GREMLIN Database
T0926_1_88 - T0926 1-88
ID: 92 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (74)
Sequences: 240 (174)
Seq/√Len: 20.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_Y52_N2.9150.99
22_E25_Q2.4580.97
24_L42_L2.3840.97
76_D80_K2.2870.96
24_L31_L2.1440.94
39_L74_L2.1260.93
77_I87_C2.0650.92
23_L26_N1.9620.90
77_I84_Y1.8950.89
70_V73_L1.7680.85
46_E84_Y1.6950.82
80_K83_V1.6660.81
42_L74_L1.5590.76
28_A31_L1.5530.76
28_A35_A1.4950.73
42_L49_Y1.4920.73
18_R39_L1.4860.73
32_L35_A1.4610.71
26_N30_T1.4140.69
17_A39_L1.3920.68
24_L66_L1.3660.66
31_L35_A1.3360.64
29_K33_A1.3330.64
28_A66_L1.3250.64
19_R38_K1.3180.63
63_L66_L1.2870.61
26_N36_N1.2590.60
84_Y87_C1.2450.59
16_D57_E1.2410.58
27_E59_K1.2280.58
43_E79_E1.2050.56
38_K49_Y1.1570.53
57_E80_K1.0960.49
40_Q54_K1.0960.49
75_K80_K1.0750.48
67_E84_Y1.0660.47
20_K28_A1.0510.46
21_A63_L1.0470.46
16_D54_K1.0370.45
26_N37_S1.0040.43
51_D58_D0.9950.43
85_S88_L0.9940.42
45_L81_V0.9880.42
36_N54_K0.9510.40
78_S85_S0.9460.39
62_E76_D0.9350.39
68_G82_A0.9200.38
59_K73_L0.9200.38
67_E86_T0.9170.38
19_R72_S0.8820.36
37_S41_L0.8510.34
23_L51_D0.8420.33
41_L59_K0.8320.33
18_R22_E0.8260.32
21_A29_K0.8260.32
61_Q69_E0.8240.32
67_E85_S0.8160.32
68_G72_S0.8140.32
59_K67_E0.8100.31
28_A63_L0.7930.30
16_D19_R0.7930.30
25_Q49_Y0.7810.30
31_L66_L0.7800.30
25_Q28_A0.7760.30
25_Q85_S0.7650.29
18_R50_E0.7640.29
38_K74_L0.7600.29
53_Q77_I0.7520.28
21_A73_L0.7520.28
21_A24_L0.7440.28
82_A85_S0.7380.27
63_L70_V0.7360.27
51_D55_Y0.7140.26
54_K72_S0.7140.26
45_L67_E0.7110.26
31_L45_L0.7070.26
38_K60_A0.7030.26
21_A32_L0.7010.26
69_E78_S0.6890.25
36_N43_E0.6800.25
52_N56_L0.6770.24
60_A69_E0.6710.24
23_L30_T0.6640.24
21_A56_L0.6460.23
42_L65_R0.6430.23
23_L75_K0.6350.22
57_E64_V0.6260.22
32_L81_V0.6240.22
33_A43_E0.6190.22
58_D61_Q0.5960.21
26_N70_V0.5770.20
45_L56_L0.5700.20
18_R35_A0.5680.20
62_E71_R0.5620.19
37_S58_D0.5590.19
37_S65_R0.5500.19
17_A57_E0.5440.19
38_K46_E0.5390.18
74_L87_C0.5320.18
70_V77_I0.5280.18
49_Y55_Y0.5260.18
44_D58_D0.5200.18
33_A41_L0.5200.18
48_K80_K0.5170.18
15_A43_E0.5160.18
82_A86_T0.5140.17
63_L80_K0.5110.17
55_Y69_E0.5090.17
41_L67_E0.5080.17
45_L49_Y0.5010.17
30_T40_Q0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c9i_A 1 1 88.8 0.692 Contact Map
4lin_A 1 1 83.7 0.714 Contact Map
5bu8_A 1 0.1477 81.3 0.722 Contact Map
4cgk_A 1 0.8409 78.9 0.729 Contact Map
1i84_S 1 0.0682 74.8 0.738 Contact Map
4q4g_X 1 0 73.7 0.74 Contact Map
3ghg_A 1 0.9659 73.5 0.741 Contact Map
1deq_A 1 0.9886 72.8 0.742 Contact Map
2dfs_A 1 0.875 71.2 0.745 Contact Map
4rsi_B 1 1 64.9 0.756 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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