GREMLIN Database
T0927_1_91 - T0927 1-91
ID: 93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (91)
Sequences: 218 (145)
Seq/√Len: 15.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_V54_I4.3061.00
17_L50_Q2.8680.97
17_L24_L2.7290.96
79_P82_C2.6570.96
24_L39_K2.0860.86
82_C89_E2.0010.83
36_L50_Q1.8480.78
67_D70_N1.7980.76
22_G26_K1.7630.74
39_K78_L1.6260.68
43_L50_Q1.6230.68
50_Q61_I1.5800.66
38_R45_S1.5410.64
64_I68_I1.5340.63
85_T90_K1.4950.61
2_G20_I1.4910.61
53_A71_L1.4470.59
10_D42_D1.4470.59
2_G6_L1.4350.58
51_E72_E1.4100.57
24_L28_K1.3950.56
44_E58_N1.3870.55
88_I91_P1.3470.53
5_Q10_D1.3000.51
40_V61_I1.2940.50
2_G71_L1.2760.49
2_G88_I1.2390.47
67_D79_P1.2240.46
85_T91_P1.2140.46
72_E84_N1.1970.45
44_E67_D1.1970.45
44_E72_E1.1970.45
80_T86_P1.1930.45
64_I71_L1.1620.43
50_Q78_L1.1440.42
11_T62_A1.1310.41
87_S90_K1.1080.40
21_E44_E1.1000.39
47_A64_I1.0970.39
71_L90_K1.0910.39
11_T23_S1.0840.39
58_N66_K1.0840.39
78_L82_C1.0810.38
50_Q64_I1.0710.38
25_N62_A1.0380.36
74_I79_P1.0190.35
35_D57_Y1.0090.35
67_D74_I1.0090.35
8_Q40_V0.9940.34
63_E66_K0.9860.33
66_K80_T0.9820.33
75_K91_P0.9820.33
61_I67_D0.9790.33
68_I91_P0.9610.32
5_Q16_K0.9570.32
33_A69_H0.9510.32
58_N78_L0.9490.32
40_V56_D0.9290.31
61_I65_I0.9260.30
69_H76_K0.9240.30
9_L15_N0.9190.30
70_N74_I0.9180.30
4_D29_D0.8990.29
7_G75_K0.8920.29
68_I88_I0.8920.29
77_T90_K0.8900.29
19_E51_E0.8860.29
87_S91_P0.8860.29
36_L64_I0.8790.28
49_K67_D0.8770.28
2_G68_I0.8760.28
42_D66_K0.8750.28
47_A73_D0.8700.28
17_L81_G0.8670.28
21_E72_E0.8620.28
45_S60_D0.8540.27
13_D20_I0.8530.27
24_L27_A0.8290.26
51_E61_I0.8120.25
6_L28_K0.8090.25
26_K86_P0.7950.25
72_E75_K0.7940.25
18_N54_I0.7750.24
4_D22_G0.7730.24
81_G86_P0.7620.23
70_N82_C0.7610.23
35_D59_R0.7570.23
10_D40_V0.7480.23
35_D38_R0.7470.23
37_D55_M0.7350.22
25_N31_M0.7230.22
37_D86_P0.7150.21
19_E22_G0.7100.21
32_K37_D0.6990.21
44_E53_A0.6930.21
2_G28_K0.6900.20
4_D25_N0.6800.20
80_T83_F0.6790.20
72_E76_K0.6790.20
20_I68_I0.6790.20
21_E37_D0.6760.20
73_D76_K0.6680.20
30_E77_T0.6640.20
8_Q28_K0.6610.19
3_F81_G0.6570.19
12_V53_A0.6560.19
56_D76_K0.6460.19
47_A63_E0.6410.19
48_R60_D0.6210.18
74_I82_C0.6050.18
9_L43_L0.6030.17
16_K35_D0.6030.17
3_F27_A0.6020.17
36_L43_L0.6010.17
37_D51_E0.5970.17
27_A42_D0.5940.17
46_E49_K0.5930.17
17_L78_L0.5920.17
57_Y87_S0.5900.17
41_S59_R0.5810.17
85_T88_I0.5800.17
29_D45_S0.5730.16
19_E33_A0.5690.16
82_C88_I0.5580.16
71_L82_C0.5510.16
40_V69_H0.5470.16
7_G43_L0.5460.16
67_D78_L0.5440.16
36_L84_N0.5400.15
39_K48_R0.5310.15
43_L57_Y0.5250.15
44_E62_A0.5210.15
83_F89_E0.5170.15
4_D26_K0.5170.15
14_L36_L0.5020.14
29_D35_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5bu8_A 1 0.1429 93.9 0.716 Contact Map
3c9i_A 1 0.9451 93.8 0.716 Contact Map
3ghg_B 1 0.978 68.8 0.798 Contact Map
3ghg_C 1 0.978 65.2 0.802 Contact Map
3ghg_A 1 1 64.2 0.804 Contact Map
1deq_A 1 0.9231 59.7 0.809 Contact Map
1m1j_B 1 1 54.3 0.815 Contact Map
4rsj_A 1 0.7802 53.1 0.816 Contact Map
4lin_A 1 0.967 52.7 0.817 Contact Map
4cgk_A 1 0.8681 52.3 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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