_D48_T1.2100.99
31_S35_F1.2000.99
107_L264_T1.2000.99
26_L30_E1.1950.99
148_R151_K1.1920.99
145_L182_V1.1740.99
5_V37_I1.1700.99
264_T283_Y1.1680.99
180_A206_V1.1640.99
25_E39_F1.1520.99
107_L261_L1.1420.99
144_M147_D1.1350.99
71_S95_A1.1310.99
50_V54_Q1.1160.99
42_G73_A1.1060.99
129_A154_V1.1030.99
260_D290_G1.1010.99
57_V86_I1.0940.99
105_I280_F1.0940.99
52_A56_L1.0860.99
74_S88_H1.0780.99
66_V261_L1.0770.99
86_I276_P1.0760.99
82_A102_G1.0740.99
170_L199_A1.0710.99
125_F180_A1.0680.99
42_G49_A1.0680.99
5_V28_L1.0650.99
5_V24_V1.0600.99
26_L242_A1.0570.99
88_H104_T1.0510.98
131_L170_L1.0460.98
264_T297_F1.0450.98
207_G211_I1.0450.98
4_G62_N1.0400.98
3_V265_L1.0380.98
242_A246_R1.0340.98
239_F255_G1.0340.98
87_F276_P1.0330.98
245_D248_G1.0260.98
18_V22_R1.0210.98
66_V89_V1.0200.98
18_V21_Q1.0190.98
26_L247_Y1.0170.98
272_G279_L1.0150.98
139_S143_R1.0120.98
54_Q58_R1.0110.98
62_N65_A1.0080.98
271_Q285_G1.0040.98
22_R249_L0.9990.98
26_L246_R0.9980.98
90_A93_S0.9970.98
193_A205_L0.9940.98
115_Q141_W0.9930.98
27_A266_S0.9920.98
3_V64_A0.9870.98
27_A262_C0.9850.98
31_S262_C0.9830.98
8_P42_G0.9810.98
224_N314_E0.9760.98
9_F39_F0.9750.97
131_L169_Q0.9750.97
174_K177_D0.9720.97
116_E148_R0.9710.97
70_S73_A0.9710.97
129_A178_S0.9620.97
115_Q119_A0.9520.97
20_Q69_C0.9470.97
89_V261_L0.9430.97
95_A106_R0.9390.97
267_R286_N0.9350.97
19_E252_G0.9350.97
258_A262_C0.9350.97
99_T302_D0.9330.97
121_Y206_V0.9320.97
280_F284_A0.9290.97
134_D160_N0.9260.97
130_V142_I0.9240.97
154_V178_S0.9240.97
24_V258_A0.9180.96
23_A27_A0.9110.96
23_A258_A0.9110.96
23_A255_G0.9090.96
272_G278_A0.9040.96
196_A201_I0.9040.96
27_A263_T0.8900.96
5_V39_F0.8880.96
9_F21_Q0.8880.96
171_A175_A0.8880.96
94_A111_V0.8880.96
154_V176_R0.8860.96
122_L125_F0.8850.96
267_R285_G0.8790.95
103_H280_F0.8720.95
48_T52_A0.8700.95
81_A88_H0.8690.95
132_A142_I0.8680.95
63_L86_I0.8650.95
52_A55_D0.8640.95
138_G184_I0.8630.95
170_L196_A0.8590.95
221_A314_E0.8500.94
27_A31_S0.8500.94
132_A156_A0.8490.94
197_R222_F0.8440.94
120_A148_R0.8440.94
142_I156_A0.8420.94
106_R302_D0.8410.94
24_V66_V0.8390.94
163_Q166_I0.8380.94
227_V311_K0.8320.94
8_P17_A0.8270.94
38_V62_N0.8250.94
75_S98_R0.8250.94
79_P83_E0.8250.94
121_Y309_F0.8180.93
118_L206_V0.8150.93
256_V291_A0.8140.93
170_L192_I0.8130.93
173_I178_S0.8100.93
277_K280_F0.8100.93
74_S90_A0.8090.93
260_D292_L0.8080.93
4_G38_V0.8080.93
38_V56_L0.8080.93
122_L128_I0.7940.92
16_I69_C0.7930.92
72_W93_S0.7920.92
160_N163_Q0.7900.92
268_A283_Y0.7890.92
82_A103_H0.7890.92
