T0920_2_322 - CASP12 - GREMLIN Contacts

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T0920_2_322 - T0920 2-322

ID:	94	Sequences: PVVGVILPFSSAFEDIAVEQQRAVELALAESGSAFEIVFKDGGADVDTAVQAFQDLVRSQENLAAVVSCSSWASSAIHPLAAEKDIFHVAIGSAALKRTEPGHTIRLTVGVQQEQEQLAAYLTDFERIAVLAMDNNLGSSWIRMLEDRFPKQVVAAQEYNPQQMDIAAQLATIKARDSEALVLISAGEAATIAKQARQAGIKAQLVGTRPIQRAEVLAASAFTNGLVYTYPSYNQDHPFMSAFTDRYGLEPGFFGVEAYDLCTTLSRALEQGRQTPKALFEWYAGNTFTGALGKVTFANDGDASYPYIFKKVTESGFRVAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	321 (315)
Sequences:	3833 (2272)
Seq/√Len:	128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
29_A	246_R	5.604	1.00
146_E	156_A	3.882	1.00
2_V	36_E	3.777	1.00
241_S	245_D	3.485	1.00
267_R	270_E	3.199	1.00
49_A	73_A	3.181	1.00
267_R	271_Q	3.035	1.00
31_S	266_S	3.015	1.00
21_Q	25_E	3.010	1.00
237_H	241_S	2.969	1.00
157_Q	172_T	2.883	1.00
238_P	242_A	2.824	1.00
40_K	55_D	2.783	1.00
4_G	56_L	2.736	1.00
266_S	270_E	2.641	1.00
85_D	103_H	2.617	1.00
30_E	242_A	2.612	1.00
43_G	48_T	2.611	1.00
278_A	281_E	2.435	1.00
25_E	29_A	2.400	1.00
275_T	278_A	2.295	1.00
127_R	177_D	2.282	1.00
6_I	53_F	2.199	1.00
129_A	155_A	2.185	1.00
22_R	243_F	2.162	1.00
128_I	180_A	2.142	1.00
64_A	265_L	2.130	1.00
65_A	81_A	2.108	1.00
287_T	296_T	2.091	1.00
44_A	70_S	2.080	1.00
30_E	263_T	2.077	1.00
244_T	250_E	2.055	1.00
28_L	262_C	1.968	1.00
121_Y	227_V	1.902	1.00
126_E	179_E	1.895	1.00
238_P	241_S	1.888	1.00
289_T	294_K	1.858	1.00
40_K	52_A	1.812	1.00
235_Q	289_T	1.810	1.00
272_G	282_W	1.767	1.00
85_D	277_K	1.766	1.00
242_A	245_D	1.749	1.00
96_L	112_Q	1.748	1.00
35_F	266_S	1.734	1.00
127_R	152_Q	1.729	1.00
162_Q	188_E	1.720	1.00
132_A	158_E	1.717	1.00
24_V	262_C	1.703	1.00
21_Q	39_F	1.699	1.00
68_S	74_S	1.692	1.00
284_A	301_G	1.687	1.00
28_L	37_I	1.674	1.00
146_E	150_P	1.671	1.00
89_V	265_L	1.671	1.00
30_E	259_Y	1.663	1.00
129_A	157_Q	1.657	1.00
262_C	266_S	1.641	1.00
143_R	147_D	1.640	1.00
127_R	154_V	1.590	1.00
64_A	279_L	1.586	1.00
31_S	263_T	1.583	1.00
40_K	60_Q	1.538	1.00
68_S	77_I	1.521	1.00
265_L	269_L	1.505	1.00
277_K	281_E	1.504	1.00
234_N	238_P	1.497	1.00
55_D	60_Q	1.497	1.00
2_V	62_N	1.490	1.00
25_E	246_R	1.474	1.00
147_D	151_K	1.474	1.00
24_V	37_I	1.467	1.00
57_V	80_L	1.466	1.00
129_A	176_R	1.459	1.00
53_F	65_A	1.450	1.00
131_L	192_I	1.439	1.00
6_I	77_I	1.415	1.00
287_T	294_K	1.393	1.00
