GREMLIN Database
T0925_1_87 - T0925 1-87
ID: 91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (78)
Sequences: 155 (117)
Seq/√Len: 13.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_I68_L4.8041.00
72_A76_A3.0860.97
67_L71_R1.8920.74
29_L37_M1.8690.73
77_A82_A1.7690.69
10_N13_V1.6560.64
69_I76_A1.6440.63
82_A85_A1.5830.60
25_M30_A1.5750.60
12_T15_E1.5550.59
36_D40_Q1.5470.58
17_N21_H1.5320.57
42_N78_S1.5240.57
36_D39_M1.4520.53
42_N85_A1.4310.52
68_L71_R1.4260.52
16_T79_I1.4080.51
14_Q21_H1.3900.50
65_I71_R1.3730.49
18_D36_D1.3560.48
71_R79_I1.3480.48
55_E83_V1.3480.48
43_L70_S1.3230.46
27_T30_A1.3220.46
22_N27_T1.3130.46
27_T31_G1.2970.45
25_M29_L1.2920.45
62_L84_S1.2490.43
69_I72_A1.2350.42
82_A87_R1.2060.40
61_N72_A1.1660.38
33_K37_M1.1520.38
15_E22_N1.1410.37
14_Q46_D1.1350.37
38_E58_L1.1350.37
47_R53_T1.0910.35
41_A54_L1.0780.34
71_R76_A1.0700.34
23_S49_K1.0610.33
13_V17_N1.0540.33
31_G42_N1.0510.33
20_L77_A1.0430.32
57_N65_I1.0400.32
66_K73_R1.0320.32
65_I82_A0.9870.30
19_L23_S0.9840.30
25_M28_L0.9730.29
32_R43_L0.9630.29
14_Q20_L0.9410.28
56_E80_K0.9240.27
73_R76_A0.9230.27
24_T30_A0.9210.27
19_L25_M0.8980.26
11_A15_E0.8970.26
33_K42_N0.8920.26
55_E84_S0.8910.26
10_N32_R0.8850.26
21_H24_T0.8830.26
33_K61_N0.8640.25
23_S37_M0.8630.25
61_N69_I0.8600.25
10_N14_Q0.8530.24
10_N35_K0.8420.24
31_G58_L0.8330.24
46_D52_K0.8200.23
11_A14_Q0.8180.23
33_K62_L0.8140.23
66_K76_A0.8120.23
39_M46_D0.7960.22
14_Q17_N0.7820.22
73_R77_A0.7760.21
37_M59_S0.7570.21
70_S85_A0.7440.20
23_S72_A0.7440.20
61_N87_R0.7280.20
74_K79_I0.7280.20
47_R86_D0.7260.20
55_E64_E0.7260.20
21_H32_R0.7220.20
67_L84_S0.7220.20
10_N18_D0.7010.19
58_L83_V0.7000.19
48_L68_L0.6900.19
15_E21_H0.6900.19
29_L34_M0.6900.19
11_A17_N0.6860.18
11_A21_H0.6810.18
41_A86_D0.6800.18
17_N37_M0.6770.18
54_L72_A0.6590.18
68_L78_S0.6580.18
62_L86_D0.6530.17
30_A81_V0.6530.17
13_V20_L0.6520.17
42_N47_R0.6500.17
20_L53_T0.6390.17
11_A18_D0.6200.16
10_N16_T0.6200.16
35_K84_S0.6080.16
26_T65_I0.6030.16
19_L26_T0.5980.16
57_N69_I0.5960.16
34_M62_L0.5950.16
75_Q80_K0.5940.16
67_L76_A0.5870.16
36_D46_D0.5870.16
41_A55_E0.5750.15
79_I83_V0.5600.15
34_M68_L0.5580.15
63_S67_L0.5550.15
48_L61_N0.5440.14
70_S74_K0.5340.14
64_E83_V0.5330.14
71_R82_A0.5170.14
75_Q81_V0.5060.13
36_D77_A0.5060.13
24_T47_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c9i_A 1 1 85.8 0.765 Contact Map
5bu8_A 1 0.1609 80.2 0.779 Contact Map
4q4g_X 1 0 79.4 0.781 Contact Map
4cgk_A 1 0.8506 78.5 0.783 Contact Map
2yko_A 1 0.6092 44.2 0.827 Contact Map
4lin_A 1 1 39.9 0.831 Contact Map
5amo_A 1 0 37 0.834 Contact Map
2ch7_A 1 0.9195 34.8 0.837 Contact Map
4uxv_A 1 0.9655 30.5 0.841 Contact Map
4rh7_A 1 0.954 29.2 0.843 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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