142_I146_E0.7890.92
57_V65_A0.7870.92
134_D139_S0.7830.92
129_A173_I0.7810.92
170_L201_I0.7780.91
197_R202_K0.7760.91
44_A73_A0.7750.91
194_K198_Q0.7740.91
181_L196_A0.7700.91
13_F70_S0.7680.91
240_M244_T0.7680.91
213_R252_G0.7660.91
119_A145_L0.7590.90
211_I226_L0.7550.90
130_V156_A0.7510.90
183_L192_I0.7500.90
63_L269_L0.7490.90
205_L226_L0.7480.90
56_L62_N0.7480.90
53_F77_I0.7470.90
89_V107_L0.7470.90
111_V140_S0.7450.90
87_F280_F0.7430.89
3_V262_C0.7430.89
57_V81_A0.7400.89
122_L145_L0.7390.89
9_F17_A0.7380.89
269_L274_Q0.7380.89
63_L276_P0.7360.89
243_F247_Y0.7340.89
166_I195_Q0.7320.89
135_N161_P0.7310.89
129_A172_T0.7310.89
75_S97_K0.7310.89
267_R288_F0.7300.89
182_V229_T0.7290.89
164_M191_T0.7240.88
155_A172_T0.7220.88
181_L201_I0.7210.88
243_F255_G0.7210.88
50_V80_L0.7190.88
131_L173_I0.7180.88
244_T248_G0.7180.88
174_K203_A0.7140.88
90_A98_R0.7140.88
131_L183_L0.7130.87
57_V84_K0.7110.87
53_F84_K0.7100.87
268_A279_L0.7080.87
118_L182_V0.7080.87
35_F262_C0.7060.87
94_A108_T0.7040.87
271_Q286_N0.7000.86
58_R84_K0.7000.86
174_K201_I0.6990.86
71_S106_R0.6980.86
150_P153_V0.6960.86
63_L87_F0.6950.86
2_V60_Q0.6920.86
238_P245_D0.6900.86
64_A269_L0.6870.85
77_I81_A0.6850.85
125_F179_E0.6840.85
221_A224_N0.6820.85
8_P68_S0.6810.85
237_H245_D0.6800.85
61_E85_D0.6790.85
195_Q199_A0.6780.85
37_I49_A0.6780.85
143_R156_A0.6770.85
54_Q80_L0.6760.85
194_K220_S0.6750.84
146_E153_V0.6700.84
189_A216_V0.6700.84
116_E120_A0.6700.84
93_S98_R0.6690.84
172_T175_A0.6690.84
196_A204_Q0.6680.84
165_D195_Q0.6670.84
53_F57_V0.6660.84
239_F251_P0.6660.84
42_G68_S0.6650.84
109_V114_E0.6610.83
111_V137_L0.6590.83
105_I297_F0.6580.83
13_F44_A0.6560.83
268_A272_G0.6560.83
145_L149_F0.6560.83
75_S95_A0.6550.83
26_L243_F0.6550.83
122_L180_A0.6530.82
271_Q282_W0.6520.82
141_W182_V0.6510.82
159_Y192_I0.6480.82
105_I301_G0.6470.82
224_N313_T0.6460.82
89_V283_Y0.6430.81
55_D59_S0.6420.81
4_G65_A0.6420.81
50_V76_A0.6400.81
94_A106_R0.6390.81
267_R282_W0.6370.81
64_A87_F0.6370.81
26_L29_A0.6350.81
29_A242_A0.6340.81
70_S93_S0.6330.80
285_G296_T0.6310.80
7_L21_Q0.6300.80
271_Q284_A0.6280.80
24_V28_L0.6240.80
172_T176_R0.6230.79
280_F301_G0.6230.79
240_M251_P0.6210.79
115_Q137_L0.6200.79
82_A101_P0.6130.78
139_S158_E0.6130.78
10_S14_E0.6120.78
243_F251_P0.6120.78
257_E261_L0.6120.78
74_S98_R0.6110.78
235_Q238_P0.6100.78
2_V61_E0.6080.78
118_L229_T0.6070.78
61_E278_A0.6050.77
100_E300_D0.6040.77
181_L266_S0.6030.77
30_E238_P0.6020.77
103_H277_K0.6020.77
78_H101_P0.6010.77
8_P44_A0.5990.77