6_I	52_A	1.392	1.00
159_Y	185_S	1.388	1.00
122_L	206_V	1.386	1.00
20_Q	258_A	1.373	1.00
163_Q	169_Q	1.373	1.00
170_L	195_Q	1.372	1.00
274_Q	278_A	1.366	1.00
6_I	42_G	1.339	1.00
22_R	247_Y	1.329	1.00
128_I	149_F	1.328	1.00
232_S	237_H	1.320	1.00
40_K	56_L	1.312	1.00
269_L	279_L	1.307	1.00
185_S	192_I	1.301	1.00
263_T	266_S	1.289	1.00
22_R	25_E	1.289	1.00
74_S	93_S	1.285	1.00
195_Q	198_Q	1.280	1.00
38_V	60_Q	1.276	1.00
241_S	244_T	1.273	1.00
53_F	81_A	1.270	1.00
215_E	218_A	1.260	1.00
27_A	259_Y	1.255	1.00
105_I	283_Y	1.246	1.00
99_T	106_R	1.245	1.00
270_E	273_R	1.228	1.00
181_L	205_L	1.222	0.99
281_E	284_A	1.219	0.99
25_E	37_I	1.219	0.99
2_V	38_V	1.210	0.99
45_D	48_T	1.210	0.99
31_S	35_F	1.200	0.99
107_L	264_T	1.200	0.99
26_L	30_E	1.195	0.99
148_R	151_K	1.192	0.99
145_L	182_V	1.174	0.99
5_V	37_I	1.170	0.99
264_T	283_Y	1.168	0.99
180_A	206_V	1.164	0.99
25_E	39_F	1.152	0.99
107_L	261_L	1.142	0.99
144_M	147_D	1.135	0.99
71_S	95_A	1.131	0.99
50_V	54_Q	1.116	0.99
42_G	73_A	1.106	0.99
129_A	154_V	1.103	0.99
260_D	290_G	1.101	0.99
57_V	86_I	1.094	0.99
105_I	280_F	1.094	0.99
52_A	56_L	1.086	0.99
74_S	88_H	1.078	0.99
66_V	261_L	1.077	0.99
86_I	276_P	1.076	0.99
82_A	102_G	1.074	0.99
170_L	199_A	1.071	0.99
125_F	180_A	1.068	0.99
42_G	49_A	1.068	0.99
5_V	28_L	1.065	0.99
5_V	24_V	1.060	0.99
26_L	242_A	1.057	0.99
88_H	104_T	1.051	0.98
131_L	170_L	1.046	0.98
264_T	297_F	1.045	0.98
207_G	211_I	1.045	0.98
4_G	62_N	1.040	0.98
3_V	265_L	1.038	0.98
242_A	246_R	1.034	0.98
239_F	255_G	1.034	0.98
87_F	276_P	1.033	0.98
245_D	248_G	1.026	0.98
18_V	22_R	1.021	0.98
66_V	89_V	1.020	0.98
18_V	21_Q	1.019	0.98
26_L	247_Y	1.017	0.98
272_G	279_L	1.015	0.98
139_S	143_R	1.012	0.98
54_Q	58_R	1.011	0.98
62_N	65_A	1.008	0.98
271_Q	285_G	1.004	0.98
22_R	249_L	0.999	0.98
26_L	246_R	0.998	0.98
90_A	93_S	0.997	0.98
193_A	205_L	0.994	0.98
115_Q	141_W	0.993	0.98
27_A	266_S	0.992	0.98
3_V	64_A	0.987	0.98
27_A	262_C	0.985	0.98
31_S	262_C	0.983	0.98
8_P	42_G	0.981	0.98
224_N	314_E	0.976	0.98
9_F	39_F	0.975	0.97
131_L	169_Q	0.975	0.97
174_K	177_D	0.972	0.97
116_E	148_R	0.971	0.97
70_S	73_A	0.971	0.97
129_A	178_S	0.962	0.97
115_Q	119_A	0.952	0.97
20_Q	69_C	0.947	0.97
89_V	261_L	0.943	0.97
95_A	106_R	0.939	0.97
267_R	286_N	0.935	0.97
19_E	252_G	0.935	0.97
258_A	262_C	0.935	0.97
99_T	302_D	0.933	0.97
121_Y	206_V	0.932	0.97
280_F	284_A	0.929	0.97
134_D	160_N	0.926	0.97
130_V	142_I	0.924	0.97
154_V	178_S	0.924	0.97
24_V	258_A	0.918	0.96
23_A	27_A	0.911	0.96
23_A	258_A	0.911	0.96
23_A	255_G	0.909	0.96
272_G	278_A	0.904	0.96
196_A	201_I	0.904	0.96
27_A	263_T	0.890	0.96
5_V	39_F	0.888	0.96
9_F	21_Q	0.888	0.96
171_A	175_A	0.888	0.96
94_A	111_V	0.888	0.96
154_V	176_R	0.886	0.96
122_L	125_F	0.885	0.96
267_R	285_G	0.879	0.95
103_H	280_F	0.872	0.95
48_T	52_A	0.870	0.95
81_A	88_H	0.869	0.95
132_A	142_I	0.868	0.95
63_L	86_I	0.865	0.95
52_A	55_D	0.864	0.95
138_G	184_I	0.863	0.95
170_L	196_A	0.859	0.95
221_A	314_E	0.850	0.94
27_A	31_S	0.850	0.94
132_A	156_A	0.849	0.94
197_R	222_F	0.844	0.94
120_A	148_R	0.844	0.94
142_I	156_A	0.842	0.94
106_R	302_D	0.841	0.94
24_V	66_V	0.839	0.94
163_Q	166_I	0.838	0.94
227_V	311_K	0.832	0.94
8_P	17_A	0.827	0.94
38_V	62_N	0.825	0.94
75_S	98_R	0.825	0.94
79_P	83_E	0.825	0.94
121_Y	309_F	0.818	0.93
118_L	206_V	0.815	0.93
256_V	291_A	0.814	0.93
170_L	192_I	0.813	0.93
173_I	178_S	0.810	0.93
277_K	280_F	0.810	0.93
74_S	90_A	0.809	0.93
260_D	292_L	0.808	0.93
4_G	38_V	0.808	0.93
38_V	56_L	0.808	0.93
122_L	128_I	0.794	0.92
16_I	69_C	0.793	0.92
72_W	93_S	0.792	0.92
160_N	163_Q	0.790	0.92
268_A	283_Y	0.789	0.92
82_A	103_H	0.789	0.92
142_I	146_E	0.789	0.92
57_V	65_A	0.787	0.92
134_D	139_S	0.783	0.92
129_A	173_I	0.781	0.92
170_L	201_I	0.778	0.91
197_R	202_K	0.776	0.91
44_A	73_A	0.775	0.91
194_K	198_Q	0.774	0.91
181_L	196_A	0.770	0.91
13_F	70_S	0.768	0.91
240_M	244_T	0.768	0.91
213_R	252_G	0.766	0.91
119_A	145_L	0.759	0.90
211_I	226_L	0.755	0.90
130_V	156_A	0.751	0.90
183_L	192_I	0.750	0.90
63_L	269_L	0.749	0.90
205_L	226_L	0.748	0.90
56_L	62_N	0.748	0.90
53_F	77_I	0.747	0.90
89_V	107_L	0.747	0.90
111_V	140_S	0.745	0.90
87_F	280_F	0.743	0.89
3_V	262_C	0.743	0.89
57_V	81_A	0.740	0.89
122_L	145_L	0.739	0.89
9_F	17_A	0.738	0.89
269_L	274_Q	0.738	0.89
63_L	276_P	0.736	0.89
243_F	247_Y	0.734	0.89
166_I	195_Q	0.732	0.89
135_N	161_P	0.731	0.89
129_A	172_T	0.731	0.89
75_S	97_K	0.731	0.89
267_R	288_F	0.730	0.89
182_V	229_T	0.729	0.89
164_M	191_T	0.724	0.88
155_A	172_T	0.722	0.88
181_L	201_I	0.721	0.88
243_F	255_G	0.721	0.88
50_V	80_L	0.719	0.88
131_L	173_I	0.718	0.88
244_T	248_G	0.718	0.88
174_K	203_A	0.714	0.88
90_A	98_R	0.714	0.88
131_L	183_L	0.713	0.87
57_V	84_K	0.711	0.87
53_F	84_K	0.710	0.87