148_R152_Q0.5990.77
135_N139_S0.5970.76
236_D240_M0.5960.76
25_E247_Y0.5930.76
16_I210_P0.5880.75
54_Q84_K0.5860.75
9_F40_K0.5840.75
95_A111_V0.5830.75
115_Q182_V0.5820.75
69_C92_G0.5810.75
83_E171_A0.5810.75
29_A247_Y0.5770.74
80_L83_E0.5770.74
28_L266_S0.5770.74
53_F56_L0.5760.74
189_A211_I0.5750.74
207_G226_L0.5750.74
127_R179_E0.5750.74
154_V157_Q0.5720.73
181_L203_A0.5710.73
122_L304_S0.5700.73
212_Q228_Y0.5690.73
11_S17_A0.5680.73
141_W209_R0.5660.73
3_V66_V0.5650.73
25_E36_E0.5640.72
23_A262_C0.5640.72
87_F283_Y0.5630.72
235_Q263_T0.5620.72
8_P69_C0.5600.72
236_D291_A0.5590.72
295_V303_A0.5580.72
256_V292_L0.5580.72
230_Y253_F0.5570.71
144_M148_R0.5570.71
127_R150_P0.5570.71
130_V153_V0.5560.71
101_P104_T0.5530.71
113_Q117_Q0.5530.71
16_I254_F0.5520.71
78_H98_R0.5520.71
36_E241_S0.5510.71
196_A205_L0.5510.71
120_A152_Q0.5500.71
278_A282_W0.5500.71
114_E141_W0.5480.70
276_P279_L0.5460.70
127_R176_R0.5430.70
20_Q92_G0.5430.70
58_R80_L0.5410.69
292_L305_Y0.5410.69
74_S106_R0.5400.69
26_L259_Y0.5400.69
116_E147_D0.5390.69
6_I68_S0.5390.69
65_A68_S0.5380.69
260_D263_T0.5370.69
173_I192_I0.5350.68
91_I258_A0.5350.68
86_I103_H0.5350.68
243_F249_L0.5340.68
279_L282_W0.5340.68
50_V78_H0.5330.68
193_A216_V0.5320.68
84_K87_F0.5310.68
217_L223_T0.5300.68
48_T51_Q0.5290.68
107_L288_F0.5280.67
234_N237_H0.5270.67
49_A52_A0.5270.67
10_S41_D0.5260.67
141_W184_I0.5260.67
273_R278_A0.5250.67
2_V152_Q0.5250.67
186_A210_P0.5240.67
87_F279_L0.5240.67
271_Q287_T0.5220.67
312_V315_S0.5210.66
269_L273_R0.5200.66
8_P70_S0.5190.66
20_Q91_I0.5190.66
78_H81_A0.5180.66
34_A245_D0.5170.66
263_T288_F0.5160.66
137_L184_I0.5150.66
126_E245_D0.5150.66
147_D150_P0.5130.65
137_L141_W0.5130.65
167_A199_A0.5120.65
75_S79_P0.5110.65
54_Q57_V0.5100.65
236_D256_V0.5060.64
7_L69_C0.5060.64
74_S78_H0.5060.64
31_S34_A0.5060.64
267_R287_T0.5050.64
234_N245_D0.5050.64
115_Q307_Y0.5040.64
261_L297_F0.5040.64
217_L220_S0.5040.64
266_S269_L0.5040.64
259_Y263_T0.5010.63
233_Y236_D0.5000.63
68_S181_L0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h5l_A 1 0.9938 100 0.332 Contact Map
4xfk_A 1 0.9938 100 0.334 Contact Map
4gnr_A 1 0.891 100 0.335 Contact Map
4zpj_A 1 1 100 0.339 Contact Map
1pea_A 1 0.9938 100 0.345 Contact Map
3td9_A 1 0.9969 100 0.347 Contact Map
4n0q_A 1 0.9907 100 0.347 Contact Map
4maa_A 1 0.9969 100 0.349 Contact Map
4mpt_A 1 0.9969 100 0.355 Contact Map
1usg_A 1 0.9938 100 0.359 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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