268_A	279_L	0.708	0.87
118_L	182_V	0.708	0.87
35_F	262_C	0.706	0.87
94_A	108_T	0.704	0.87
271_Q	286_N	0.700	0.86
58_R	84_K	0.700	0.86
174_K	201_I	0.699	0.86
71_S	106_R	0.698	0.86
150_P	153_V	0.696	0.86
63_L	87_F	0.695	0.86
2_V	60_Q	0.692	0.86
238_P	245_D	0.690	0.86
64_A	269_L	0.687	0.85
77_I	81_A	0.685	0.85
125_F	179_E	0.684	0.85
221_A	224_N	0.682	0.85
8_P	68_S	0.681	0.85
237_H	245_D	0.680	0.85
61_E	85_D	0.679	0.85
195_Q	199_A	0.678	0.85
37_I	49_A	0.678	0.85
143_R	156_A	0.677	0.85
54_Q	80_L	0.676	0.85
194_K	220_S	0.675	0.84
146_E	153_V	0.670	0.84
189_A	216_V	0.670	0.84
116_E	120_A	0.670	0.84
93_S	98_R	0.669	0.84
172_T	175_A	0.669	0.84
196_A	204_Q	0.668	0.84
165_D	195_Q	0.667	0.84
53_F	57_V	0.666	0.84
239_F	251_P	0.666	0.84
42_G	68_S	0.665	0.84
109_V	114_E	0.661	0.83
111_V	137_L	0.659	0.83
105_I	297_F	0.658	0.83
13_F	44_A	0.656	0.83
268_A	272_G	0.656	0.83
145_L	149_F	0.656	0.83
75_S	95_A	0.655	0.83
26_L	243_F	0.655	0.83
122_L	180_A	0.653	0.82
271_Q	282_W	0.652	0.82
141_W	182_V	0.651	0.82
159_Y	192_I	0.648	0.82
105_I	301_G	0.647	0.82
224_N	313_T	0.646	0.82
89_V	283_Y	0.643	0.81
55_D	59_S	0.642	0.81
4_G	65_A	0.642	0.81
50_V	76_A	0.640	0.81
94_A	106_R	0.639	0.81
267_R	282_W	0.637	0.81
64_A	87_F	0.637	0.81
26_L	29_A	0.635	0.81
29_A	242_A	0.634	0.81
70_S	93_S	0.633	0.80
285_G	296_T	0.631	0.80
7_L	21_Q	0.630	0.80
271_Q	284_A	0.628	0.80
24_V	28_L	0.624	0.80
172_T	176_R	0.623	0.79
280_F	301_G	0.623	0.79
240_M	251_P	0.621	0.79
115_Q	137_L	0.620	0.79
82_A	101_P	0.613	0.78
139_S	158_E	0.613	0.78
10_S	14_E	0.612	0.78
243_F	251_P	0.612	0.78
257_E	261_L	0.612	0.78
74_S	98_R	0.611	0.78
235_Q	238_P	0.610	0.78
2_V	61_E	0.608	0.78
118_L	229_T	0.607	0.78
61_E	278_A	0.605	0.77
100_E	300_D	0.604	0.77
181_L	266_S	0.603	0.77
30_E	238_P	0.602	0.77
103_H	277_K	0.602	0.77
78_H	101_P	0.601	0.77
8_P	44_A	0.599	0.77
148_R	152_Q	0.599	0.77
135_N	139_S	0.597	0.76
236_D	240_M	0.596	0.76
25_E	247_Y	0.593	0.76
16_I	210_P	0.588	0.75
54_Q	84_K	0.586	0.75
9_F	40_K	0.584	0.75
95_A	111_V	0.583	0.75
115_Q	182_V	0.582	0.75
69_C	92_G	0.581	0.75
83_E	171_A	0.581	0.75
29_A	247_Y	0.577	0.74
80_L	83_E	0.577	0.74
28_L	266_S	0.577	0.74
53_F	56_L	0.576	0.74
189_A	211_I	0.575	0.74
207_G	226_L	0.575	0.74
127_R	179_E	0.575	0.74
154_V	157_Q	0.572	0.73
181_L	203_A	0.571	0.73
122_L	304_S	0.570	0.73
212_Q	228_Y	0.569	0.73
11_S	17_A	0.568	0.73
141_W	209_R	0.566	0.73
3_V	66_V	0.565	0.73
25_E	36_E	0.564	0.72
23_A	262_C	0.564	0.72
87_F	283_Y	0.563	0.72
235_Q	263_T	0.562	0.72
8_P	69_C	0.560	0.72
236_D	291_A	0.559	0.72
295_V	303_A	0.558	0.72
256_V	292_L	0.558	0.72
230_Y	253_F	0.557	0.71
144_M	148_R	0.557	0.71
127_R	150_P	0.557	0.71
130_V	153_V	0.556	0.71
101_P	104_T	0.553	0.71
113_Q	117_Q	0.553	0.71
16_I	254_F	0.552	0.71
78_H	98_R	0.552	0.71
36_E	241_S	0.551	0.71
196_A	205_L	0.551	0.71
120_A	152_Q	0.550	0.71
278_A	282_W	0.550	0.71
114_E	141_W	0.548	0.70
276_P	279_L	0.546	0.70
127_R	176_R	0.543	0.70
20_Q	92_G	0.543	0.70
58_R	80_L	0.541	0.69
292_L	305_Y	0.541	0.69
74_S	106_R	0.540	0.69
26_L	259_Y	0.540	0.69
116_E	147_D	0.539	0.69
6_I	68_S	0.539	0.69
65_A	68_S	0.538	0.69
260_D	263_T	0.537	0.69
173_I	192_I	0.535	0.68
91_I	258_A	0.535	0.68
86_I	103_H	0.535	0.68
243_F	249_L	0.534	0.68
279_L	282_W	0.534	0.68
50_V	78_H	0.533	0.68
193_A	216_V	0.532	0.68
84_K	87_F	0.531	0.68
217_L	223_T	0.530	0.68
48_T	51_Q	0.529	0.68
107_L	288_F	0.528	0.67
234_N	237_H	0.527	0.67
49_A	52_A	0.527	0.67
10_S	41_D	0.526	0.67
141_W	184_I	0.526	0.67
273_R	278_A	0.525	0.67
2_V	152_Q	0.525	0.67
186_A	210_P	0.524	0.67
87_F	279_L	0.524	0.67
271_Q	287_T	0.522	0.67
312_V	315_S	0.521	0.66
269_L	273_R	0.520	0.66
8_P	70_S	0.519	0.66
20_Q	91_I	0.519	0.66
78_H	81_A	0.518	0.66
34_A	245_D	0.517	0.66
263_T	288_F	0.516	0.66
137_L	184_I	0.515	0.66
126_E	245_D	0.515	0.66
147_D	150_P	0.513	0.65
137_L	141_W	0.513	0.65
167_A	199_A	0.512	0.65
75_S	79_P	0.511	0.65
54_Q	57_V	0.510	0.65
236_D	256_V	0.506	0.64
7_L	69_C	0.506	0.64
74_S	78_H	0.506	0.64
31_S	34_A	0.506	0.64
267_R	287_T	0.505	0.64
234_N	245_D	0.505	0.64
115_Q	307_Y	0.504	0.64
261_L	297_F	0.504	0.64
217_L	220_S	0.504	0.64
266_S	269_L	0.504	0.64
259_Y	263_T	0.501	0.63
233_Y	236_D	0.500	0.63
68_S	181_L	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3h5l_A	1	0.9938	100	0.332	Contact Map
4xfk_A	1	0.9938	100	0.334	Contact Map
4gnr_A	1	0.891	100	0.335	Contact Map
4zpj_A	1	1	100	0.339	Contact Map
1pea_A	1	0.9938	100	0.345	Contact Map
3td9_A	1	0.9969	100	0.347	Contact Map
4n0q_A	1	0.9907	100	0.347	Contact Map
4maa_A	1	0.9969	100	0.349	Contact Map
4mpt_A	1	0.9969	100	0.355	Contact Map
1usg_A	1	0.9938	100	0.359	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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